The scabrous gene encodes a secreted glycoprotein dimer and regulates proneural development in Drosophila eyes

Molecular and Cellular Biology

Volumn 16, Issue 3, 1996, Pages 1179-1188

  Lee, E Chiang ^a   Hu, Xiaoxi ^a   Yu, Sung Yun ^a   Baker, Nicholas E ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN; TENASCIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL INTERACTION; DIMERIZATION; DROSOPHILA; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; NERVE CELL DIFFERENTIATION; NONHUMAN; PHENOTYPE; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN SECRETION;

ANIMALIA;

EID: 0030043945     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.3.1179     Document Type: Article

References (51)

1. Artavanis-Tsakonas, S., K. Matsuno, and M. E. Fortini. 1995. Notch signalling. Science 268:225-232.
2. Ashburner, M., and J. J. Bonner. 1979. The induction of gene activity in Drosophila by heat shock. Cell 17:241-254.
3. Baker, N. E., M. Mlodzik, and G. M. Rubin. 1990. Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous. Science 250:1370-1377.
4. Baker, N. E., and G. M. Rubin. 1992. Ellipse mutations in the Drosophila homologue of the EGF receptor affect pattern formation, cell division, and cell death in eye imaginal discs. Dev. Biol. 150:381-396.
5. Baker, N. E., and A. E. Zitron. 1995. Drosophlla eye development: Notch and Delta amplify a neurogenic pattern conferred on the morphogenetic furrow by scabrous. Mech. Dev. 49:173-189.
6. Bernfield, M., R. Kokenyesi, M. Kato, M. T. Hinkes, J. Spring, R. L. Gallo, and E. J. Lose. 1992. Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycans. Annu. Rev. Cell Biol. 8:365-393.
7. Bradley, R. S., and A. M. C. Brown. 1990. The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix. EMBO J. 9:1569-1575.
8. Brown, N. L., S. A. Sattler, S. W. Paddock, and S. B. Carroll. 1995. hairy and emc negatively regulate morphogenetic furrow progression in the developing Drosophila eye. Cell 80:879-887.
9. Bunch, T. A., Y. Grinblat, and L. S. B. Goldstein. 1988. Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells. Nucleic Acids Res. 16:1043-1061.
10. Clarkson, E. N. K. 1975. The evolution of the eye in Trilobites. Fossils Strata 4:7-31.
11. Cubas, P., J.-F. de Celis, S. Campuzano, and J. Modolell. 1991 Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosopkila imaginal wing disc. Genes Dev. 5:996-1008.
12. Doe, C. Q., and C. S. Goodman. 1985. Early events in insect neurogenesis. II. The role of cell interactions and cell lineage in the development of neuronal precursor cells. Dev. Biol. 111:206-219
13. Doolittle, R. F. 1992 A detailed consideration of a principal domain of vertebrate fibrinogen and its relatives. Protein Sci 1:1563-1577.
14. Doolittle, R. F. 1994. The molecular biology of fibrin. In G Stammatoyannopoulos (ed ), p 701-723. The molecular basis of blood diseases, 2nd ed. W B. Saunders, Philadelphia.
15. Edge, A. S. B., C. R. Faltynek, L. Hof, L. E. Reichert, Jr., and P. Weber. 1981. Deglycosylation of glycoproteins by trifluoromethanesulfonic acid. Anal. Biochem. 118:131-137.
16. Ellis, M. C., U. Weber, V. Wiersdorff, and M. Mlodzik. 1994. Confrontation of scabrous expressing and non-expressing cells is essential for normal ommatidial spacing in the Drosophila eye. 120:1959-1969.
17. Erickson, H. P. 1993. Tenascin-C, tenascin-R, and tenascin-X: a family of talented proteins in search of functions Curr Opin Cell Biol. 5:869-876.
18. Fradkin, L. G., J. N. Noordermeer, and R. Nusse. 1995. The Drosophila Wnt protein DWnt-3 is a secreted glycoprotein localized on the axon tracts of the embryonic CNS. Dev Biol 168:202-213.
19. Hager, D. A., and R. R. Burgess. 1980. Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecy; sulfate, and renaturation of enzymatic activity: results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes. Anal Biochem. 169:76-55.
20. Harlow, E., and D. Lane. 1988 Antibodies. A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
21. Heitzler, P., and P. Simpson. 1991. The choice of cell fate in the epidermis of Drosophila. Cell 64:1083-1092.
22. Heitzler, P., and P. Simpson. 1993. Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions. Development 117:1113-1123
23. Hu, X., E.-C. Lee, and N. E. Baker. 1995. Molecular analysis of scabrous mutant alleles from Drosophila indicates a secreted protein with two functional domains. Genetics 141:607-617.
24. Jarman, A. P., E. H. Grell, L. Ackerman, L. Y. Jan, and Y. N. Jan. 1994. atonal is the proneural gene for Drosophila photoreceptors. Nature (London) 369:398-400.
25. Jarman, A. P., Y. Sun, L. Y. Jan, and Y. N. Jan. 1995 Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. Development 121:2019-2030.
26. Jokerst, R. S., J. R. Weeks, W. A. Zehring, and A. L. Greenleaf. 1989. Analysis of the gene encoding the largest subunit of RNA polymerase II in Drosophila. Mol. Gen. Genet. 215:266-275.
27. Kiefer, P., G. Peters, and C. Dickson. 1991. The Int-2/Fgf-3 oncogene prodiuct is secreted and associates with extracellular matrix: implications for cell transformation. Mol. Cell. Biol. 11:5929-5936.
28. Lee, E., and N. Baker. Unpublished data.
29. Lindquist, S. 1981. Regulation of protein synthesis during heat shock. Nature (London) 293:311-314.
30. Mlodzik, M., N. E. Baker, and G. M. Rubin. 1990. Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila. Genes Dev. 4:1848-3861
31. Panganiban, G., K. E. Rahka, M. D. Neitzel, and F. M. Hoffmann. 1990. Biochemical characterization of the Drosophila dpp protein, a member of the transforming growth factor β family of growth factors. Mol. Cell. Biol. 10:2669-2677
32. Papkoff, J., and B. Schryver. 1990. Secreted int-1 protein is associated with the cell surface. Mol. Cell. Biol. 10:2723-2730.
33. Parks, A. L., R. F. Turner, and M. A. T. Muskavitch. 1995. Relationships between complex Delta expression and the specification of retinal fates during Drosophila eye development. Mech. Dev. 50:201-216.
34. Ready, D. F., T. E. Hanson, and S. Benzer. 1976. Development of the Drosophila retina, a neurocrystalline lattice. Dev. Biol. 53:217-240.
35. Rettenmier, C. W., M. F. Roussel, R. A. Ashmun, P. Ralph, K. Price, and C. J. Sherr. 1987. Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes. Mol. Cell. Biol. 7:2378-2387.
36. Rio, D. C., and G. M. Rubin. 1985. Transformation of cultured Drosophila melanogaster cells with a dominant selectable marker. Mol. Cell. Biol. 5:1833-1838.
37. Schweitzer, R., M. Shaharabany, R. Seger, and B.-Z. Shilo. 1995. Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ectoderm determination. Genes Dev. 9:1518-1529.
38. Simon, M. A., D. D. L. Bowtell, and G. M. Rubin. 1989. Structure and activity of the sevenless protein: a protein tyrosine kinase receptor required for photoreceptor development in Drosophila. Proc. Natl. Acad. Sci. 86:8333-8337.
39. Simpson, P. 1990. Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila. Development 109:509-519.
40. Simpson, P. 1990. Notch and the choice of cell fate in Drosophila neuroepithelium. Trends Genet. 6:343-345.
41. Singson, A., M. W. Leviten, A. G. Bang, X. H. Hua, and J. W. Posakony. 1994. Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signalling. Genes Dev. 8:2058-2071.
42. Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptdies expressed in Escherichia coli as fusions with glutathione-S-transferase Gene 67:31-40.
43. Studier, F. W., and B. A. Moffatt. 1986. Use of bacteriophage T7 polymerase to direct selective high-level expression of cloned genes. J. Mol. Biol. 189: 113-130.
44. Tomlinson, A., and D. F. Ready. 1987. Neuronal differentiation in the Drosophila ommatidium. Dev. Biol. 120:366-376.
45. van den Heuvel, M., C. Harryman-Samos, J. Klingensmith, N. Perrimon, and R. Nusse. 1993. Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. EMBO J. 12:5293-5302
46. Vincent, J. P., and P. A. Lawrence. 1994 Drosophila wingless sustains engrailed expression only in adjoining cells: evidence from mosaic embryos Cell 77:909-915.
47. Wigglesworth, V. B. 1940. Local and general factors in the development of "pattern" in Rhodnius prolixus (Hemiptera). J. Exp. Biol. 17:180-220.
48. Wolff, T., and D. F. Ready. 1991. The beginning of pattern formation in the Drosophila compound eye the morphogenetic furrow and the second mitotic wave. Development 113:841-850.
49. Yost, H. J., and S. Lindquist. 1986. RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis. Cell 45:185-193.
50. Zipursky, S. L., and G. M. Rubin. 1994. Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Annu. Rev Neurosci. 17:373-397
51. Zitron, A., and N. Baker. Unpublished data