Management of hyperglycemia in the pediatric intensive care unit; implementation of a glucose control protocol

Pediatric Critical Care Medicine

Volumn 10, Issue 6, 2009, Pages 648-652

  Verhoeven, Jennifer J ^a   Brand, Jeannette B ^a   vandePolder, Mirjam M ^a   Joosten, Koen F M ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

child; critical illness; hyperglycemia; insulin

Indexed keywords

GLUCOSE; INSULIN;

ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL PROTOCOL; CRITICAL ILLNESS; DISEASE SEVERITY; FEMALE; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN TREATMENT; INTENSIVE CARE UNIT; MALE; MULTIPLE ORGAN FAILURE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY;

BLOOD GLUCOSE; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; FEMALE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INFANT; INFUSIONS, INTRAVENOUS; INSULIN; INTENSIVE CARE UNITS, PEDIATRIC; MALE; MULTIPLE ORGAN FAILURE; NETHERLANDS; PROSPECTIVE STUDIES;

EID: 75149198062     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181ae787b     Document Type: Article

References (25)

1. Branco RG, Garcia PC, Piva JP, et al: Glucose level and risk of mortality in pediatric septic shock. Pediatr Crit Care Med 2005; 6:470-472
2. Hall NJ, Peters M, Eaton S, et al: Hyperglycemia is associated with increased morbidity and mortality rates in neonates with necrotizing enterocolitis. J Pediatr Surg 2004; 39:898-901; discussion 898-901
3. Gore DC, Chinkes D, Heggers J, et al: Association of hyperglycemia with increased mortality after severe burn injury. J Trauma 2001; 51:540-544
4. Faustino EV, Apkon M: Persistent hyperglycemia in critically ill children. J Pediatr 2005; 146:30-34
5. Falcao G, Ulate K, Kouzekanani K, et al: Impact of postoperative hyperglycemia following surgical repair of congenital cardiac defects. Pediatr Cardiol 2008; 29:628-636
6. Cochran A, Scaife ER, Hansen KW, et al: Hyperglycemia and outcomes from pediatric traumatic brain injury. J Trauma 2003; 55:1035-1038
7. Chiaretti A, De Benedictis R, Langer A, et al: Prognostic implications of hyperglycaemia in paediatric head injury. Childs Nerv Syst 1998; 14:455-459
8. Hirshberg E, Larsen G, Van Duker H: Alterations in glucose homeostasis in the pediatric intensive care unit: Hyperglycemia and glucose variability are associated with increased mortality and morbidity. Pediatr Crit Care Med 2008; 9:361-366
9. Srinivasan V, Spinella PC, Drott HR, et al: Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatr Crit Care Med 2004; 5:329-336
10. Yung M, Wilkins B, Norton L, et al: Glucose control, organ failure, and mortality in pediatric intensive care. Pediatr Crit Care Med 2008; 9:147-152
11. Yates AR, Dyke PC 2nd, Taeed R, et al: Hyperglycemia is a marker for poor outcome in the postoperative pediatric cardiac patient. Pediatr Crit Care Med 2006; 7:351-355
12. Wintergerst KA, Buckingham B, Gandrud L, et al: Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit. Pediatrics 2006; 118:173-179
13. Van den Berghe G, Wouters P, Weekers F, et al: Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345:1359-1367
14. Van den Berghe G, Wilmer A, Hermans G, et al: Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354:449-461
15. Brunkhorst FM, Engel C, Bloos F, et al: Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358:125-139
16. Pham TN, Warren AJ, Phan HH, et al: Impact of tight glycemic control in severely burned children. J Trauma 2005; 59:1148-1154
17. Jeschke MG, Klein D, Herndon DN: Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann Surg 2004; 239:553-560
18. Verbruggen SC, Joosten KF, Castillo L, et al: Insulin therapy in the pediatric intensive care unit. Clin Nutr 2007; 26:677-690
19. Kong MY, Alten J, Tofil N: Should you treat high glucose? A critical appraisal of “Persistent hyperglycemia in critically ill children” by Faustino and Apkon. (J Pediatr 2005; 146:30-34). Pediatr Crit Care Med 2007 May29. Epub ahead of print
20. Krinsley JS, Grover A: Severe hypoglycemia in critically ill patients: Risk factors and outcomes. Crit Care Med 2007; 35:2262-2267
21. Merz TM, Finfer S: Procon debate: Is intensive insulin therapy targeting tight blood glucose control of benefit in critically ill patients? Crit Care 2008; 12:212
22. Vriesendorp TM, van Santen S, DeVries JH, et al: Predisposing factors for hypoglycemia in the intensive care unit. Crit Care Med 2006; 34:96-101
23. Vriesendorp TM, DeVries JH, van Santen S, et al: Evaluation of short-term consequences of hypoglycemia in an intensive care unit. Crit Care Med 2006; 34:2714-2718
24. Malesker MA, Foral PA, McPhillips AC, et al: An efficiency evaluation of protocols for tight glycemic control in intensive care units. Am J Crit Care 2007; 16:589-598
25. Vogelzang M, Zijlstra F, Nijsten MWN: Design and implementation of GRIP: A computerized glucose control system at a surgical intensive care unit. BMC Med Inform Decis Mak 2005; 5:38