Influence of phase I duration on phase II V̇O2 kinetics parameter estimates in older and young adults

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 301, Issue 1, 2011, Pages

  Murias, Juan M ^a   Spencer, Matthew D ^a   Kowalchuk, John M ^a   Paterson, Donald H ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Aging; Kinetics; Phase II fitting; V o2

Indexed keywords

ADULT; AGED; AGING; ARTICLE; BREATHING; CONTROLLED STUDY; ERGOMETRY; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HUMAN; HUMAN EXPERIMENT; KINETICS; LUNG; LUNG GAS EXCHANGE; MALE; MASS SPECTROMETER; MASS SPECTROMETRY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TURBIDIMETRY;

ADULT; AGED; AGING; EXERCISE; FEMALE; HUMANS; LUNG; MALE; MIDDLE AGED; OXYGEN; OXYGEN CONSUMPTION; PULMONARY GAS EXCHANGE; RESPIRATORY MECHANICS; TIME FACTORS;

EID: 79960026657     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00060.2011     Document Type: Article

References (34)

1. Babcock MA, Paterson DH, Cunningham DA, Dickinson JR. Exercise on-transient gas exchange kinetics are slowed as a function of age. Med Sci Sports Exerc 26: 440-446, 1994.
2. Barstow TJ, Lamarra N, Whipp BJ. Modulation of muscle and pulmonary O2 uptakes by circulatory dynamics during exercise. J Appl Physiol 68: 979-989, 1990.
3. Bearden SE. Effect of aging on the structure and function of skeletal muscle microvascular networks. Microcirculation 13: 279-288, 2006.
4. Beaver WL, Lamarra N, Wasserman K. Breath-by-breath measurement of true alveolar gas exchange. J Appl Physiol 51: 1662-1675, 1981.
5. Beebe-Dimmer JL, Pfeifer JR, Engle JS, Schottenfeld D. The epidemiology of chronic venous insufficiency and varicose veins. Ann Epidemiol 15: 175-184, 2005.
6. Behnke BJ, Kindig CA, Musch TI, Koga S, Poole DC. Dynamics of microvascular oxygen pressure across the rest-exercise transition in rat skeletal muscle. Respir Physiol 126: 53-63, 2001.
7. Bell C, Paterson DH, Kowalchuk JM, Cunningham DA. Oxygen uptake kinetics of older humans are slowed with age but are unaffected by hyperoxia. Exp Physiol 84: 747-759, 1999.
8. Bell C, Paterson DH, Kowalchuk JM, Padilla J, Cunningham DA. A comparison of modelling techniques used to characterise oxygen uptake kinetics during the on-transient of exercise. Exp Physiol 86: 667-676, 2001.
9. Chilibeck PD, Paterson DH, Petrella RJ, Cunningham DA. The influence of age and cardiorespiratory fitness on-kinetics of oxygen uptake. Can J Appl Physiol 21: 185-196, 1996.
10. Chin LM, Leigh RJ, Heigenhauser GJ, Rossiter HB, Paterson DH, Kowalchuk JM. Hyperventilation-induced hypocapnic alkalosis slows the adaptation of pulmonary O2 uptake during the transition to moderateintensity exercise. J Physiol 583: 351-364, 2007.
11. DeLorey DS, Kowalchuk JM, Paterson DH. Adaptation of pulmonary O2 uptake kinetics and muscle deoxygenation at the onset of heavyintensity exercise in young and older adults. J Appl Physiol 98: 1697-1704, 2005.
12. DeLorey DS, Kowalchuk JM, Paterson DH. Effect of age on O2 uptake kinetics and the adaptation of muscle deoxygenation at the onset of moderate-intensity cycling exercise. J Appl Physiol 97: 165-172, 2004.
13. DeLorey DS, Kowalchuk JM, Paterson DH. Relationship between pulmonary O2 uptake kinetics and muscle deoxygenation during moderate-intensity exercise. J Appl Physiol 95: 113-120, 2003.
14. 2 utilization and muscle oxygenation during the transition to moderateintensity exercise. Appl Physiol Nutr Metab 32: 1251-1262, 2007.
15. 2 uptake kinetics during transitions to high-intensity exercise at extreme pedal rates. J Appl Physiol 106: 432-442, 2009.
16. 2 on-kinetics in isolated in situ canine muscle. J Appl Physiol 85: 1394-1403, 1998.
17. 2 on-kinetics in isolated in situ canine muscle. J Appl Physiol 85: 1404-1412, 1998.
18. Grassi B, Hogan MC, Greenhaff PL, Hamann JJ, Kelley KM, Aschenbach WG, Constantin-Teodosiu D, Gladden LB. Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. J Physiol 538: 195-207, 2002.
19. Grassi B, Poole DC, Richardson RS, Knight DR, Erickson BK, Wagner PD. Muscle O2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol 80: 988-998, 1996.
20. Gurd BJ, Peters SJ, Heigenhauser GJ, LeBlanc PJ, Doherty TJ, Paterson DH, Kowalchuk JM. O2 uptake kinetics, pyruvate dehydrogenase activity, and muscle deoxygenation in young and older adults during the transition to moderate-intensity exercise. Am J Physiol Regul Integr Comp Physiol 294: R577-R584, 2008.
21. Gurd BJ, Peters SJ, Heigenhauser GJ, LeBlanc PJ, Doherty TJ, Paterson DH, Kowalchuk JM. Prior heavy exercise elevates pyruvate dehydrogenase activity and speeds O2 uptake kinetics during infsequent moderate-intensity exercise in healthy young adults. J Physiol 577: 985-996, 2006.
22. Hogan MC. Fall in intracellular Po2 at the onset of contractions in Xenopus single skeletal muscle fibers. J Appl Physiol 90: 1871-1876, 2001.
23. Howlett RA, Hogan MC. Dichloroacetate accelerates the fall in intracellular Po2 at onset of contractions in Xenopus single muscle fibers. Am J Physiol Regul Integr Comp Physiol 284: R481-R485, 2003.
24. Hughson RL, Cochrane JE, Butler GC. Faster O2 uptake kinetics at onset of supine exercise with than without lower body negative pressure. J Appl Physiol 75: 1962-1967, 1993.
25. 2 kinetics in the transition to moderate-intensity exercise in man. J Physiol 552: 265-272, 2003.
26. Jones AM, Wilkerson DP, Wilmshurst S, Campbell IT. Influence of L-NAME on pulmonary O2 uptake kinetics during heavy-intensity cycle exercise. J Appl Physiol 96: 1033-1038, 2004.
27. McCreary CR, Chilibeck PD, Marsh GD, Paterson DH, Cunningham DA, Thompson RT. Kinetics of pulmonary oxygen uptake and muscle phosphates during moderate-intensity calf exercise. J Appl Physiol 81: 1331-1338, 1996.
28. 2 on-kinetics in healthy humans. Am J Physiol Regul Integr Comp Physiol 299: R968-R976, 2010.
29. 2 delivery to muscle O2 utilization. J Appl Physiol 108: 913-922, 2010.
30. Radegran G, Saltin B. Muscle blood flow at onset of dynamic exercise in humans. Am J Physiol Heart Circ Physiol 274: H314-H322, 1998.
31. Rossiter HB, Ward SA, Doyle VL, Howe FA, Griffiths JR, Whipp BJ. Inferences from pulmonary O2 uptake with respect to intramuscular [phosphocreatine] kinetics during moderate exercise in humans. J Physiol 518: 921-932, 1999.
32. 2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans. J Appl Physiol 95: 1105-1115, 2003.
33. Scheuermann BW, Bell C, Paterson DH, Barstow TJ, Kowalchuk JM. Oxygen uptake kinetics for moderate exercise are speeded in older humans by prior heavy exercise. J Appl Physiol 92: 609-616, 2002.
34. Whipp BJ, Ward SA, Lamarra N, Davis JA, Wasserman K. Parameters of ventilatory and gas exchange dynamics during exercise. J Appl Physiol 52: 1506-1513, 1982.