Remodeling of retinal small arteries in hypertension

American Journal of Hypertension

Volumn 24, Issue 12, 2011, Pages 1267-1273

  Lehmann, Marina V ^a   Schmieder, Roland E ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

blood pressure; hypertension; lumen diameter; retinal capillary flow; retinal vessels; SLDF; wall to lumen ratio

Indexed keywords

IRBESARTAN; VALSARTAN;

ANTIHYPERTENSIVE THERAPY; ARTERIAL PRESSURE; ARTICLE; CAROTID ARTERY DISEASE; CAROTID ATHEROSCLEROSIS; COGNITIVE DEFECT; HEART DISEASE; HUMAN; HYPERTENSION; KIDNEY DYSFUNCTION; LASER DOPPLER FLOWMETRY; PRIORITY JOURNAL; RETINA ARTERY; RETINA ARTERY REMODELING; RETINA BLOOD VESSEL; RETINA CAPILLARY; STROKE;

ANIMALS; ARTERIOLES; ATHEROSCLEROSIS; DIAGNOSTIC IMAGING; FEMALE; HUMANS; HYPERTENSION; MALE; NITRIC OXIDE; RATS; RETINA; RETINAL ARTERY; RETINAL DISEASES; VASCULAR RESISTANCE;

EID: 81155148208     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1038/ajh.2011.166     Document Type: Article

References (53)

1. Wolf-Maier K, Cooper RS, Banegas JR, Giampaoli S, Hense HW, Joffres M, Kastarinen M, Poulter N, Primatesta P, Rodríguez-Artalejo F, Stegmayr B, Thamm M, Tuomilehto J, Vanuzzo D, Vescio F. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA 2003; 289:2363-2369. (Pubitemid 37430168)
2. Schiffrin EL, Park JB, Intengan HD, Touyz RM. Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan. Circulation 2000; 101:1653-1659. (Pubitemid 30196624)
3. Schiffrin EL. Remodeling of resistance arteries in essential hypertension and effects of antihypertensive treatment. Am J Hypertens 2004; 17:1192-1200. (Pubitemid 40029420)
4. Witt N, Wong TY, Hughes AD, Chaturvedi N, Klein BE, Evans R, McNamara M, Thom SA, Klein R. Abnormalities of retinal microvascular structure and risk of mortality from ischemic heart disease and stroke. Hypertension 2006; 47:975-981. (Pubitemid 44297571)
5. Heagerty AM. Predicting hypertension complications from small artery structure. J Hypertens 2007; 25:939-940. (Pubitemid 46573110)
6. Izzard AS, Rizzoni D, Agabiti-Rosei E, Heagerty AM. Small artery structure and hypertension: adaptive changes and target organ damage. J Hypertens 2005; 23:247-250. (Pubitemid 40279623)
7. De Ciuceis C, Porteri E, Rizzoni D, Rizzardi N, Paiardi S, Boari GE, Miclini M, Zani F, Muiesan ML, Donato F, Salvetti M, Castellano M, Tiberio GA, Giulini SM, Agabiti Rosei E. Structural alterations of subcutaneous small-resistance arteries may predict major cardiovascular events in patients with hypertension. Am J Hypertens 2007; 20:846-852. (Pubitemid 47176353)
8. Patton N, Aslam T, Macgillivray T, Pattie A, Deary IJ, Dhillon B. Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anat 2005; 206:319-348. (Pubitemid 40542839)
9. Ritt M, Harazny JM, Ott C, Schlaich MP, Schneider MP, Michelson G, Schmieder RE. Analysis of retinal arteriolar structure in never-treated patients with essential hypertension. J Hypertens 2008; 26:1427-1434.
10. Schmieder RE. Hypertensive retinopathy: a window to vascular remodeling in arterial hypertension. Hypertension 2008; 51:43-44. (Pubitemid 350307101)
11. Ritt M, Schmieder RE. Wall-to-lumen ratio of retinal arterioles as a tool to assess vascular changes. Hypertension 2009; 54:384-387.
12. Wong TY, Mitchell P. Hypertensive retinopathy. N Engl J Med 2004; 351:2310-2317. (Pubitemid 39552747)
13. Harazny JM, Raff U, Welzenbach J, Ott C, Ritt M, Lehmann M, Michelson G, Schmieder RE. New software analyses increase the reliability of measurements of retinal arterioles morphology by scanning laser Doppler flowmetry in humans. J Hypertens 2011; 29:777-782.
14. Agabiti-Rosei E, Heagerty AM, Rizzoni D. Effects of antihypertensive treatment on small artery remodelling. J Hypertens 2009; 27:1107-1114.
15. Aalkjaer C, Heagerty AM, Petersen KK, Swales JD, Mulvany MJ. Evidence for increased media thickness, increased neuronal amine uptake, and depressed excitation-contraction coupling in isolated resistance vessels from essential hypertensives. Circ Res 1987; 61:181-186. (Pubitemid 17137117)
16. Rosei EA, Rizzoni D, Castellano M, Porteri E, Zulli R, Muiesan ML, Bettoni G, Salvetti M, Muiesan P, Giulini SM. Media: lumen ratio in human small resistance arteries is related to forearm minimal vascular resistance. J Hypertens 1995; 13:341-347.
17. Schiffrin EL, Hayoz D. How to assess vascular remodelling in small and mediumsized muscular arteries in humans. J Hypertens 1997; 15:571-584. (Pubitemid 27246532)
18. Bund SJ, West KP, Heagerty AM. Effects of protection from pressure on resistance artery morphology and reactivity in spontaneously hypertensive and Wistar-Kyoto rats. Circ Res 1991; 68:1230-1240.
19. Boari GE, Rizzoni D, De Ciuceis C, Porteri E, Avanzi D, Platto C, Mazza M, Brignani A, Rosei CA, Ricotta D, Caimi L, Rosei EA. Structural alterations in subcutaneous small resistance arteries predict changes in the renal function of hypertensive patients. J Hypertens 2010; 28:1951-1958.
20. Rizzoni D, Porteri E, Boari GE, De Ciuceis C, Sleiman I, Muiesan ML, Castellano M, Miclini M, Agabiti-Rosei E. Prognostic significance of small-artery structure in hypertension. Circulation 2003; 108:2230-2235. (Pubitemid 37363040)
21. Mathiassen ON, Buus NH, Sihm I, Thybo NK, Mørn B, Schroeder AP, Thygesen K, Aalkjaer C, Lederballe O, Mulvany MJ, Christensen KL. Small artery structure is an independent predictor of cardiovascular events in essential hypertension. J Hypertens 2007; 25:1021-1026. (Pubitemid 46573121)
22. Rizzoni D, Porteri E, Guelfi D, Muiesan ML, Valentini U, Cimino A, Girelli A, Rodella L, Bianchi R, Sleiman I, Rosei EA. Structural alterations in subcutaneous small arteries of normotensive and hypertensive patients with non-insulin-dependent diabetes mellitus. Circulation 2001; 103:1238-1244. (Pubitemid 32221346)
23. Rizzoni D, De Ciuceis C, Porteri E, La Boria E, Duse S, Semeraro F, Costagliola C, Sebastiani A, Danzi A, Tiberio GAM, Giulini SM, Agabiti Rosei C, Sarkar A, Avanzi D, Agabiti Rosei E. Close relationship between media to lumen ratio of subcutaneos small arteries and wall to lumen ratio of retinal arterioles evaluated non invasively by scanning laser Doppler flowmetry. J Hypertens 2011; 29: e11.
24. Wong TY, Wong T, Mitchell P. The eye in hypertension. Lancet 2007; 369:425-435. (Pubitemid 46188480)
25. 1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Subcommittee. J Hypertens 1999; 17:151-183.
26. August P. Initial treatment of hypertension. N Engl J Med 2003; 348:610-617. (Pubitemid 36204956)
27. Wong TY, Shankar A, Klein R, Klein BE, Hubbard LD. Prospective cohort study of retinal vessel diameters and risk of hypertension. BMJ 2004; 329:79.
28. Smith W, Wang JJ, Wong TY, Rochtchina E, Klein R, Leeder SR, Mitchell P. Retinal arteriolar narrowing is associated with 5-year incident severe hypertension: the Blue Mountains Eye Study. Hypertension 2004; 44:442-447. (Pubitemid 39281493)
29. Wong TY, McIntosh R. Systemic associations of retinal microvascular signs: a review of recent population-based studies. Ophthalmic Physiol Opt 2005; 25:195-204. (Pubitemid 41702436)
30. Wong TY, Klein R, Sharrett AR, Duncan BB, Couper DJ, Klein BE, Hubbard LD, Nieto FJ; Atherosclerosis Risk in Communities Study. Retinal arteriolar diameter and risk for hypertension. Ann Intern Med 2004; 140:248-255.
31. Dimmitt SB, West JN, Eames SM, Gibson JM, Gosling P, Littler WA. Usefulness of ophthalmoscopy in mild to moderate hypertension. Lancet 1989; 1:1103-1106. (Pubitemid 19128042)
32. van den Born BJ, Hulsman CA, Hoekstra JB, Schlingemann RO, van Montfrans GA. Value of routine funduscopy in patients with hypertension: systematic review. BMJ 2005; 331:73.
33. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K, Ruilope L, Rynkiewicz A, Schmieder RE, Boudier HA, Zanchetti A; ESH-ESC Task Force on the Management of Arterial Hypertension. 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension. J Hypertens 2007; 25:1751-1762. (Pubitemid 47356612)
34. Harazny JM, Ritt M, Baleanu D, Ott C, Heckmann J, Schlaich MP, Michelson G, Schmieder RE. Increased wall:lumen ratio of retinal arterioles in male patients with a history of a cerebrovascular event. Hypertension 2007; 50:623-629. (Pubitemid 47442724)
35. Wong TY, Klein R, Sharrett AR, Nieto FJ, Boland LL, Couper DJ, Mosley TH, Klein BE, Hubbard LD, Szklo M. Retinal microvascular abnormalities and cognitive impairment in middle-aged persons: the Atherosclerosis Risk in Communities Study. Stroke 2002; 33:1487-1492. (Pubitemid 34619944)
36. Wong TY, Klein R, Sharrett AR, Couper DJ, Klein BE, Liao DP, Hubbard LD, Mosley TH; ARIC Investigators. Atheroslerosis Risk in Communities Study. Cerebral white matter lesions, retinopathy, and incident clinical stroke. JAMA 2002; 288:67-74. (Pubitemid 34705520)
37. Kwa VI, van der Sande JJ, Stam J, Tijmes N, Vrooland JL; Amsterdam Vascular Medicine Group. Retinal arterial changes correlate with cerebral small-vessel disease. Neurology 2002; 59:1536-1540. (Pubitemid 35387058)
38. Mitchell P, Wang JJ, Wong TY, Smith W, Klein R, Leeder SR. Retinal microvascular signs and risk of stroke and stroke mortality. Neurology 2005; 65:1005-1009. (Pubitemid 41429622)
39. Baleanu D, Ritt M, Harazny J, Heckmann J, Schmieder RE, Michelson G. Wall-tolumen ratio of retinal arterioles and arteriole-to-venule ratio of retinal vessels in patients with cerebrovascular damage. Invest Ophthalmol Vis Sci 2009; 50: 4351-4359.
40. Ritt M, Harazny JM, Ott C, Schneider MP, Schlaich MP, Michelson G, Schmieder RE. Wall-to-lumen ratio of retinal arterioles is related with urinary albumin excretion and altered vascular reactivity to infusion of the nitric oxide synthase inhibitor N-monomethyl-L-arginine. J Hypertens 2009; 27:2201-2208.
41. Ritt M, Harazny JM, Ott C, Raff U, Schneider MP, Michelson G, Schmieder RE. Basal nitric oxide activity is an independent determinant of arteriolar structure in the human retinal circulation. J Hypertens 2011; 29:123-129.
42. Folkow B. Structure and function of the arteries in hypertension. Am Heart J 1987; 114:938-948. (Pubitemid 17155076)
43. Heagerty AM, Aalkjaer C, Bund SJ, Korsgaard N, Mulvany MJ. Small artery structure in hypertension. Dual processes of remodeling and growth. Hypertension 1993; 21:391-397. (Pubitemid 23095149)
44. Liew G, Mitchell P, Leeder SR, Smith W, Wong TY, Wang JJ. Regular aspirin use and retinal microvascular signs: the Blue Mountains Eye Study. J Hypertens 2006; 24:1329-1335. (Pubitemid 43948332)
45. Lévy BI. [The importance of microcirculation and tissue perfusion in hypertension]. Curr Med Res Opin 2005; 21 Suppl 5:S1-S6.
46. Ott C, Schlaich MP, Harazny J, Schmidt BM, Michelson G, Schmieder RE. Effects of angiotensin II type 1-receptor blockade on retinal endothelial function. J Hypertens 2008; 26:516-522. (Pubitemid 351317261)
47. Delles C, Michelson G, Harazny J, Oehmer S, Hilgers KF, Schmieder RE. Impaired endothelial function of the retinal vasculature in hypertensive patients. Stroke 2004; 35:1289-1293. (Pubitemid 38697445)
48. Schneider MP, Schlaich MP, Harazny JM, Raff U, Ritt M, Ott C, Schmieder RE. Folic acid treatment normalizes NOS-dependence of vascular tone in the metabolic syndrome. Obesity (Silver Spring) 2011; 19:960-967.
49. Klingbeil AU, John S, Schneider MP, Jacobi J, Handrock R, Schmieder RE. Effect of AT1 receptor blockade on endothelial function in essential hypertension. Am J Hypertens 2003; 16:123-128. (Pubitemid 36143430)
50. Schiffrin EL, Pu Q, Park JB. Effect of amlodipine compared to atenolol on small arteries of previously untreated essential hypertensive patients. Am J Hypertens 2002; 15:105-110. (Pubitemid 34161083)
51. Taddei S, Virdis A, Ghiadoni L, Magagna A, Favilla S, Pompella A, Salvetti A. Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension. Hypertension 2001; 37:943-948. (Pubitemid 32221618)
52. Schocket LS, Grunwald JE, Dupont J. Effect of oral felodipine on ocular circulation. Int Ophthalmol 1999; 23:79-84. (Pubitemid 32041063)
53. Oehmer S, Harazny J, Delles C, Schwarz T, Handrock R, Michelson G, Schmieder RE. Valsartan and retinal endothelial function in elderly hypertensive patients. Blood Press 2006; 15:185-191. (Pubitemid 44644472)