Valsartan and retinal endothelial function in elderly hypertensive patients

Blood Pressure

Volumn 15, Issue 3, 2006, Pages 185-191

  Oehmer, Sebastian ^a   Harazny, Joanna ^a   Delles, Christian ^a   Schwarz, Thomas ^a   Handrock, Renate ^a   Michelson, Georg ^a   Schmieder, Roland E ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Angiotensin II; Endothelial function; Hypertension; Retinal vascular bed

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DIURETIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; VALSARTAN; DRUG DERIVATIVE; TETRAZOLE DERIVATIVE; VALINE;

ADULT; AGED; ARTERY PERFUSION; ARTICLE; BLOOD FLOW VELOCITY; CAPILLARY FLOW; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; DISEASE SEVERITY; DOPPLER ECHOGRAPHY; ELDERLY CARE; ENDOTHELIUM CELL; ESSENTIAL HYPERTENSION; HUMAN; LASER DOPPLER FLOWMETRY; MALE; MEAN ARTERIAL PRESSURE; OPEN STUDY; PHOTOSTIMULATION; PRIORITY JOURNAL; PULSE WAVE; RETINA; RETINA ARTERY; RETINA BLOOD FLOW; RETINA CAPILLARY; SHORT COURSE THERAPY; BLOOD; DRUG EFFECT; HEMODYNAMICS; HYPERTENSION; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; VASCULAR ENDOTHELIUM;

AGED; AGED, 80 AND OVER; BLOOD FLOW VELOCITY; CHOLESTEROL, LDL; ENDOTHELIUM, VASCULAR; HEMODYNAMIC PROCESSES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; OMEGA-N-METHYLARGININE; RETINAL ARTERY; TETRAZOLES; VALINE;

EID: 33749042344     PISSN: 08037051     EISSN: 16511999     Source Type: Journal    
DOI: 10.1080/08037050600772680     Document Type: Article

References (19)

1. Bronner, L. L. and Kanter, D. S. and Manson, J. E. (1995) Primary prevention of stroke. N Engl J Med, 333, pp. 1392-1400.
2. Julius, S. and Kjeldsen, S. E. and Weber, M. and Brunner, H. R. and Ekman, S. and Hansson, L. and VALUE trial group. (2004) Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: The VALUE randomised trial. Lancet, 363, pp. 2022-2031.
3. Dahlof, B. and Devereux, R. B. and Kjeldsen, S. E. and Julius, S. and Beevers, G. and de Faire, U. and LIFE Study Group. (2002) Cardiovascular morbidity and mortality in the Losartan Intervention FOR Endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol. Lancet, 359, pp. 995-1003.
4. Ito, T. and Yamakawa, H. and Bregonzio, C. and Terron, J. A. and Falcon-Neri, A. and Saavedra, J. M. (2002) Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an AT1 antagonist. Stroke, 33, pp. 2297-2303.
5. Ludwig, M. and Stapff, M. and Ribeiro, A. and Fritschka, E. and Tholl, U. and Smith, R. D. and (2002) Comparison of the effect of losartan and atenolol on common carotid artery intima-media thickness in patients with hypertension. Clin Ther, 24, pp. 1175-1193.
6. Uchiyama-Tanaka, Y. and Mori, Y. and Kishimoto, N. and Fukui, M. and Nose, A. and Kijima, Y. and (2005) Comparison of the effects of quinapril and losartan on carotid artery intima-media thickness in patients with mild-to-moderate arterial hypertension. Kidney Blood Press Res, 28, pp. 111-116.
7. Hilton, E. J. and Hosking, Sl. and Betts, T. (2002) Epilepsy patients treated with antiepileptic drug exhibit compromised ocular perfusion characteristics. Epilepsia, 43, pp. 1346-1350.
8. Delles, C. and Michelson, G. and Harazny, J. and Oehmer, S. and Hilgers, K. F. and Schmieder, R. E. (2004) Impaired endothelial function of the retinal vasculature in hypertensive patients. Stroke, 35, pp. 1289-1293.
9. Michelson, G. and Welzenbach, J. and Pal, I. and Harazny, J. (1998) Automatic full field analysis of perfusion images gained by scanning laser Doppler flowmetry. Br J Ophthalmol, 82, pp. 1294-1300.
10. Michelson, G. and Patzelt, A. and Harazny, J. (2002) Flickering light increases retinal blood flow. Retina, 22, pp. 336-343.
11. Kondo, M. and Wang, L. and Bill, A. (1997) The role of nitric oxide in hyperaemic response to flicker in the retina and optic nerve in cats. Acta Ophthalmol Scand, 75, pp. 232-235.
12. Donati, G. and Pournaras, C. J. and Munoz, J. L. and Poitry, S. and Poitry-Yamate, C. L. and Tsacopoulos, M. (1995) Nitric oxide controls arteriolar tone in the retina of the miniature pig. Invest Ophthalmol Vis Sci, 36, pp. 2228-2237.
13. Buerk, D. G. and Riva, C. E. and Cranstoun, S. D. (1996) Nitric oxide has a vasodilatory role in cat optic nerve head during flicker stimuli. Microvasc Res, 52, pp. 13-26.
14. Dorner, G. T. and Garhofer, G. and Kiss, B. and Polska, E. and Polak, K. and Riva, C. E. and (2003) Nitric oxide regulates retinal vascular tone in humans. Am J Physiol Heart Circ Physiol, 285, pp. H631-H636.
15. Mayer, B. X. and Mensik, C. and Krishnaswami, S. and Derendorf, H. and Eichler, H. G. and Schmetterer, L. and (1999) Pharmacokinetic-pharmacodynamic profile of systemic nitric oxide-synthase inhibition with L-NMMA in humans. Br J Clin Pharmacol, 47, pp. 539-544.
16. Delles, C. and Jacobi, J. and Schlaich, M. P. and John, S. and Schmieder, R. E. (2002) Assessment of endothelial function of the renal vasculature in human subjects. Am J Hypertens, 15, pp. 3-9.
17. Delles, C. and Jacobi, J. and John, S. and Fleischmann, I. and Schmieder, R. E. (2002) Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension. Kidney Int, 61, pp. 1462-1468.
18. Ghiadoni, L. and Virdis, A. and Magagna, A. and Taddei, S. and Salvetti, A. (2000) Effect of the angiotensin II type 1 receptor blocker candesartan on endothelial function in patients with essential hypertension. Hypertension, 35, pp. 501-506.
19. Prasad, A. and Halcox, J. P. and Waclawiw, M. A. and Quyyumi, A. A. (2001) Angiotensin type 1 receptor antagonism reverses abnormal coronary vasomotion in atherosclerosis. J Am Coll Cardiol, 38, pp. 1089-1095.