Role of Endogenous Retroviruses in Autoimmune Diseases

Infectious Disease Clinics of North America

Volumn 20, Issue 4, 2006, Pages 913-929

  Colmegna, Ines ^a   Garry, Robert F ^b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

ALOPECIA; AUTOIMMUNE DISEASE; AUTOIMMUNITY; ENDOGENOUS VIRUS; FRAMESHIFT MUTATION; GENE DELETION; GENETIC TRANSCRIPTION; HUMAN; IMMUNOREGULATION; INSULIN DEPENDENT DIABETES MELLITUS; JUVENILE RHEUMATOID ARTHRITIS; MULTIPLE SCLEROSIS; NONHUMAN; RETROVIRUS; RETROVIRUS INFECTION; REVIEW; RHEUMATOID ARTHRITIS; SCHIZOPHRENIA; SEMINOMA; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; TESTIS CANCER; VIRAL GENETICS; VIRUS GENOME; VIRUS INFECTIVITY; VIRUS VIRULENCE;

ANIMALS; AUTOIMMUNE DISEASES; ENDOGENOUS RETROVIRUSES; HUMANS; RETROVIRIDAE INFECTIONS;

EID: 33751019657     PISSN: 08915520     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.idc.2006.09.008     Document Type: Review

References (70)

1. Muir A., Lever A., and Moffett A. Expression and functions of human endogenous retroviruses in the placenta: an update. Placenta 18 (2004) S16-S25
2. Nelson P.N., Carnegie P.R., Martin J., et al. Demystified. Human endogenous retroviruses. Mol Pathol 56 (2003) 11-18
3. Lower R., Lower J., and Kurth R. The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences. Proc Natl Acad Sci USA 93 (1996) 5177-5184
4. Mi S., Lee X., Li X., et al. Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 403 (2000) 785-789
5. Turner G., Barbulescu M., Su M., et al. Insertional polymorphisms of full-length endogenous retroviruses in humans. Curr Biol 11 (2001) 1531-1535
6. Nakagawa K., and Harrison L.C. The potential roles of endogenous retroviruses in autoimmunity. Immunol Rev 152 (1996) 193-236
7. Ryan F.P. Human endogenous retroviruses in health and disease: a symbiotic perspective. J R Soc Med 97 (2004) 560-565
8. Portis J.L. Perspectives on the role of endogenous human retroviruses in autoimmune diseases. Virology 296 (2002) 1-5
9. Sutkowski N., Conrad B., Thorley-Lawson D.A., et al. Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen. Immunity 15 (2001) 579-589
10. Stauffer Y., Marguerat S., Meylan F., et al. Interferon-alpha-induced endogenous superantigen: a model linking environment and autoimmunity. Immunity 15 (2001) 591-601
11. Posnett D.N., and Yarilina A.A. Sleeping with the enemy-endogenous superantigens in humans. Immunity 15 (2001) 503-506
12. Meylan F., De Smedt M., Leclercq G., et al. Negative thymocyte selection to HERV-K18 superantigens in humans. Blood 105 (2005) 4377-4382
13. Query C.C., and Keene J.D. A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. Cell 51 (1987) 211-220
14. Christensen T. Association of human endogenous retroviruses with multiple sclerosis and possible interactions with herpes viruses. Rev Med Virol 15 (2005) 179-211
15. Rolland A., Jouvin-Marche E., Saresella M., et al. Correlation between disease severity and in vitro cytokine production mediated by MSRV (multiple sclerosis associated retroviral element) envelope protein in patients with multiple sclerosis. J Neuroimmunol 160 (2005) 195-203
16. Talal N., Dauphinee M.J., Dang H., et al. Detection of serum antibodies to retroviral proteins in patients with primary Sjögren 's syndrome (autoimmune exocrinopathy). Arthritis Rheum 33 (1990) 774-781
17. Deas J.E., Liu L.G., Thompson J.J., et al. Reactivity of sera from systemic lupus erythematosus and Sjögren 's syndrome patients with peptides derived from human immunodeficiency virus p24 capsid antigen. Clin Diagn Lab Immunol 5 (1998) 181-185
18. Blomberg J., Nived O., Pipkorn R., et al. Increased antiretroviral antibody reactivity in sera from a defined population of patients with systemic lupus erythematosus. Correlation with autoantibodies and clinical manifestations. Arthritis Rheum 37 (1994) 57-66
19. Bengtsson A., Blomberg J., Nived O., et al. Selective antibody reactivity with peptides from human endogenous retroviruses and nonviral poly(amino acids) in patients with systemic lupus erythematosus. Arthritis Rheum 39 (1996) 1654-1663
20. Perl A., Colombo E., Dai H., et al. Antibody reactivity to the HRES-1 endogenous retroviral element identifies a subset of patients with systemic lupus erythematosus and overlap syndromes. Correlation with antinuclear antibodies and HLA class II alleles. Arthritis Rheum 38 (1995) 1660-1671
21. Sander D.M., Szabo S., Gallaher W.R., et al. Involvement of human intracisternal A-type retroviral particles in autoimmunity. Microsc Res Tech 68 (2005) 222-234
22. Gergely Jr. P., Pullmann R., Stancato C., et al. Increased prevalence of transfusion-transmitted virus and cross-reactivity with immunodominant epitopes of the HRES-1/p28 endogenous retroviral autoantigen in patients with systemic lupus erythematosus. Clin Immunol 116 (2005) 124-134
23. Adelman M.K., and Marchalonis J.J. Endogenous retroviruses in systemic lupus erythematosus: candidate lupus viruses. Clin Immunol 102 (2002) 107-116
24. Krieg A.M., Khan A.S., and Steinberg A.D. Expression of an endogenous retroviral transcript is associated with murine lupus. Arthritis Rheum 32 (1989) 322-329
25. Wu J., Zhou T., He J., et al. Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene. J Exp Med 178 (1993) 461-468
26. Chu J.L., Drappa J., Parnassa A., et al. The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn. J Exp Med 178 (1993) 723-730
27. Ogasawara H., Hishikawa T., Sekigawa I., et al. Sequence analysis of human endogenous retrovirus clone 4-1 in systemic lupus erythematosus. Autoimmunity 33 (2000) 15-21
28. Hishikawa T., Ogasawara H., Kaneko H., et al. Detection of antibodies to a recombinant gag protein derived from human endogenous retrovirus like sequence, clone 4-1, in autoimmune diseases. Viral Immunol 10 (1997) 137-147
29. Sekigawa I., Naito T., Hira K., et al. Possible mechanisms of gender bias in SLE: a new hypothesis involving a comparison of SLE with atopy. Lupus 13 (2004) 217-222
30. Naito T., Ogasawara H., Kaneko H., et al. Immune abnormalities induced by human endogenous retroviral peptides: with reference to the pathogenesis of systemic lupus erythematosus. J Clin Immunol 23 (2003) 371-376
31. Sekigawa I., Ogasawara H., Kaneko H., et al. Retroviruses and autoimmunity. Intern Med 40 (2001) 80-86
32. Piotrowski P.C., Duriagin S., and Jagodzinski P.P. Expression of human endogenous retrovirus clone 4-1 may correlate with blood plasma concentration of anti-U1 RNP and anti-Sm nuclear antibodies. Clin Rheumatol 24 (2005) 620-624
33. Okada M., Ogasawara H., Kaneko H., et al. Role of DNA methylation in transcription of human endogenous retrovirus in the pathogenesis of systemic lupus erythematosus. J Rheum 29 (2002) 1678-1682
34. Ogasawara H., Okada M., Kaneko H., et al. Possible role of DNA hypomethylation in the induction of SLE: relationship to the transcription of human endogenous retroviruses. Clin Exp Rheumatol 21 (2003) 733-738
35. Hohenadl C., Germaier H., Walchner M., et al. Transcriptional activation of endogenous retroviral sequences in human epidermal keratinocytes by UVB irradiation. J Invest Dermatol 113 (1999) 587-594
36. Perron H., Garson J.A., Bedin F., et al. Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. The Collaborative Research Group on Multiple Sclerosis. Proc Natl Acad Sci USA 94 (1997) 7583-7588
37. Grason J.A., Tuke P.W., Giraud P., et al. Detection of virion-associated MSRV-RNA in serum of patients with multiple sclerosis. Lancet 351 (1998) 33
38. Sotgiu S., Serra C., Mameli G., et al. Multiple sclerosis-associated retrovirus and MS prognosis: an observational study. Neurology 59 (2002) 1071-1073
39. Nowak J., Januszkiewicz D., Pernak M., et al. Multiple sclerosis-associated virus-related pol sequences found both in multiple sclerosis and healthy donors are more frequently expressed in multiple sclerosis patients. J Neurovirol 9 (2003) 112-117
40. Perron H., Jouvin-Marche E., Michel M., et al. Multiple sclerosis retrovirus particles and recombinant envelope trigger an abnormal immune response in vitro, by inducing polyclonal Vbeta16 T-lymphocyte activation. Virology 287 (2001) 321-332
41. Lafon M., Jouvin-Marche E., Marche P.N., et al. Human viral superantigens: to be or not to be transactivated?. Trends Immunol 23 (2002) 238-239
42. Ruprecht K., Obojes K., Wengel V., et al. Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1: implications for multiple sclerosis. J Neurovirol 12 (2006) 65-71
43. Firouzi R., Rolland A., Michel M., et al. Multiple sclerosis-associated retrovirus particles cause T lymphocyte-dependent death with brain hemorrhage in humanized SCID mice model. J Neurovirol 9 (2003) 79-93
44. Antony J.M., van Marle G., Opii W., et al. Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. Nat Neurosci 7 (2004) 1088-1095
45. Perron H., Lazarini F., Ruprecht K., et al. Human endogenous retrovirus (HERV)-W ENV and GAG proteins: physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions. J Neurovirol 11 (2005) 23-33
46. Serra C., Mameli G., Arru G., et al. In vitro modulation of the multiple sclerosis (MS)-associated retrovirus by cytokines: implications for MS pathogenesis. J Neurovirol 9 (2003) 637-643
47. Rolland A., Jouvin-Marche E., Viret C., et al. The envelope protein of a human endogenous retrovirus-W family activates innate immunity through CD14/TLR4 and promotes Th1-like responses. J Immunol 176 (2006) 7636-7644
48. Pasare C., and Medzhitov R. Toll pathway-dependent blockade of CD4+ CD25+ T cell-mediated suppression by dendritic cells. Science 299 (2003) 1033-1036
49. Christensen T., Dissing Sorensen P., Riemann H., et al. Molecular characterization of HERV-H variants associated with multiple sclerosis. Acta Neurol Scand 101 (2000) 229-238
50. Brudek T., Christensen T., Hansen H.J., et al. Simultaneous presence of endogenous retrovirus and herpes virus antigens has profound effect on cell-mediated immune responses: implications for multiple sclerosis. AIDS Res Hum Retroviruses 20 (2004) 415-423
51. Marguerat S., Wang W.Y., Todd J.A., et al. Association of human endogenous retrovirus K-18 polymorphisms with type 1 diabetes. Diabetes 53 (2004) 852-854
52. Conrad B., Weidmann E., Trucco G., et al. Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Nature 371 (1994) 351-355
53. La Placa M., Vitone F., Bianchi T., et al. Serum antibodies against human intracisternal A-type particle (HIAP) endogenous retrovirus in Alopecia areata patients: a hallmark of autoimmune disease?. J Invest Dermatol 123 (2004) 407-409
54. Griffiths D.J., Cooke S.P., Herve C., et al. Detection of human retrovirus 5 in patients with arthritis and systemic lupus erythematosus. Arthritis Rheum 42 (1999) 448-454
55. Piper K.E., Hanssen A.D., Lewallen D.G., et al. Lack of detection of human retrovirus-5 proviral DNA in synovial tissue and blood specimens from individuals with rheumatoid arthritis or osteoarthritis. Arthritis Rheum 55 (2006) 123-125
56. Herve C.A., Lugli E.B., Brand A., et al. Autoantibodies to human endogenous retrovirus-K are frequently detected in health and disease and react with multiple epitopes. Clin Exp Immunol 128 (2002) 75-82
57. Ejtehadi H.D., Freimanis G.L., Ali H.A., et al. The potential role of human endogenous retrovirus K10 in the pathogenesis of rheumatoid arthritis: a preliminary study. Ann Rheum Dis 65 (2006) 612-616
58. Ehlhardt S., Seifert M., Schneider J., et al. Human endogenous retrovirus HERV-K(HML-2) Rec expression and transcriptional activities in normal and rheumatoid arthritis synovia. J Rheumatol 33 (2006) 16-23
59. Sicat J., Sutkowski N., and Huber B.T. Expression of human endogenous retrovirus HERV-K18 superantigen is elevated in juvenile rheumatoid arthritis. J Rheumatol 32 (2005) 1821-1831
60. Yamano S., Renard J.N., Mizuno F., et al. Retrovirus in salivary glands from patients with Sjogren's syndrome. J Clin Pathol 50 (1997) 223-230
61. Garry R.F., Fermin C.D., Hart D.J., et al. Detection of a human intracisternal A-type retroviral particle antigenically related to HIV. Science 250 (1990) 1127-1129
62. Eguchi K., Matsuoka N., Ida H., et al. Primary Sjögren's syndrome with antibodies to HTLV-I: clinical and laboratory features. Ann Rheum Dis 51 (1992) 769-776
63. Terada K., Katamine S., Eguchi K., et al. Prevalence of serum and salivary antibodies to HTLV-1 in Sjögren 's syndrome. Lancet 344 (1994) 1116-1119
64. Moyes D.L., Martin A., Sawcer S., et al. The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease. Genomics 86 (2005) 337-341
65. Morgan D., and Brodsky I. Human endogenous retrovirus (HERV-K) particles in megakaryocytes cultured from essential thrombocythemia peripheral blood stem cells. Exp Hematol 32 (2004) 520-525
66. Foerster J., Nolte I., Junge J., et al. Haplotype sharing analysis identifies a retroviral dUTPase as candidate susceptibility gene for psoriasis. J Invest Dermatol 124 (2005) 99-102
67. Bessis D., Moles J.P., Basset-Seguin N., et al. Differential expression of a human endogenous retrovirus E transmembrane envelope glycoprotein in normal, psoriatic and atopic dermatitis human skin. Br J Dematol 151 (2004) 737-745
68. Moles J.P., Tesniere A., and Guilhou J.J. A new endogenous retroviral sequence is expressed in skin of patients with psoriasis. Br J Dermatol 153 (2005) 83-89
69. Moles J.P., Hadi J.C., and Guilhou J.J. High prevalence of an IgG response against murine leukemia virus (MLV) in patients with psoriasis. Virus Res 94 (2003) 97-101
70. Perl A. Role of endogenous retroviruses in autoimmune diseases. Rheum Dis Clin N Am 29 (2003) 123-143