Glucagon like peptide-2 induces intestinal restitution through VEGF release from subepithelial myofibroblasts

European Journal of Pharmacology

Volumn 578, Issue 2-3, 2008, Pages 279-285

  Bulut, Kerem ^a   Pennartz, Christian ^a   Felderbauer, Peter ^a   Meier, Juris J ^a   Banasch, Matthias ^a   Bulut, Daniel ^a   Schmitz, Frank ^a   Schmidt, Wolfgang E ^a   Hoffmann, Peter ^b  

^a ST JOSEF HOSPITAL   (Germany)

^b KLINIKEN ESSEN MITTE   (Germany)

Author keywords

Glucagon like peptide 2; Intestinal cell proliferation; Intestinal wound healing; Mucosal injury; Subepithelial myofibroblast; VEGF

Indexed keywords

3 (4,5 DIMETHYLTHIAZOL 2 YL) 2,5 DIPHENYL TETRAZOLIUM BROMIDE; BROMINE DERIVATIVE; GLUCAGON LIKE PEPTIDE 2; KERATINOCYTE GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN ANTIBODY;

ANIMAL CELL; ARTICLE; ASSAY; CANCER CELL; CANCER CELL CULTURE; CELL MIGRATION; CELL VIABILITY; COLON; COLON CANCER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; HORMONE RELEASE; HUMAN; HUMAN CELL; ILEUM; MYOFIBROBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SMALL INTESTINE; STATISTICAL SIGNIFICANCE; WOUND HEALING;

ANIMALS; ANTIBODIES, MONOCLONAL; CACO-2 CELLS; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; COLON; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FIBROBLAST GROWTH FACTOR 7; FIBROBLASTS; GLUCAGON-LIKE PEPTIDE 2; HUMANS; ILEUM; PARACRINE COMMUNICATION; RATS; RECEPTORS, GLUCAGON; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 37449017943     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.08.044     Document Type: Article

References (24)

1. Alon T., Hemo I., Itin A., Pe`er J., Stone J., and Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat. Med. 1 (1995) 1024-1028
2. Beck P.L., Rosenberg I., Xavier R.J., Koh T., Wong J.F., and Podolsky D.K. Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am. J. Pathol. 162 (2003) 597-608
3. Bulut K., Meier J.J., Ansorge N., Felderbauer P., Schmitz F., Hoffmann P., Schmidt W.E., and Gallwitz B. Glucagon-like peptide 2 improves intestinal wound healing through induction of epithelial cell migration in vitro - evidence for a TGF-beta mediated effect. Reg. Peptides 121 (2004) 137-143
4. Bulut K., Pennartz C., Felderbauer P., Ansorge N., Banasch M., Schmitz F., Schmidt W.E., and Hoffmann P. Vascular endothelial growth factor (VEGF 164) ameliorates intestinal epithelial injury in vitro in IEC-18 and Caco-2 monolayers via induction of TGF-beta release from epithelial cells. Scand. J. Gastroenterol. 41 (2006) 1-6
5. Ciacci C., Lind S., and Podolsky D.K. Transforming growth factor regulation of migration in wounded rat intestinal epithelial monolayers. Gastroenterology 105 (1993) 93-101
6. Cucina A., Borelli V., Randone B., Coluccia P., Sapienza P., and Cavallaro A. Vascular endothelial growth factor increases the migration of smooth muscle cells through the mediation of growth factors released by endothelial cells. J. Surg. Res. 109 (2003) 16-23
7. Dignass A.U., and Podolsky D. Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor. Gastroenterology 105 (1993) 1323-1332
8. Drucker D.J. Minireview, the Glucagon-like peptides. Endocrinology 142 (2001) 521-527
9. Drucker D.J., Ehrlich P., Asa S.L., and Brubaker P.L. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc. Natl. Acad. Sci. 23 (1996) 7911-7916
10. Ferrara N. Vascular endothelial growth factor. Eur. J. Cancer. 32 (1996) 2413-2422
11. Ferrer F.A., Miller L., Lindquist R., et al. Expression of vascular endothelial growth factor receptors in human prostate cancer. Urology 54 (1999) 567-572
12. Jasleen J., Ashley S., Shimoda N., Zinner M.J., and Whang E.E. Glucagon-like peptide 2 stimulates intestinal epithelial proliferation in vitro. Dig. Dis. Sci. 47 (2002) 1135-1140
13. Jeppesen P.B., Hartmann B., Thulesen J., Graff J., Lohmann J., Hansen B.S., Tofteng F., Paulsen S.S., Madsen J.L., Holst J.J., and Mortensen P.B. Glucagon-like peptide 2 improves nutrient adsorption and nutritional status in short-bowel patients with no colon. Gastroenterology 120 (2001) 806-815
14. Leung D.W., Cachianes G., Kuang W.J., Goeddel D.V., and Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246 (1989) 1306-1309
15. Moses H.L., Coffey R.J., Leof E.B., Lyons R.M., and Keski-Oka J. Transforming growth factor regulation of cell proliferation. J. Cell Physiol. 5 (1987) 1-7
16. Orskov C., Hartmann B., Poulsen S.S., Thulesen J., Hare K.J., and Holst J.J. GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors. Regul. Pept. 124 (2005) 05-12
17. Parvadia, J.K., Kesnawi, S.G., Vaikunth, S., Maldonado, A.R., Marwan, A., Stehr, W., Uzvolgyi, E., Warner, B.W., Yamano, S., Taichman, N., Crombleholme, T.M., in press. Role of vascular endothelial growth factor (VEGF) in small bowel adaptation after resection: the adaptive response is angiogenesis dependent. Am. J. Physiol. Gastrointest. Liver Physiol. (Electronic publication ahead of print).
18. Prasad R., Alavi K., and Schwartz M.Z. GLP-2alpha accelerates recovery of mucosal absorptive function after intestinal ischemia/reperfusion. J. Pediatr. Surg. 36 (2001) 570-572
19. Ramsanahie A.P., Perez A., Duensing A.U., Zinner M.J., Ashley S.W., and Whang E.E. Glucagon-like peptide 2 enhances intestinal epithelial restitution. J. Surg. Res. 107 (2002) 44-49
20. Sams A., Hastrup S., Andersen M., and Thim L. Naturally occuring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines. Eur. J. Pharmacol. 532 (2006) 18-23
21. Scott R.B., Kirk D., MacNaughton W.K., and Meddings J.B. GLP-2 augments the adaptive response to massive intestinal resection in rat. Am. J. Physiol. Endocrinol. Metabol. 275 (1998) G911-G921
22. Thulesen J., Hartmann B., Hare K.J., Kissow H., Orskov C., Holst J.J., and Poulsen S.S. Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice. Gut 53 (2004) 1145-1150
23. Xiao Q., Boushey R., Cino M., Drucker D.J., and Brubaker P.L. Circulating levels of glukagon-like peptide-2 in human subjects with inflammatory bowel disease. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278 (2000) R1057-R1063
24. Zhu C., Ying D., Zhou D., Mi J., Zhang W., Chang Q., and Li L. Expression of TGF-beta 1 in smooth muscle cells regulates endothelial progenitor cells migration and differentiation. J. Surg. Res. 12 (2005) 151-156