Hyperglycaemia results from beta-cell dysfunction in critically ill children with respiratory and cardiovascular failure: A prospective observational study

Critical Care

Volumn 13, Issue 1, 2009, Pages

  Preissig, Catherine M ^a   Rigby, Mark R ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE;

ARTICLE; ARTIFICIAL VENTILATION; CELL FUNCTION; CHILD; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CRITICALLY ILL PATIENT; DIETARY INTAKE; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HEART FAILURE; HUMAN; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INTENSIVE CARE UNIT; LENGTH OF STAY; MALE; OBSERVATIONAL STUDY; PANCREAS ISLET BETA CELL; PANCREAS ISLET BETA CELL DYSFUNCTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY FAILURE; ADOLESCENT; COMPARATIVE STUDY; CRITICAL ILLNESS; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; FEMALE; HEART FAILURE; HUMANS; HYPERGLYCEMIA; INSULIN-SECRETING CELLS; MALE; PROSPECTIVE STUDIES; RESPIRATORY INSUFFICIENCY;

EID: 61849129537     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc7732     Document Type: Article

References (53)

1. Berghe Van den G Wouters P Weekers F Verwaest C Bruyninckx F Schetz M Vlasselaers D Ferdinand P Lauwers P Bouillon R Intensive insulin therapy in the critically ill patients The New England journal of medicine 2001, 345:1359-67. 10.1056/NEJMoa011300 11794168
2. Berghe Van den G Wilmer A Hermans G Intensive insulin therapy in the medical ICU The New England journal of medicine 2006, 354:449-61. 10.1056/NEJMoa052521 16452557
3. Finney SJ Zekveld C Elia A Evans TW Glucose control and mortality in critically ill patients Jama 2003, 290:2041-7. 10.1001/jama.290.15.2041 14559958
4. Van den Berghe G Schoonheydt K Becz P Bruyninckz F Wouters PJ Insulin therapy protects the central and peripheral nervous system of intensive care patients Neurology 2005, 64:1348-53. 15851721
5. Jeremitsky E Omert LA Dunham CM Wilberger J Rodriguez A The impact of hyperglycemia on patients with severe brain injury The Journal of trauma 2005, 58:47-50. 10.1097/01.TA.0000135158.42242.B1 15674149
6. Chavez PN Stanley WC McElfresh TA Huang H Sterk JP Chandler MP Effect of hyperglycemia and fatty acid oxidation inhibition during aerobic conditions and demand-induced ischemia Am J Physiol Heart Circ Physiol 2003, 284:H1521-7. 12521928
7. Inzucchi SE Clinical practice. Management of hyperglycemia in the hospital setting New England journal of medicine 2006, 355:1903-11. 10.1056/NEJMcp060094 17079764
8. Ingels C Debaveye Y Milants I Strict blood glucose control with insulin during intensive care after cardiac surgery: Impact on 4-years survival, dependency on medical care, and quality-of-life European heart journal 2006, 27:2716-24. 10.1093/eurheartj/ehi855 16608860
9. Hermans G Wilmer A Meersseman W Impact of intensive insulin therapy on neuromuscular complications and ventilator-dependency in MICU Am J Respir Crit Care Med 2006. 17138955
10. Krinsley J Perioperative glucose control Current opinion in anaesthesiology 2006, 19:111-6. 10.1097/01.aco.0000192767.12206.ec 16552215
11. Krinsley JS Glycemic control, diabetic status, and mortality in a heterogeneous population of critically ill patients before and during the era of intensive glycemic management: Six and one-half years experience at a university-affiliated community hospital Semin Thorac Cardiovasc Surg. 2006, 18:317-25. 10.1053/j.semtcvs.2006.12.003 17395028
12. Krinsley JS Effect of an intensive glucose management protocol on the mortality of critically ill adult patients Mayo Clinic proceedings 2004, 79:992-1000. 10.4065/79.8.992 15301325
13. Laird AM Miller PR Kilgo PD Meredith JW Chang MC Relationship of early hyperglycemia to mortality in trauma patients The Journal of trauma 2004, 56:1058-62. 10.1097/01.TA.0000123267.39011.9F 15179246
14. Paolino AS Garner KM Effects of hyperglycemia on neurologic outcome in stroke patients J Neurosci Nurs 2005, 37:130-5. 10.1097/ 01376517-200506000-00002 16001816
15. Vanhorebeek I De Vos R Mesotten D Wouters PJ De Wolf-Peeters C Berghe Van den G Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients Lancet 2005, 365:53-9. 10.1016/S0140-6736(04)17665-4 15639679
16. Andreelli F Jacquier D Troy S Molecular aspects of insulin therapy in critically ill patients Curr Opin Clin Nutr Metab Care 2006, 9:124-30. 10.1097/01.mco.0000214571.97933.0a 16477177
17. Langouche L Vanhorebeek I Vlasselaers D Vander Perre S Wouters PJ Skogstrand K Hansen TK Van den Berghe G Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 2005, 115:2277-2286. 10.1172/JCI25385 16075063 1180545
18. Saltiel AR Kahn R Insulin signalling and reglulation of glucose and lipid metabolism Nature 2001, 414:799-804. 10.1038/414799a 11742412
19. Vasa FR Molitch ME Endocrine problems in the chronically critically ill patient Clinics in chest medicine 2001, 22:193-208. 10.1016/ S0272-5231(05)70034-4 11315456
20. Delarue J Magnan C Free fatty acids and insulin resistance Curr Opin Clin Nutr Metab Care 2007, 10:142-148. 10.1097/MCO.0b013e328042ba90 17285001
21. Mesotten D Swinnen JV Vanderhoydonc F Wouters PJ Berghe Van den G Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy J Clin Endocrinol Metab 2004, 89:219-226. 10.1210/jc.2003-030760 14715853
22. Aoki K Nishina M Yoshino A Neuroendocrine response to critical illness and nutritional pharmacology Nippon Geka Gakkai zasshi 2003, 104:816-21. 14733163
23. Kollind M Adamson U Lins PE Hamberger B Transient insulin resistance following infusion of adrenaline in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1988, 3:603-606. 10.1007/BF00264767
24. Soop M Nygren J Thorell A Llungqvist O Stress-induced insulin resistance: Recent developments Curr Opin Clin Nutr Metab Care 2007, 10:181-186. 10.1097/MCO.0b013e32801481df 17285007
25. Robinson LE van Soeren MH Insulin resistance and hyperglycemia in critical illness: Role of insulin in glycemic control AACN clinical issues 2004, 15:45-62. 14767364
26. Schulze M Relationship between adiponectin and glycemic control, blood lipids, and inflammatory markers in men with type 2 diabetes Diabetes Care 2004, 27:1680-1687. 10.2337/diacare.27.7.1680 15220246
27. Langouche L Vander Perre S Wouters PJ D'Hoore A Hansen TK Van den Berghe G Effect of intensive insulin therapy on insulin sensitivity in the critically ill. J Clin Endocrinol Metab 2007, 92:3890-3897. 10.1210/ jc.2007-0813 17666481
28. Faustino EV Apkon M Persistent hyperglycemia in critically ill children The Journal of pediatrics 2005, 146:30-4. 10.1016/j.jpeds.2004.08.076 15644818
29. Cochran A Scaife ER Hansen KW Downey EC Hyperglycemia and outcomes from pediatric traumatic brain injury The Journal of trauma 2003, 55:1035-8. 10.1097/01.TA.0000031175.96507.48 14676647
30. Srinivasan V Spinella PC Drott HR Roth CL Helfaer MA Nadkarni V Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children Pediatr Crit Care Med 2004, 5:329-36. 10.1097/01.PCC.0000128607.68261.7C 15215001
31. Wintergerst KA Buckingham B Gandrud L Wong BJ Kache S Wilson DM Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit Pediatrics 2006, 118:173-9. 10.1542/peds.2005-1819 16818563
32. Yates AR Dyke PC 2nd Taeed R Hyperglycemia is a marker for poor outcome in the postoperative pediatric cardiac patient Pediatr Crit Care Med 2006, 7:351-5. 10.1097/01.PCC.0000227755.96700.98 16738506
33. Branco R Garcia R Piva J Casartelli C Seibel V Tasker R Glucose level and risk of mortality in pediatric septic shock Pediatr Crit Care Med 2005, 6:470-2. 10.1097/01.PCC.0000161284.96739.3A 15982437
34. Yung M Wilkins B Norton L Slater A Glucose control, organ failure, and mortality in pediatric intensive care Pediatr Crit Care Med 2008, 9:147-52. 10.1097/PCC.0b013e3181668c22 18477927
35. Preissig CM Hansen I Roerig P-L Rigby MR A protocolized approach to identify and manage hyperglycemia in a pediatric critical care unit Pediatr Crit Care Med 18838924
36. Clark L Preissig CM Rigby MR Bowyer F Endocrinologic Issues in Pediatric Intensive Care Pediatric Clinics of North America Elsevier James P Orlowski 2008:55. 18501767
37. Branco RG Tasker RC Glycemic level in mechanically ventilated children with bronchiolitis Pediatr Crit Care Med 2007, 8:546-550. 17906595
38. Hirshberg E Larsen G Van Duker H Alterations in glucose homeostasis in the pediatric intensive care unit: Hyperglycemia and glucose variability are associated with increased mortality and morbidity Pediatr Crit Care Med 2008, 9:361-366. 18496414
39. Leteurtre S Martinot A Duhamel A et al. Validation of the paediatric logistic organ dysfunction (PELOD) score: Prospective, observational, multicentre study Lancet 2003, 362:192-7. 10.1016/S0140-6736(03)13908-6 12885479
40. Hatherill M Tibby SM Hilliard T Turner C Murdoch IA Adrenal insufficiency in septic shock Arch Dis Child 1999, 80:51-55. 1717803 10325759 10.1136/adc.80.1.51
41. Tsai EB Sherry NA Palmer JP Herold KC The rise and fall of insulin secretion in type 1 diabetes mellitus Diabetologia 2006, 49:261-270. 10.1007/s00125-005-0100-8 16404554
42. Liu RH Mizuta M Kurose T Matsukura S Early events involved in the development of insulin resistance in Zucker fatty rats International Journal of Obesity 2002, 26:318-26. 10.1038/sj.ijo.0801924 11896486
43. Ehtisham S Crabtree N Clark P Shaw N Barrett T Ethnic differences in insulin resistance and body composition in United Kingdom adolescents J Clin Endocrinol Metab 2005, 90:3963-3969. 10.1210/jc.2004-2001 15840754
44. Kasim-Karakas SE Ethnic differences in the insulin resistance syndrome Am J Clin Nutr 2000, 71:670-671. 10702157
45. Dahn MS Lange MP Mitchell RA Lobdell K Wilson RF Insulin production following injury and sepsis J Trauma 1987, 27:1031-1038. 10.1097/ 00005373-198709000-00013 3309352
46. Carey LC Cloutier CT Lowery BD Growth hormone and adrenal cortical response to shock nd trauma in the human Ann Surg 1971, 174:451-58. 1397593 5111288
47. Clowes GH Martin H Walji S Hircsh E Gazitua R Goodfellow R Blood insulin responses to blood glucose levels in high output sepsis and septic shock Am J Surg 1978, 135:577-583. 10.1016/0002-9610(78)90040-5 345832
48. Van Waardenburg DA Jansen TC Vos GD Buurman WA Hyperglycemia in children with meningococcal sepsis and septic shock: The relation between plasma levels of insulin and inflammatory mediators J Clin Endocrinol Metab 2006, 91:3916-3921. 10.1210/jc.2006-0525 16735484
49. Leahy JL Bonner-Weir S Weir GC Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion Diabetes Care 1992, 15:442-455. 10.2337/ diacare.15.3.442 1559411
50. Krauss S Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta-cell dysfunction J Clin Invest 2003, 112:1831-42. 297000 14679178
51. Brownlee M A radical explanation for glucose-induced beta-cell dysfunction J Clin Invest 2003, 112:1788-90. 297003 14679173
52. Van den Berghe G How does blood glucose control with insulin save lives in intensive care? J Clin Invest 2004, 114:1187-1195. 524243 15520847
53. Ellger E Survival benefits of intensive insulin therapy in critical illness: Impact of maintaining normoglycemia vs. glycemia-Independent actions of insulin Diabetes 2006, 55:1096-1105. 10.2337/ diabetes.55.04.06.db05-1434 16567534