Herbal cocktail Ka-Mi-Kae-Kyuk-Tang stimulates mouse bone marrow stem cell hematopoiesis and Janus-activated kinase 2/signal transducer and activator of transcription 5 pathway

American Journal of Chinese Medicine

Volumn 39, Issue 6, 2011, Pages 1235-1252

  Lee, Jeong Eun ^a   Seo, Inweon ^a   Jeong, Soo Jin ^a   Koh, Wonil ^a   Jung, Ji Hoon ^a   Kwon, Tae Rin ^a   Lee, Hyo Jung ^a   Han, Ihn ^a   Lee, Hyo Jeong ^a   Lee, Eun Ok ^a   Kim, Sun Hyung ^a   Jung, Hee Jae ^a   Lu, Junxuan ^b   Kim, Sung Hoon ^a,b  

^a Kyung Hee University   (South Korea)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cytokines; Hematopoiesis; JAK2 STAT5; Ka Mi Kae Kyuk Tang

Indexed keywords

CYCLOPHOSPHAMIDE; ERYTHROPOIETIN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HERBACEOUS AGENT; INTERLEUKIN 3; JANUS KINASE 2; KA MI KAE KYUK TANG; MESSENGER RNA; STAT5 PROTEIN; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD TOXICITY; BURST FORMING UNIT; CELL GROWTH; CELL ISOLATION; CELL STIMULATION; COLONY FORMING UNIT; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; ERYTHROCYTE; ERYTHROID CELL; GRANULOCYTE; GROWTH RATE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKOPENIA; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; GENE EXPRESSION REGULATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-3; JANUS KINASE 2; MALE; MICE; MICE, INBRED C57BL; PLANT EXTRACTS; PLANTS, MEDICINAL; STAT5 TRANSCRIPTION FACTOR; STEM CELL FACTOR;

EID: 81155153680     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X11009524     Document Type: Article

References (40)

1. Aburada, M., S. Takeda, E. Ito, M. Nakamura and E. Hosoya. Protective effects of juzentaihoto, dried decoctum of 10 Chinese herbs mixture, upon the adverse effects of mitomycin C in mice. J. Pharmacobiodyn. 6: 1000-1004, 1983.
2. Allen, T.D. and T.M. Dexter. The essential cells of the hemopoietic microenvironment. Exp. Hematol. 12: 517-521, 1984.
3. Barreda, D.R., P.C. Hanington and M. Belosevic. Regulation of myeloid development and function by colony stimulating factors. Dev. Comp. Immunol. 28: 509-554, 2004.
4. Basile, L.A., T.K. Gallaher, D. Shibata, J.D. Miller and D. Douer. Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice. J. Transl. Med. 6: 26, 2008.
5. Bociek, R.G. and J.O. Armitage. Hematopoietic growth factors. CA Cancer J. Clin. 46: 165-184, 1996.
6. Brugger, W., W. Mocklin, S. Heimfeld, R.J. Berenson, R. Mertelsmann and L. Kanz. Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, inter-leukin-1 beta (IL-1 beta), IL-6, IL-3, interferon-gamma, and erythropoietin. Blood 81: 2579-2584, 1993.
7. Cui, Y., G. Riedlinger, K. Miyoshi, W. Tang, C. Li, C.X. Deng, G.W. Robinson and L. Hennigh-ausen. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol. Cell. Biol. 24: 8037-8047, 2004.
8. Deans, R.J. and A.B. Moseley. Mesenchymal stem cells: biology and potential clinical uses. Exp. Hematol. 28: 875-884, 2000.
9. Deberry, C., S. Mou and D. Linnekin. Stat1 associates with c-kit and is activated in response to stem cell factor. Biochem. J. 327(Pt. 1): 73-80, 1997.
10. Dong, D.C. Changes of the hypercoagulative state and renal functions in chronic renal failure treated with Radix salviae miltiorrhizae. Zhonghua Nei Ke Za Zhi 21: 583-586, 1982.
11. Gardner, R.V. Long term hematopoietic damage after chemotherapy and cytokine. Front. Biosci. 4: e47-e57, 1999.
12. Gardner, R.V., E. McKinnon, C. Poretta and L. Leiva. Hemopoietic function after use of IL-1 with chemotherapy or irradiation. J. Immunol. 171: 1202-1206, 2003.
13. Grebien, F., M.A. Kerenyi, B. Kovacic, T. Kolbe, V. Becker, H. Dolznig, K. Pfeffer, U. Klingmuller, M. Muller, H. Beug, E.W. Mullner and R. Moriggl. Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood 111: 4511-4522, 2008.
14. Gunsilius, E., G. Gastl and A.L. Petzer. Hematopoietic stem cells. Biomed. Pharmacother. 55: 186-194, 2001.
15. Haznedaroglu, I.C., M. Arici and Y. Buyukasik. A unifying hypothesis for the renin-angiotensin system and hematopoiesis: sticking the pieces together with the JAK-STAT pathway. Med. Hypotheses 54: 80-83, 2000.
16. Huang, E.J., K.H. Nocka, J. Buck and P. Besmer. Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2. Mol. Biol. Cell 3: 349-362, 1992.
17. Huang, H., J.L. Rose and D.G. Hoyt. p38 Mitogen-activated protein kinase mediates synergistic induction of inducible nitric-oxide synthase by lipopolysaccharide and interferon-gamma through signal transducer and activator of transcription 1 Ser727 phosphorylation in murine aortic endothelial cells. Mol. Pharmacol. 66: 302-311, 2004.
18. Jiang, C., H.J. Lee, G.X. Li, J. Guo, B. Malewicz, Y. Zhao, E.O. Lee, J.H. Lee, M.S. Kim, S.H. Kim and J. Lu. Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer. Cancer Res. 66: 453-463, 2006.
19. Kaushansky, K. Thrombopoietin: basic biology, clinical promise. Int. J. Hematol. 62: 7-15, 1995.
20. Kaushansky, K., V.C. Broudy, N. Lin, M.J. Jorgensen, J. McCarty, N. Fox, D. Zucker-Franklin and C. Lofton-Day. Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development. Proc. Natl. Acad. Sci. USA 92: 3234-3238, 1995.
21. Koo, B.S., T.S. Kwon and C.H. Kim. Salviae miltiorrhizae radix inhibits superoxide generation by activated rat microglias and mimics the action of amphetamine on in vitro rat striatal dopamine release. Neurochem. Res. 29: 1837-1845, 2004.
22. Lee, H.J., E.O. Lee, Y.H. Rhee, K.S. Ahn, G.X. Li, C. Jiang, J. Lu and S.H. Kim. An Oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis. Carcinogenesis 27: 2455-2463, 2006.
23. Lee, J., J.S. Shin, J.Y. Park, D. Kwon, S.J. Choi, S.J. Kim and I.H. Choi. p38 mitogen-activated protein kinase modulates expression of tumor necrosis factor-related apoptosis-inducing ligand induced by interferon-gamma in fetal brain astrocytes. J. Neurosci. Res. 74: 884-890, 2003.
24. Linnekin, D. Early signaling pathways activated by c-Kit in hematopoietic cells. Int. J. Biochem. Cell. Biol. 31: 1053-1074, 1999.
25. Lu, L. and X.Q. Jia. Effects of naturin 2 on colony formation by hematopoietic progenitor cells in human umbilical cord blood mediated by induction of release of growth factors. In Vivo 14: 441-446, 2000.
26. Metcalf, D. Hematopoietic regulators: redundancy or subtlety? Blood 82: 3515-3523, 1993.
27. Moriggl, R., V. Gouilleux-Gruart, R. Jahne, S. Berchtold, C. Gartmann, X. Liu, L. Hennighausen, A. Sotiropoulos, B. Groner and F. Gouilleux. Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype. Mol. Cell. Biol. 16: 5691-5700, 1996.
28. Morstyn, G., S. Brown, M. Gordon, J. Crawford, G. Demetri, W. Rich, B. McGuire, M. Foote and I. McNiece. Stem cell factor is a potent synergistic factor in hematopoiesis. Oncology 51: 205-214, 1994.
29. Muller-Sieburg, C.E., K. Townsend, I.L. Weissman and D. Rennick. Proliferation and differentiation of highly enriched mouse hematopoietic stem cells and progenitor cells in response to defined growth factors. J. Exp. Med. 167: 1825-1840, 1988.
30. Nosaka, T. and T. Kitamura. Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) in hematopoietic cells. Int. J. Hematol. 71: 309-319, 2000.
31. O'Shea, J.J., M. Gadina and R.D. Schreiber. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 109(Suppl): S121-131, 2002.
32. Parganas, E., D. Wang, D. Stravopodis, D.J. Topham, J.C. Marine, S. Teglund, E.F. Vanin, S. Bodner, O.R. Colamonici, J.M. van Deursen, G. Grosveld, J.N. Ihle, A. Schaefer, M. Magocsi and H. Marquardt. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93: 385-395, 1998.
33. Park, W.H., J.C. Ahn, H.M. Kim, Y.C. Lee and C.H. Kim. Effects of a Korean herbal formulation, Silsosangami, consisting of seven medicinal herbs, and its seven herbs on endotoxin-induced experimental thrombosis in rats. Phytother. Res. 18: 224-229, 2004.
34. Ramana, C.V., N. Grammatikakis, M. Chernov, H. Nguyen, K.C. Goh, B.R. Williams and G.R. Park. Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways. EMBO. J. 19: 263-272, 2000.
35. Sattler, M., M.A. Durstin, D.A. Frank, K. Okuda, K. Kaushansky, R. Salgia and J.D. Griffin. The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases. Exp. Hematol. 23: 1040-1048, 1995.
36. Schaefer, A., M. Magocsi and H. Marquardt. Signalling mechanisms in erythropoiesis: the enigmatic role of calcium. Cell Signal 9: 483-495, 1997.
37. Slovak, M.L., V. Bedell, D. Lew, K.S. Albain, G.K. Ellis, R.B. Livingston, S. Martino, E.A. Perez, G.N. Hortobagyi, D. Sher and W. Stock. Screening for clonal hematopoiesis as a predictive marker for development of therapy-related myeloid neoplasia (t-MN) following neoadjuvant therapy for breast cancer: a Southwest Oncology Group study (S0012). Breast Cancer Res. Treat. 119: 391-398, 2010.
38. Tortolani, P.J., B.K. Lal, A. Riva, J.A. Johnston, Y.Q. Chen, G.H. Reaman, M. Beckwith, D. Longo, J.R. Ortaldo, K. Bhatia, I. McGrath, J. Kehrl, J. Tuscano, D.W. McVicar and J.J. O'Shea. Regulation of JAK3 expression and activation in human B cells and B cell malignancies. J. Immunol. 155: 5220-5226, 1995.
39. Tseng, J. and T.L. Li. Si-jun-zi-tang regulate granulocyte macrophage colony-stimulating factor secretion by human peripheral blood mononuclear cells. Am. J. Chin. Med. 24: 45-52, 1996.
40. Uddin, S., F. Lekmine, A. Sassano, H. Rui, E.N. Fish and L.C. Platanias. Role of Stat5 in type I interferon-signaling and transcriptional regulation. Biochem. Biophys. Res. Commun. 308: 325-330, 2003.