Speeding of VO2 kinetics during moderate-intensity exercise subsequent to heavy-intensity exercise is associated with improved local O 2 distribution

Journal of Applied Physiology

Volumn 111, Issue 5, 2011, Pages 1410-1415

  Murias, Juan M ^a,b   Spencer, Matthew D ^a,b   DeLorey, Darren S ^c   Gurd, Brendon J ^d   Kowalchuk, John M ^a,b   Paterson, Donald H ^a,b  

^a Canadian Centre for Activity and Aging   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

^d QUEEN S UNIVERSITY   (Canada)

Author keywords

Muscle blood flow; Near infrared spectroscopy; O2 extraction

Indexed keywords

OXYGEN;

ADAPTATION; ADULT; ARTICLE; EXERCISE; HUMAN; LUNG GAS EXCHANGE; MALE; METABOLISM; METHODOLOGY; MICROVASCULATURE; NEAR INFRARED SPECTROSCOPY; OXYGEN CONSUMPTION; PHYSIOLOGY; SKELETAL MUSCLE; VASCULARIZATION;

ADAPTATION, PHYSIOLOGICAL; ADULT; EXERCISE; HUMANS; MALE; MICROVESSELS; MUSCLE, SKELETAL; OXYGEN; OXYGEN CONSUMPTION; PULMONARY GAS EXCHANGE; SPECTROSCOPY, NEAR-INFRARED;

EID: 81355132685     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00607.2011     Document Type: Article

References (33)

1. Babcock MA, Paterson DH, Cunningham DA, Dickinson JR. Exercise on-transient gas exchange kinetics are slowed as a function of age. Med Sci Sports Exerc 26: 440-446, 1994. (Pubitemid 24116561)
2. Beaver WL, Lamarra N, Wasserman K. Breath-by-breath measurement of true alveolar gas exchange. J Appl Physiol 51: 1662-1675, 1981. (Pubitemid 12209955)
3. Bell C, Paterson DH, Kowalchuk JM, Padilla J, Cunningham DA. A comparison of modelling techniques used to characterise oxygen uptake kinetics during the on-transient of exercise. Exp Physiol 86: 667-676, 2001. (Pubitemid 32910357)
4. Burnley M, Jones AM, Carter H, Doust JH. Effects of prior heavy exercise on phase II pulmonary oxygen uptake kinetics during heavy exercise. J Appl Physiol 89: 1387-1396, 2000.
5. DeLorey DS, Kowalchuk JM, Paterson DH. Effects of prior heavyintensity exercise on pulmonary O2 uptake and muscle deoxygenation kinetics in young and older adult humans. J Appl Physiol 97: 998-1005, 2004. (Pubitemid 39121425)
6. DeLorey DS, Kowalchuk JM, Paterson DH. Relationship between pulmonary O2 uptake kinetics and muscle deoxygenation during moderate-intensity exercise. J Appl Physiol 95: 113-120, 2003. (Pubitemid 36753791)
7. DeLorey DS, Paterson DH, Kowalchuk JM. Effects of ageing on muscle O2 utilization and muscle oxygenation during the transition to moderateintensity exercise. Appl Physiol Nutr Metab 32: 1251-1262, 2007.
8. Elwell C. A Practical Users Guide To Near Infrared Spectroscopy. London: Hamamatsu Photonics KK: 1995, p. 1-155.
9. Gerbino A, Ward SA, Whipp BJ. Effects of prior exercise on pulmonary gas-exchange kinetics during high-intensity exercise in humans. J Appl Physiol 80: 99-107, 1996.
10. Grassi B. Regulation of oxygen consumption at exercise onset: is it really controversial? Exerc Sport Sci Rev 29: 134-138, 2001. (Pubitemid 33597236)
11. Grassi B, Poole DC, Richardson RS, Knight DR, Erickson BK, Wagner PD. Muscle O2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol 80: 988-998, 1996. (Pubitemid 26087267)
12. Grassi B, Rossiter HB, Hogan MC, Howlett RA, Harris JE, Goodwin ML, Dobson JL, Gladden LB. Faster O2 uptake kinetics in canine skeletal muscle in situ after acute creatine kinase inhibition. J Physiol 589: 221-233, 2011.
13. Gurd BJ, Peters SJ, Heigenhauser GJ, LeBlanc PJ, Doherty TJ, Paterson DH, Kowalchuk JM. O2 uptake kinetics, pyruvate dehydrogenase activity, and muscle deoxygenation in young and older adults during the transition to moderate-intensity exercise. Am J Physiol Regul Integr Comp Physiol 294: R577-R584, 2008. (Pubitemid 351213764)
14. Gurd BJ, Peters SJ, Heigenhauser GJ, LeBlanc PJ, Doherty TJ, Paterson DH, Kowalchuk JM. Prior heavy exercise elevates pyruvate dehydrogenase activity and speeds O2 uptake kinetics during subsequent moderate-intensity exercise in healthy young adults. J Physiol 577: 985-996, 2006. (Pubitemid 44873660)
15. Gurd BJ, Scheuermann BW, Paterson DH, Kowalchuk JM. Prior heavy-intensity exercise speeds V ? O2 kinetics during moderate-intensity exercise in young adults. J Appl Physiol 98: 1371-1378, 2005. (Pubitemid 40396513)
16. Haram PM, Adams V, Kemi OJ, Brubakk AO, Hambrecht R, Ellingsen O, Wisloff U. Time-course of endothelial adaptation following acute and regular exercise. Eur J Cardiovasc Prev Rehabil 13: 585-591, 2006. (Pubitemid 44162161)
17. Hughson RL, Tschakovsky ME, Houston ME. Regulation of oxygen consumption at the onset of exercise. Exerc Sport Sci Rev 29: 129-133, 2001. (Pubitemid 33597235)
18. Jones AM, Wilkerson DP, Koppo K, Wilmshurst S, Campbell IT. Inhibition of nitric oxide synthase by L-NAME speeds phase II pulmonary V ? O2 kinetics in the transition to moderate-intensity exercise in man. J Physiol 552: 265-272, 2003. (Pubitemid 37265484)
19. Kindig CA, Howlett RA, Stary CM, Walsh B, Hogan MC. Effects of acute creatine kinase inhibition on metabolism and tension development in isolated single myocytes. J Appl Physiol 98: 541-549, 2005. (Pubitemid 40129963)
20. Kindig CA, McDonough P, Erickson HH, Poole DC. Nitric oxide synthase inhibition speeds oxygen uptake kinetics in horses during moderate domain running. Respir Physiol Neurobiol 132: 169-178, 2002. (Pubitemid 34876821)
21. Koppo K, Wilkerson DP, Bouckaert J, Wilmshurst S, Campbell IT, Jones AM. Influence of DCA on pulmonary V ? O2 kinetics during moderate-intensity cycle exercise. Med Sci Sports Exerc 36: 1159-1164, 2004. (Pubitemid 38878989)
22. Meyer RA. A linear model of muscle respiration explains monoexponential phosphocreatine changes. Am J Physiol Cell Physiol 254: C548-C553, 1988.
23. Murias JM, Kowalchuk JM, Paterson DH. Speeding ofV ? O2 kinetics in response to endurance-training in older and young women. Eur J Appl Physiol 111: 235-243, 2010.
24. Murias JM, Kowalchuk JM, Paterson DH. Speeding of V ? O2 kinetics with endurance training in old and young men is associated with improved matching of local O2 delivery to muscle O2 utilization. J Appl Physiol 108: 913-922, 2010.
25. Murias JM, Spencer MD, Kowalchuk JM, Paterson DH. Influence of phase I duration on phase IIV ? O2 kinetics parameter estimates in older and young adults. Am J Physiol Regul Integr Comp Physiol 301: R218-R224, 2011.
26. Murias JM, Spencer MD, Kowalchuk JM, Paterson DH. Muscle deoxygenation to V O2 relationship differs in young subjects with varying V O2. Eur J Appl Physiol In press.
27. Poole DC, Barstow TJ, McDonough P, Jones AM. Control of oxygen uptake during exercise. Med Sci Sports Exerc 40: 462-474, 2008. (Pubitemid 351294661)
28. Poole DC, Ferreira LF, Behnke BJ, Barstow TJ, Jones AM. The final frontier: oxygen flux into muscle at exercise onset. Exerc Sport Sci Rev 35: 166-173, 2007. (Pubitemid 47537901)
29. Poole DC, Musch TI. Mechanistic insights into how advanced age moves the site of V O2 kinetics limitation upstream. J Appl Physiol 108: 5-6, 2010.
30. Rossiter HB, Ward SA, Doyle VL, Howe FA, Griffiths JR, Whipp BJ. Inferences from pulmonary O2 uptake with respect to intramuscular [phosphocreatine] kinetics during moderate exercise in humans. J Physiol 518: 921-932, 1999. (Pubitemid 29387258)
31. Rossiter HB, Ward SA, Howe FA, Wood DM, Kowalchuk JM, Griffiths JR, Whipp BJ. Effects of dichloroacetate onV ? O2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans. J Appl Physiol 95: 1105-1115, 2003. (Pubitemid 37034007)
32. Scheuermann BW, Bell C, Paterson DH, Barstow TJ, Kowalchuk JM. Oxygen uptake kinetics for moderate exercise are speeded in older humans by prior heavy exercise. J Appl Physiol 92: 609-616, 2002. (Pubitemid 34671027)
33. Walsh B, Howlett RA, Stary CM, Kindig CA, Hogan MC. Determinants of oxidative phosphorylation onset kinetics in isolated myocytes. Med Sci Sports Exerc 37: 1551-1558, 2005. (Pubitemid 41368500)