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Volumn 4, Issue 1, 2011, Pages 189-196

Emerging treatment options for short bowel syndrome: Potential role of teduglutide

Author keywords

Glucagon like peptide 2; Intestinal adaptation; Intestinal failure; Parenteral nutrition

Indexed keywords

GATTEX; GLUCAGON LIKE PEPTIDE 2; INTERLEUKIN 10; PLACEBO; TEDUGLUTIDE; UNCLASSIFIED DRUG;

EID: 80955136824     PISSN: None     EISSN: 11787023     Source Type: Journal    
DOI: 10.2147/CEG.S13906     Document Type: Review
Times cited : (22)

References (48)
  • 1
    • 46049089136 scopus 로고    scopus 로고
    • Survival of patients identifed as candidates for intestinal transplantation: A 3-year prospective follow-up
    • Pironi L, Forbes A, Joly F, et al. Survival of patients identifed as candidates for intestinal transplantation: a 3-year prospective follow-up. Gastroenterolog y. 2008;135(1):61-71.
    • (2008) Gastroenterolog Y , vol.135 , Issue.1 , pp. 61-71
    • Pironi, L.1    Forbes, A.2    Joly, F.3
  • 3
    • 0030856777 scopus 로고    scopus 로고
    • Effect of growth hormone, glutamine, and diet on adaptation in short-bowel syndrome: A randomized, controlled study
    • Scolapio JS, Camilleri M, Fleming CR, et al. Effect of growth hormone, glutamine, and diet on adaptation in short-bowel syndrome: a randomized, controlled study. Gastroenterolog y. 1997;113(4):1074-1081.
    • (1997) Gastroenterolog Y , vol.113 , Issue.4 , pp. 1074-1081
    • Scolapio, J.S.1    Camilleri, M.2    Fleming, C.R.3
  • 4
    • 0037308230 scopus 로고    scopus 로고
    • Low-dose growth hormone in adult home parenteral nutrition-dependent short bowel syndrome patients: A positive study
    • Seguy D, Vahedi K, Kapel N, Souberbielle J-C, Messing B. Low-dose growth hormone in adult home parenteral nutrition-dependent short bowel syndrome patients: a positive study. Gastroenterology. 2003; 124(2):293-302.
    • (2003) Gastroenterology , vol.124 , Issue.2 , pp. 293-302
    • Seguy, D.1    Vahedi, K.2    Kapel, N.3    Souberbielle, J.-C.4    Messing, B.5
  • 5
    • 0033915693 scopus 로고    scopus 로고
    • Effect of high dose growth hormone with glutamine and no change in diet on intestinal absorption in short bowel patients: A randomised, double blind, crossover, placebo controlled study
    • Szkudlarek J, Jeppesen PB, Mortensen PB. Effect of high dose growth hormone with glutamine and no change in diet on intestinal absorption in short bowel patients: a randomised, double blind, crossover, placebo controlled study. Gut. 2000;47(2):199-205.
    • (2000) Gut , vol.47 , Issue.2 , pp. 199-205
    • Szkudlarek, J.1    Jeppesen, P.B.2    Mortensen, P.B.3
  • 6
    • 33746087091 scopus 로고    scopus 로고
    • Guidelines for management of patients with a short bowel
    • and Small Bowel and Nutrition Committee of the British Society of Gastroenterology
    • Nightingale J, Woodward JM; and Small Bowel and Nutrition Committee of the British Society of Gastroenterology. Guidelines for management of patients with a short bowel. Gut. 2006;55(Suppl 4):iv1-iv12.
    • (2006) Gut , vol.55 , Issue.SUPPL. 4
    • Nightingale, J.1    Woodward, J.M.2
  • 7
    • 79954470583 scopus 로고    scopus 로고
    • The therapeutic potential of targeting the glucagon-like peptide-2 receptor in gastrointestinal disease
    • Hornby PJ, Moore BA. The therapeutic potential of targeting the glucagon-like peptide-2 receptor in gastrointestinal disease. Expert Opin Ther Targets. 2011;15(5):637-646.
    • (2011) Expert Opin Ther Targets , vol.15 , Issue.5 , pp. 637-646
    • Hornby, P.J.1    Moore, B.A.2
  • 9
    • 0347990354 scopus 로고    scopus 로고
    • Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2
    • Brubaker PL, Anini Y. Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2. Can J Physiol Pharmacol. 2003;81(11):1005-1012.
    • (2003) Can J Physiol Pharmacol , vol.81 , Issue.11 , pp. 1005-1012
    • Brubaker, P.L.1    Anini, Y.2
  • 10
    • 0031735064 scopus 로고    scopus 로고
    • GLP-2 augments the adaptive response to massive intestinal resection in rat
    • Scott RB, Kirk D, MacNaughton WK, Meddings JB. GLP-2 augments the adaptive response to massive intestinal resection in rat. Am J Physiol. 1998;275:911-921.
    • (1998) Am J Physiol , vol.275 , pp. 911-921
    • Scott, R.B.1    Kirk, D.2    Macnaughton, W.K.3    Meddings, J.B.4
  • 11
    • 0029795016 scopus 로고    scopus 로고
    • Induction of intestinal epithelial proliferation by glucagon-like peptide 2
    • Drucker DJ, Erlich P, Asa SL, Brubaker PL. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci U S A. 1996;93(15):7911-7926.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.15 , pp. 7911-7926
    • Drucker, D.J.1    Erlich, P.2    Asa, S.L.3    Brubaker, P.L.4
  • 12
    • 11144229673 scopus 로고    scopus 로고
    • Glucagon-like peptide 2 dose-dependently activates intestinal cell survival and proliferation in neonatal piglets
    • Burrin DG, Stoll B, Guan X, Cui L, Chang X, Holst JJ. Glucagon-like peptide 2 dose-dependently activates intestinal cell survival and proliferation in neonatal piglets. Endocrinology. 2005;146(1): 22-32.
    • (2005) Endocrinology , vol.146 , Issue.1 , pp. 22-32
    • Burrin, D.G.1    Stoll, B.2    Guan, X.3    Cui, L.4    Chang, X.5    Holst, J.J.6
  • 13
    • 42449099912 scopus 로고    scopus 로고
    • Exogenous glucagon-like peptide-2 (GLP-2) augments GLP-2 receptor mRNA and maintains proglucagon mRNA levels in resected rats
    • Koopmann MC, Nelson DW, Murali SG, et al. Exogenous glucagon-like peptide-2 (GLP-2) augments GLP-2 receptor mRNA and maintains proglucagon mRNA levels in resected rats. JPEN J Parenter Enteral Nutr. 2008;32(3):254-265.
    • (2008) JPEN J Parenter Enteral Nutr , vol.32 , Issue.3 , pp. 254-265
    • Koopmann, M.C.1    Nelson, D.W.2    Murali, S.G.3
  • 14
    • 30044441999 scopus 로고    scopus 로고
    • Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans
    • Meier JJ, Nauck MA, Pott A, et al. Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans. Gastroenterology. 2006;130(1):44-54.
    • (2006) Gastroenterology , vol.130 , Issue.1 , pp. 44-54
    • Meier, J.J.1    Nauck, M.A.2    Pott, A.3
  • 15
    • 1942485485 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 inhibits antral emptying in man, but is not as potent as glucagon-like peptide-1
    • Nagell C F, Wettergren A, Pedersen J F, Mortensen D, Holst JJ. Glucagon-like peptide-2 inhibits antral emptying in man, but is not as potent as glucagon-like peptide-1. Scand J Gastroenterol. 2004;39(4): 353-358.
    • (2004) Scand J Gastroenterol , vol.39 , Issue.4 , pp. 353-358
    • Nagell, C.F.1    Wettergren, A.2    Pedersen, J.F.3    Mortensen, D.4    Holst, J.J.5
  • 16
    • 0033944863 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse
    • Benjamin MA, McKay DM, Yang PC, Cameron H, Perdue MH. Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse. Gut. 2000; 47(1):112-119.
    • (2000) Gut , vol.47 , Issue.1 , pp. 112-119
    • Benjamin, M.A.1    McKay, D.M.2    Yang, P.C.3    Cameron, H.4    Perdue, M.H.5
  • 17
    • 59649128123 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 reduces intestinal permeability but does not modify the onset of type 1 diabetes in the nonobese diabetic mouse
    • Hadjiyanni I, Li KK, Drucker DJ. Glucagon-like peptide-2 reduces intestinal permeability but does not modify the onset of type 1 diabetes in the nonobese diabetic mouse. Endocrinology. 2009;150(2): 592-599.
    • (2009) Endocrinology , vol.150 , Issue.2 , pp. 592-599
    • Hadjiyanni, I.1    Li, K.K.2    Drucker, D.J.3
  • 19
    • 30044434156 scopus 로고    scopus 로고
    • GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood fow
    • Guan X, Karpen HE, Stephens J, et al. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood fow. Gastroenterolog y. 2006;130(1):150-164.
    • (2006) Gastroenterolog Y , vol.130 , Issue.1 , pp. 150-164
    • Guan, X.1    Karpen, H.E.2    Stephens, J.3
  • 20
    • 0033858090 scopus 로고    scopus 로고
    • Enteroendocrine localization of GLP-2 receptor expression in humans and rodents
    • Yusta B, Huang L, Munroe D, et al. Enteroendocrine localization of GLP-2 receptor expression in humans and rodents. Gastroenterology. 2000;119(3):744-755.
    • (2000) Gastroenterology , vol.119 , Issue.3 , pp. 744-755
    • Yusta, B.1    Huang, L.2    Munroe, D.3
  • 21
    • 8444230951 scopus 로고    scopus 로고
    • GLP-2 stimulates colonic growth via KGF, released by subepithelial myofbroblasts with GLP-2 receptors
    • Ørskov C, Hartmann B, Poulsen SS, Thulesen J, Hare KJ, Holst JJ. GLP-2 stimulates colonic growth via KGF, released by subepithelial myofbroblasts with GLP-2 receptors. Regul Pept. 2005;124(1-2): 105-112.
    • (2005) Regul Pept , vol.124 , Issue.1-2 , pp. 105-112
    • ørskov, C.1    Hartmann, B.2    Poulsen, S.S.3    Thulesen, J.4    Hare, K.J.5    Holst, J.J.6
  • 22
    • 34547618796 scopus 로고    scopus 로고
    • Frontiers in glucagon-like peptide-2: Multiple actions, multiple mediators
    • Dubé PE, Brubaker PL. Frontiers in glucagon-like peptide-2: multiple actions, multiple mediators. Am J Physiol Endocrinol Metab. 2007; 293(2):460-465.
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , Issue.2 , pp. 460-465
    • Dubé, P.E.1    Brubaker, P.L.2
  • 23
    • 33746524497 scopus 로고    scopus 로고
    • The essential role of insulin-like growth factor-1 in the intestinal trophic effects of glucagon-like peptide-2 in mice
    • Dubé PE, Forse CL, Bahrami J, Brubaker PL. The essential role of insulin-like growth factor-1 in the intestinal trophic effects of glucagon-like peptide-2 in mice. Gastroenterology. 2006;131(2):589-605.
    • (2006) Gastroenterology , vol.131 , Issue.2 , pp. 589-605
    • Dubé, P.E.1    Forse, C.L.2    Bahrami, J.3    Brubaker, P.L.4
  • 24
    • 37449017943 scopus 로고    scopus 로고
    • Glucagon like pep-tide-2 induces intestinal restitution through VEGF release from subepithelial myofibroblasts
    • Bulut K, Pennartz C, Felderbauer P, et al. Glucagon like pep-tide-2 induces intestinal restitution through VEGF release from subepithelial myofibroblasts. Eur J Pharmacol. 2008;578(2-3): 279-285.
    • (2008) Eur J Pharmacol , vol.578 , Issue.2-3 , pp. 279-285
    • Bulut, K.1    Pennartz, C.2    Felderbauer, P.3
  • 25
    • 34547123593 scopus 로고    scopus 로고
    • Enteric neural pathways mediate the anti-infammatory actions of glucagon-like peptide 2
    • Sigalet DL, Wallace LE, Holst JJ, et al. Enteric neural pathways mediate the anti-infammatory actions of glucagon-like peptide 2. Am J Physiol Gastrointest Liver Physiol. 2007;293(1):211-221.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.293 , Issue.1 , pp. 211-221
    • Sigalet, D.L.1    Wallace, L.E.2    Holst, J.J.3
  • 27
    • 0034457973 scopus 로고    scopus 로고
    • In vivo and in vitro degradation of glucagon-like peptide-2 in humans
    • Hartmann B, Harr MB, Jeppesen PB, et al. In vivo and in vitro degradation of glucagon-like peptide-2 in humans. J Clin Endocrinol Metab. 2000;85(8):2884-2888.
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.8 , pp. 2884-2888
    • Hartmann, B.1    Harr, M.B.2    Jeppesen, P.B.3
  • 28
    • 0033680541 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition enhances the intestinotrophic effect of glucagon-like peptide-2 in rats and mice
    • Hartmann B, Thulesen J, Kissow H, et al. Dipeptidyl peptidase IV inhibition enhances the intestinotrophic effect of glucagon-like peptide-2 in rats and mice. Endocrinology. 2000;141(11):4013-4020.
    • (2000) Endocrinology , vol.141 , Issue.11 , pp. 4013-4020
    • Hartmann, B.1    Thulesen, J.2    Kissow, H.3
  • 29
    • 0032885117 scopus 로고    scopus 로고
    • Impaired meal stimulated glucagon-like peptide 2 response in ileal resected short bowel patients with intestinal failure
    • Jeppesen PB, Hartmann B, Hansen BS, Thulesen J, Holst JJ, Mortensen PB. Impaired meal stimulated glucagon-like peptide 2 response in ileal resected short bowel patients with intestinal failure. Gut. 1999;45(4):559-563.
    • (1999) Gut , vol.45 , Issue.4 , pp. 559-563
    • Jeppesen, P.B.1    Hartmann, B.2    Hansen, B.S.3    Thulesen, J.4    Holst, J.J.5    Mortensen, P.B.6
  • 30
    • 0033857217 scopus 로고    scopus 로고
    • Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon
    • Jeppesen PB, Hartmann B, Thulesen J, et al. Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon. Gut. 2000;47(3):370-376.
    • (2000) Gut , vol.47 , Issue.3 , pp. 370-376
    • Jeppesen, P.B.1    Hartmann, B.2    Thulesen, J.3
  • 31
    • 0035123108 scopus 로고    scopus 로고
    • Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon
    • Jeppesen PB, Hartmann B, Thulesen J, et al. Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon. Gastroenterology. 2001;120(4): 806-815.
    • (2001) Gastroenterology , vol.120 , Issue.4 , pp. 806-815
    • Jeppesen, P.B.1    Hartmann, B.2    Thulesen, J.3
  • 32
    • 23944517753 scopus 로고    scopus 로고
    • Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients
    • Jeppesen PB, Sanguinetti EL, Buchman A, et al. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients. Gut. 2005;54(9):1224-1231.
    • (2005) Gut , vol.54 , Issue.9 , pp. 1224-1231
    • Jeppesen, P.B.1    Sanguinetti, E.L.2    Buchman, A.3
  • 33
    • 79958187560 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome
    • Jeppesen PB, Gilroy R, Pertkiewicz M, Allard J P, Messing B, O'Keefe SJ. Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome. Gut. 2011;60(7): 902-914.
    • (2011) Gut , vol.60 , Issue.7 , pp. 902-914
    • Jeppesen, P.B.1    Gilroy, R.2    Pertkiewicz, M.3    Allard, J.P.4    Messing, B.5    O'Keefe, S.J.6
  • 34
    • 68449086313 scopus 로고    scopus 로고
    • Teduglutide, a glucagon-like peptide-2 (GLP-2) analog, improves fluid balance in short bowel syndrome (SBS) patients depending on parenteral support (PN)
    • Jeppesen PB, Messing B, Pertkiewicz M, Cyran J, Demchyshyn LL, Kershner R. Teduglutide, a glucagon-like peptide-2 (GLP-2) analog, improves fluid balance in short bowel syndrome (SBS) patients depending on parenteral support (PN). Gastroenterology. 2008;134(4): A110-A111.
    • (2008) Gastroenterology , vol.134 , Issue.4
    • Jeppesen, P.B.1    Messing, B.2    Pertkiewicz, M.3    Cyran, J.4    Demchyshyn, L.L.5    Kershner, R.6
  • 35
    • 76649131122 scopus 로고    scopus 로고
    • Treatment out to 1 year with a GLP-2 analog, teduglutide, safely reduces parenteral nutrition (PN) needs in PN-dependent short bowel syndrome (SBS) patients
    • Gilroy R, Allard J, Jeppesen PB, et al. Treatment out to 1 year with a GLP-2 analog, teduglutide, safely reduces parenteral nutrition (PN) needs in PN-dependent short bowel syndrome (SBS) patients. Am J Gastroenterol. 2008;103:S105-S106.
    • (2008) Am J Gastroenterol , vol.103
    • Gilroy, R.1    Allard, J.2    Jeppesen, P.B.3
  • 37
    • 10744224629 scopus 로고    scopus 로고
    • Role of gastrointestinal hormones in postprandial reduction of bone resorption
    • Henriksen DB, Alexandersen P, Bjarnason NH, et al. Role of gastrointestinal hormones in postprandial reduction of bone resorption. J Bone Miner Res. 2003;18(12):2180-2189.
    • (2003) J Bone Miner Res , vol.18 , Issue.12 , pp. 2180-2189
    • Henriksen, D.B.1    Alexandersen, P.2    Bjarnason, N.H.3
  • 38
    • 18344384045 scopus 로고    scopus 로고
    • Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon
    • Short-term administration of glucagon-like peptide-2
    • Haderslev K V, Jeppesen PB, Hartmann B, et al. Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon. Scand J Gasterol. 2002;37(4):392-398.
    • (2002) Scand J Gasterol , vol.37 , Issue.4 , pp. 392-398
    • Haderslev, K.V.1    Jeppesen, P.B.2    Hartmann, B.3
  • 39
    • 54349104953 scopus 로고    scopus 로고
    • Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome
    • Gottschalck IB, Jeppesen PB, Hartmann B, et al. Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome. Scand J Gastroenterol. 2008;43(11):1304-1310.
    • (2008) Scand J Gastroenterol , vol.43 , Issue.11 , pp. 1304-1310
    • Gottschalck, I.B.1    Jeppesen, P.B.2    Hartmann, B.3
  • 40
    • 69249219020 scopus 로고    scopus 로고
    • Short bowel patients treated for two years with glucagon-like peptide-2: Effects on intestinal morphology and absorption, renal function, bone and body composition, and muscle function
    • Jeppesen PB, Lund P, Gottschalck IB, et al. Short bowel patients treated for two years with glucagon-like peptide-2: effects on intestinal morphology and absorption, renal function, bone and body composition, and muscle function. Gastroenterol Res Pract. 2009; 2009:616054.
    • (2009) Gastroenterol Res Pract. 2009 , pp. 616054
    • Jeppesen, P.B.1    Lund, P.2    Gottschalck, I.B.3
  • 42
    • 77952679996 scopus 로고    scopus 로고
    • Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohn's disease
    • For the Teduglutide Study Group
    • Buchman AL, Katz S, Fang JC, Bernstein CN, Abou-Assi SG; For the Teduglutide Study Group. Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohn's disease. Infamm Bowel Dis. 2010;16(6): 962-973.
    • (2010) Infamm Bowel Dis , vol.16 , Issue.6 , pp. 962-973
    • Buchman, A.L.1    Katz, S.2    Fang, J.C.3    Bernstein, C.N.4    Abou-Assi, S.G.5
  • 43
    • 13544254373 scopus 로고    scopus 로고
    • The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways
    • Koehler JA, Yusta B, Drucker DJ. The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways. Mol Endocrinol. 2005; 19(2):459-473.
    • (2005) Mol Endocrinol , vol.19 , Issue.2 , pp. 459-473
    • Koehler, J.A.1    Yusta, B.2    Drucker, D.J.3
  • 45
    • 54249088472 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells
    • Koehler JA, Harper W, Barnard M, Yusta B, Drucker DJ. Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells. Cancer Res. 2008;19(2):7897-7904.
    • (2008) Cancer Res , vol.19 , Issue.2 , pp. 7897-7904
    • Koehler, J.A.1    Harper, W.2    Barnard, M.3    Yusta, B.4    Drucker, D.J.5
  • 46
    • 4143085801 scopus 로고    scopus 로고
    • Glucagon-like peptide-2: Divergent signaling pathways
    • Rocha FG, Shen KR, Jasleen J, et al. Glucagon-like peptide-2: divergent signaling pathways. J Surg Res. 2004;121(1):5-12.
    • (2004) J Surg Res , vol.121 , Issue.1 , pp. 5-12
    • Rocha, F.G.1    Shen, K.R.2    Jasleen, J.3
  • 47
    • 69249150959 scopus 로고    scopus 로고
    • Carcinogenic effects if exogenous and endogenous glucagon-like peptide-2 in azoxymethane-treated mice
    • Iakoubov R, Lauffer LM, Trivedi S, Kim YI, Brubaker PL. Carcinogenic effects if exogenous and endogenous glucagon-like peptide-2 in azoxymethane-treated mice. Endocrinology. 2009;150(9):4033-4043.
    • (2009) Endocrinology , vol.150 , Issue.9 , pp. 4033-4043
    • Iakoubov, R.1    Lauffer, L.M.2    Trivedi, S.3    Kim, Y.I.4    Brubaker, P.L.5
  • 48
    • 3242728399 scopus 로고    scopus 로고
    • Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice
    • Thulesen J, Hartmann B, Hare KJ, et al. Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice. Gut. 2004;53(8):1145-1150.
    • (2004) Gut , vol.53 , Issue.8 , pp. 1145-1150
    • Thulesen, J.1    Hartmann, B.2    Hare, K.J.3


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