Epithelial marker expression does not rule out a diagnosis of Ewing's sarcoma family of tumours

Virchows Archiv

Volumn 459, Issue 4, 2011, Pages 409-414

  MacHado, Isidro ^a,b   Navarro, Samuel ^a   López Guerrero, Jose A ^b   Alberghini, Marco ^c   Picci, Piero ^c   Llombart Bosch, Antonio ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b INSTITUTO VALENCIANO DE ONCOLOGÍA   (Spain)

^c RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

CEA; CK; EMA; Epithelial markers; Ewing's sarcoma; Immunohistochemistry

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN 1; CYTOKERATIN 18; EPITHELIAL MEMBRANE ANTIGEN; UVOMORULIN;

ARTICLE; DESMOPLASTIC SMALL ROUND CELL TUMOR; DIFFERENTIAL DIAGNOSIS; EWING SARCOMA; GENE EXPRESSION; GENE FUSION; HISTOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PREVALENCE; PRIORITY JOURNAL;

BONE NEOPLASMS; CARCINOEMBRYONIC ANTIGEN; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; MUCIN-1; SARCOMA, EWING'S; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 80855132809     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-011-1138-2     Document Type: Article

References (29)

1. I Machado R Noguera A Pellin, et al. 2009 Molecular diagnosis of Ewing sarcoma family of tumors: a comparative analysis of 560 cases with FISH and RT-PCR Diagn Mol Pathol 18 189 199 19861898 10.1097/PDM.0b013e3181a06f66 1:CAS:528:DC%2BD1MXhsV2isrjK
2. A Llombart-Bosch I Machado S Navarro, et al. 2009 Histological heterogeneity of Ewing's sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical support Virchows Arch 455 397 411 19841938 10.1007/s00428-009-0842-7 1:CAS:528:DC%2BD1MXhtlKhtL3I
3. I Machado R Noguera EA Mateos, et al. 2011 The many faces of atypical Ewing's sarcoma. A true entity mimicking sarcomas, carcinomas and lymphomas Virchows Arch 458 281 290 21181413 10.1007/s00428-010-1023-4
4. S Romeo AP Dei Tos 2010 Soft tissue tumors associated with EWSR1 translocation Virchows Arch 456 219 234 19936782 10.1007/s00428-009-0854-3 1:CAS:528:DC%2BC3cXisV2ms7s%3D
5. JL Ordóñez D Osuna DJ García-Domínguez, et al. 2010 The clinical relevance of molecular genetics in soft tissue sarcomas Adv Anat Pathol 17 162 181 20418671 10.1097/PAP.0b013e3181d98cbf
6. G Gamberi S Cocchi S Benini, et al. 2011 Molecular diagnosis in Ewing family tumors: the Rizzoli experience-222 consecutive cases in four years J Mol Diagn 13 313 324 21458383 10.1016/j.jmoldx.2011.01.004 1:CAS:528: DC%2BC3MXntlyisrg%3D
7. J Sumegi J Nishio M Nelson RW Frayer D Perry JA Bridge 2011 A novel t(4;22)(q31;q12) produces an EWSR1-SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor Mod Pathol 24 333 342 21113140 10.1038/modpathol.2010.201 1:CAS:528:DC%2BC3MXisFaruro%3D
8. M Gu CR Antonescu G Guiter AG Huvos M Ladanyi MF Zakowski 2000 Cytokeratin immunoreactivity in Ewing's sarcoma: prevalence in 50 cases confirmed by molecular diagnostic studies Am J Surg Pathol 24 410 416 10716155 10.1097/00000478-200003000-00010 1:STN:280:DC%2BD3c7nvVyquw%3D%3D (Pubitemid 30127477)
9. P Collini G Sampietro R Bertulli, et al. 2001 Cytokeratin immunoreactivity in 41 cases of ES/PNET confirmed by molecular diagnostic studies Am J Surg Pathol 25 273 274 11176079 10.1097/00000478-200102000-00022 1:STN:280:DC%2BD3M7is1OqsQ%3D%3D (Pubitemid 32167512)
10. RE Jimenez AL Folpe RL Lapham, et al. 2002 Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 cases Am J Surg Pathol 26 320 327 11859203 10.1097/00000478-200203000-00005 (Pubitemid 34184455)
11. AL Folpe CE Hill DM Parham PA O'Shea SW Weiss 2000 Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing's sarcoma/primitive neuroectodermal tumor Am J Surg Pathol 24 1657 1662 11117787 10.1097/00000478-200009000-00007 1:STN:280:DC%2BD3M%2FmtlWqtw%3D%3D
12. A Srivastava AE Rosenberg M Selig BP Rubin GP Nielsen 2005 Keratin-positive Ewing's sarcoma: an ultrastructural study of 12 cases Int J Surg Pathol 13 43 50 15735854 10.1177/106689690501300106 (Pubitemid 40224096)
13. H Woestenborghs M Debiec-Rychter M Renard P Demaerel F Van Calenbergh S Van Gool R Sciot 2005 Cytokeratin-positive meningeal peripheral PNET/Ewing's sarcoma of the cervical spinal cord: diagnostic value of genetic analysis Int J Surg Pathol 13 93 97 15735862 10.1177/106689690501300114 (Pubitemid 40224104)
14. AL Folpe JR Goldblum BP Rubin, et al. 2005 Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases Am J Surg Pathol 29 1025 1033 16006796 (Pubitemid 41045546)
15. DM Parham Y Hijazi SM Steinberg, et al. 1999 Neuroectodermal differentiation in Ewing's sarcoma family of tumors does not predict tumor behavior Hum Pathol 30 911 918 10452503 10.1016/S0046-8177(99)90244-7 1:STN:280:DyaK1MznvFGksA%3D%3D (Pubitemid 29380514)
16. AN Schuetz BP Rubin JR Goldblum, et al. 2005 Intercellular junctions in Ewing sarcoma/primitive neuroectodermal tumor: additional evidence of epithelial differentiation Mod Pathol 18 1403 1410 15920547 10.1038/modpathol.3800435 1:CAS:528:DC%2BD2MXhtFahur7K (Pubitemid 41509393)
17. SL Hasegawa JM Davison A Rutten JA Fletcher CD Fletcher 1998 Primary cutaneous Ewing's sarcoma: immunophenotypic and molecular cytogenetic evaluation of five cases Am J Surg Pathol 22 310 318 9500772 10.1097/00000478-199803000- 00005 1:STN:280:DyaK1c7mtVCjuw%3D%3D (Pubitemid 28108412)
18. J Gonin F Larousserie B Dousset, et al. 2011 An unusual adrenal tumor: Ewing tumor Ann Pathol 31 28 31 21349385 10.1016/j.annpat.2010.07.043
19. A Peydro-Olaya A Llombart-Bosch C Carda-Batalla JA Lopez-Guerrero 2003 Electron microscopy and other ancillary techniques in the diagnosis of small round cell tumors Semin Diagn Pathol 20 25 45 12693673 (Pubitemid 36378626)
20. RVP Hutter FW Foote Jr KC Francis RS Sherman 1965 Primitive multipotential primary sarcoma of bone Cancer 19 1 25 10.1002/1097-0142(196601) 19:1<1::AID-CNCR2820190102>3.0.CO;2-Z
21. R Moll I Lee VE Gould R Berndt A Roessner WW Franke 1987 Immunocytochemical analysis of Ewing's tumors. Patterns of expression of intermediate filaments and desmosomal proteins indicate cell type heterogeneity and pluripotential differentiation Am J Pathol 127 288 304 2437802 1:STN:280:DyaL2s3htVGiug%3D%3D (Pubitemid 17086963)
22. S Navarro AO Cavazzana A Llombart-Bosch TJ Triche 1994 Comparison of Ewing's sarcoma of bone and peripheral neuroepithelioma. An immunocytochemical and ultrastructural analysis of two primitive neuroectodermal neoplasms Arch Pathol Lab Med 118 608 615 8204006 1:STN:280:DyaK2c3mtlegsw%3D%3D (Pubitemid 24173617)
23. AM Dierick H Roels M Langlois 1993 The immunophenotype of Ewing's sarcoma. An immunohistochemical analysis Pathol Res Pract 189 26 32 8516214 1:STN:280:DyaK3s3ps1Shsg%3D%3D (Pubitemid 23117647)
24. M Miettinen V-P Lehto I Virtanen 1982 Histogenesis of Ewing's sarcoma. An evaluation of intermediate filaments and endothelial cell markers Virchows Arch 41 277 284 1:STN:280:DyaL3s3ltVOiug%3D%3D (Pubitemid 13217451)
25. CR Antonescu N Katabi L Zhang, et al. 2011 EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland Genes Chromosomes Cancer 50 559 570 21484932 10.1002/gcc.20881 1:CAS:528:DC%2BC3MXlslChsbw%3D
26. M El-Kabany R Al-Abdulghani AE Ali IM Francis SA Hussein 2011 Soft tissue high grade myoepithelial carcinoma with round cell morphology: report of a newly described entity with EWSR1 gene rearrangement Gulf J Oncolog 1 73 77 21177214 1:STN:280:DC%2BC3M%2FmtFSkuw%3D%3D
27. P Brandal I Panagopoulos B Bjerkehagen S Heim 2009 t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma Genes Chromosomes Cancer 48 1051 1056 19760602 10.1002/gcc.20706 1:CAS:528:DC%2BD1MXht1KrtbrF
28. VS Malone SM Dobin KA Jones LR Donner 2010 CD99-positive large cell neuroendocrine carcinoma with rearranged EWSR1 gene in an infant: a case of prognostically favorable tumor Virchows Arch 457 389 395 20617339 10.1007/s00428-010-0944-2
29. HG Kang JM Jenabi J Zhang, et al. 2007 E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase Cancer Res 67 3094 3105 17409416 10.1158/0008-5472.CAN-06- 3259 1:CAS:528:DC%2BD2sXksVGlurs%3D (Pubitemid 46724846)