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Volumn 22, Issue 6, 2011, Pages 373-382

Flow cytometric measurement of cellular FLICE-inhibitory protein (c-FLIP) in ovarian carcinoma effusions

Author keywords

Apoptosis; C FLIP; Cytology specimens; Flow cytometry; Ovarian carcinoma; Serous effusions

Indexed keywords

CASPASE 3; FLICE INHIBITORY PROTEIN;

EID: 81355138272     PISSN: 09565507     EISSN: 13652303     Source Type: Journal    
DOI: 10.1111/j.1365-2303.2011.00929.x     Document Type: Article
Times cited : (5)

References (42)
  • 2
    • 28244442462 scopus 로고    scopus 로고
    • Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease
    • Fadeel B, Orrenius S. Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Intern Med 2005;258:479-517.
    • (2005) J Intern Med , vol.258 , pp. 479-517
    • Fadeel, B.1    Orrenius, S.2
  • 3
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456-62.
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 4
    • 24044438464 scopus 로고    scopus 로고
    • Apoptotic pathways and therapy resistance in human malignancies
    • Viktorsson K, Lewensohn R, Zhivotovsky B. Apoptotic pathways and therapy resistance in human malignancies. Adv Cancer Res 2005;94:143-96.
    • (2005) Adv Cancer Res , vol.94 , pp. 143-196
    • Viktorsson, K.1    Lewensohn, R.2    Zhivotovsky, B.3
  • 5
    • 25144489068 scopus 로고    scopus 로고
    • Overview of cell death signaling pathways
    • Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Cancer Biol Ther 2005;4:139-63.
    • (2005) Cancer Biol Ther , vol.4 , pp. 139-163
    • Jin, Z.1    El-Deiry, W.S.2
  • 6
    • 0037169358 scopus 로고    scopus 로고
    • Apoptosis: a link between cancer genetics and chemotherapy
    • Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell 2002;108:153-64.
    • (2002) Cell , vol.108 , pp. 153-164
    • Johnstone, R.W.1    Ruefli, A.A.2    Lowe, S.W.3
  • 7
    • 0030800070 scopus 로고    scopus 로고
    • Inhibition of death receptor signals by cellular FLIP
    • Irmler M, Thome M, Hahne M et al. Inhibition of death receptor signals by cellular FLIP. Nature 1997;388:190-5.
    • (1997) Nature , vol.388 , pp. 190-195
    • Irmler, M.1    Thome, M.2    Hahne, M.3
  • 8
    • 0033556310 scopus 로고    scopus 로고
    • The role of c-FLIP in modulation of CD95-induced apoptosis
    • Scaffidi C, Schmitz I, Krammer PH, Peter ME. The role of c-FLIP in modulation of CD95-induced apoptosis. J Biol Chem 1999;274:1541-8.
    • (1999) J Biol Chem , vol.274 , pp. 1541-1548
    • Scaffidi, C.1    Schmitz, I.2    Krammer, P.H.3    Peter, M.E.4
  • 9
    • 73749083635 scopus 로고    scopus 로고
    • Cellular FLICE-inhibitory protein (c-FLIP) signalling: a key regulator of receptor-mediated apoptosis in physiologic context and in cancer
    • Bagnoli M, Canevari S, Mezzanzanica D. Cellular FLICE-inhibitory protein (c-FLIP) signalling: a key regulator of receptor-mediated apoptosis in physiologic context and in cancer. Int J Biochem Cell Biol 2010;42:210-3.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 210-213
    • Bagnoli, M.1    Canevari, S.2    Mezzanzanica, D.3
  • 10
    • 0035827569 scopus 로고    scopus 로고
    • Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex
    • Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J Biol Chem 2001;276:20633-40.
    • (2001) J Biol Chem , vol.276 , pp. 20633-20640
    • Krueger, A.1    Schmitz, I.2    Baumann, S.3    Krammer, P.H.4    Kirchhoff, S.5
  • 11
    • 33344476184 scopus 로고    scopus 로고
    • cFLIP regulation of lymphocyte activation and development
    • Budd RC, Yeh WC, Tschopp J. cFLIP regulation of lymphocyte activation and development. Nat Rev Immunol 2006;6:196-204.
    • (2006) Nat Rev Immunol , vol.6 , pp. 196-204
    • Budd, R.C.1    Yeh, W.C.2    Tschopp, J.3
  • 12
    • 27544432516 scopus 로고    scopus 로고
    • Nonapoptotic functions of FADD-binding death receptors and their signaling molecules
    • Park SM, Schickel R, Peter ME. Nonapoptotic functions of FADD-binding death receptors and their signaling molecules. Curr Opin Cell Biol 2005;17:610-6.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 610-616
    • Park, S.M.1    Schickel, R.2    Peter, M.E.3
  • 14
    • 18744425429 scopus 로고    scopus 로고
    • The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways
    • Kataoka T, Budd RC, Holler N et al. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Curr Biol 2000;10:640-8.
    • (2000) Curr Biol , vol.10 , pp. 640-648
    • Kataoka, T.1    Budd, R.C.2    Holler, N.3
  • 15
    • 4344660599 scopus 로고    scopus 로고
    • Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis
    • Chawla-Sarkar M, Bae SI, Reu FJ et al. Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ 2004;11:915-23.
    • (2004) Cell Death Differ , vol.11 , pp. 915-923
    • Chawla-Sarkar, M.1    Bae, S.I.2    Reu, F.J.3
  • 16
    • 34548842228 scopus 로고    scopus 로고
    • Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients
    • Ullenhag GJ, Mukherjee A, Watson NF et al. Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients. Clin Cancer Res 2007;13:5070-5.
    • (2007) Clin Cancer Res , vol.13 , pp. 5070-5075
    • Ullenhag, G.J.1    Mukherjee, A.2    Watson, N.F.3
  • 17
    • 34447515452 scopus 로고    scopus 로고
    • c-FLIP expression in colorectal carcinomas: association with Fas/FasL expression and prognostic implications
    • Korkolopoulou P, Saetta AA, Levidou G et al. c-FLIP expression in colorectal carcinomas: association with Fas/FasL expression and prognostic implications. Histopathology 2007;51:150-6.
    • (2007) Histopathology , vol.51 , pp. 150-156
    • Korkolopoulou, P.1    Saetta, A.A.2    Levidou, G.3
  • 18
    • 21644443678 scopus 로고    scopus 로고
    • Regulation of the resistance to TRAIL-induced apoptosis as a new strategy for pancreatic cancer
    • Mori T, Doi R, Toyoda E et al. Regulation of the resistance to TRAIL-induced apoptosis as a new strategy for pancreatic cancer. Surgery 2005;138:450-5.
    • (2005) Surgery , vol.138 , pp. 450-455
    • Mori, T.1    Doi, R.2    Toyoda, E.3
  • 19
    • 59149087882 scopus 로고    scopus 로고
    • Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells
    • Murtaza I, Saleem M, Adhami VM, Hafeez BB, Mukhtar H. Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells. Cancer Res 2009;69:1156-65.
    • (2009) Cancer Res , vol.69 , pp. 1156-1165
    • Murtaza, I.1    Saleem, M.2    Adhami, V.M.3    Hafeez, B.B.4    Mukhtar, H.5
  • 20
    • 34250730846 scopus 로고    scopus 로고
    • Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells
    • Rogers KM, Thomas M, Galligan L et al. Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells. Mol Cancer Ther 2007;6:1544-51.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1544-1551
    • Rogers, K.M.1    Thomas, M.2    Galligan, L.3
  • 21
    • 77951937736 scopus 로고    scopus 로고
    • The role of c-FLIP(L) in ovarian cancer: chaperoning tumor cells from immunosurveillance and increasing their invasive potential
    • El-Gazzar A, Wittinger M, Perco P et al. The role of c-FLIP(L) in ovarian cancer: chaperoning tumor cells from immunosurveillance and increasing their invasive potential. Gynecol Oncol 2010;117:451-9.
    • (2010) Gynecol Oncol , vol.117 , pp. 451-459
    • El-Gazzar, A.1    Wittinger, M.2    Perco, P.3
  • 22
    • 29344473740 scopus 로고    scopus 로고
    • Perturbation of the tumor necrosis factor - related apoptosis-inducing ligand cascade in ovarian cancer: overexpression of FLIPL and deregulation of the functional receptors DR4 and DR5
    • Horak P, Pils D, Kaider A et al. Perturbation of the tumor necrosis factor - related apoptosis-inducing ligand cascade in ovarian cancer: overexpression of FLIPL and deregulation of the functional receptors DR4 and DR5. Clin Cancer Res 2005;11:8585-91.
    • (2005) Clin Cancer Res , vol.11 , pp. 8585-8591
    • Horak, P.1    Pils, D.2    Kaider, A.3
  • 23
    • 33845722121 scopus 로고    scopus 로고
    • Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis
    • Clarke P, Tyler KL. Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis. Apoptosis 2007;12:211-23.
    • (2007) Apoptosis , vol.12 , pp. 211-223
    • Clarke, P.1    Tyler, K.L.2
  • 24
    • 4143049125 scopus 로고    scopus 로고
    • CD95-mediated apoptosis is impaired at receptor level by cellular FLICE-inhibitory protein (long form) in wild-type p53 human ovarian carcinoma
    • Mezzanzanica D, Balladore E, Turatti F et al. CD95-mediated apoptosis is impaired at receptor level by cellular FLICE-inhibitory protein (long form) in wild-type p53 human ovarian carcinoma. Clin Cancer Res 2004;10:5202-14.
    • (2004) Clin Cancer Res , vol.10 , pp. 5202-5214
    • Mezzanzanica, D.1    Balladore, E.2    Turatti, F.3
  • 25
    • 4844220794 scopus 로고    scopus 로고
    • Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro
    • Abedini MR, Qiu Q, Yan X, Tsang BK. Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro. Oncogene 2004;23:6997-7004.
    • (2004) Oncogene , vol.23 , pp. 6997-7004
    • Abedini, M.R.1    Qiu, Q.2    Yan, X.3    Tsang, B.K.4
  • 26
    • 0037015675 scopus 로고    scopus 로고
    • Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia
    • MacFarlane M, Harper N, Snowden RT et al. Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia. Oncogene 2002;21:6809-18.
    • (2002) Oncogene , vol.21 , pp. 6809-6818
    • MacFarlane, M.1    Harper, N.2    Snowden, R.T.3
  • 27
    • 33644885746 scopus 로고    scopus 로고
    • cFLIP expression correlates with tumour progression and patient outcome in non-Hodgkin lymphomas of low grade of malignancy
    • Valente G, Manfroi F, Peracchio C et al. cFLIP expression correlates with tumour progression and patient outcome in non-Hodgkin lymphomas of low grade of malignancy. Br J Haematol 2006;132:560-70.
    • (2006) Br J Haematol , vol.132 , pp. 560-570
    • Valente, G.1    Manfroi, F.2    Peracchio, C.3
  • 28
    • 0037854571 scopus 로고    scopus 로고
    • Phenoxodiol - an isoflavone analog - induces apoptosis in chemoresistant ovarian cancer cells
    • Kamsteeg M, Rutherford T, Sapi E et al. Phenoxodiol - an isoflavone analog - induces apoptosis in chemoresistant ovarian cancer cells. Oncogene 2003;22:2611-20.
    • (2003) Oncogene , vol.22 , pp. 2611-2620
    • Kamsteeg, M.1    Rutherford, T.2    Sapi, E.3
  • 29
    • 2942692083 scopus 로고    scopus 로고
    • Differential induction of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand in human ovarian carcinoma cells
    • Lane D, Cartier A, L'Espérance S et al. Differential induction of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand in human ovarian carcinoma cells. Gynecol Oncol 2004;93:594-604.
    • (2004) Gynecol Oncol , vol.93 , pp. 594-604
    • Lane, D.1    Cartier, A.2    L'Espérance, S.3
  • 30
    • 37449023100 scopus 로고    scopus 로고
    • Death receptor expression is associated with poor response to chemotherapy and shorter survival in metastatic ovarian carcinoma
    • Dong HP, Kleinberg L, Silins I et al. Death receptor expression is associated with poor response to chemotherapy and shorter survival in metastatic ovarian carcinoma. Cancer 2008;112:84-93.
    • (2008) Cancer , vol.112 , pp. 84-93
    • Dong, H.P.1    Kleinberg, L.2    Silins, I.3
  • 31
    • 67349160447 scopus 로고    scopus 로고
    • Cleaved caspases and NF-κB p65 are prognostic factors in metastatic ovarian carcinoma
    • Kleinberg L, Dong HP, Holth A et al. Cleaved caspases and NF-κB p65 are prognostic factors in metastatic ovarian carcinoma. Hum Pathol 2009;40:795-806.
    • (2009) Hum Pathol , vol.40 , pp. 795-806
    • Kleinberg, L.1    Dong, H.P.2    Holth, A.3
  • 32
    • 35748978560 scopus 로고    scopus 로고
    • Flow cytometric immunphenotyping of epithelial cancer cells in effusions - technical considerations and pitfalls
    • Dong HP, Holth A, Berner A, Davidson B, Risberg B. Flow cytometric immunphenotyping of epithelial cancer cells in effusions - technical considerations and pitfalls. Cytometry B Clin Cytom 2007;72B:332-43.
    • (2007) Cytometry B Clin Cytom , vol.72 , pp. 332-343
    • Dong, H.P.1    Holth, A.2    Berner, A.3    Davidson, B.4    Risberg, B.5
  • 33
    • 44949109325 scopus 로고    scopus 로고
    • Methods for simultaneous measurement of apoptosis and cell surface phenotype of epithelial cells in effusions by flow cytometry
    • Dong HP, Kleinberg L, Davidson B, Risberg B. Methods for simultaneous measurement of apoptosis and cell surface phenotype of epithelial cells in effusions by flow cytometry. Nat Protoc 2008;3:955-64.
    • (2008) Nat Protoc , vol.3 , pp. 955-964
    • Dong, H.P.1    Kleinberg, L.2    Davidson, B.3    Risberg, B.4
  • 34
    • 81355139228 scopus 로고    scopus 로고
    • Measurement of ZAP-70 expression in CLL using an optimized flow cytometric assay for ZAP-70 protein levels in whole blood samples. Miami, FL: Beckman Coulter, Inc. Available at
    • Shankey TV, Cobb J, Scibelli P et al. Measurement of ZAP-70 expression in CLL using an optimized flow cytometric assay for ZAP-70 protein levels in whole blood samples. Miami, FL: Beckman Coulter, Inc. Available at
    • Shankey, T.V.1    Cobb, J.2    Scibelli, P.3
  • 35
    • 70449715615 scopus 로고    scopus 로고
    • Evaluation of cell surface expression of phosphatidylserine in ovarian carcinoma effusions using the Annexin-V/7-AAD assay - clinical relevance and comparison to other apoptosis parameters
    • Dong HP, Holth A, Kleinberg L et al. Evaluation of cell surface expression of phosphatidylserine in ovarian carcinoma effusions using the Annexin-V/7-AAD assay - clinical relevance and comparison to other apoptosis parameters. Am J Clin Pathol 2009;132:756-62.
    • (2009) Am J Clin Pathol , vol.132 , pp. 756-762
    • Dong, H.P.1    Holth, A.2    Kleinberg, L.3
  • 36
    • 0035234038 scopus 로고    scopus 로고
    • Strategies for cell permeabilization and fixation in detecting surface and intracellular antigens
    • Koester SK, Bolton WE. Strategies for cell permeabilization and fixation in detecting surface and intracellular antigens. Methods Cell Biol 2001;63:253-68.
    • (2001) Methods Cell Biol , vol.63 , pp. 253-268
    • Koester, S.K.1    Bolton, W.E.2
  • 38
    • 79953172890 scopus 로고    scopus 로고
    • Titration of fluorochrome-conjugated antibodies for labeling cell surface markers on live cells
    • Chapter 6, Unit 629
    • Hulspas R. Titration of fluorochrome-conjugated antibodies for labeling cell surface markers on live cells. Curr Protoc Cytom 2010;Chapter 6:Unit 6.29.
    • (2010) Curr Protoc Cytom
    • Hulspas, R.1
  • 39
    • 0030803825 scopus 로고    scopus 로고
    • Comparative analysis of different permeabilization methods for the flow cytometry measurement of cytoplasmic myeloperoxidase and lysozyme in normal and leukemic cells
    • Lanza F, Latorraca A, Moretti S et al. Comparative analysis of different permeabilization methods for the flow cytometry measurement of cytoplasmic myeloperoxidase and lysozyme in normal and leukemic cells. Cytometry 1997;30:134-44.
    • (1997) Cytometry , vol.30 , pp. 134-144
    • Lanza, F.1    Latorraca, A.2    Moretti, S.3
  • 40
    • 0032787815 scopus 로고    scopus 로고
    • Comparative study of five commercial reagents for preparing normal and leukaemic lymphocytes for immunophenotypic analysis by flow cytometry
    • Macey MG, McCarthy DA, Milne T, Cavenagh JD, Newland AC. Comparative study of five commercial reagents for preparing normal and leukaemic lymphocytes for immunophenotypic analysis by flow cytometry. Cytometry 1999;38:153-60.
    • (1999) Cytometry , vol.38 , pp. 153-160
    • Macey, M.G.1    McCarthy, D.A.2    Milne, T.3    Cavenagh, J.D.4    Newland, A.C.5
  • 41
    • 75749132740 scopus 로고    scopus 로고
    • The extrinsic apoptosis pathway and its prognostic impact in ovarian cancer
    • Duiker EW, van der Zee AG, de Graeff P et al. The extrinsic apoptosis pathway and its prognostic impact in ovarian cancer. Gynecol Oncol 2010;116:549-55.
    • (2010) Gynecol Oncol , vol.116 , pp. 549-555
    • Duiker, E.W.1    van der Zee, A.G.2    de Graeff, P.3
  • 42
    • 67650485930 scopus 로고    scopus 로고
    • c-FLIPL expression defines two ovarian cancer patient subsets and is a prognostic factor of adverse outcome
    • Bagnoli M, Ambrogi F, Pilotti S et al. c-FLIPL expression defines two ovarian cancer patient subsets and is a prognostic factor of adverse outcome. Endocr Relat Cancer 2009;16:443-53.
    • (2009) Endocr Relat Cancer , vol.16 , pp. 443-453
    • Bagnoli, M.1    Ambrogi, F.2    Pilotti, S.3


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