The association of age, illness severity, and glycemic status in a pediatric intensive care unit

Pediatric Critical Care Medicine

Volumn 12, Issue 6, 2011, Pages

  Ognibene, Kristin L ^a   Vawdrey, David K ^b   Biagas, Katherine V ^a  

^a College of Physicians and Surgeons ^*  (United States)

^b Columbia University ^*  (United States)

Author keywords

critical care; hyperglycemia; hypoglycemia; insulin; intensive care units; pediatric; severity of illness index

Indexed keywords

ADOLESCENT; ADULT; AGE; ARTICLE; ARTIFICIAL VENTILATION; CHILD; DISEASE SEVERITY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; NEWBORN; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCORING SYSTEM;

EID: 81155134787     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3182192c53     Document Type: Article

References (25)

1. Zander R, Boldt J, Engelmann L, et al: The design of the VISEP trial. Critical appraisal [in German]. Anaesthesist 2007; 56:71-77
2. Preiser JC, Devos P, Ruiz-Santana S, et al: A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: The Glucontrol study. Intensive Care Med 2009; 35:1738-1748
3. Krinsley JS, Grover A: Severe hypoglycemia in critically ill patients: Risk factors and outcomes. Crit Care Med 2007; 35:2262-2267
4. Kosiborod M, Inzucchi SE, Goyal A, et al: Relationship between spontaneous and iatrogenic hypoglycemia and mortality in patients hospitalized with acute myocardial infarction. JAMA 2009; 301:1556-1564
5. Srinivasan V, Spinella PC, Drott HR, et al: Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatr Crit Care Med 2004; 5:329-336
6. Faustino EV, Apkon M: Persistent hyperglycemia in critically ill children. J Pediatr 2005; 146:30-34
7. Vlasselaers D, Milants I, Desmet L, et al: Intensive insulin therapy for patients in paediatric intensive care: A prospective, randomised controlled study. Lancet 2009; 373: 547-556
8. Van den Berghe G, Wilmer A, Hermans G, et al: Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354:449-461
9. Cullen DJ, Civetta JM, Briggs BA, et al: Therapeutic intervention scoring system: A method for quantitative comparison of patient care. Crit Care Med 1974; 2:57-60
10. Pollack MM, Patel KM, Ruttimann UE: The Pediatric Risk of Mortality III-Acute Physiology Score (PRISM III-APS): A method of assessing physiologic instability for pediatric intensive care unit patients. J Pediatr 1997; 131:575-581
11. Hirshberg E, Larsen G, Van Duker H: Alterations in glucose homeostasis in the pediatric intensive care unit: Hyperglycemia and glucose variability are associated with increased mortality and morbidity. Pediatr Crit Care Med 2008; 9:361-366
12. Vriesendorp TM, DeVries JH, van Santen S, et al: Evaluation of short-term consequences of hypoglycemia in an intensive care unit. Crit Care Med 2006; 34:2714-2718
13. Preissig CM, Rigby MR: Hyperglycaemia results from beta-cell dysfunction in critically ill children with respiratory and cardiovascular failure: A prospective observational study. Crit Care 2009; 13:R27
14. Vannucci SJ, Simpson IA: Developmental switch in brain nutrient transporter expression in the rat. Am J Physiol Endocrinol Metab 2003; 285:E1127-E1134
15. Biagas KV, Babic B, Vannucci SJ: Expression of transcription factor genes at the blood brain barrier. Crit Care Med 2005; 33:A100
16. Biagas KV, Babic B, Vannucci SJ: Gene expression of the blood brain barrier in normal development. Crit Care Med 2006; 34:A121
17. Vannucci RC, Vannucci SJ: Hypoglycemic brain injury. Semin Neonatol 2001; 6:147-155
18. Daneman D, Frank M, Perlman K, et al: The infant and toddler with diabetes: Challenges of diagnosis and management. Paediatr Child Health 1999; 4:57-63
19. Reichard P, Nilsson BY, Rosenqvist U: The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. N Engl J Med 1993; 329:304-309
20. Wintergerst KA, Buckingham B, Gandrud L, et al: Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit. Pediatrics 2006; 118:173-179
21. Faustino EV, Bogue CW: Relationship between hypoglycemia and mortality in critically ill children. Pediatr Crit Care Med 2010; 11:690-698
22. Preissig CM, Hansen I, Roerig PL, et al: A protocolized approach to identify and manage hyperglycemia in a pediatric critical care unit. Pediatr Crit Care Med 2008; 9:581-588
23. Verhoeven JJ, Brand JB, van de Polder MM, et al: Management of hyperglycemia in the pediatric intensive care unit; implementation of a glucose control protocol. Pediatr Crit Care Med 2009; 10:648-652
24. Macrae D, Pappachan J, Grieve R, et al: Control of hyperglycaemia in paediatric intensive care (CHiP): Study protocol. BMC Pediatr 2010; 10:5
25. Rigby MR, Pressig C: Pediatric Intensive Care Units (ICUs) at Emory-Children's Center Glycemic Control: The PedETrol Trial. Available at: http://clinicaltrials.gov/ct2/show/NCT01116752. Accessed December 11, 2010