Inhibition of hepatitis B virus (HBV) by LNA-mediated nuclear interference with HBV DNA transcription

Biochemical and Biophysical Research Communications

Volumn 409, Issue 3, 2011, Pages 430-435

  Sun, Zhen ^a,b   Xiang, Wenqing ^b   Guo, Yajuan ^b   Chen, Zhi ^c   Liu, Wei ^b   Lu, Daru ^a  

^a FUDAN UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Hepatocyte; Lipofectamine; Oligonucleotide; RNA interference; Triple helix

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CELL NUCLEUS DNA; GENOMIC DNA; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; LOCKED NUCLEIC ACID; LOCKED NUCLEIC ACID OLIGONUCLEOTIDE; PREGENOMIC RNA; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS DNA;

5' UNTRANSLATED REGION; ANTISENSE THERAPY; ANTIVIRAL THERAPY; ARTICLE; CELL MEMBRANE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DNA INTERFERENCE; DNA TRANSCRIPTION; GENE EXPRESSION REGULATION; GENETIC REGULATION; HEPATITIS B VIRUS; LIPID TRANSPORT; LIPOSOMAL GENE DELIVERY SYSTEM; LIVER CELL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA DEGRADATION; RNA INTERFERENCE; TRANSCRIPTION REGULATION; VIRUS REPLICATION;

BASE SEQUENCE; CELL LINE, TUMOR; CELL NUCLEUS; DNA REPLICATION; DNA, VIRAL; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; LIPIDS; OLIGONUCLEOTIDES; TRANSCRIPTION, GENETIC; TRANSFECTION; VIRUS REPLICATION;

HEPATITIS B VIRUS;

EID: 80955180549     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.05.016     Document Type: Article

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