Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans

Gastroenterology

Volumn 130, Issue 1, 2006, Pages 44-54

  Meier, Juris J ^a,d   Nauck, Michael A ^b   Pott, Andrea ^a   Heinze, Kai ^a   Goetze, Oliver ^a   Bulut, Kerem ^a   Schmidt, Wolfgang E ^a   Gallwitz, Baptist ^a   Holst, Jens J ^c  

^a ST JOSEF HOSPITAL   (Germany)

^b Diabeteszentrum   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CARBON 13; FATTY ACID; GLUCAGON; GLUCAGON LIKE PEPTIDE 2; GLUCOSE; GLYCEROL; INSULIN; OCTANOIC ACID; PENTAGASTRIN; PLACEBO; TRIACYLGLYCEROL;

ADULT; ARTICLE; BREATH ANALYSIS; CONTROLLED STUDY; DIET RESTRICTION; DRUG EFFECT; GLUCAGON RELEASE; HUMAN; LIPID ABSORPTION; MALE; PRIORITY JOURNAL; STOMACH ACID SECRETION; STOMACH EMPTYING; TEST MEAL;

EID: 30044441999     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2005.10.004     Document Type: Article

References (55)

1. C. Ørskov, J.J. Holst Radio-immunoassays for glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) Scand J Clin Lab Invest 47 1987 165 174
2. Q. Xiao, R.P. Boushey, D.J. Drucker, P.L. Brubaker Secretion of the intestinotropic hormone glucagon-like peptide 2 is differentially regulated by nutrients in humans Gastroenterology 117 1999 99 105
3. B. Hartmann, A.H. Johnsen, C. Orskov, K. Adelhorst, L. Thim, J.J. Holst Structure, measurement, and secretion of human glucagon-like peptide-2 Peptides 21 2000 73 80
4. W.E. Schmidt, E.G. Siegel, W. Creutzfeldt Glucagon-like peptide 1 but not glucagon-like peptide 2 stimulates insulin release from isolated rat pancreatic islets Diabetologia 28 1985 704 707
5. J.J. Holst Glucagon-like peptide 1 (GLP-1) an intestinal hormone, signalling nutritional abundance, with an unusual therapeutic potential Trends Endocrinol Metab 10 1999 229 235
6. D.J. Drucker Enhancing incretin action for the treatment of type 2 diabetes Diabetes Care 26 2003 2929 2940
7. J.J. Meier, M.A. Nauck The potential role of glucagon-like peptide 1 in diabetes Curr Opin Investig Drugs 5 2004 402 410
8. D.J. Drucker, P. Ehrlich, S.L. Asa, P.L. Brubaker Induction of intestinal epithelial proliferation by glucagon-like peptide 2 Proc Natl Acad Sci U S A 93 1996 7911 7916
9. D.G. Burrin, B. Stoll, R. Jiang, Y. Petersen, J. Elnif, R.K. Buddington, M. Schmidt, J.J. Holst, B. Hartmann, P.T. Sangild GLP-2 stimulates intestinal growth in premature TPN-fed pigs by suppressing proteolysis and apoptosis Am J Physiol Gastrointest Liver Physiol 279 2000 G1249 G1256
10. Y.M. Petersen, D.G. Burrin, P.T. Sangild GLP-2 has differential effects on small intestine growth and function in fetal and neonatal pigs Am J Physiol Regul Integr Comp Physiol 281 2001 R1986 R1993
11. K. Bulut, J.J. Meier, N. Ansorge, P. Felderbauer, F. Schmitz, P. Hoffmann, W.E. Schmidt, B. Gallwitz Glucagon-like peptide 2 improves intestinal wound healing through induction of epithelial cell migration in vitro - evidence for a TGF-β-mediated effect Regul Pept 121 2004 137 143
12. D.J. Drucker, B. Yusta, R.P. Boushey, L. DeForest, P.L. Brubaker Human [Gly2] GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis Am J Physiol 276 1999 G76 G91
13. P.B. Jeppesen, B. Hartmann, J. Thulesen, J. Graff, J. Lohmann, B. Stenbaek Hansen, F. Tofteng, S.S. Poulsen, J.L. Madsen, J.J. Holst, P.B. Mortensen Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon Gastroenterology 120 2001 806 815
14. K.V. Haderslev, P.B. Jeppesen, B. Hartmann, J. Thulesen, H.A. Sorensen, J. Graff, B.S. Hansen, F. Tofteng, S.S. Poulsen, J.L. Madsen, J.J. Holst, M. Staun, P.B. Mortensen Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon Scand J Gastroenterol 37 2002 392 398
15. B. Hartmann, M.B. Harr, P.B. Jeppesen, M. Wojdemann, C.F. Deacon, P.B. Mortensen, J.J. Holst In vivo and in vitro degradation of glucagon-like peptide-2 in humans J Clin Endocrinol Metab 85 2000 2884 2888
16. P.B. Jeppesen, E.L. Sanguinetti, A. Buchman, L. Howard, J.S. Scolapio, T.R. Ziegler, J. Gregory, K.A. Tappenden, J. Holst, P.B. Mortensen Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients Gut 54 2005 1224 1231
17. B. Kreymann, G. Williams, M.A. Ghatei, S.R. Bloom Glucagon-like peptide-1 [7-36] a physiological incretin in man Lancet 2 1987 1300 1304
18. M.A. Nauck, E. Bartels, C. Ørskov, R. Ebert, W. Creutzfeldt Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations J Clin Endocrinol Metab 76 1993 912 917
19. A. Hvidberg, M.T. Nielsen, J. Hilsted, C. Ørskov, J.J. Holst Effect of glucagon-like peptide-1 (proglucagon 78-107amide) on hepatic glucose production in healthy man Metabolism 43 1994 104 108
20. M.A. Nauck, N. Kleine, C. Ørskov, J.J. Holst, B. Willms, W. Creutzfeldt Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients Diabetologia 36 1993 741 744
21. M.A. Nauck, A. Sauerwald, R. Ritzel, J.J. Holst, W. Schmiegel Influence of glucagon-like peptide 1 on fasting glycemia in type 2 diabetic patients treated with insulin after sulfonylurea failure Diabetes Care 21 1998 1925 1931
22. A. Wettergren, B. Schjoldager, P.E. Mortensen, J. Myhre, J. Christiansen, J.J. Holst Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man Dig Dis Sci 38 1993 665 673
23. M.A. Nauck, U. Niedereichholz, R. Ettler, J.J. Holst, C. Orskov, R. Ritzel, W.H. Schmiegel Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans Am J Physiol (Endocrinol Metab) 273 1997 E981 E988
24. M. Wøjdemann, A. Wettergren, B. Hartmann, L. Hilsted, J.J. Holst Inhibition of sham feeding-stimulated human gastric acid secretion by glucagon-like peptide-2 J Clin Endocrinol Metab 84 1999 2513 2517
25. C.F. Nagell, A. Wettergren, J.F. Pedersen, D. Mortensen, J.J. Holst Glucagon-like peptide-2 inhibits antral emptying in man, but is not as potent as glucagon-like peptide-1 Scand J Gastroenterol 39 2004 353 358
26. P.T. Schmidt, E. Naslund, P. Gryback, H. Jacobsson, B. Hartmann, J.J. Holst, P.M. Hellstrom Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety Regul Pept 116 2003 21 25
27. M.A. Nauck, E. Bartels, C. Ørskov, R. Ebert, W. Creutzfeldt Lack of effect of synthetic human gastric inhibitory polypeptide and glucagon-like peptide 1 [7-36 amide] infused at near-physiological concentrations on pentagastrin-stimulated gastric acid secretion in normal human subjects Digestion 52 1992 214 221
28. J.J. Meier, K. Hücking, J.J. Holst, C. Deacon, W. Schmiegel, M.A. Nauck Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes Diabetes 50 2001 2497 2504
29. B. Hartmann, A.H. Johnsen, C. Orskov, K. Adelhorst, L. Thim, J.J. Holst Structure, measurement, and secretion of human glucagon-like peptide-2 Peptides 21 2000 73 80
30. J.J. Holst Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residues 33-69) of glicentin Biochem J 207 1982 381 388
31. F.R. Chowdhury, H. Rodman, S. Bleicher Glycerol-like contamination of commercial blood sampling tubes J Lipid Res 12 1971 116
32. J.J. Meier, B. Gallwitz, S. Salmen, O. Goetze, J.J. Holst, W.E. Schmidt, M.A. Nauck Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes J Clin Endocrinol Metab 88 2003 2719 2725
33. J.J. Meier, O. Goetze, J. Anstipp, D. Hagemann, J.J. Holst, W.E. Schmidt, B. Gallwitz, M.A. Nauck Gastric inhibitory polypeptide (GIP) does not inhibit gastric emptying in man Am J Physiol (Endocrinol Metab) 286 2004 E621 E625
34. Y.F. Ghoos, B.D. Maes, B.J. Geypens, G. Mys, M.I. Hiele, P.J. Rutgeerts, G. Vantrappen Measurement of gastric emptying rate of solid meals by means of a carbon-labeled octanoic acid breath test Gastroenterology 104 1993 1640 1647
35. L.B. Sørensen, A. Flint, A. Raben, B. Hartmann, J.J. Holst, A. Astrup No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects Int J Obes Relat Metab Disord 27 2003 450 456
36. R.A. Pederson, J.C. Brown Interaction of gastric inhibitory polypeptide, glucose, and arginine on insulin and glucagon secreton from the perfused rat pancreas Endocrinology 103 1978 610 615
37. J.J. Meier, B. Gallwitz, N. Siepmann, J.J. Holst, C.F. Deacon, W.E. Schmidt, M.A. Nauck Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia Diabetologia 46 2003 798 801
38. R.S. Sherwin, M. Fisher, R. Hendler, P. Felig Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects N Engl J Med 294 1976 455 461
39. J.E. Gerich, M. Lorenzi, D.M. Bier, E. Tsalikian, V. Schneider, J.H. Karam, P.H. Forsham Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin J Clin Invest 57 1976 875 884
40. R.H. Unger, L. Orci Role of glucagon in diabetes Arch Intern Med 137 1977 482 491
41. J.B. Field Extraction of insulin by liver Annu Rev Med 24 1973 309 314
42. K.S. Polonsky, A.H. Rubenstein C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations Diabetes 33 1984 486 494
43. X. Guan, B. Stoll, X. Lu, K.A. Tappenden, J.J. Holst, B. Hartmann, D.G. Burrin GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets 1 Gastroenterology 125 2003 136 147
44. P.J. Lefebvre Glucagon and its family revisited Diabetes Care 18 1995 715 730
45. M.D. Jensen, V.J. Heiling, J.M. Miles Effects of glucagon on free fatty acid metabolism in humans J Clin Endocrinol Metab 72 1991 308 315
46. M.G. Carlson, W.L. Snead, P.J. Campbell Regulation of free fatty acid metabolism by glucagon J Clin Endocrinol Metab 77 1993 11 15
47. C.H. Gravholt, N. Moller, M.D. Jensen, J.S. Christiansen, O. Schmitz Physiological levels of glucagon do not influence lipolysis in abdominal adipose tissue as assessed by microdialysis J Clin Endocrinol Metab 86 2001 2085 2089
48. C.T. Richardson, J.H. Walsh, K.A. Cooper, M. Feldman, J.S. Fordtran Studies on the role of cephalic-vagal stimulation in the acid secretory response to eating in normal human subjects J Clin Invest 60 1977 435 441
49. J.G. Moore, D. Motoki Gastric secretory and humoral responses to anticipated feeding in five men Gastroenterology 76 1979 71 75
50. G.J. Dockray Gastrin Best Res Pract Clin Endocrinol Metab 18 2004 555 568
51. K. Ljungmann, B. Hartmann, P. Kissmeyer-Nielsen, A. Flyvbjerg, J.J. Holst, S. Laurberg Time-dependent intestinal adaptation and GLP-2 alterations after small bowel resection in rats Am J Physiol Gastrointest Liver Physiol 281 2001 G779 G785
52. Q. Xiao, R.P. Boushey, M. Cino, D.J. Drucker, P.L. Brubaker Circulating levels of glucagon-like peptide-2 in human subjects with inflammatory bowel disease Am J Physiol Regul Integr Comp Physiol 278 2000 R1057 R1063
53. P.B. Jeppesen, B. Hartmann, J. Thulesen, B.S. Hansen, J.J. Holst, S.S. Poulsen, P.B. Mortensen Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon Gut 47 2000 370 376
54. G.R. Martin, L.E. Wallace, B. Hartmann, J.J. Holst, L. Demchyshyn, K. Toney, D.L. Sigalet Nutrient-stimulated GLP-2 release and crypt cell proliferation in experimental short bowel syndrome (E-pub September 23, 2004) Am J Physiol Gastrointest Liver Physiol 288 2005 G431 G438
55. J.W. Frank, M. Camilleri, G.M. Thomforde, S.F. Dinneen, R.A. Rizza Effects of glucagon on postprandial carbohydrate metabolism in nondiabetic humans Metabolism 47 1998 7 12