Investigation of the insulin-like properties of zinc(II) complexes of 3-hydroxy-4-pyridinones: Identification of a compound with glucose lowering effect in STZ-induced type i diabetic animals

Journal of Inorganic Biochemistry

Volumn 105, Issue 12, 2011, Pages 1675-1682

  Moniz, Tânia ^a   Amorim, M João ^a   Ferreira, Rita ^a   Nunes, Ana ^a   Silva, Ana ^a   Queirós, Carla ^a   Leite, Andreia ^a   Gameiro, Paula ^a   Sarmento, Bruno ^a,b   Remião, Fernando ^a   Yoshikawa, Yutaka ^c   Sakurai, Hiromu ^d   Rangel, Maria ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY INSTITUTE OF HEALTH SCIENCES IUCS   (Portugal)

^c KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^d SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

3 hydroxy 4 pyridinones; Diabetes; Glucose lowering; Keywords; Zinc; Zn(dmpp) 2

Indexed keywords

ANTIDIABETIC AGENT; BIS(1 ETHYL 3 HYDROXY 2 METHYL 4 PYRIDONATE)ZINC; BIS(1,2 DIETHYL 3 HYDROXY 4 PYRIDONATE)ZINC; BIS(1,2 DIMETHYL 3 HYDROXY 4 PYRIDONATE)ZINC; BIS(2 ETHYL 3 HYDROXY 1 METHYL 4 PYRIDONATE)ZINC; BIS(2 ETHYL 3 HYDROXY 4 PYRIDONATE)ZINC; BIS(3 HYDROXY 2 METHYL 4 PYRIDONATO)ZINC; BIS[3 HYDROXY 1 (2 HYDROXYETHYL) 2 ETHYL 4 PYRIDONATE]ZINC; BIS[3 HYDROXY 1 (2 HYDROXYETHYL) 2 METHYL 4 PYRIDONATE]ZINC; FATTY ACID; GLUCOSE; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG; ZINC 3 HYDROXY 4 PYRIDINONATE COMPLEX; ZINC COMPLEX; ZINC SULFATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; IC 50; INHIBITION KINETICS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN LIKE ACTIVITY; LIVER CELL; MALE; NONHUMAN; RAT; STREPTOZOCIN DIABETES;

ADIPOCYTES; ANIMALS; BLOOD GLUCOSE; CELL SURVIVAL; COORDINATION COMPLEXES; DIABETES MELLITUS, EXPERIMENTAL; DRUG STABILITY; FATTY ACIDS, NONESTERIFIED; HEPATOCYTES; HYPOGLYCEMIC AGENTS; INHIBITORY CONCENTRATION 50; MALE; PYRIDONES; RATS; STREPTOZOCIN; ZINC;

ANIMALIA; RATTUS;

EID: 81055137648     PISSN: 01620134     EISSN: 18733344     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2011.09.005     Document Type: Conference Paper

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