Glucocorticoids are gastroprotective under physiologic conditions

Therapeutic Advances in Chronic Disease

Volumn 2, Issue 5, 2011, Pages 333-342

  Filaretova, Ludmila ^a  

^a PAVLOV INSTITUTE OF PHYSIOLOGY   (Russian Federation)

Author keywords

anti inflammatory drugs; gastric erosion; gastroprotection; glucocorticoids; hypothalamic pituitary adrenocortical axis; stress

Indexed keywords

ACETYLSALICYLIC ACID; CAPSAICIN; CORTICOSTERONE; CORTICOTROPIN; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR ANTAGONIST; HYDROCORTISONE; INDOMETACIN; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; RU 38286; UNCLASSIFIED DRUG;

CONCENTRATION RESPONSE; CORTICOSTERONE RELEASE; DISEASE EXACERBATION; HOMEOSTASIS; HORMONE ACTION; HORMONE DEFICIENCY; HORMONE RESPONSE; HORMONE SUBSTITUTION; HORMONE SYNTHESIS; HUMAN; INFLAMMATION; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; REVIEW; SENSORY NERVE CELL; STOMACH BLOOD FLOW; STOMACH EROSION; STOMACH FUNCTION; STOMACH MOTILITY; STOMACH PROTECTION; STOMACH ULCER; STRESS ULCER; TREATMENT DURATION; ULCEROGENESIS;

EID: 81355132284     PISSN: 20406223     EISSN: 20406231     Source Type: Journal    
DOI: 10.1177/2040622311412420     Document Type: Review

References (54)

1. Alexandrova M. (1994) Stress induced tyrosine aminotransferase activity via glucocorticoid receptor. Horm Metab Res 26: 97–99.
2. Bandyopadhyay U. Biswas K. Bandyopadhyay D. Ganguly C.K. Banerjee R.K. (1999) Dexamethasone makes the gastric mucosa susceptible to ulceration by inhibiting prostaglandin synthetase and peroxidase - two important gastroprotective enzymes. Mol Cell Biochem 202: 31–36.
3. Black H.E. (1988) The effects of steroids upon the gastrointestinal tract. Toxicol Pathol 16: 213–222.
4. Bobryshev P. Yu., Bagaeva T.R. Podvigina T.T. Filaretova L. (2005) Gastroprotective action of glucocorticoid hormones in rats with desensitization of capsaicin-sensitive sensory neurons. Inflammopharmacology 13: 217–228.
5. Bobryshev P. Podvigina T. Maltcev N. Filaretova L. (2006) Gastric microcirculation as target of gastroprotective action of glucocorticoid hormones in rats with desensitization of capsaicin-sensitive sensory neurons. Inflammopharmacology 14: 236–242.
6. Chan O. Chan S. Inouye K. Shum K. Matthews S.G. Vranic M. (2002) Diabetes impairs hypothalamo–pituitary–adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses. Diabetes 51: 1681–1689.
7. Derelanko M.J. Long J.F. (1982) Influence of prednisolone on ethanol-induced gastric injury in the rat. Dig Dis Sci 27: 149–154.
8. Filaretova L. (1990) The dependence of the formation of stress gastric ulcers on the function of hypothalamo–hypophyseal–adrenocortical system. Sechenov Physiol J USSR 76: 1594–1600.
9. Filaretova L. Bagaeva T. Amagase K. Takeuchi K. (2008) Contribution of glucocorticoids to protective influence of preconditioning mild stress against stress-induced gastric erosions. Ann N Y Acad Sci 1148: 209–212.
10. Filaretova L. Bagaeva T. Podvigina T. Makara G. (2001 a) Various ulcerogenic stimuli are potentiated by glucocorticoid deficiency in rats. J Physiol Paris 95: 59–65.
11. Filaretova L. Bobryshev P. Bagaeva T. Podvigina T. Takeuchi K. (2007) Compensatory gastroprotective role of glucocorticoid hormones during inhibition of prostaglandin and nitric oxide production and desensitization of capsaicin-sensitive sensory neurons. Inflammopharmacology 5: 146–153.
12. Filaretova L. Morozova O. Bagaeva T. Podvigina T. (2009 a) From gastroprotective to proulcerogenic action of glucocorticoids on the gastric mucosa. J Physiol Pharmacol 60(Suppl. 7): 79–86.
13. Filaretova L. Podvigina T. Bagaeva T. Makara G. (2001 b) Gastroprotective action of glucocorticoids during the formation and the healing of indomethacin-induced gastric erosions in rats. J Physiol Paris 95: 201–208.
14. Filaretova L. Podvigina T. Bagaeva T. Morozova O. (2009 b) Dual action of glucocorticoid hormones on the gastric mucosa: how the gastroprotective action can be transformed to the ulcerogenic one. Inflammopharmacology 17: 15–22.
15. Filaretova L. Podvigina T. Bobryshev P. Bagaeva T. Tanaka A. Takeuchi K. (2006) Hypothalamic–pituitary–adrenocortical axis: the hidden gold in gastric mucosal homeostasis. Inflammopharmacology 14: 207–213.
16. Filaretova L. Tanaka A. Komoike Y. Takeuchi K. (2002 a) Selective cyclooxygenase-2 inhibitor induces gastric mucosal damage in adrenalectomized rats. Inflammopharmacology 10: 413–422.
17. Filaretova L. Tanaka A. Miyazawa T. Kato S. Takeuchi K. (2002 b) Mechanisms by which endogenous glucocorticoids protects against indomethacin-induced gastric injury in rats. Am J Physiol 283: G1082–G1089.
18. Filaretova L.P. (2006) The hypothalamic–pituitary–adrenocortical system: hormonal brain–gut interaction and gastroprotection. Autonomic Neurosci Basic and Clinical 125: 86–93.
19. Filaretova L.P. Bagaeva T.R. Makara G.B. (2002 c) Aggravation of nonsteroidal antiinflammatory drug gastropathy by glucocorticoid deficiency or blockade of glucocorticoid receptor in rats. Life Sci 71: 2457–2468.
20. Filaretova L.P. Filaretov A. Makara G.B. (1998) Corticosterone increase inhibits stress-induced gastric erosions in rats. Am J Physiol 274: G1024–G1030.
21. Filaretova L.P. Maltcev A.N. Bogdanov A.I. Levkovich, Yu I. (1999) Role of gastric microcirculation in the gastroprotection by glucocorticoids released during water-restraint stress in rats. Chin J Physiol 42: 145–152.
22. Filaretova L.P. Podvigina T.T. Bagaeva T.R. Tanaka A. Takeuchi K. (2005) Gastroprotective action of glucocorticoid hormones during NSAID treatment. Inflammopharmacology 13: 27–43.
23. Filaretova L.P. Podvigina T.T. Bagaeva T.R. Tanaka A. Takeuchi K. (2004) Mechanisms underlying gastroprotective action of glucocorticoids released in response to ulcerogenic stress factors. Ann NY Acad Sci 1018: 288–293.
24. Guth P.H. (1992) Current concept in gastric microcirculatory pathophysiology. Yale J Biol Med 65: 677–688.
25. Hawkey C.J. (2000) Nonsteroidal anti-inflammatory drug gastropathy. Gastroenterology 119: 521–535.
26. Heitzer M.D. Wolf I.M. Sanchez E.R. Witchel S.F. de Franco D.B. (2007) Glucocorticoid receptor physiology. Rev Endocr Metab Disord 8: 321–330.
27. Holzer P. (1998) Neural emergency system in the stomach. Gastroenterology 114: 823–839.
28. Kanemasa H. Ozawa H. Konishi H. Ito T. Nishi M. Mitsufuji S. et al (1999) Distribution of glucocorticoid receptor immunoreactivity in gastric mucosa of normal and adrenalectomized rats. Dig Dis Sci 44: 2081–2087.
29. Laine L. Takeuchi K. Tarnawski A. (2008) Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 135: 41–60.
30. Lu N.Z. Cidlowski J.A. (2005) Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol Cell 18: 331–342.
31. Luo J.C. Chang F.Y. Chen T.S. Ng Y.Y. Lin H.C. Lu C.L. et al (2009) Gastric mucosal injury in systemic lupus erythematosus patients receiving pulse methylprednisolone therapy. Br J Clin Pharmacol 68: 252–259.
32. McCafferty D.M. Granger D.N. Wallace J.L. (1995) Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats. Gastroenterology 109: 1173–1180.
33. Mersereau W.A. Hinchey E.J. (1982) Prevention of phenylbutazone ulcer in the rat by glucose: role of a glycoprivic receptor system. Am J Physiol 242: G429–G432.
34. Moguilewski M. Philibert D. (1984) RU 38486: potent antiglucocorticoid activity correlated with strong binding to cytosolic glucocorticoid receptor followed by an impaired activation. J Steroid Biochem 20: 271–276.
35. Munck A. Guyre P.M. Holbrook N.J. (1984) Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev 5: 25–44.
36. Murphy H.M. Wideman C.H. Brown T.S. (1979) Plasma corticosterone levels and ulcer formation in rats with hippocampal lesions. Neuroendocrinology 28: 123–130.
37. Olsen M. Christensen S. Riis A. Thomsen R.W. (2010) Preadmission use of systemic glucocorticoids and 30-day mortality following bleeding peptic ulcer: a population-based cohort study. Am J Ther 17: 23–29.
38. Papi A. Papadopoulos N.G. Degitz K. Holgate S.T. Johnston S.L. (2000) Corticosteroids inhibit rhinovirus-induced intercellular adhesion molecule-1 up-regulation and promoter activation on respiratory epithelial cells. J Allergy Clin Immunol 105: 318–326.
39. Perretti M. Mugridge K.G. Wallace J.L. Parénte L. (1992) Reduction of aspirin-induced gastric damage in rats by interleukin-1 beta: possible involvement of endogenous corticosteroids. J Pharmacol Exp Ther 261: 1238–1247.
40. Selye H. (1967) In Vivo. The case for supramolecular biology presented in six informal, illustrated lectures Liveright: New York.
41. Suzuki H. Miura S. Mori M. Akiba Y. Nagahashi S. Zweifach B.W. et al (1999) Protective role of adrenal glucocorticoids for gastric mucosa in spontaneously hypertensive rats. J Gastroenterol Hepatol 14: 376–383.
42. Szabo S. Callagher G.T. Horner H.C. Frankel P.W. Underwood R.H. Konturek S.J. et al (1983) Role of the adrenal cortex in gastric mucosal protection by prostaglandins, sulfhydryls, and cimetidine in the rat. Gastroenterology 85: 1384–1390.
43. Takeuchi K. Nishiwaki H. Okada M. Niida H. Okabe S. (1989) Bilateral adrenalectomy worsens gastric mucosal lesions induced by indomethacin in the rat. Role of enhanced gastric motility. Gastroenterology 97: 284–293.
44. Takeuchi K. Tanaka A. Suzuki K. Mizoguchi H. (2001) Gastrointestinal sparing anti-inflammatory drugs – effects on ulcerogenic and healing responses. Curr Pharm Des 7: 49–69.
45. Takeuchi K. Ueshima K. Hironaka Y. Fujioka Y. Matsumoto J. Okabe S. (1991) Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Digestion 49: 175–184.
46. Takeuchi Y. Takahashi M. Fuchikami J. (2008) Vulnerability of gastric mucosa to prednisolone in rats chronically exposed to cigarette smoke. J Pharmacol Sci 106: 585–592.
47. Tempel D.L. McEwen B.S. Leibowitz S.F. (1993) Adrenal steroid receptors in the PVN: studies with steroid antagonists in relation to macronutrient intake. Neuroendocrinology 57: 1106–1113.
48. Wallace J.L. (1997) Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology 112: 1000–1016.
49. Wallace J.L. McKnight W. Miyasaka M. Tamatani T. Paulson J. Anderson D.C. (1993) Role of endothelial adhesion molecules in NSAID-induced gastric mucosal injury. Am J Physiol 265: G993–G998.
50. Weiss J.M. (1971) Effects of coping behavior in different warning signal conditions on stress pathology in rats. J Comp Physiol Psychol 77: 1–13.
51. Whitehouse M.W. (2011) Anti-inflammatory glucocorticoid drugs: reflections after 60 years. Inflammopharmacology 19: 1–19.
52. Whittle B.J.R. Lopez-Belmonte J. Moncada S. (1990) Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rats. Br J Pharmacol 99: 606–611.
53. Zanardo R.C. Perretti M. Wallace J.L. (2005) Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage. Am J Physiol 288: G481–G486.
54. Zhou X.F. Jhamandas K.H. Livett B.G. (1990) Capsaicin-sensitive nerves are required for glucostasis but not for catecholamine output during hypoglycemia in rats. Am J Physiol 258: E212–E219.