A network of broadly expressed hlh genes regulates tissue-specific cell fates

Cell

Volumn 147, Issue 4, 2011, Pages 881-892

  Bhattacharya, Abhishek ^a   Baker, Nicholas E ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; PROTEIN; PROTEIN DA; PROTEIN EMC; UNCLASSIFIED DRUG;

ADIPOSE TISSUE CELL; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; DIMERIZATION; DROSOPHILA; MAMMAL CELL; NEUROECTODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION;

MAMMALIA;

EID: 81055144810     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2011.08.055     Document Type: Article

References (120)

1. U. Alon Network motifs: theory and experimental approaches Nat. Rev. Genet. 8 2007 450 461
2. A. Aronheim, R. Shiran, A. Rosen, and M.D. Walker The E2A gene product contains two separable and functionally distinct transcription activation domains Proc. Natl. Acad. Sci. USA 90 1993 8063 8067
3. N.E. Baker, A. Bhattacharya, and L.C. Firth Regulation of Hh signal transduction as Drosophila eye differentiation progresses Dev. Biol. 335 2009 356 366
4. R. Benezra An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures Cell 79 1994 1057 1067
5. R. Benezra, R.L. Davis, D. Lockshon, D.L. Turner, and H. Weintraub The protein Id: a negative regulator of helix-loop-helix DNA binding proteins Cell 61 1990 49 59
6. A. Bhattacharya, and N.E. Baker The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eye Dev. Biol. 327 2009 288 300
7. M.D. Boos, Y. Yokota, G. Eberl, and B.L. Kee Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity J. Exp. Med. 204 2007 1119 1130
8. J. Botas, J. Moscoso del Prado, and A. García-Bellido Gene-dose titration analysis in the search of trans-regulatory genes in Drosophila EMBO J. 1 1982 307 310
9. N.L. Brown, C.A. Sattler, S.W. Paddock, and S.B. Carroll Hairy and emc negatively regulate morphogenetic furrow progression in the Drosophila eye Cell 80 1995 879 887
10. N.L. Brown, S.W. Paddock, C.A. Sattler, C. Cronmiller, B.J. Thomas, and S.B. Carroll daughterless is required for Drosophila photoreceptor cell determination, eye morphogenesis, and cell cycle progression Dev. Biol. 179 1996 65 78
11. C.V. Cabrera, and M.C. Alonso Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila EMBO J. 10 1991 2965 2973
12. K.M. Cadigan, A.D. Jou, and R. Nusse Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless Development 129 2002 3393 3402
13. S. Campuzano Emc, a negative HLH regulator with multiple functions in Drosophila development Oncogene 20 2001 8299 8307
14. P. Cubas, and J. Modolell The extramacrochaetae gene provides information for sensory organ patterning EMBO J. 11 1992 3385 3393
15. J. Curtiss, and M. Mlodzik Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent Development 127 2000 1325 1336
16. R.L. Davis, H. Weintraub, and A.B. Lassar Expression of a single transfected cDNA converts fibroblasts to myoblasts Cell 51 1987 987 1000
17. P.M. Domingos, S. Brown, R. Barrio, K. Ratnakumar, B.J. Frankfort, G. Mardon, H. Steller, and B. Mollereau Regulation of R7 and R8 differentiation by the spalt genes Dev. Biol. 273 2004 121 133
18. H.M. Ellis, D.R. Spann, and J.W. Posakony extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins Cell 61 1990 27 38
19. L.C. Firth, W. Li, H. Zhang, and N.E. Baker Analyses of RAS regulation of eye development in Drosophila melanogaster Methods Enzymol. 407 2006 711 721
20. L.A. García Alonso, and A. García-Bellido Extramacrochaetae, a trans-acting gene of the achaete-scute complex of Drosophila involved in cell communication Roux. Arch. Dev. Biol. 197 1988 328 338
21. A. García-Bellido Genetic Analysis of the Achaete-Scute System of DROSOPHILA MELANOGASTER Genetics 91 1979 491 520
22. A. García-Bellido, and J.F. de Celis The complex tale of the achaete-scute complex: a paradigmatic case in the analysis of gene organization and function during development Genetics 182 2009 631 639
23. J. Garrell, and J. Modolell The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein Cell 61 1990 39 48
24. N. Giagtzoglou, P. Alifragis, K.A. Koumbanakis, and C. Delidakis Two modes of recruitment of E(spl) repressors onto target genes Development 130 2003 259 270
25. K.G. Golic Site-specific recombination between homologous chromosomes in Drosophila Science 252 1991 958 961
26. J.L. Gómez-Skarmeta, S. Campuzano, and J. Modolell Half a century of neural prepatterning: the story of a few bristles and many genes Nat. Rev. Neurosci. 4 2003 587 598
27. S.E. Goulding, P. zur Lage, and A.P. Jarman amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge Neuron 25 2000 69 78
28. S. Greenwood, and G. Struhl Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway Development 126 1999 5795 5808
29. A.C. Groth, M. Fish, R. Nusse, and M.P. Calos Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31 Genetics 166 2004 1775 1782
30. P. Henthorn, M. Kiledjian, and T. Kadesch Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif Science 247 1990 467 470
31. U. Hinz, B. Giebel, and J.A. Campos-Ortega The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes Cell 76 1994 77 87
32. M.L. Huang, C.H. Hsu, and C.T. Chien The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system Neuron 25 2000 57 67
33. J. Ik Tsen Heng, and S.S. Tan The role of class I HLH genes in neural development - have they been overlooked? Bioessays 25 2003 709 716
34. A.P. Jarman, Y. Grau, L.Y. Jan, and Y.N. Jan atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system Cell 73 1993 1307 1321
35. A.P. Jarman, E.H. Grell, L. Ackerman, L.Y. Jan, and Y.N. Jan Atonal is the proneural gene for Drosophila photoreceptors Nature 369 1994 398 400
36. A.P. Jarman, Y. Sun, L.Y. Jan, and Y.N. Jan Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors Development 121 1995 2019 2030
37. Y. Jen, H. Weintraub, and R. Benezra Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins Genes Dev. 6 1992 1466 1479
38. M. Jord, A. Vinyals, A. Marazuela, E. Cubillo, D. Olmeda, E. Valero, A. Cano, and A. Fabra Id-1 is induced in MDCK epithelial cells by activated Erk/MAPK pathway in response to expression of the Snail and E47 transcription factors Exp. Cell Res. 313 2007 2389 2403
39. B.L. Kee E and ID proteins branch out Nat. Rev. Immunol. 9 2009 175 184
40. B.E. Kimmel, U. Heberlein, and G.M. Rubin The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype Genes Dev. 4 1990 712 727
41. A.B. Lassar, B.M. Paterson, and H. Weintraub Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts Cell 47 1986 649 656
42. T. Lee, and L. Luo Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis Neuron 22 1999 451 461
43. E.C. Lee, X. Hu, S.Y. Yu, and N.E. Baker The scabrous gene encodes a secreted glycoprotein dimer and regulates proneural development in Drosophila eyes Mol. Cell. Biol. 16 1996 1179 1188
44. S.H. Lee, E. Hao, A. Kiselyuk, J. Shapiro, D.J. Shields, A. Lowy, F. Levine, and P. Itkin-Ansari The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma Mol. Cancer Res. 9 2011 782 790
45. M.E. Massari, and C. Murre Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms Mol. Cell. Biol. 20 2000 429 440
46. D. Melicharek, A. Shah, G. DiStefano, A.J. Gangemi, A. Orapallo, A.D. Vrailas-Mortimer, and D.R. Marenda Identification of novel regulators of atonal expression in the developing Drosophila retina Genetics 180 2008 2095 2110
47. M. Mlodzik, N.E. Baker, and G.M. Rubin Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila Genes Dev. 4 1990 1848 1861
48. C. Murre, P.S. McCaw, and D. Baltimore A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins Cell 56 1989 777 783
49. C. Murre, P.S. McCaw, H. Vaessin, M. Caudy, L.Y. Jan, Y.N. Jan, C.V. Cabrera, J.N. Buskin, S.D. Hauschka, and A.B. Lassar Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence Cell 58 1989 537 544
50. C. Murre, G. Bain, M.A. van Dijk, I. Engel, B.A. Furnari, M.E. Massari, J.R. Matthews, M.W. Quong, R.R. Rivera, and M.H. Stuiver Structure and function of helix-loop-helix proteins Biochim. Biophys. Acta 1218 1994 129 135
51. R. Nolo, L.A. Abbott, and H.J. Bellen Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila Cell 102 2000 349 362
52. Y. Ozaki, S. Sasagawa, and S. Kuroda Dynamic characteristics of transient responses J. Biochem. 137 2005 659 663
53. H. Pi, S.K. Huang, C.Y. Tang, Y.H. Sun, and C.T. Chien phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development Proc. Natl. Acad. Sci. USA 101 2004 8378 8383
54. J.Y. Roignant, and J.E. Treisman Pattern formation in the Drosophila eye disc Int. J. Dev. Biol. 53 2009 795 804
55. S.E. Ross, M.E. Greenberg, and C.D. Stiles Basic helix-loop-helix factors in cortical development Neuron 39 2003 13 25
56. G. Rothschild, X. Zhao, A. Iavarone, and A. Lasorella E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells Mol. Cell. Biol. 26 2006 4351 4361
57. R. Schotte, W. Dontje, M. Nagasawa, Y. Yasuda, A.Q. Bakker, H. Spits, and B. Blom Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development J. Immunol. 184 2010 6670 6679
58. R. Schwartz, I. Engel, M. Fallahi-Sichani, H.T. Petrie, and C. Murre Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development Proc. Natl. Acad. Sci. USA 103 2006 9976 9981
59. C.P. Shen, and T. Kadesch B-cell-specific DNA binding by an E47 homodimer Mol. Cell. Biol. 15 1995 4518 4524
60. O. Shoval, and U. Alon SnapShot: network motifs Cell 143 2010 326-e1
61. A. Singson, M.W. Leviten, A.G. Bang, X.H. Hua, and J.W. Posakony Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling Genes Dev. 8 1994 2058 2071
62. J.E. Smith III, and C. Cronmiller The Drosophila daughterless gene autoregulates and is controlled by both positive and negative cis regulation Development 128 2001 4705 4714
63. G.M. Süel, J. Garcia-Ojalvo, L.M. Liberman, and M.B. Elowitz An excitable gene regulatory circuit induces transient cellular differentiation Nature 440 2006 545 550
64. Y. Sun, L.Y. Jan, and Y.N. Jan Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system Development 125 1998 3731 3740
65. H. Vaessin, M. Brand, L.Y. Jan, and Y.N. Jan daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo Development 120 1994 935 945
66. M. Van Doren, H.M. Ellis, and J.W. Posakony The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes Development 113 1991 245 255
67. M. Van Doren, P.A. Powell, D. Pasternak, A. Singson, and J.W. Posakony Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae Genes Dev. 6 12B 1992 2592 2605
68. E. Villa-Cuesta, J. de Navascués, M. Ruiz-Gómez, R. Diez del Corral, M. Domínguez, J.F. de Celis, and J. Modolell Tufted is a gain-of-function allele that promotes ectopic expression of the proneural gene amos in Drosophila Genetics 163 2003 1403 1412
69. R. Villares, and C.V. Cabrera The achaete-scute gene complex of D. melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc Cell 50 1987 415 424
70. H. Weintraub, S.J. Tapscott, R.L. Davis, M.J. Thayer, M.A. Adam, A.B. Lassar, and A.D. Miller Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD Proc. Natl. Acad. Sci. USA 86 1989 5434 5438
71. N.M. White, and A.P. Jarman Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signalling Development 127 2000 1681 1689
72. J. Wildonger, and R.S. Mann Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling Dev. Biol. 286 2005 507 520
73. A. Wodarz, U. Hinz, M. Engelbert, and E. Knust Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila Cell 82 1995 67 76
74. T. Wolff, and D.F. Ready Pattern formation in the Drosophila retina M. Bate, A. Martinez Arias, The Development of Drosophila melanogaster 1993 Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY 1277 1325
75. T. Xu, and G.M. Rubin Analysis of genetic mosaics in developing and adult Drosophila tissues Development 117 1993 1223 1237
76. Abdelilah-Seyfried, S.; Chan, Y.M.; Zeng, C.; Justice, N.J.; Younger-Shepherd, S.; Sharp, L.E.; Barbel, S.; Meadows, S.A.; Jan, L.Y.; and Jan, Y.N. (2000). A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Genetics 155, 733-752.
77. Arora, K.; Dai, H.; Kazuko, S.G.; Jamal, J.; O'Connor, M.B.; Letsou, A.; and Warrior, R. (1995). The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family. Cell 81, 781-790.
78. Barolo, S.; Carver, L.A.; and Posakony, J.W. (2000). GFP and beta-galactosidase transformation vectors for promoter/enhancer analysis in Drosophila. Biotechniques 29, 726-732, 728, 730, 732.
79. Bhattacharya, A.; and Baker, N.E. (2009). The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eye. Dev. Biol. 327, 288-300.
80. Bischof, J.; Maeda, R.K.; Hediger, M.; Karch, F.; and Basler, K. (2007). An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc. Natl. Acad. Sci. USA 104, 3312-3317.
81. Brand, M.; and Campos-Ortega, J.A. (1990). Second-site modifiers of the split mutation of Notch define genes involved in neurogenesis in Drosophila melanogaster. Roux. Arch. Dev. Biol. 198, 275-285.
82. Brown, N.L.; Sattler, C.A.; Paddock, S.W.; and Carroll, S.B. (1995). Hairy and emc negatively regulate morphogenetic furrow progression in the Drosophila eye. Cell 80, 879-887.
83. Brown, N.L.; Paddock, S.W.; Sattler, C.A.; Cronmiller, C.; Thomas, B.J.; and Carroll, S.B. (1996). daughterless is required for Drosophila photoreceptor cell determination, eye morphogenesis, and cell cycle progression. Dev. Biol. 179, 65-78.
84. Caudy, M.; Vässin, H.; Brand, M.; Tuma, R.; Jan, L.Y.; and Jan, Y.N. (1988). daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex. Cell 55, 1061-1067.
85. Chen, Y.; and Struhl, G. (1998). In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Development 125, 4943-4948.
86. Cronmiller, C.; and Cline, T.W. (1987). The Drosophila sex determination gene daughterless has different functions in the germ line versus the soma. Cell 48, 479-487.
87. Cronmiller, C.; and Cummings, C.A. (1993). The daughterless gene product in Drosophila is a nuclear protein that is broadly expressed throughout the organism during development. Mech. Dev. 42, 159-169.
88. Domingos, P.M.; Brown, S.; Barrio, R.; Ratnakumar, K.; Frankfort, B.J.; Mardon, G.; Steller, H.; and Mollereau, B. (2004). Regulation of R7 and R8 differentiation by the spalt genes. Dev. Biol. 273, 121-133.
89. Duffy, J.B.; Kania, M.A.; and Gergen, J.P. (1991). Expression and function of the Drosophila gene runt in early stages of neural development. Development 113, 1223-1230.
90. Ellis, H.M. (1994). Embryonic expression and function of the Drosophila helix-loop-helix gene, extramacrochaetae. Mech. Dev. 47, 65-72.
91. Firth, L.C.; Li, W.; Zhang, H.; and Baker, N.E. (2006). Analyses of RAS regulation of eye development in Drosophila melanogaster. Methods Enzymol. 407, 711-721.
92. Freeman, M. (1996). Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87, 651-660.
93. Hinz, U.; Giebel, B.; and Campos-Ortega, J.A. (1994). The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 76, 77-87.
94. Janody, F.; Lee, J.D.; Jahren, N.; Hazelett, D.J.; Benlali, A.; Miura, G.I.; Draskovic, I.; and Treisman, J.E. (2004). A mosaic genetic screen reveals distinct roles for trithorax and polycomb group genes in Drosophila eye development. Genetics 166, 187-200.
95. Jarman, A.P.; Grell, E.H.; Ackerman, L.; Jan, L.Y.; and Jan, Y.N. (1994). Atonal is the proneural gene for Drosophila photoreceptors. Nature 369, 398-400.
96. Jen, Y.; Weintraub, H.; and Benezra, R. (1992). Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins. Genes Dev. 6, 1466-1479.
97. Kaminker, J.S.; Canon, J.; Salecker, I.; and Banerjee, U. (2002). Control of photoreceptor axon target choice by transcriptional repression of Runt. Nat. Neurosci. 5, 746-750.
98. Klemenz, R.; Weber, U.; and Gehring, W.J. (1987). The white gene as a marker in a new P-element vector for gene transfer in Drosophila. Nucleic Acids Res. 15, 3947-3959.
99. Kühnlein, R.P.; Frommer, G.; Friedrich, M.; Gonzalez-Gaitan, M.; Weber, A.; Wagner-Bernholz, J.F.; Gehring, W.J.; Jäckle, H.; and Schuh, R. (1994). spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo. EMBO J. 13, 168-179.
100. Lee, E.C.; Hu, X.; Yu, S.Y.; and Baker, N.E. (1996). The scabrous gene encodes a secreted glycoprotein dimer and regulates proneural development in Drosophila eyes. Mol. Cell. Biol. 16, 1179-1188.
101. Lee, T.; and Luo, L. (1999). Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 22, 451-461.
102. Lehmann, R.; Jimenez, F.; Dietrich, U.; Campos-Ortega, J.A. (1983). On the phenotype and development of mutants of early neurogenesis in Drosophila melanogaster. Roux. Arch. Dev. Biol. 192, 62-74.
103. Ngre, N.; Brown, C.D.; Shah, P.K.; Kheradpour, P.; Morrison, C.A.; Henikoff, J.G.; Feng, X.; Ahmad, K.; Russell, S.; White, R.A.; et al. (2010). A comprehensive map of insulator elements for the Drosophila genome. PLoS Genet. 6, e1000814.
104. Neufeld, T.P.; de la Cruz, A.F.; Johnston, L.A.; and Edgar, B.A. (1998). Coordination of growth and cell division in the Drosophila wing. Cell 93, 1183-1193.
105. Nolo, R.; Abbott, L.A.; and Bellen, H.J. (2000). Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 102, 349-362.
106. Parras, C.; García-Alonso, L.A.; Rodriguez, I.; and Jiménez, F. (1996). Control of neural precursor specification by proneural proteins in the CNS of Drosophila. EMBO J. 15, 6394-6399.
107. Pfeiffer, B.D.; Jenett, A.; Hammonds, A.S.; Ngo, T.T.; Misra, S.; Murphy, C.; Scully, A.; Carlson, J.W.; Wan, K.H.; Laverty, T.R.; et al. (2008). Tools for neuroanatomy and neurogenetics in Drosophila. Proc. Natl. Acad. Sci. USA 105, 9715-9720.
108. Pignoni, F.; and Zipursky, S.L. (1997). Induction of Drosophila eye development by decapentaplegic. Development 124, 271-278.
109. Price, J.V.; Clifford, R.J.; and Schüpbach, T. (1989). The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog. Cell 56, 1085-1092.
110. Raftery, L.A.; Twombly, V.; Wharton, K.; and Gelbart, W.M. (1995). Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139, 241-254.
111. Roy, S.; Ernst, J.; Kharchenko, P.V.; Kheradpour, P.; Negre, N.; Eaton, M.L.; Landolin, J.M.; Bristow, C.A.; Ma, L.; Lin, M.F.; et al; modENCODE Consortium. (2010). Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science 330, 1787-1797.
112. Sekelsky, J.J.; Newfeld, S.J.; Raftery, L.A.; Chartoff, E.H.; and Gelbart, W.M. (1995). Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139, 1347-1358.
113. Shi, W.; Stampas, A.; Zapata, C.; and Baker, N.E. (2003). The pineapple eye gene is required for survival of Drosophila imaginal disc cells. Genetics 165, 1869-1879.
114. Sidén-Kiamos, I.; Saunders, R.D.; Spanos, L.; Majerus, T.; Treanear, J.; Savakis, C.; Louis, C.; Glover, D.M.; Ashburner, M.; and Kafatos, F.C. (1990). Towards a physical map of the Drosophila melanogaster genome: mapping of cosmid clones within defined genomic divisions. Nucleic Acids Res. 18, 6261-6270.
115. Smith, J.E.; III, and Cronmiller, C. (2001). The Drosophila daughterless gene autoregulates and is controlled by both positive and negative cis regulation. Development 128, 4705-4714.
116. Swevers, L.; Cherbas, L.; Cherbas, P.; and Iatrou, K. (1996). Bombyx EcR (BmEcR) and Bombyx USP (BmCF1) combine to form a functional ecdysone receptor. Insect Biochem. Mol. Biol. 26, 217-221.
117. Vincent, J.P.; Girdham, C.H.; and O'Farrell, P.H. (1994). A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics. Dev. Biol. 164, 328-331.
118. Wang, S.S.; Kamphuis, W.; Huitinga, I.; Zhou, J.N.; and Swaab, D.F. (2008). Gene expression analysis in the human hypothalamus in depression by laser microdissection and real-time PCR: the presence of multiple receptor imbalances. Mol. Psychiatry 13, 786-799.
119. Wehrli, M.; Dougan, S.T.; Caldwell, K.; O'Keefe, L.; Schwartz, S.; Vaizel-Ohayon, D.; Schejter, E.; Tomlinson, A.; and DiNardo, S. (2000). arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 407, 527-530.
120. Wodarz, A.; Hinz, U.; Engelbert, M.; and Knust, E. (1995). Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell 82, 67-76.