Synthesis and biological evaluation of novel dimethyl[1,1′-biphenyl]- 2,2′-dicarboxylate derivatives containing thiazolidine-2,4-dione for the treatment of concanavalin A-induced acute liver injury of BALB/c mice

European Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2011, Pages 5941-5948

  Wang, Guangcheng ^a,c   Deng, Chongyang ^a   Xie, Caifeng ^a   Ma, Liang ^a   Yang, Jincheng ^a,c   Qiu, Neng ^a   Xu, Qinyuan ^a   Chen, Tao ^a   Peng, Fei ^a   Chen, Jinying ^a   Qiu, Jingxiang ^a   Peng, Aihua ^a,b   Wei, Yuquan ^a   Chen, Lijuan ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Anti inflammation; Bifendate; Hepatoprotective; Thiazolidine 2,4 dione

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 (2 BROMO 4 FORMYLPHENYL) 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 (2 ETHOXY 4 FORMYLPHENYL) 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 (2 FLUORO 4 FORMYLPHENYL) 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 (2 FORMYLPHENYL) 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 (2,4 DIBROMO 6 FORMYLPHENYL) 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 (2,4 DICHLORO 6 FORMYLPHENYL) 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 (3 FORMYLPHENYL) 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 (4 CHLORO 2 FORMYLPHENYL) 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO [D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 (4 FORMYL 2 METHOXYPHENYL) 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 (4 FORMYL 2,6 DIMETHOXYPHENYL) 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 (4 FORMYLPHENYL) 5 METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 (5 FORMYL 2 METHOXYPHENYL) 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 [2 [(2,4 DIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL] 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 [2 BROMO 4 [(2,4 DIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL] 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 [2,4 DIBROMO 6 [(2,4 DIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL] 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 [2,4 DICHLORO 6 [(2,4 DIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL] 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 [3 [(2,4 DIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL] 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 [4 [(2,4 DIOXOTHIAZOLIDIN 5 YLIDENE)METHYL] 2 ETHOXYPHENYL] 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 [4 [(2,4 DIOXOTHIAZOLIDIN 5 YLIDENE)METHYL] 2 FLUOROPHENYL] 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 [4 [(2,4 DIOXOTHIAZOLIDIN 5 YLIDENE)METHYL] 2 METHOXYPHENYL] 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 [4 [(2,4 DIOXOTHIAZOLIDIN 5 YLIDENE)METHYL] 2,6 DIMETHOXYPHENYL] 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 [4 [(2,4 DIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL] 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 [4 CHLORO 2 [(2,4 DIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL] 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; 5 [5 [(2,4 DIOXOTHIAZOLIDIN 5 YLIDENE)METHYL] 2 METHOXYPHENYL] 5' METHYL 7,7' DIMETHOXY 4,4' BIBENZO[D][1,3]DIOXOLE 5,5' DICARBOXYLATE; CARBOXYLIC ACID DERIVATIVE; CARRAGEENAN; CONCANAVALIN A; LIPOPOLYSACCHARIDE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BAGG ALBINO MOUSE; CONTROLLED STUDY; DRUG INDUCED DISEASE; DRUG SYNTHESIS; HISTOPATHOLOGY; IN VIVO STUDY; LIVER INJURY; LIVER PROTECTION; MOUSE; NONHUMAN; PAW EDEMA;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIPHENYL COMPOUNDS; CELL LINE; CONCANAVALIN A; EDEMA; FEMALE; HEPATITIS, ANIMAL; LIPOPOLYSACCHARIDES; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; NITRIC OXIDE; RATS;

EID: 80955136564     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.005     Document Type: Article

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