[6]-Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system

Food and Chemical Toxicology

Volumn 49, Issue 6, 2011, Pages 1261-1269

  Lee, Chan ^a   Park, Gyu Hwan ^b   Kim, Chang Yul ^a   Jang, Jung Hee ^c  

^a Daegu Haany University   (South Korea)

^b CHA University   (South Korea)

^c Keimyung University   (South Korea)

Author keywords

Amyloid; 6 Gingerol; Antioxidant enzymes; Apoptotic cell death; NF E2 related factor 2; Oxidative and or nitrosative stress

Indexed keywords

(6) GINGEROL; AMYLOID BETA PROTEIN; CASPASE 3; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DISRUPTION; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEUROPROTECTION; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; UPREGULATION;

AMYLOID BETA-PEPTIDES; ANTIOXIDANTS; APOPTOSIS; CATECHOLS; CELL LINE, TUMOR; CELL SURVIVAL; FATTY ALCOHOLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEUROBLASTOMA; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; OXIDOREDUCTASES; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TRANSFECTION;

ZINGIBER OFFICINALE;

EID: 79955674768     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2011.03.005     Document Type: Article

References (34)

1. Aeschbach R., Löliger J., Scott B.C., Murcia A., Butler J., Halliwell B., Aruoma O.I. Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem. Toxicol. 1994, 32:31-36.
2. Ali B.H., Blunden G., Tanira M.O., Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem. Toxicol. 2008, 46:409-420.
3. Aruoma O.I., Bahorun T., Jen L.S. Neuroprotection by bioactive components in medicinal and food plant extracts. Mutat. Res. 2003, 544:203-215.
4. Bar-Am O., Weinreb O., Amit T., Youdim M.B. Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine. FASEB J. 2005, 19:1899-1901.
5. Citron M. Strategies for disease modification in alzheimer's disease. Nat. Rev. Neurosci. 2004, 5:677-685.
6. Chauhan V., Chauhan A. Oxidative stress in Alzheimer's disease. Pathophysiology 2006, 13:195-208.
7. Crouch P.J., Harding S.M., White A.R., Camakaris J., Bush A.I., Masters C.L. Mechanisms of Aβ mediated neurodegeneration in Alzheimer's disease. Int. J. Biochem. Cell Biol. 2008, 40:181-198.
8. Cuadrado A., Rojo A.I. Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections. Curr. Pharm. Des. 2008, 14:429-442.
9. de Vries H.E., Witte M., Hondius D., Rozemuller A.J., Drukarch B., Hoozemans J., van Horssen J. Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?. Free Radical Biol. Med. 2008, 45:1375-1383.
10. Farfara D., Lifshitz V., Frenkel D. Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease. J. Cell. Mol. Med. 2008, 12:762-780.
11. Guix F.X., Uribesalgo I., Coma M., Muñoz F.J. The physiology and pathophysiology of nitric oxide in the brain. Prog. Neurobiol. 2005, 76:126-152.
12. Hardy J., Duff K., Hardy K.G., Perez-Tur J., Hutton M. Gentic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nat. Neurosci. 1998, 1:355-358.
13. Ippoushi K., Azuma K., Ito H., Horie H., Higashio H. [6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Life Sci. 2003, 73:3427-3437.
14. Ippoushi K., Ito H., Horie H., Azuma K. Mechanism of inhibition of peroxynitrite-induced oxidation and nitration by [6]-gingerol. Planta Med. 2005, 71:563-566.
15. Jang J.H., Aruoma O.I., Jen L.S., Chung H.Y., Surh Y.J. Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death. Free Radical Biol. Med. 2004, 36:288-299.
16. Jang J.H., Surh Y.J. Potentiation of cellular antioxidant capacity by Bcl-2: implications for its antiapoptotic function. Biochem. Pharmacol. 2003, 66:1371-1379.
17. Jin D.Q., Park B.C., Lee J.S., Choi H.D., Lee Y.S., Yang J.H., Kim J.A. Mycelial extract of Cordyceps ophioglossoides prevents neuronal cell death and ameliorates beta-amyloid peptide-induced memory deficits in rats. Biol. Pharm. Bull. 2004, 27:1126-1129.
18. Johnson J.A., Johnson D.A., Kraft A.D., Calkins M.J., Jakel R.J., Vargas M.R., Chen P.C. The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration. Ann. NY Acad. Sci. 2008, 1147:61-69.
19. Kaminsky Y.G., Marlatt M.W., Smith M.A., Kosenko E.A. Subcellular and metabolic examination of amyloid-β peptides in Alzheimer disease pathogenesis: evidence for Aβ25-35. Exp. Neurol. 2010, 221:26-37.
20. Kim C.Y., Lee C., Park G.H., Jang J.H. Neuroprotective effect of epigallocatechin-3-gallate against beta-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity. Arch. Pharm. Res. 2009, 32:869-881.
21. Klaassen C.D., Reisman S.A. Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. Toxicol. Appl. Pharmacol. 2010, 244:57-65.
22. Kyung K.S., Gon J.H., Geun K.Y., Sup J.J., Suk W.J., Ho K.J. 6-Shogaol, a natural product, reduces cell death and restores motor function in rat spinal cord injury. Eur. J. Neurosci. 2006, 24:1042-1052.
23. Liu X.P., Goldring C.E., Copple I.M., Wang H.Y., Wei W., Kitteringham N.R., Park B.K. Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway. Life Sci. 2007, 80:1586-1591.
24. Park S.H., Jang J.H., Li M.H., Na H.K., Cha Y.N., Surh Y.J. Nrf2-mediated heme oxygenase-1 induction confers adaptive survival response to tetrahydropapaveroline-induced oxidative PC12 cell death. Antioxid. Redox Signaling 2007, 9:2075-2086.
25. Ramassamy C. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur. J. Pharmacol. 2006, 545:51-64.
26. Rebrin I., Sohal R.S. Pro-oxidant shift in glutathione redox state during aging. Adv. Drug Deliv. Rev. 2008, 60:1545-1552.
27. Shukla Y., Singh M. Cancer preventive properties of ginger: a brief review. Food Chem. Toxicol. 2007, 45:683-690.
28. Skaper S.D. The brain as a target for inflammatory processes and neuroprotective strategies. Ann. NY Acad. Sci. 2007, 1122:23-34.
29. Surh Y.J. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat. Res. 1999, 428:305-327.
30. Torreilles F., Salman-Tabcheh S., Guérin M., Torreilles J. Neurodegenerative disorders: the role of peroxynitrite. Brain Res. Brain Res. Rev. 1999, 30:153-163.
31. Townsend K.P., Praticò D. Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs. FASEB J. 2005, 19:1592-1601.
32. Uttara B., Singh A.V., Zamboni P., Mahajan R.T. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr. Neuropharmacol. 2009, 7:65-74.
33. Wang R., Tang X.C. Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease. Neurosignals 2005, 14:71-82.
34. White B. Ginger: an overview. Am. Fam. Physician 2007, 75:1689-1691.