메뉴 건너뛰기




Volumn 9, Issue 11, 2011, Pages 1264-1269

6-gingerol, an active ingredient of ginger, protects acetaminophen-induced hepatotoxicity in mice

Author keywords

6 gingerol; Antioxidants; Hepatoprotective; Lipid peroxidation; Mice; Plant extracts

Indexed keywords

6 GINGEROL; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CATALASE; GINGEROL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; MALONALDEHYDE; PARACETAMOL; SILYMARIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

EID: 81155153862     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20111116     Document Type: Article
Times cited : (42)

References (27)
  • 1
    • 33748797162 scopus 로고    scopus 로고
    • Metabolic profiling of in vitro micro-propagated and conventionally greenhouse grown ginger (Zingiber officinale)
    • Ma X, Gang DR. Metabolic profiling of in vitro micro-propagated and conventionally greenhouse grown ginger (Zingiber officinale). Phytochemistry. 2006; 67(20): 2239-2255.
    • (2006) Phytochemistry , vol.67 , Issue.20 , pp. 2239-2255
    • Ma, X.1    Gang, D.R.2
  • 2
    • 34047135039 scopus 로고    scopus 로고
    • [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo
    • Kim JK, Kim Y, Na KM, Surh YJ, Kim TY. [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo. Free Radic Res. 2007; 41(5): 603-614.
    • (2007) Free Radic Res , vol.41 , Issue.5 , pp. 603-614
    • Kim, J.K.1    Kim, Y.2    Na, K.M.3    Surh, Y.J.4    Kim, T.Y.5
  • 4
    • 0028938125 scopus 로고
    • Antiplatelet effect of gingerol isolated from Zingiber officinale
    • Guh JH, Ko FN, Jong TT, Teng CM. Antiplatelet effect of gingerol isolated from Zingiber officinale. J Pharm Pharmacol. 1995; 47(4): 329-332.
    • (1995) J Pharm Pharmacol , vol.47 , Issue.4 , pp. 329-332
    • Guh, J.H.1    Ko, F.N.2    Jong, T.T.3    Teng, C.M.4
  • 6
    • 21544454944 scopus 로고    scopus 로고
    • Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kjB and p38 MAPK in mouse skin
    • Kim SO, Chun KS, Kundu JK, Surh YJ. Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kjB and p38 MAPK in mouse skin. Biofactors. 2004; 21(1-4): 27-31.
    • (2004) Biofactors , vol.21 , Issue.1-4 , pp. 27-31
    • Kim, S.O.1    Chun, K.S.2    Kundu, J.K.3    Surh, Y.J.4
  • 7
    • 4644244276 scopus 로고    scopus 로고
    • Acetaminophen hepatotoxicity: NO to the rescue
    • Wallace JL. Acetaminophen hepatotoxicity: NO to the rescue. Br J Pharmacol. 2004; 143(1): 1-2.
    • (2004) Br J Pharmacol , vol.143 , Issue.1 , pp. 1-2
    • Wallace, J.L.1
  • 8
    • 4043081258 scopus 로고    scopus 로고
    • S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice
    • Song Z, McClain CJ, Chen T. S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice. Pharmacology. 2004; 71(4): 199-208.
    • (2004) Pharmacology , vol.71 , Issue.4 , pp. 199-208
    • Song, Z.1    McClain, C.J.2    Chen, T.3
  • 11
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979; 95(2): 351-358.
    • (1979) Anal Biochem , vol.95 , Issue.2 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 12
    • 0016272750 scopus 로고
    • Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase
    • Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974; 47(3): 469-474.
    • (1974) Eur J Biochem , vol.47 , Issue.3 , pp. 469-474
    • Marklund, S.1    Marklund, G.2
  • 13
    • 0015353270 scopus 로고
    • Colorimetric assay of catalase
    • Sinha AK. Colorimetric assay of catalase. Anal Biochem. 1972; 47(2): 389-394.
    • (1972) Anal Biochem , vol.47 , Issue.2 , pp. 389-394
    • Sinha, A.K.1
  • 15
    • 0023257674 scopus 로고
    • Formation and reduction of glutathione-protein mixed disulfides during oxidative stress: A study with isolated hepatocytes and menadione (2-methyl-l, 4-naphthoquinone)
    • Bellomo G, Mirabelli F, DiMonte D, Richelmi P, Thor H, Orrenius C, Orrenius S. Formation and reduction of glutathione-protein mixed disulfides during oxidative stress: a study with isolated hepatocytes and menadione (2-methyl-l, 4-naphthoquinone). Biochem Pharmacol. 1987; 36(8): 1313-1320.
    • (1987) Biochem Pharmacol , vol.36 , Issue.8 , pp. 1313-1320
    • Bellomo, G.1    Mirabelli, F.2    Dimonte, D.3    Richelmi, P.4    Thor, H.5    Orrenius, C.6    Orrenius, S.7
  • 16
    • 0016275313 scopus 로고
    • Glutathione S-transferases: The first enzymatic step in mercapturic acid formation
    • Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem. 1974; 249(22): 7130-7139.
    • (1974) J Biol Chem , vol.249 , Issue.22 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 17
    • 0018327389 scopus 로고
    • Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver
    • Moron MS, Depierre JW, Mannervik B. Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta. 1979; 582(1): 67-78.
    • (1979) Biochim Biophys Acta , vol.582 , Issue.1 , pp. 67-78
    • Moron, M.S.1    Depierre, J.W.2    Mannervik, B.3    Moron, M.S.4    Depierre, J.W.5    Mannervik, B.6
  • 19
    • 84984541256 scopus 로고    scopus 로고
    • Antioxidant and hepatoprotective activity of aqueous extract of Solanum fastigiatum (false Jurubeba) against paracetamol-induced liver damage in mice
    • Sabir SM, Rocha JB. Antioxidant and hepatoprotective activity of aqueous extract of Solanum fastigiatum (false Jurubeba) against paracetamol-induced liver damage in mice. J Ethnopharmacol. 2008; 120(2): 226-232.
    • (2008) J Ethnopharmacol , vol.120 , Issue.2 , pp. 226-232
    • Sabir, S.M.1    Rocha, J.B.2
  • 20
    • 77952772366 scopus 로고    scopus 로고
    • Therapeutic effect of Indian Ayurvedic herbal formulation Triphala on acetaminophen-induced hepatotoxicity in mice
    • Rasool MK, Sabina EP, Lavanya K, Nithya P. Therapeutic effect of Indian Ayurvedic herbal formulation Triphala on acetaminophen-induced hepatotoxicity in mice. J Pharmacol Toxicol. 2007: 2(8): 725-731.
    • (2007) J Pharmacol Toxicol , vol.2 , Issue.8 , pp. 725-731
    • Rasool, M.K.1    Sabina, E.P.2    Lavanya, K.3    Nithya, P.4
  • 22
    • 34548819875 scopus 로고    scopus 로고
    • Zingiber off icinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status
    • Ajith TA, Hema U, Aswathy MS. Zingiber off icinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status. Food Chem Toxicol. 2007; 45(11): 2267-2272.
    • (2007) Food Chem Toxicol , vol.45 , Issue.11 , pp. 2267-2272
    • Ajith, T.A.1    Hema, U.2    Aswathy, M.S.3
  • 23
    • 0142250773 scopus 로고    scopus 로고
    • [6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions
    • Ippoushi K, Azuma K, Ito H, Horie H, Higashio H. [6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Life Sci. 2003; 73(26): 3427-3437.
    • (2003) Life Sci , vol.73 , Issue.26 , pp. 3427-3437
    • Ippoushi, K.1    Azuma, K.2    Ito, H.3    Horie, H.4    Higashio, H.5
  • 24
    • 63349089720 scopus 로고    scopus 로고
    • 6-Gingerol inhibits ROS and iNOS through the suppression of PKC-a and NF-kjB pathways in lipopolysaccharide-stimulated mouse macrophages
    • Lee TY, Lee KC, Chen SY, Chang HH. 6-Gingerol inhibits ROS and iNOS through the suppression of PKC-a and NF-kjB pathways in lipopolysaccharide-stimulated mouse macrophages. Biochem Biophys Res Commun. 2009; 382(1): 134-139.
    • (2009) Biochem Biophys Res Commun , vol.382 , Issue.1 , pp. 134-139
    • Lee, T.Y.1    Lee, K.C.2    Chen, S.Y.3    Chang, H.H.4
  • 25
    • 79955674768 scopus 로고    scopus 로고
    • [6]-Gingerol attenuates (3-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system
    • Lee C, Park GH, Kim CY, Jang JH. [6]-Gingerol attenuates (3-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system. Food Chem Toxicol. 2011; 49(6): 1261-1269.
    • (2011) Food Chem Toxicol , vol.49 , Issue.6 , pp. 1261-1269
    • Lee, C.1    Park, G.H.2    Kim, C.Y.3    Jang, J.H.4
  • 26
    • 0036424515 scopus 로고    scopus 로고
    • Radioprotective effect of silymarin against radiation induced hepatotoxicity
    • Ramadan LA, Roushdy HM, Abu Senna GM, Amin NE, El-Deshw OA. Radioprotective effect of silymarin against radiation induced hepatotoxicity. Pharmacol Res. 2002; 45(6): 447-454.
    • (2002) Pharmacol Res , vol.45 , Issue.6 , pp. 447-454
    • Ramadan, L.A.1    Roushdy, H.M.2    Abu, S.G.M.3    Amin, N.E.4    El-Deshw, O.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.