메뉴 건너뛰기




Volumn 81, Issue 1, 2000, Pages 17-30

Hepatocyte growth factor/scatter factor-induced intracellular signalling

Author keywords

c MET; ECM; Hepatocyte; HGF; Scattering

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; SCATTER FACTOR; SCATTER FACTOR RECEPTOR;

EID: 0034107193     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.2000.00138.x     Document Type: Review
Times cited : (107)

References (177)
  • 1
    • 0029013646 scopus 로고
    • Roles of prostaglandin production and mitogen-activated protein kinase activation in HGF-mediated rat hepatocyte proliferation
    • ADACHI T., NAKASHIMA T., SAJI T., NAKAMURA T. & NOZAWA Y. (1995) Roles of prostaglandin production and mitogen-activated protein kinase activation in HGF-mediated rat hepatocyte proliferation. Hepatology 21, 668-674.
    • (1995) Hepatology , vol.21 , pp. 668-674
    • Adachi, T.1    Nakashima, T.2    Saji, T.3    Nakamura, T.4    Nozawa, Y.5
  • 2
    • 0026646967 scopus 로고
    • HGF. induces calcium mobilization and inositol phosphate production in rat hepatocytes
    • BAFFY T., YANG T., MICHALOPOULOS G.K. & WILLIAMSON J.R. (1992) HGF. induces calcium mobilization and inositol phosphate production in rat hepatocytes. J. Cell Physiol. 153, 332-339.
    • (1992) J. Cell Physiol. , vol.153 , pp. 332-339
    • Baffy, T.1    Yang, T.2    Michalopoulos, G.K.3    Williamson, J.R.4
  • 3
    • 0026644455 scopus 로고
    • Autophosphorylation promotes complex formation of recombinant HGF receptor with cytoplasmic effectors containing SH2 domains
    • BARDELLI T., MAINA T., GOUT I. ET AL. (1992) Autophosphorylation promotes complex formation of recombinant HGF receptor with cytoplasmic effectors containing SH2 domains. Oncogene 7, 1973-1978.
    • (1992) Oncogene , vol.7 , pp. 1973-1978
    • Bardelli, T.1    Maina, T.2    Gout, I.3
  • 4
    • 0028500509 scopus 로고
    • Identification of functional domains in the hepatocyte growth factor and its receptor by molecular engineering
    • BARDELLI T., PONZETTO C. & COMOGLIO P.M. (1994) Identification of functional domains in the hepatocyte growth factor and its receptor by molecular engineering. J. Biotech 37, 109-122.
    • (1994) J. Biotech , vol.37 , pp. 109-122
    • Bardelli, T.1    Ponzetto, C.2    Comoglio, P.M.3
  • 6
    • 0029040133 scopus 로고
    • The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor
    • BATZER A.G., BLAIKIE T., NELSON T., SCHLESSINGER J. & MARGOLIS B. (1995) The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor. Mol Cell Biol. 15, 4403-4409.
    • (1995) Mol Cell Biol. , vol.15 , pp. 4403-4409
    • Batzer, A.G.1    Blaikie, T.2    Nelson, T.3    Schlessinger, J.4    Margolis, B.5
  • 7
    • 0026468827 scopus 로고
    • SF/HGF: Activities, properties, and mechanism
    • BHARGAVA T., JOSEPH T., KNESEL J. ET AL. (1992) SF/HGF: activities, properties, and mechanism. Cell Growth Differ. 3, 11-20.
    • (1992) Cell Growth Differ. , vol.3 , pp. 11-20
    • Bhargava, T.1    Joseph, T.2    Knesel, J.3
  • 8
    • 0029018739 scopus 로고
    • Hypocalcemia decreases the early and late responses to epidermal growth factor in rat hepatocytes
    • BILODEAU T., PROVENCHER S.J., NERON T., HADDAD T., VALLIERES S. & GASCON BARRE M. (1995) Hypocalcemia decreases the early and late responses to epidermal growth factor in rat hepatocytes. Hepatology 21, 1576-1584.
    • (1995) Hepatology , vol.21 , pp. 1576-1584
    • Bilodeau, T.1    Provencher, S.J.2    Neron, T.3    Haddad, T.4    Vallieres, S.5    Gascon Barre, M.6
  • 9
    • 0027233448 scopus 로고
    • Signal transduction via the MAP kinase: Proceed at your own RSK
    • BLENIS J. (1993) Signal transduction via the MAP kinase: proceed at your own RSK. Proc. Natl. Acad Sci. USA 90, 5889-5892.
    • (1993) Proc. Natl. Acad Sci. USA , vol.90 , pp. 5889-5892
    • Blenis, J.1
  • 10
    • 0025805633 scopus 로고
    • Identification of the hepatocyte growth factor receptor as the c-met protooncogene product
    • BOTTARO D.P., RUBIN J.S., FALETTO D.L. ET AL. (1991) Identification of the hepatocyte growth factor receptor as the c-met protooncogene product. Science 251, 802-804.
    • (1991) Science , vol.251 , pp. 802-804
    • Bottaro, D.P.1    Rubin, J.S.2    Faletto, D.L.3
  • 11
    • 0026722243 scopus 로고
    • HGF. is potent angiogenic factor which stimulates endothelial cell motility and growth
    • BUSSOLINO T., DI RENZO M.F., ZICHE M. ET AL. (1992) HGF. is potent angiogenic factor which stimulates endothelial cell motility and growth. J. Cell Biol. 119, 629-641.
    • (1992) J. Cell Biol. , vol.119 , pp. 629-641
    • Bussolino, T.1    Di Renzo, M.F.2    Ziche, M.3
  • 12
    • 0026320865 scopus 로고
    • Identification of a competitive HGF antagonist encoded by an alternative transcript
    • CHAN A.M., RUBIN J.S., BOTTARO D.P., HIRSCHFIELD D.W., CHEDID T. & AARONSON S.A. (1991) Identification of a competitive HGF antagonist encoded by an alternative transcript. Science 254, 1382-1385.
    • (1991) Science , vol.254 , pp. 1382-1385
    • Chan, A.M.1    Rubin, J.S.2    Bottaro, D.P.3    Hirschfield, D.W.4    Chedid, T.5    Aaronson, S.A.6
  • 14
    • 0027348905 scopus 로고
    • Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells
    • COMOGLIO P.M. (1993) Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. EXS. 65, 131-165.
    • (1993) EXS , vol.65 , pp. 131-165
    • Comoglio, P.M.1
  • 15
    • 0027965513 scopus 로고
    • Binding of the Grb2, SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for SOS proline-rich motifs
    • CUSSAC T., FRECH M. & CHARDIN P. (1994) Binding of the Grb2, SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for SOS proline-rich motifs. EMBO J. 13, 4011-4021.
    • (1994) EMBO J. , vol.13 , pp. 4011-4021
    • Cussac, T.1    Frech, M.2    Chardin, P.3
  • 17
    • 0026758356 scopus 로고
    • The growth arrest-specific gene, gas1, is involved in growth suppression
    • DEL SAL T., RUARO M.E., PHILIPSON L. & SCHNEIDER C. (1992) The growth arrest-specific gene, gas1, is involved in growth suppression. Cell 70, 595-607.
    • (1992) Cell , vol.70 , pp. 595-607
    • Del Sal, T.1    Ruaro, M.E.2    Philipson, L.3    Schneider, C.4
  • 18
    • 0028814087 scopus 로고
    • HGF-mediated chemotaxis and tubulogenesis require activation of the phophatidylinositol 3 kinase
    • DERMAN M.P., CUNHA M.J., BARROS E.J., NIGAM S.K. & CANTLEY L.G. (1995) HGF-mediated chemotaxis and tubulogenesis require activation of the phophatidylinositol 3 kinase. Am. J. Physiol. 268, F1211-F1217.
    • (1995) Am. J. Physiol. , vol.268
    • Derman, M.P.1    Cunha, M.J.2    Barros, E.J.3    Nigam, S.K.4    Cantley, L.G.5
  • 19
    • 0028170110 scopus 로고
    • Overexpression of the Met/HGF receptor in ovarian cancer
    • DIRENZO M.F., OLIVERO T., KATSAROS D. ET AL. (1994) Overexpression of the Met/HGF receptor in ovarian cancer. Int J. Cancer 58, 658-662.
    • (1994) Int J. Cancer , vol.58 , pp. 658-662
    • Direnzo, M.F.1    Olivero, T.2    Katsaros, D.3
  • 20
    • 0028915371 scopus 로고
    • Overexpression of the c-met-HGF receptor in human thyroid carcinoma derived from the follicular epithelium
    • DIRENZO M.F., OLIVERO T., SERINI G. ET AL. (1995) Overexpression of the c-met-HGF receptor in human thyroid carcinoma derived from the follicular epithelium. J. Endocrinol. Invest. 18, 134-139.
    • (1995) J. Endocrinol. Invest. , vol.18 , pp. 134-139
    • Direnzo, M.F.1    Olivero, T.2    Serini, G.3
  • 21
    • 0028567137 scopus 로고
    • Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP)
    • DONATE L.E., GHERARDI T., SRINIVASAN T., SOWDHAMINI T., APARICIO S. & BLUNDELL T.L. (1994) Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP). Protein Sci. 3, 2378-2394.
    • (1994) Protein Sci. , vol.3 , pp. 2378-2394
    • Donate, L.E.1    Gherardi, T.2    Srinivasan, T.3    Sowdhamini, T.4    Aparicio, S.5    Blundell, T.L.6
  • 22
    • 0027939437 scopus 로고
    • Coexpression of the c-met proto-oncogene and HGF in human pancreatic cancer
    • EBERT T., YOKOYAMA T., FRIESS T., BUCHLER M.W. & KORC M. (1994) Coexpression of the c-met proto-oncogene and HGF in human pancreatic cancer. Cancer Res. 54, 5775-5778.
    • (1994) Cancer Res. , vol.54 , pp. 5775-5778
    • Ebert, T.1    Yokoyama, T.2    Friess, T.3    Buchler, M.W.4    Korc, M.5
  • 23
    • 0026267171 scopus 로고
    • Growth factors in liver development, regeneration and carcinogenesis
    • FAUSTO N. (1991) Growth factors in liver development, regeneration and carcinogenesis. Prog. Growth Factor Res. 3, 219-234.
    • (1991) Prog. Growth Factor Res. , vol.3 , pp. 219-234
    • Fausto, N.1
  • 24
    • 0029557319 scopus 로고
    • Role of growth factors and cytokines in hepatic regeneration
    • FAUSTO T., LAIRDA D. & WEBBER E.M. (1995) Role of growth factors and cytokines in hepatic regeneration. FASEB J. 9, 1527-1536.
    • (1995) FASEB J. , vol.9 , pp. 1527-1536
    • Fausto, T.1    Lairda, D.2    Webber, E.M.3
  • 25
    • 0028909659 scopus 로고
    • The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit
    • FERRACINI T., DIRENZO M.F., SCOTLANDI K. ET AL. (1995) The Met/ HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. Oncogene 10, 739-749.
    • (1995) Oncogene , vol.10 , pp. 739-749
    • Ferracini, T.1    Direnzo, M.F.2    Scotlandi, K.3
  • 26
    • 0025941095 scopus 로고
    • Identification of the major autophosphorylation site of the Met/HGF recptor tyrosine kinase
    • FERRACINI T., LONGATI T., NALDINI T., VIGNA E. & COMOGLIO P.M. (1991) Identification of the major autophosphorylation site of the Met/HGF recptor tyrosine kinase. J. Biol. Chem. 266, 19558-19564.
    • (1991) J. Biol. Chem. , vol.266 , pp. 19558-19564
    • Ferracini, T.1    Longati, T.2    Naldini, T.3    Vigna, E.4    Comoglio, P.M.5
  • 27
    • 0028631896 scopus 로고
    • HGF. region specifically stimulates gastro-intestinal epithelial growth in primary culture
    • FUKAMACHI T., ICHINOSE T., TSUKADA S. ET AL. (1994) HGF. region specifically stimulates gastro-intestinal epithelial growth in primary culture. Biochem. Biophy Res. Commun. 205, 1445-1451.
    • (1994) Biochem. Biophy Res. Commun. , vol.205 , pp. 1445-1451
    • Fukamachi, T.1    Ichinose, T.2    Tsukada, S.3
  • 28
    • 0025916479 scopus 로고
    • Comparison of biological and immunochemical properties indicates that scatter factor and HGF are indistinguishable
    • FURLONG R.A., TAKEHARA T., TAYLOR W.G., NAKAMURA T. & RUBIN J.S. (1991) Comparison of biological and immunochemical properties indicates that scatter factor and HGF are indistinguishable. J. Cell Sci. 100, 173-177.
    • (1991) J. Cell Sci. , vol.100 , pp. 173-177
    • Furlong, R.A.1    Takehara, T.2    Taylor, W.G.3    Nakamura, T.4    Rubin, J.S.5
  • 29
    • 0027948378 scopus 로고
    • HGF. induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors
    • GALIMI T., BAGNARA G.P., BONSI L. ET AL. (1994) HGF. induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors. J. Cell Biol. 127, 1743-1754.
    • (1994) J. Cell Biol. , vol.127 , pp. 1743-1754
    • Galimi, T.1    Bagnara, G.P.2    Bonsi, L.3
  • 31
    • 0028084984 scopus 로고
    • Phosphorylation of serine 985 negatively regulates the HGF receptor kinase
    • GAUDINO T., LONGATI T., MEDICO T., PRAT M. & COMOGLIO P.M. (1994) Phosphorylation of serine 985 negatively regulates the HGF receptor kinase. J. Biol. Chem. 269, 1815-1820.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1815-1820
    • Gaudino, T.1    Longati, T.2    Medico, T.3    Prat, M.4    Comoglio, P.M.5
  • 32
    • 0025333360 scopus 로고
    • Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein
    • GAUDINO T., DI RENZO M.F., GIORDANO S. & BUSSOLINO F. (1990) Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein. Oncogene 5, 721-725.
    • (1990) Oncogene , vol.5 , pp. 721-725
    • Gaudino, T.1    Di Renzo, M.F.2    Giordano, S.3    Bussolino, F.4
  • 33
    • 0026051633 scopus 로고
    • Intracellular calcium regulates the tyrosine kinase receptor encoded by the Met oncogene
    • GAUDINO T., MUNARON T., NALDINI T., FERRACINI T., MAGNI M. & COMOGLIO P.M. (1991) Intracellular calcium regulates the tyrosine kinase receptor encoded by the Met oncogene. J. Biol. Chem. 266, 16098-16104.
    • (1991) J. Biol. Chem. , vol.266 , pp. 16098-16104
    • Gaudino, T.1    Munaron, T.2    Naldini, T.3    Ferracini, T.4    Magni, M.5    Comoglio, P.M.6
  • 34
    • 0028123022 scopus 로고
    • Ron is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP
    • GAUDINO T., FOLLENZI T., NALDINI L. ET AL. (1994) Ron is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J. 13, 3524-3532.
    • (1994) EMBO J. , vol.13 , pp. 3524-3532
    • Gaudino, T.1    Follenzi, T.2    Naldini, L.3
  • 35
    • 0029564158 scopus 로고
    • Phospholipase A. 2 is activated by TNF-alpha in primary hepatocytes stimulated by a deleted form of HGF
    • GEORGAKOPOULOS T., MCMENAMIN M. & SKOUTERIS G.G. (1995) Phospholipase A. 2 is activated by TNF-alpha in primary hepatocytes stimulated by a deleted form of HGF. Biochem. Biophys. Res. Commun. 217, 1263-1270.
    • (1995) Biochem. Biophys. Res. Commun. , vol.217 , pp. 1263-1270
    • Georgakopoulos, T.1    McMenamin, M.2    Skouteris, G.G.3
  • 36
    • 0029147459 scopus 로고
    • Tyrosine kinase growth factor receptors but not seven-membrane spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes
    • GINES T., LI T., ZAMARRIPA J.L. ET AL. (1995) Tyrosine kinase growth factor receptors but not seven-membrane spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes. Hepatology 22, 1296-1303.
    • (1995) Hepatology , vol.22 , pp. 1296-1303
    • Gines, T.1    Li, T.2    Zamarripa, J.L.3
  • 40
    • 0028143178 scopus 로고
    • MAP kinase binds to the NH-2-terminal activation domain of c-myc
    • GUPTA S. & DAVIS R.J. (1994) MAP kinase binds to the NH-2-terminal activation domain of c-myc. FEBS Lett. 353, 281-285.
    • (1994) FEBS Lett. , vol.353 , pp. 281-285
    • Gupta, S.1    Davis, R.J.2
  • 41
    • 0027450156 scopus 로고
    • HGF. stimulates phosphoinositide hydrolysis and mitogenesis in cultured renal epithelial cells
    • HARRIS R.C., BURNS K.D., ALATTAR T., HOMMA T. & NAKAMURA T. (1993) HGF. stimulates phosphoinositide hydrolysis and mitogenesis in cultured renal epithelial cells. Life Sci. 52, 1091-1100.
    • (1993) Life Sci. , vol.52 , pp. 1091-1100
    • Harris, R.C.1    Burns, K.D.2    Alattar, T.3    Homma, T.4    Nakamura, T.5
  • 42
    • 0028932435 scopus 로고
    • Association of phosphatidylinositol 3 kinase with SHC in chronic myelogeneous leukemia cells
    • HARRISON FINDIK T., SUSA M. & VARTIKOVSKI L. (1995) Association of phosphatidylinositol 3 kinase with SHC in chronic myelogeneous leukemia cells. Oncogene 10, 1385-1391.
    • (1995) Oncogene , vol.10 , pp. 1385-1391
    • Harrison Findik, T.1    Susa, M.2    Vartikovski, L.3
  • 43
    • 0026485023 scopus 로고
    • A. Functional domain in the heavy chain of scatter factor/HGF binds the c-met receptor and induces cell dissociation but not mitogenesis
    • HARTMANN T., NALDINI T., WEIDNER K.M. ET AL. (1992) A. functional domain in the heavy chain of scatter factor/HGF binds the c-met receptor and induces cell dissociation but not mitogenesis. Proc. Natl. Acad. Sci. USA 89, 11574-11578.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11574-11578
    • Hartmann, T.1    Naldini, T.2    Weidner, K.M.3
  • 44
    • 0028142230 scopus 로고
    • The motility signal of HGF/SF mediated through the receptor tyrosine kinase Met requires intracellular action od Ras
    • HARTMANN T., WEIDNER K.M., SCHWARZ H. & BIRCHMEIER W. (1994) The motility signal of HGF/SF mediated through the receptor tyrosine kinase Met requires intracellular action od Ras. J. Biol. Chem. 269, 21936-21939.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21936-21939
    • Hartmann, T.1    Weidner, K.M.2    Schwarz, H.3    Birchmeier, W.4
  • 45
    • 0028897113 scopus 로고
    • Transcriptional regulation by extracellular signals. Mechanisms and specificity
    • HILL C.S. & TREISMAN R. (1995) Transcriptional regulation by extracellular signals. Mechanisms and specificity. Cell 80, 199-211.
    • (1995) Cell , vol.80 , pp. 199-211
    • Hill, C.S.1    Treisman, R.2
  • 46
    • 0027199983 scopus 로고
    • The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the met/HGF/SF receptor
    • HUFF J.L., JELINEK M.A., BORGMAN C.A., LANSING T.J. & PARSONS J.T. (1993) The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the met/HGF/SF receptor. Proc. Natl. Acad Sci. USA. 90, 6140-6144.
    • (1993) Proc. Natl. Acad Sci. USA , vol.90 , pp. 6140-6144
    • Huff, J.L.1    Jelinek, M.A.2    Borgman, C.A.3    Lansing, T.J.4    Parsons, J.T.5
  • 47
    • 0029082188 scopus 로고
    • HGF and its receptor (c-met) in prostatic carcinoma
    • HUMPHREY P.A., ZHU T., ZARNEGAR R. ET AL. (1995) HGF and its receptor (c-met) in prostatic carcinoma. Am. J. Pathol. 147, 386-396.
    • (1995) Am. J. Pathol. , vol.147 , pp. 386-396
    • Humphrey, P.A.1    Zhu, T.2    Zarnegar, R.3
  • 48
    • 0028838971 scopus 로고
    • Protein kinases and phosphatases. The yin and yang of protein phosphorylation and signaling
    • HUNTER T. (1995) Protein kinases and phosphatases. The yin and yang of protein phosphorylation and signaling. Cell 80, 225-236.
    • (1995) Cell , vol.80 , pp. 225-236
    • Hunter, T.1
  • 49
    • 84889129526 scopus 로고
    • HGF inhibits intercellular communication via gap junctions in rat hepatocytes
    • IKEJIMA T., WATANABE T., KITAMURA T., HIROSE T., MIYAZAKI A. & SATO N. (1995) HGF inhibits intercellular communication via gap junctions in rat hepatocytes. J. Biochem. 117, 671-676.
    • (1995) J. Biochem. , vol.117 , pp. 671-676
    • Ikejima, T.1    Watanabe, T.2    Kitamura, T.3    Hirose, T.4    Miyazaki, A.5    Sato, N.6
  • 50
    • 0029149768 scopus 로고
    • Inhibition of HGF/SF induced membrane ruffling and cell motility by transient elevation of cytosolic free Ca (2+)
    • JIANG W.G., HISCOX T., SINGHRAO S.K., NAKAMURA T., PUNTIS M.C. & HALLETT M.B. (1995) Inhibition of HGF/SF induced membrane ruffling and cell motility by transient elevation of cytosolic free Ca (2+). Exp Cell Res. 220, 424-433.
    • (1995) Exp Cell Res. , vol.220 , pp. 424-433
    • Jiang, W.G.1    Hiscox, T.2    Singhrao, S.K.3    Nakamura, T.4    Puntis, M.C.5    Hallett, M.B.6
  • 51
    • 0027256029 scopus 로고
    • HGF induces proliferation and morphogenesis in non-parenchymal epithelial liver cells
    • JOHNSON T., KOUKOULIS T., MATSUMOTO T., KAKAMURA T. & IYER A. (1993) HGF induces proliferation and morphogenesis in non-parenchymal epithelial liver cells. Hepatology 7, 1052-1061.
    • (1993) Hepatology , vol.7 , pp. 1052-1061
    • Johnson, T.1    Koukoulis, T.2    Matsumoto, T.3    Kakamura, T.4    Iyer, A.5
  • 52
    • 0028168441 scopus 로고
    • The met/HGF receptor gene is overexpressed in some cases of human leukemia and lymphoma
    • JUCKER T., GUNTHER T., GRADL G. ET AL. (1994) The met/HGF receptor gene is overexpressed in some cases of human leukemia and lymphoma. Leuk Res. 18, 7-16.
    • (1994) Leuk Res. , vol.18 , pp. 7-16
    • Jucker, T.1    Gunther, T.2    Gradl, G.3
  • 53
    • 0026010993 scopus 로고
    • HGF/hepatopoietin A. Stimulates the growth of rat kidney proximall tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE
    • KAN T., ZHANG G.H., ZARNEGAR R. ET AL. (1991) HGF/hepatopoietin A. stimulates the growth of rat kidney proximall tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE. Biochem. Biophys. Res. Commun. 174, 331-337.
    • (1991) Biochem. Biophys. Res. Commun. , vol.174 , pp. 331-337
    • Kan, T.1    Zhang, G.H.2    Zarnegar, R.3
  • 54
    • 0027382453 scopus 로고
    • HGF transforms immortalized mouse liver epithelial cells
    • KANDA T., TAJIMA T., LEE G.H. ET AL. (1993) HGF transforms immortalized mouse liver epithelial cells. Oncogene 8, 3047-3053.
    • (1993) Oncogene , vol.8 , pp. 3047-3053
    • Kanda, T.1    Tajima, T.2    Lee, G.H.3
  • 55
    • 0029114536 scopus 로고
    • Activation of Na (+)/H (+) exchanger by HGF in hepatocytes
    • KANEKO T., HAYASHI T., TANAKA Y. ET AL. (1995) Activation of Na (+) /H (+) exchanger by HGF in hepatocytes. Hepatology 22, 629-636.
    • (1995) Hepatology , vol.22 , pp. 629-636
    • Kaneko, T.1    Hayashi, T.2    Tanaka, Y.3
  • 56
    • 0027586078 scopus 로고
    • GC. factor represses transcription of several growth factor/ receptor genes and causes growth inhibition of human gastric carcinoma cell lines
    • KITADAI T., YAMAZAKI T., YASUI W. ET AL. (1993) GC. factor represses transcription of several growth factor/ receptor genes and causes growth inhibition of human gastric carcinoma cell lines. Cell Growth Differ. 4, 291-296.
    • (1993) Cell Growth Differ. , vol.4 , pp. 291-296
    • Kitadai, T.1    Yamazaki, T.2    Yasui, W.3
  • 57
    • 0026485121 scopus 로고
    • HGF is a synergistic factor for the growth of hematopoietic progenitor cells
    • KMIECIK T.E., KELLER J.R., ROSEN E. & VANDE WOUDE GF. (1992) HGF is a synergistic factor for the growth of hematopoietic progenitor cells. Blood 80, 2454-2457.
    • (1992) Blood , vol.80 , pp. 2454-2457
    • Kmiecik, T.E.1    Keller, J.R.2    Rosen, E.3    Vande Woude, G.F.4
  • 58
    • 0028121002 scopus 로고
    • HGF elevates the activity levels of glycolipid sulfotransferases in renal cell carcinoma cells
    • KOBAYASHI T., HONKE T., GASA S. ET AL. (1994) HGF elevates the activity levels of glycolipid sulfotransferases in renal cell carcinoma cells. Eur J. Biochem. 219, 407-413.
    • (1994) Eur J. Biochem. , vol.219 , pp. 407-413
    • Kobayashi, T.1    Honke, T.2    Gasa, S.3
  • 59
    • 0028174871 scopus 로고
    • PDGF. -independent activation of PDGF-beta receptors in NIH-3T3 cells transformed by c-met proto-oncogene
    • KOCHHAR K.S., LINNEKIN D. & IYER A.P. (1994) PDGF. -independent activation of PDGF-beta receptors in NIH-3T3 cells transformed by c-met proto-oncogene. Exp Cell Res. 212, 414-421.
    • (1994) Exp Cell Res. , vol.212 , pp. 414-421
    • Kochhar, K.S.1    Linnekin, D.2    Iyer, A.P.3
  • 61
    • 0027264590 scopus 로고
    • The cell dissociation and motility triggered bt HGF/SF are mediated through the cytoplasmic domain of the c-met receptor
    • KOMADA M. & KITAMURA N. (1993) The cell dissociation and motility triggered bt HGF/SF are mediated through the cytoplasmic domain of the c-met receptor. Oncogene 8, 2381-2390.
    • (1993) Oncogene , vol.8 , pp. 2381-2390
    • Komada, M.1    Kitamura, N.2
  • 63
    • 0030070506 scopus 로고    scopus 로고
    • Interaction of mutants of tissue-type plasminogen activator with liver cells: Effect of domain deletions
    • KUIPER T., VAN'T-HOF T., OTTER T., BIESSEN T., RIJKEN D. & VANBERKEL T. (1996) Interaction of Mutants of tissue-type plasminogen activator with liver cells: effect of domain deletions. Biochem. J. 313, 775-780.
    • (1996) Biochem. J. , vol.313 , pp. 775-780
    • Kuiper, T.1    Van't-Hof, T.2    Otter, T.3    Biessen, T.4    Rijken, D.5    Vanberkel, T.6
  • 66
    • 0027965021 scopus 로고
    • Identification of a novel type of alternative spilicing of a tyrosine kinase receptor
    • LEE C.C. & YAMADA K.M. (1994) Identification of a novel type of alternative spilicing of a tyrosine kinase receptor. J. Biol. Chem. 269, 19457-19461.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19457-19461
    • Lee, C.C.1    Yamada, K.M.2
  • 68
    • 0026725139 scopus 로고
    • Effects of scatter factor and HGF on motility and morphology of MDCK cells in vitro
    • LI T., JOSEPH T., BHARGAVA M.M., ROSEN E.M., NAKAMURA T. & GOLDBERG I. (1992) Effects of scatter factor and HGF on motility and morphology of MDCK cells in vitro. Cell Dev Biol. 28A, 364-368.
    • (1992) Cell Dev Biol. , vol.28 A , pp. 364-368
    • Li, T.1    Joseph, T.2    Bhargava, M.M.3    Rosen, E.M.4    Nakamura, T.5    Goldberg, I.6
  • 70
    • 0024231918 scopus 로고
    • Serum from partially hepatectomized rats induces primary hepatocytes to enter S phase: Role for prostaglandins?
    • LITTLE T., SKOUTERIS G.G., ORD M.G. & STOCKEN L.A. (1988) Serum from partially hepatectomized rats induces primary hepatocytes to enter S phase: role for prostaglandins? J. Cell Sci. 91, 549-553.
    • (1988) J. Cell Sci. , vol.91 , pp. 549-553
    • Little, T.1    Skouteris, G.G.2    Ord, M.G.3    Stocken, L.A.4
  • 71
    • 0026595807 scopus 로고
    • Overexpression of c-met proto-oncogene but not epidermal growth factor receptor or c-erbB-2 in primary human colorectal carcinomas
    • LIU T., PARK M. & TSAO M.S. (1992) Overexpression of c-met proto-oncogene but not epidermal growth factor receptor or c-erbB-2 in primary human colorectal carcinomas. Oncogene 7, 181-185.
    • (1992) Oncogene , vol.7 , pp. 181-185
    • Liu, T.1    Park, M.2    Tsao, M.S.3
  • 72
    • 0027721936 scopus 로고
    • In vitro and in vivo expression of transforming growth factor-alpha and tyrosine kinase receptor in human non-small-cell lung carcinoma
    • LIU C. & TSAO M.S. (1993a) In vitro and in vivo expression of transforming growth factor-alpha and tyrosine kinase receptor in human non-small-cell lung carcinoma. Am. J. Pathol. 14, 1155-1162.
    • (1993) Am. J. Pathol. , vol.14 , pp. 1155-1162
    • Liu, C.1    Tsao, M.S.2
  • 73
    • 0027518618 scopus 로고
    • Proto-oncogene and growth factor/receptor expression in the establishment of primary human non-small cell lung carcinoma cell lines
    • LIU C. & TSAO M.S. (1993b) Proto-oncogene and growth factor/ receptor expression in the establishment of primary human non-small cell lung carcinoma cell lines. Am. J. Pathol. 142, 413-423.
    • (1993) Am. J. Pathol. , vol.142 , pp. 413-423
    • Liu, C.1    Tsao, M.S.2
  • 74
    • 0027205562 scopus 로고
    • Activation of phospholipase A-2 and stimulation of prostaglandin E-2 production by transforming growth factor-alpha in rat thymic epithelial cells requires influx of calcium
    • LIU T., WEN T., SUN L. & HAYASHI J. (1993) Activation of phospholipase A-2 and stimulation of prostaglandin E-2 production by transforming growth factor-alpha in rat thymic epithelial cells requires influx of calcium. Biochem. J. 293, 109-113.
    • (1993) Biochem. J. , vol.293 , pp. 109-113
    • Liu, T.1    Wen, T.2    Sun, L.3    Hayashi, J.4
  • 75
    • 0028025345 scopus 로고
    • Structural and functional characterisation of the mouse hepatocyte growth factor gene promoter
    • LIU T., MICHALOPOULOS G.K. & ZARNEGAR R. (1994) Structural and functional characterisation of the mouse hepatocyte growth factor gene promoter. J. Biol. Chem 269, 52-60.
    • (1994) J. Biol. Chem , vol.269 , pp. 52-60
    • Liu, T.1    Michalopoulos, G.K.2    Zarnegar, R.3
  • 76
    • 0028177817 scopus 로고
    • Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of HGF identifies amino acid side chains important for interaction with the c-met receptor
    • LOKKER N.A., PRESTA L.G. & GODOWSKI P.J. (1994) Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of HGF identifies amino acid side chains important for interaction with the c-met receptor. Protein Eng 7, 895-903.
    • (1994) Protein Eng , vol.7 , pp. 895-903
    • Lokker, N.A.1    Presta, L.G.2    Godowski, P.J.3
  • 77
    • 0028181118 scopus 로고
    • Tyrosines (1234-1235) are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor)
    • LONGATI T., BARDELLI T., PONZETTO T., NALDINI L. & COMOGLIO P.M. (1994) Tyrosines (1234-1235) are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor). Oncogene 9, 49-57.
    • (1994) Oncogene , vol.9 , pp. 49-57
    • Longati, T.1    Bardelli, T.2    Ponzetto, T.3    Naldini, L.4    Comoglio, P.M.5
  • 78
    • 13344294396 scopus 로고    scopus 로고
    • A. family of transmembrane proteins with homology to the Met-HGF receptor
    • MAESTRINI T., TAMAGNONE T., LONGATI P. ET AL. (1996) A. family of transmembrane proteins with homology to the Met-HGF receptor. Proc. Natl. Acad. Sci. USA. 93, 674-678.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 674-678
    • Maestrini, T.1    Tamagnone, T.2    Longati, P.3
  • 79
    • 0029115343 scopus 로고
    • Signal transduction by the alph-6 beta-4 integrin: Distinct beta-4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesosomes
    • MAINIERO T., PEPE T., WARY K.K. ET AL. (1995) Signal transduction by the alph-6 beta-4 integrin: Distinct beta-4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesosomes. EMBO J. 14, 4470-4481.
    • (1995) EMBO J. , vol.14 , pp. 4470-4481
    • Mainiero, T.1    Pepe, T.2    Wary, K.K.3
  • 81
    • 0026768884 scopus 로고
    • Role of the adenylate cyclase, phosphoinositidase C and receptor tyrosyl kinase systems in the control of hepatocyte proliferation by HGF
    • MARKER A.J., GALLOWAY T., PALMER S. ET AL. (1992) Role of the adenylate cyclase, phosphoinositidase C and receptor tyrosyl kinase systems in the control of hepatocyte proliferation by HGF. Biochem. Pharmacol. 44, 1037-1043.
    • (1992) Biochem. Pharmacol. , vol.44 , pp. 1037-1043
    • Marker, A.J.1    Galloway, T.2    Palmer, S.3
  • 82
    • 0027761342 scopus 로고
    • Activation of hepatocyte growth factor by the plasminogen activators
    • MARS W.M., ZARNEGAR R. & MICHALOPOULOS G.K. (1993) Activation of hepatocyte growth factor by the plasminogen activators. Am. J. Pathol 143, 949-958.
    • (1993) Am. J. Pathol , vol.143 , pp. 949-958
    • Mars, W.M.1    Zarnegar, R.2    Michalopoulos, G.K.3
  • 83
    • 0028070429 scopus 로고
    • Involvement of annexin I and annexin II in hepatocyte proliferation: Can annexins I and II be markers for proliferative hepatocytes?
    • MASAKI T., TOKUDA T., FUJIMURA T. ET AL. (1994) Involvement of annexin I and annexin II in hepatocyte proliferation: Can annexins I and II be markers for proliferative hepatocytes? Hepatology 20, 425-435.
    • (1994) Hepatology , vol.20 , pp. 425-435
    • Masaki, T.1    Tokuda, T.2    Fujimura, T.3
  • 85
    • 0025870823 scopus 로고
    • HGF. is a potent stimulator of human melanocyte DNA synthesis and growth
    • MATSUMOTO T., TAJIMA H. & NAKAMURA T. (1991) HGF. is a potent stimulator of human melanocyte DNA synthesis and growth. Biochem. Biophys. Res. Commun. 176, 45-51.
    • (1991) Biochem. Biophys. Res. Commun. , vol.176 , pp. 45-51
    • Matsumoto, T.1    Tajima, H.2    Nakamura, T.3
  • 86
  • 87
    • 0027985758 scopus 로고
    • Pleiotropic roles of HGF in mitogenesis, morphogenesis, and organ regeneration
    • MATSUMOTO K. & NAKAMURA T. (1994) Pleiotropic roles of HGF in mitogenesis, morphogenesis, and organ regeneration. Gann Monogr. Cancer Res. 42, 91-112.
    • (1994) Gann Monogr. Cancer Res. , vol.42 , pp. 91-112
    • Matsumoto, K.1    Nakamura, T.2
  • 89
    • 0028942672 scopus 로고
    • Novel function of prostaglandins as inducers of gene expression of HGF and putative mediators of tissue regeneration
    • MATSUMOTO T., OKAZAKI H. & NAKAMURA T. (1995b) Novel function of prostaglandins as inducers of gene expression of HGF and putative mediators of tissue regeneration. J. Biochem. 117, 458-464.
    • (1995) J. Biochem. , vol.117 , pp. 458-464
    • Matsumoto, T.1    Okazaki, H.2    Nakamura, T.3
  • 90
    • 0019458617 scopus 로고
    • DNA. synthesis in primary cultures of adult rat hepatocytes in a defined medium: Effects of epidermal growth factor, insulin, glucagon, and cyclic-AMP
    • MCGOWAN J.A., STRAIN A.J. & BUCHER N.L. (1981) DNA. synthesis in primary cultures of adult rat hepatocytes in a defined medium: Effects of epidermal growth factor, insulin, glucagon, and cyclic-AMP. J. Cell Physiol. 108, 353-363.
    • (1981) J. Cell Physiol. , vol.108 , pp. 353-363
    • McGowan, J.A.1    Strain, A.J.2    Bucher, N.L.3
  • 91
    • 0001870863 scopus 로고
    • Hepatocyte proliferation in culture
    • Eds. A. GUILLOUZO & C. GUGUEN-GUILLOUZO. Paris: EUROTEXT Ltd.
    • MCGOWAN J.A. (1986) Hepatocyte proliferation in culture. In: Isolated and Cultured Hepatocytes. Eds. A. GUILLOUZO & C. GUGUEN-GUILLOUZO. Paris: EUROTEXT Ltd. pp. 13-88.
    • (1986) Isolated and Cultured Hepatocytes , pp. 13-88
    • McGowan, J.A.1
  • 93
    • 0026321390 scopus 로고
    • Comparison of effects of HGF and EGF on cellular calcium in rat hepatocyte
    • MINE T., KOJIMA T., OGATA E. & NAKAMURA T. (1991) Comparison of effects of HGF and EGF on cellular calcium in rat hepatocyte. Biochem. Biophys. Res. Commun. 181, 1173-1180.
    • (1991) Biochem. Biophys. Res. Commun. , vol.181 , pp. 1173-1180
    • Mine, T.1    Kojima, T.2    Ogata, E.3    Nakamura, T.4
  • 94
    • 0025812020 scopus 로고
    • An alternatively processed mRNA generatedd from human HGF gene
    • MIYAZAWA T., KITAMURA T., NAKA D. & KITAMURA N. (1991) An alternatively processed mRNA generatedd from human HGF gene. Eur J. Biochem. 197, 15-22.
    • (1991) Eur J. Biochem. , vol.197 , pp. 15-22
    • Miyazawa, T.1    Kitamura, T.2    Naka, D.3    Kitamura, N.4
  • 96
    • 0027074266 scopus 로고
    • Proteolytic activation of a single chain precursor of hepatocyte growth factor by extracellular serine-protease
    • MIZUNO T., TAKEHARA T. & NAKAMURA T. (1992) Proteolytic activation of a single chain precursor of hepatocyte growth factor by extracellular serine-protease. Biochem. Biophys. Res. Commun 189, 1631-1638.
    • (1992) Biochem. Biophys. Res. Commun , vol.189 , pp. 1631-1638
    • Mizuno, T.1    Takehara, T.2    Nakamura, T.3
  • 97
    • 0027348749 scopus 로고
    • Molecular characterisation of HGF and the gene, and its biochemical aspects
    • MIZUNO K. & NAKAMURA T. (1993) Molecular characterisation of HGF and the gene, and its biochemical aspects. EXS. 65, 1-29.
    • (1993) EXS , vol.65 , pp. 1-29
    • Mizuno, K.1    Nakamura, T.2
  • 99
    • 0028123481 scopus 로고
    • Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hepatocyte growth factor
    • MIZUNO T., INOUE T., HAGIYA M. ET AL. (1994) Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hepatocyte growth factor. J. Biol. Chem 269, 1131-1136.
    • (1994) J. Biol. Chem , vol.269 , pp. 1131-1136
    • Mizuno, T.1    Inoue, T.2    Hagiya, M.3
  • 100
    • 0028318915 scopus 로고
    • Modulation of c-met proto-oncogene (HGF receptor) mRNA abundance by cytokines and hormones. Evidence for rapid decay of the 8kb c-met transcript
    • MOGHUL T., LIN T., BEEDLE A. ET AL. (1994) Modulation of c-met proto-oncogene (HGF receptor) mRNA abundance by cytokines and hormones. Evidence for rapid decay of the 8kb c-met transcript. Oncogene 9, 2045-2052.
    • (1994) Oncogene , vol.9 , pp. 2045-2052
    • Moghul, T.1    Lin, T.2    Beedle, A.3
  • 101
    • 0029125390 scopus 로고
    • HGF/SF. inhibits junctional communication
    • MOORBY C.D., STOKER M. & GHERARDI E. (1995) HGF/SF. inhibits junctional communication. Exp Cell Res. 219, 657-663.
    • (1995) Exp Cell Res. , vol.219 , pp. 657-663
    • Moorby, C.D.1    Stoker, M.2    Gherardi, E.3
  • 102
    • 0029115405 scopus 로고
    • Concomitant expression of HGF, HGF activator and c-met genes in human glioma cells in vitro
    • MORIYAMA T., KATAOKA T., TSUBOUCHI H. & KOONO M. (1995) Concomitant expression of HGF, HGF activator and c-met genes in human glioma cells in vitro. FEBS-Lett. 372, 78-82.
    • (1995) FEBS-lett. , vol.372 , pp. 78-82
    • Moriyama, T.1    Kataoka, T.2    Tsubouchi, H.3    Koono, M.4
  • 103
    • 0024427178 scopus 로고
    • Molecular cloning and expression of the human hepatocyte growth factor
    • NAKAMURA T., NISHIZAWA T., HAGIYA M. ET AL. (1989) Molecular cloning and expression of the human hepatocyte growth factor. Nature 342, 440-443.
    • (1989) Nature , vol.342 , pp. 440-443
    • Nakamura, T.1    Nishizawa, T.2    Hagiya, M.3
  • 104
    • 0026287917 scopus 로고
    • Structure and function of HGF
    • NAKAMURA T. (1991) Structure and function of HGF. Prog. Growth Factor Res. 3, 67-85.
    • (1991) Prog. Growth Factor Res. , vol.3 , pp. 67-85
    • Nakamura, T.1
  • 105
    • 0025959661 scopus 로고
    • The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation
    • NALDINI T., VIGNA T., FERRACINI R. ET AL. (1991) The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation. Mol Cell Biol. 11, 1793-1803.
    • (1991) Mol Cell Biol. , vol.11 , pp. 1793-1803
    • Naldini, T.1    Vigna, T.2    Ferracini, R.3
  • 106
    • 0028912590 scopus 로고
    • Biological activation of pro-HGF by urokinase is controlle by stoichiometric reaction
    • NALDINI T., VIGNA T., BARDELLI T., FOLLENZI T., GALIMI F. & COMOGLIO P.M. (1995) Biological activation of pro-HGF by urokinase is controlle by stoichiometric reaction. J. Biol. Chem 270, 603-611.
    • (1995) J. Biol. Chem , vol.270 , pp. 603-611
    • Naldini, T.1    Vigna, T.2    Bardelli, T.3    Follenzi, T.4    Galimi, F.5    Comoglio, P.M.6
  • 107
    • 0027382172 scopus 로고
    • Expression of the c-met/HGF receptor in human melanocytic neoplasms. Demonstration of the relationship to malignant melanoma tumour progression
    • NATALI P.G., NICOTRA M.R., DIRENZO M.F. ET AL. (1993) Expression of the c-met/HGF receptor in human melanocytic neoplasms. Demonstration of the relationship to malignant melanoma tumour progression. Br. J. Cancer. 68, 746-750.
    • (1993) Br. J. Cancer. , vol.68 , pp. 746-750
    • Natali, P.G.1    Nicotra, M.R.2    Direnzo, M.F.3
  • 108
    • 0027339018 scopus 로고
    • Characterisation of prostaglandin-F (2 alpha) binding sites on rat hepatocyte plasma membranes
    • NEUSCHAFER RUBE T., PUSCHEL G.P. & JUNGERMANN K. (1993) Characterisation of prostaglandin-F (2 alpha) binding sites on rat hepatocyte plasma membranes. Eur J. Biochem. 211, 163-169.
    • (1993) Eur J. Biochem. , vol.211 , pp. 163-169
    • Neuschafer Rube, T.1    Puschel, G.P.2    Jungermann, K.3
  • 109
    • 0028071341 scopus 로고
    • Molecular cloning and expression of a prostaglandin E-2 receptor of the EP (3 beta) subtype from rat hepatocytes
    • NEUSCHAFER RUBE T., DEVRIES T., HANECKE T., JUNGERMANN K. & PUSCHEL G.P. (1994) Molecular cloning and expression of a prostaglandin E-2 receptor of the EP (3 beta) subtype from rat hepatocytes. FEBS Lett. 351, 119-122.
    • (1994) FEBS Lett. , vol.351 , pp. 119-122
    • Neuschafer Rube, T.1    Devries, T.2    Hanecke, T.3    Jungermann, K.4    Puschel, G.P.5
  • 110
    • 0029127339 scopus 로고
    • HGF/SF. A potent cytokine for mammary growth, morphogenesis and development
    • NIRANJAN T., BULUWELA T., YANT J. ET AL. (1995) HGF/SF. A potent cytokine for mammary growth, morphogenesis and development. Development. 121, 2897-2908.
    • (1995) Development , vol.121 , pp. 2897-2908
    • Niranjan, T.1    Buluwela, T.2    Yant, J.3
  • 112
    • 0025665128 scopus 로고
    • Expression of HGF gene in endothelial and kupffer cells of damaged rat livers, as revealed by in situ hybridisation
    • NOJI T., TASHIRO T., KOYAMA E. ET AL. (1990) Expression of HGF gene in endothelial and kupffer cells of damaged rat livers, as revealed by in situ hybridisation. Biochem. Biophys. Res. Commun 173, 42-47.
    • (1990) Biochem. Biophys. Res. Commun , vol.173 , pp. 42-47
    • Noji, T.1    Tashiro, T.2    Koyama, E.3
  • 113
    • 0027292358 scopus 로고
    • Tyrosine phosphorylation of phospholipase C gamma in c-MET/HGF receptor-stimulated hepatocytes: Comparison with HepG2 hepatocarcinoma cells
    • OKANO T., MIZUNO T., OSADA T., NAKAMURA T. & NOZAWA Y. (1993) Tyrosine phosphorylation of phospholipase C gamma in c-MET/HGF receptor-stimulated hepatocytes: Comparison with HepG2 hepatocarcinoma cells. Biochem. Biophys. Res. Commun. 190, 842-848.
    • (1993) Biochem. Biophys. Res. Commun. , vol.190 , pp. 842-848
    • Okano, T.1    Mizuno, T.2    Osada, T.3    Nakamura, T.4    Nozawa, Y.5
  • 114
    • 0026516956 scopus 로고
    • HGF mediates the sustained formation of 1, 2-diacylglycerol via phosphatidylcholine-phospholipase C in cultured rat hepatocytes
    • OSADA T., NAKASHIMA T., SAJI T., NAKAMURA T. & NOZAWA Y. (1992a) HGF mediates the sustained formation of 1, 2-diacylglycerol via phosphatidylcholine-phospholipase C in cultured rat hepatocytes. FEBS Lett. 297, 271-274.
    • (1992) FEBS Lett. , vol.297 , pp. 271-274
    • Osada, T.1    Nakashima, T.2    Saji, T.3    Nakamura, T.4    Nozawa, Y.5
  • 115
    • 0026724262 scopus 로고
    • Cytosolic calcium oscillations induced by HGF in single fura-2-loaded cultured hepatocytes: Effects of extracellular calcium and protein kinase C
    • OSADA T., SAJI T., NAKAMURA T. & NOZAWA Y. (1992b) Cytosolic calcium oscillations induced by HGF in single fura-2-loaded cultured hepatocytes: Effects of extracellular calcium and protein kinase C. Biochem. Biophys. Acta. 1135, 229-232.
    • (1992) Biochem. Biophys. Acta. , vol.1135 , pp. 229-232
    • Osada, T.1    Saji, T.2    Nakamura, T.3    Nozawa, Y.4
  • 116
    • 0024473604 scopus 로고
    • G1 events and regulation of cell proliferation
    • PARDEE A.B. (1989) G1 events and regulation of cell proliferation. Science 246, 603-608.
    • (1989) Science , vol.246 , pp. 603-608
    • Pardee, A.B.1
  • 117
    • 0029007694 scopus 로고
    • The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein
    • PELICCI T., GIORDANO T., ZHEN Z. ET AL. (1995) The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein. Oncogene 10, 1631-1638.
    • (1995) Oncogene , vol.10 , pp. 1631-1638
    • Pelicci, T.1    Giordano, T.2    Zhen, Z.3
  • 119
    • 0027219258 scopus 로고
    • A. Novel recognition motif for phosphatidylinositol 3 kinase binding mediates its association with the HGF/SF receptor
    • PONZETTO T., BARDELLI T., MAINA F. ET AL. (1993) A. novel recognition motif for phosphatidylinositol 3 kinase binding mediates its association with the HGF/SF receptor. Mol Cell Biol. 13, 4600-4608.
    • (1993) Mol Cell Biol. , vol.13 , pp. 4600-4608
    • Ponzetto, T.1    Bardelli, T.2    Maina, F.3
  • 121
    • 0026526140 scopus 로고
    • The gene of HGF is expressed in fat-storing cells of rat liver and is down-regulated during cell growth and by transforming growth factor-beta
    • RAMADORI T., NEUBAUER T., ODENTHAL M. ET AL. (1992) The gene of HGF is expressed in fat-storing cells of rat liver and is down-regulated during cell growth and by transforming growth factor-beta. Biochem. Biophys. Res. Commun 183, 739-742.
    • (1992) Biochem. Biophys. Res. Commun , vol.183 , pp. 739-742
    • Ramadori, T.1    Neubauer, T.2    Odenthal, M.3
  • 122
    • 0028894787 scopus 로고
    • Regulation of HGF/SF responses by Ras, Rac, and Rho in MDCK cells
    • RIDLEY A.J., COMOGLIO P.M. & HALL A. (1995) Regulation of HGF/ SF responses by Ras, Rac, and Rho in MDCK cells. Mol Cell Biol. 15, 1110-1122.
    • (1995) Mol Cell Biol. , vol.15 , pp. 1110-1122
    • Ridley, A.J.1    Comoglio, P.M.2    Hall, A.3
  • 123
    • 0026655776 scopus 로고
    • Tumorigenicity of the met proto-oncogene and the gene for HGF
    • RONG T., BODESCOT T., BLAIR D. ET EL. (1992) Tumorigenicity of the met proto-oncogene and the gene for HGF. Mol Cell Biol. 12, 5152-5158.
    • (1992) Mol Cell Biol. , vol.12 , pp. 5152-5158
    • Rong, T.1    Bodescot, T.2    Blair, D.3
  • 124
    • 0027318311 scopus 로고
    • A novel putative receptor protein tyrosine kinase of the met family
    • RONSIN T., MUSCATELLI T., MATTEI M.G. & BREATHENACH R. (1993) A novel putative receptor protein tyrosine kinase of the met family. Oncogene 8, 1195-1202.
    • (1993) Oncogene , vol.8 , pp. 1195-1202
    • Ronsin, T.1    Muscatelli, T.2    Mattei, M.G.3    Breathenach, R.4
  • 125
    • 0026011092 scopus 로고
    • A. broad spectrum human lung fibroblast-derived mitogen is a variant of HGF
    • RUBIN J.S., CHAN A.M., BOTTARO D.P. ET AL. (1991) A. broad spectrum human lung fibroblast-derived mitogen is a variant of HGF. Proc. Natl. Acad. Sci. USA 88, 415-419.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 415-419
    • Rubin, J.S.1    Chan, A.M.2    Bottaro, D.P.3
  • 126
    • 0027390395 scopus 로고
    • Expression of the proto-oncogenes c-met and c-kit and their ligands, HGF/SF and stem cell factor, in SCLC cell lines and xenografts
    • RYGAARD T., NAKAMURA T. & SPANG-THOMSEN M. (1993) Expression of the proto-oncogenes c-met and c-kit and their ligands, HGF/SF and stem cell factor, in SCLC cell lines and xenografts. Br. J. Cancer. 67, 37-46.
    • (1993) Br. J. Cancer. , vol.67 , pp. 37-46
    • Rygaard, T.1    Nakamura, T.2    Spang-Thomsen, M.3
  • 128
    • 0027997656 scopus 로고
    • Detection of the c-met proto-oncogene product in normal skin and tumours of melanocytic origin
    • SAITOH T., TAKAHASHI T., SAWADA N. & PARSONS P.G. (1994) Detection of the c-met proto-oncogene product in normal skin and tumours of melanocytic origin. J. Pathol. 174, 191-199.
    • (1994) J. Pathol. , vol.174 , pp. 191-199
    • Saitoh, T.1    Takahashi, T.2    Sawada, N.3    Parsons, P.G.4
  • 129
    • 0027133587 scopus 로고
    • HGF. -induced tubulogenesis and branching of epithelial cells is modulated by extracellular matrix and TGF-beta
    • SANTOS O.F. & NIGAM S.K. (1993) HGF. -induced tubulogenesis and branching of epithelial cells is modulated by extracellular matrix and TGF-beta. Dev Biol. 160, 293-302.
    • (1993) Dev Biol. , vol.160 , pp. 293-302
    • Santos, O.F.1    Nigam, S.K.2
  • 130
    • 0029001626 scopus 로고
    • HGF. is involved in formation of osteoclast-like cells mediated by clonal stromal cells (MC3T3-G2/PA6)
    • SATO T., HAKEDA T., YAMAGUCHI Y. ET AL. (1995) HGF. is involved in formation of osteoclast-like cells mediated by clonal stromal cells (MC3T3-G2/PA6). J. Cell Physiol. 164, 197-204.
    • (1995) J. Cell Physiol. , vol.164 , pp. 197-204
    • Sato, T.1    Hakeda, T.2    Yamaguchi, Y.3
  • 131
    • 0028899952 scopus 로고
    • SF/HGF is essential for liver development
    • SCHMIDT T., BLADT T., GOEDECKE S. ET AL. (1995) SF/HGF is essential for liver development. Nature 373, 699-702.
    • (1995) Nature , vol.373 , pp. 699-702
    • Schmidt, T.1    Bladt, T.2    Goedecke, S.3
  • 132
    • 0023765743 scopus 로고
    • Genes specifically expressed at growth arrest of mammalian cells
    • SCHNEIDER T., KING R.M. & PHILIPSON L. (1988) Genes specifically expressed at growth arrest of mammalian cells. Cell 54, 787-793.
    • (1988) Cell , vol.54 , pp. 787-793
    • Schneider, T.1    King, R.M.2    Philipson, L.3
  • 133
    • 0025862023 scopus 로고
    • Organisation of the human hepatocyte growth factor-encoding gene
    • SEKI T., HAGIYA T., SHIMONISHI T., NAKAMURA T. & SHIMIZU S. (1991) Organisation of the human hepatocyte growth factor-encoding gene. Gene 102, 213-219.
    • (1991) Gene , vol.102 , pp. 213-219
    • Seki, T.1    Hagiya, T.2    Shimonishi, T.3    Nakamura, T.4    Shimizu, S.5
  • 134
    • 0028071919 scopus 로고
    • Expression of HGF mRNA, and c-met mRNA (HGF receptor) in human liver tumours
    • SELDEN T., FARNAUD T., DING S.F., HABIB T., FOSTER C. & HODGSON H.J. (1994) Expression of HGF mRNA, and c-met mRNA (HGF receptor) in human liver tumours. J. Hepatol. 21, 227-234.
    • (1994) J. Hepatol. , vol.21 , pp. 227-234
    • Selden, T.1    Farnaud, T.2    Ding, S.F.3    Habib, T.4    Foster, C.5    Hodgson, H.J.6
  • 135
    • 0013664240 scopus 로고
    • H6F and its variant with a deletion of five amino acids are distinguishable in biological physiochemical and immunological properties
    • Ed. G.G. SKOUTERIS. Heidelberg: Springer-Verlag
    • SHIMA N. & HIGASHIO K. (1994) H6F and its variant with a deletion of five amino acids are distinguishable in biological physiochemical and immunological properties. In: Liver Carcinogenesis: the Molecular Pathways. Series H, Vol. 88. Ed. G.G. SKOUTERIS. Heidelberg: Springer-Verlag, 55-70.
    • (1994) Liver Carcinogenesis: the Molecular Pathways. Series H , vol.88 , pp. 55-70
    • Shima, N.1    Higashio, K.2
  • 136
    • 0028280372 scopus 로고
    • HGF. and its variant with a deletion of five aminoacids are distinguishable in their biological activity and tertiary structure
    • SHIMA T., TSUDA T., GOTO M. ET AL. (1994) HGF. and its variant with a deletion of five aminoacids are distinguishable in their biological activity and tertiary structure. Biochem. Biophys. Res. Commun 200, 808-815.
    • (1994) Biochem. Biophys. Res. Commun , vol.200 , pp. 808-815
    • Shima, T.1    Tsuda, T.2    Goto, M.3
  • 137
    • 0027425237 scopus 로고
    • Hepatocyte growth factor-like protein is identical to macrophage stimulating protein
    • SHIMAMOTO T., KIMURA T., MATSUMOTO K. & NAKAMURA T. (1993) Hepatocyte growth factor-like protein is identical to macrophage stimulating protein. FEBS Lett. 333, 61-66.
    • (1993) FEBS Lett. , vol.333 , pp. 61-66
    • Shimamoto, T.1    Kimura, T.2    Matsumoto, K.3    Nakamura, T.4
  • 138
    • 0029155558 scopus 로고
    • Induction of invasive growth in a gallbladder cancer cell line by HGF in vitro
    • SHIMURA T., DATE T., MATSUMOTO T., NAKAMURA T. & TANAKA M. (1995) Induction of invasive growth in a gallbladder cancer cell line by HGF in vitro. Jpn J. Cancer Res. 86, 662-669.
    • (1995) Jpn J. Cancer Res. , vol.86 , pp. 662-669
    • Shimura, T.1    Date, T.2    Matsumoto, T.3    Nakamura, T.4    Tanaka, M.5
  • 141
    • 0028835479 scopus 로고
    • Stimulatory effects of HGF on normal and neoplastic human bronchial epithelial cells
    • SINGH KAW T., ZARNEGAR R. & SIEGFRIED J.M. (1995) Stimulatory effects of HGF on normal and neoplastic human bronchial epithelial cells. Am. J. Physiol. 268L, 1012-1020.
    • (1995) Am. J. Physiol. , vol.268 L , pp. 1012-1020
    • Singh Kaw, T.1    Zarnegar, R.2    Siegfried, J.M.3
  • 142
    • 0025925237 scopus 로고
    • Prostaglandins E-2 and F (2a) mediate the increase in c-myc expression induced by EGF in primary rat hetpatocyte cultures
    • SKOUTERIS G.G. & KASER M.R. (1991) Prostaglandins E-2 and F (2a) mediate the increase in c-myc expression induced by EGF in primary rat hetpatocyte cultures. Biochem. Biophys. Res. Commun. 178, 1240-1246.
    • (1991) Biochem. Biophys. Res. Commun. , vol.178 , pp. 1240-1246
    • Skouteris, G.G.1    Kaser, M.R.2
  • 143
    • 0029861906 scopus 로고    scopus 로고
    • The HGF receptor kinase-mediated phosphorylation of lipocortin-1 transduces the proliferating signal of the HGF
    • SKOUTERIS G.G. & SCHRÖDER C.H. (1996) The HGF receptor kinase-mediated phosphorylation of lipocortin-1 transduces the proliferating signal of the HGF. J. Biol. Chem. 271, 27266-27273.
    • (1996) J. Biol. Chem. , vol.271 , pp. 27266-27273
    • Skouteris, G.G.1    Schröder, C.H.2
  • 144
    • 0029671058 scopus 로고    scopus 로고
    • HGF-induced proliferation of primary hepatocytes is mediated by activation of phosphatidylinositol 3-kinase
    • SKOUTERIS G.G. & GEORGAKOPOULOS E. (1996) HGF-induced proliferation of primary hepatocytes is mediated by activation of phosphatidylinositol 3-kinase. Biochem. Biophys. Res. Commun. 218, 229-233.
    • (1996) Biochem. Biophys. Res. Commun. , vol.218 , pp. 229-233
    • Skouteris, G.G.1    Georgakopoulos, E.2
  • 145
    • 0023711233 scopus 로고
    • Regulation of the proliferation of primary rat hepatocytes by eicosanoids
    • SKOUTERIS G.G., ORD M.G. & STOCKEN L.A. (1988) Regulation of the proliferation of primary rat hepatocytes by eicosanoids. J. Cell Physiol. 135, 516-525.
    • (1988) J. Cell Physiol. , vol.135 , pp. 516-525
    • Skouteris, G.G.1    Ord, M.G.2    Stocken, L.A.3
  • 146
    • 0028919917 scopus 로고
    • HGF stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells
    • SORIANO J.V., PEPPER M.S., NAKAMURA T., ORCI L. & MONTESANO R. (1995) HGF stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells. J. Cell. Sci. 108, 413-430.
    • (1995) J. Cell. Sci. , vol.108 , pp. 413-430
    • Soriano, J.V.1    Pepper, M.S.2    Nakamura, T.3    Orci, L.4    Montesano, R.5
  • 147
    • 0028087992 scopus 로고
    • Comparative effects of HGF and EGF on motility, morphology, mitogenesis, and signal transduction of primary rat hepatocytes
    • STOLZ D.B. & MICHALOPOULOS G.K. (1994) Comparative effects of HGF and EGF on motility, morphology, mitogenesis, and signal transduction of primary rat hepatocytes. J. Cell Biochem. 55, 445-464.
    • (1994) J. Cell Biochem. , vol.55 , pp. 445-464
    • Stolz, D.B.1    Michalopoulos, G.K.2
  • 148
    • 0025855880 scopus 로고
    • Native and recombinant human hepatocyte growth factors are highly potent promoters of DNA synthesis in both human and rat hepatocytes
    • STRAIN A.J., ISMAIL T., TSUBOUCHI H. ET AL. (1991) Native and recombinant human hepatocyte growth factors are highly potent promoters of DNA synthesis in both human and rat hepatocytes. J. Clin. Invest 87, 1853-1857.
    • (1991) J. Clin. Invest , vol.87 , pp. 1853-1857
    • Strain, A.J.1    Ismail, T.2    Tsubouchi, H.3
  • 149
    • 0028230088 scopus 로고
    • HGF stimulates invasion across reconstituted basement membranes by a new human small intestinal cell line
    • SUNITHA T., MEIGHEN D.L., HARTMAN D.P., THOMPSON E.W., BYERS S.W. & AVIGAN M.I. (1994) HGF stimulates invasion across reconstituted basement membranes by a new human small intestinal cell line. Clin. Exp Metastasis 12, 143-154.
    • (1994) Clin. Exp Metastasis , vol.12 , pp. 143-154
    • Sunitha, T.1    Meighen, D.L.2    Hartman, D.P.3    Thompson, E.W.4    Byers, S.W.5    Avigan, M.I.6
  • 150
    • 0027967963 scopus 로고
    • Expression of the c-met proto-oncogene in human hepatocellular carcinoma
    • SUZUKI T., HAYASHI T., YAMADA Y. ET AL. (1994) Expression of the c-met proto-oncogene in human hepatocellular carcinoma. Hepatology 20, 1231-1236.
    • (1994) Hepatology , vol.20 , pp. 1231-1236
    • Suzuki, T.1    Hayashi, T.2    Yamada, Y.3
  • 151
    • 0028960496 scopus 로고
    • Genetic alterations in human gastrointestinal cancers. The application to molecular diagnosis
    • TAHARA E. (1995) Genetic alterations in human gastrointestinal cancers. the application to molecular diagnosis. Cancer 75, 1410-1417.
    • (1995) Cancer , vol.75 , pp. 1410-1417
    • Tahara, E.1
  • 152
    • 0026774146 scopus 로고
    • Regulation of cell growth and motility by HGF and receptor expression in various cell species
    • TAJIMA T., MATSUMOTO K. & NAKAMURA T. (1992) Regulation of cell growth and motility by HGF and receptor expression in various cell species. Exp Cell Res. 202, 423-431.
    • (1992) Exp Cell Res. , vol.202 , pp. 423-431
    • Tajima, T.1    Matsumoto, K.2    Nakamura, T.3
  • 153
    • 0027250936 scopus 로고
    • HGF. induces mitogenic reaction to the rabbit gastric epithelial cells in primary culture
    • TAKAHASHI T., OTA T., TERANO A. ET AL. (1993) HGF. induces mitogenic reaction to the rabbit gastric epithelial cells in primary culture. Biochem. Biophys. Res. Commun. 191, 528-534.
    • (1993) Biochem. Biophys. Res. Commun. , vol.191 , pp. 528-534
    • Takahashi, T.1    Ota, T.2    Terano, A.3
  • 154
    • 0027952703 scopus 로고
    • Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility
    • TAKAISHI T., SASAKI T., KATO M. ET AL. (1994) Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility. Oncogene 9, 273-279.
    • (1994) Oncogene , vol.9 , pp. 273-279
    • Takaishi, T.1    Sasaki, T.2    Kato, M.3
  • 155
    • 0029057923 scopus 로고
    • HGF/SF. modulates cell motility, proliferation and proteoglycan synthesis of chondrocytes
    • TAKEBAYASHI T., IWAMOTO T., JIKKO A. ET AL. (1995) HGF/SF. modulates cell motility, proliferation and proteoglycan synthesis of chondrocytes. J. Cell Biol. 129, 1411-1419.
    • (1995) J. Cell Biol. , vol.129 , pp. 1411-1419
    • Takebayashi, T.1    Iwamoto, T.2    Jikko, A.3
  • 156
    • 0027204285 scopus 로고
    • The human rky cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain
    • TAMAGNONE T., PARTANEN T., ARMSTRONG E. ET AL. (1993) The human rky cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain. Oncogene 8, 2009-2014.
    • (1993) Oncogene , vol.8 , pp. 2009-2014
    • Tamagnone, T.1    Partanen, T.2    Armstrong, E.3
  • 157
    • 0026342094 scopus 로고
    • Amplification of the epidermal growth factor receptor gene in human gliomas
    • TORP S.H., HELSETH T., RYAN T., STOLAN T., DALEN S. & UNSGAARD G. (1991) Amplification of the epidermal growth factor receptor gene in human gliomas. Anticancer Res. 11, 2095-2098.
    • (1991) Anticancer Res. , vol.11 , pp. 2095-2098
    • Torp, S.H.1    Helseth, T.2    Ryan, T.3    Stolan, T.4    Dalen, S.5    Unsgaard, G.6
  • 158
    • 0027633237 scopus 로고
    • HGF/SF. is an autocrine factor for the human normal bronchial epithelial and lung carcinoma cells
    • TSAO M.S., ZHU T., GIAID T., VIALLET T., NAKAMURA T. & PARK M. (1993) HGF/SF. is an autocrine factor for the human normal bronchial epithelial and lung carcinoma cells. Cell Growth Differ. 4, 571-579.
    • (1993) Cell Growth Differ. , vol.4 , pp. 571-579
    • Tsao, M.S.1    Zhu, T.2    Giaid, T.3    Viallet, T.4    Nakamura, T.5    Park, M.6
  • 159
    • 0028911690 scopus 로고
    • Placental defect and embryonic lethality in mice lacking HGF/SF
    • UEHARA T., MINOWA T., MORI C. ET AL. (1995) Placental defect and embryonic lethality in mice lacking HGF/SF. Nature 373, 702-705.
    • (1995) Nature , vol.373 , pp. 702-705
    • Uehara, T.1    Minowa, T.2    Mori, C.3
  • 160
    • 0026587278 scopus 로고
    • Effect of in vivo administration of an antibody to epidermal growth factor on the rapid increase in DNA synthesis induced by partial hepatectomy in the rat
    • VESEY D.A., SELDEN A.C., WOODMAN A.C. & HODGSON H.J. (1992) Effect of in vivo administration of an antibody to epidermal growth factor on the rapid increase in DNA synthesis induced by partial hepatectomy in the rat. Gut 33, 831-835.
    • (1992) Gut , vol.33 , pp. 831-835
    • Vesey, D.A.1    Selden, A.C.2    Woodman, A.C.3    Hodgson, H.J.4
  • 161
    • 0029117043 scopus 로고
    • HGF. is a potent mitogen for normal human pancreas cells in vitro
    • VILA M.R., NAKAMURA T. & REAL F.X. (1995) HGF. is a potent mitogen for normal human pancreas cells in vitro. Lab Invest. 73, 409-418.
    • (1995) Lab Invest. , vol.73 , pp. 409-418
    • Vila, M.R.1    Nakamura, T.2    Real, F.X.3
  • 162
    • 0027240189 scopus 로고
    • A. Protein tyrosine phosphatase activity associated with the HGF/SF receptor
    • VILLA MORUZZI T., LAPI T., PRAT T., GAUDINO G. & COMOGLIO PM. (1993) A. protein tyrosine phosphatase activity associated with the HGF/SF receptor. J. Biol. Chem. 268, 18176-18180.
    • (1993) J. Biol. Chem. , vol.268 , pp. 18176-18180
    • Villa Moruzzi, T.1    Lapi, T.2    Prat, T.3    Gaudino, G.4    Comoglio, P.M.5
  • 163
    • 0025780882 scopus 로고
    • Nuclear calcium gradients in cultured rat hepatocytes
    • WAYBIL M.M., YELAMARTY R.V., ZHANG Y.L. ET AL. (1991) Nuclear calcium gradients in cultured rat hepatocytes. Am. J. Physiol. 261, E49-E57.
    • (1991) Am. J. Physiol. , vol.261
    • Waybil, M.M.1    Yelamarty, R.V.2    Zhang, Y.L.3
  • 164
    • 0025119463 scopus 로고
    • Scatter factor: Molecular characteristics and effect on the invasiveness of epithelial cells
    • WEIDNER K.M., BEHRENS T., VANDEKERCKHOVE J. & BIRCHMEIET W. (1990) Scatter factor: Molecular characteristics and effect on the invasiveness of epithelial cells. J. Cell Biol. 111, 2097-2108.
    • (1990) J. Cell Biol. , vol.111 , pp. 2097-2108
    • Weidner, K.M.1    Behrens, T.2    Vandekerckhove, J.3    Birchmeiet, W.4
  • 165
    • 0025886454 scopus 로고
    • Evidence for the identity of human scatter factor and human hepatocyte growth factor
    • WEIDNER K.M., ARAKAKI T., HARTMANN G. ET AL. (1991) Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc. Natl. Acad. Sci. USA. 88, 7001-7005.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7001-7005
    • Weidner, K.M.1    Arakaki, T.2    Hartmann, G.3
  • 166
    • 0027342344 scopus 로고
    • Molecular characteristics of HGF/SF and its role in cell motility and invasion
    • WEIDNER K.M., HARTMANN T., NALDINI L. ET AL. (1993) Molecular characteristics of HGF/SF and its role in cell motility and invasion. EXS. 65, 311-328.
    • (1993) EXS , vol.65 , pp. 311-328
    • Weidner, K.M.1    Hartmann, T.2    Naldini, L.3
  • 167
    • 0028798286 scopus 로고
    • Roles of HGF/SF and the MET receptor in the early development of the metanephros
    • WOOLF A.S., KOLATSI-JOANNOU T., HARDMAN P. ET AL. (1995) Roles of HGF/SF and the MET receptor in the early development of the metanephros. J. Cell Biol. 128, 171-184.
    • (1995) J. Cell Biol. , vol.128 , pp. 171-184
    • Woolf, A.S.1    Kolatsi-Joannou, T.2    Hardman, P.3
  • 168
    • 0029133502 scopus 로고
    • Sequential requirement of HGF and neuregulin in the morphogenesis and differentiation of the mammary gland
    • YANG T., SPITZER T., MEYER D. ET AL. (1995) Sequential requirement of HGF and neuregulin in the morphogenesis and differentiation of the mammary gland. J. Cell Biol. 131, 215-226.
    • (1995) J. Cell Biol. , vol.131 , pp. 215-226
    • Yang, T.1    Spitzer, T.2    Meyer, D.3
  • 169
    • 0027312775 scopus 로고
    • Isolation of a novel receptor tyrosine kinase cDNA expressed by developing erythroid progenitors
    • YEE T., BISHOP T.R., MATHER C. & ZON L.I. (1993) Isolation of a novel receptor tyrosine kinase cDNA expressed by developing erythroid progenitors. Blood 82, 1335-1343.
    • (1993) Blood , vol.82 , pp. 1335-1343
    • Yee, T.1    Bishop, T.R.2    Mather, C.3    Zon, L.I.4
  • 170
    • 0025099390 scopus 로고
    • Tissue distribution of hepatopoietin-A: A herapin binding polypeptide growth factor for hepatocytes
    • ZARNEGAR T., MUGA T., RAHIJA R. & MICHALOPOULOS G. (1990) Tissue distribution of hepatopoietin-A: a herapin binding polypeptide growth factor for hepatocytes. Proc. Natl. Acad. Sci. USA. 87, 1252-1256.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 1252-1256
    • Zarnegar, T.1    Muga, T.2    Rahija, R.3    Michalopoulos, G.4
  • 171
    • 0026588506 scopus 로고
    • Localisation of hepatocyte growth factor (HGF) gene on human chromosome 7
    • ZARNEGAR T., PETERSEN T., DEFRANCES M.C. & MICHALOPOULOS G. (1992) Localisation of hepatocyte growth factor (HGF) gene on human chromosome 7. Genomics 12, 147-150.
    • (1992) Genomics , vol.12 , pp. 147-150
    • Zarnegar, T.1    Petersen, T.2    Defrances, M.C.3    Michalopoulos, G.4
  • 172
    • 0029444057 scopus 로고
    • Regulation of HGF and HGFR gene expression
    • ZAHNEGAR R. (1995) Regulation of HGF and HGFR gene expression. EXS. 74, 33-49.
    • (1995) EXS , vol.74 , pp. 33-49
    • Zahnegar, R.1
  • 173
    • 0028999868 scopus 로고
    • The many faces of HGF: From hepatopoiesis to hematopoiesis
    • ZARNEGAR R. & MICHALOPOULOS G.K. (1995) The many faces of HGF: From hepatopoiesis to hematopoiesis. J. Cell Biol. 129, 1177-1180.
    • (1995) J. Cell Biol. , vol.129 , pp. 1177-1180
    • Zarnegar, R.1    Michalopoulos, G.K.2
  • 174
    • 0028985591 scopus 로고
    • Effects of extracellular Ca (2+) and HCO3 (-) on epidermal growth factor-induced DNA synthesis in cultured rat hepatocytes
    • ZHANG B.H. & FARRELL G.C. (1995) Effects of extracellular Ca (2+) and HCO3 (-) on epidermal growth factor-induced DNA synthesis in cultured rat hepatocytes. Gastroenterology 108, 477-486.
    • (1995) Gastroenterology , vol.108 , pp. 477-486
    • Zhang, B.H.1    Farrell, G.C.2
  • 175
    • 0028240765 scopus 로고
    • Structural and functional domains critical for constitutive activation of the HGF-receptor (MET)
    • ZHEN T., GIORDANO T., LONGATI T., MEDICO T., CAMPIGLIO M. & COMOGLIO P.M. (1994) Structural and functional domains critical for constitutive activation of the HGF-receptor (MET). Oncogene 9, 1691-1697.
    • (1994) Oncogene , vol.9 , pp. 1691-1697
    • Zhen, T.1    Giordano, T.2    Longati, T.3    Medico, T.4    Campiglio, M.5    Comoglio, P.M.6
  • 176
    • 0028028202 scopus 로고
    • Tyrosine 1356 in the carboxyl terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis
    • ZHU T., NAUJOKAS M.A., FIXMAN E.D., TOROSSIAN K. & PARK M. (1994) Tyrosine 1356 in the carboxyl terminal tail of the HGF/ SF receptor is essential for the transduction of signals for cell motility and morphogenesis. J. Biol. Chem. 269, 29943-29948.
    • (1994) J. Biol. Chem. , vol.269 , pp. 29943-29948
    • Zhu, T.1    Naujokas, M.A.2    Fixman, E.D.3    Torossian, K.4    Park, M.5
  • 177
    • 0029034348 scopus 로고
    • Sulfated oligosaccharides promote hepatocyte growth factor association
    • ZIONCHECK T.F., RICHARDSON T., LIU J. ET AL. (1995) sulfated oligosaccharides promote hepatocyte growth factor association. J. Biol. Chem 270, 16871-16878.
    • (1995) J. Biol. Chem , vol.270 , pp. 16871-16878
    • Zioncheck, T.F.1    Richardson, T.2    Liu, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.