Synthesis, anti-inflammatory, analgesic, and antibacterial activities of some triazole, triazolothiadiazole, and triazolothiadiazine derivatives

Archives of Pharmacal Research

Volumn 34, Issue 8, 2011, Pages 1239-1250

  Hussein, Mostafa A ^a   Shaker, Refaat M ^b   Ameen, Mohammed A ^b   Mohammed, Mohammed F ^b  

^a Assiut University   (Egypt)

^b El Minia University ^*  (Egypt)

Author keywords

1,2,4 Triazoles; Analgesic; Anti inflammatory; Antibacterial; Triazolothiadiazines; Triazolothiadiazoles

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 1,3,4 THIADIAZINE DERIVATIVE; 1,3,4 THIADIAZOLE DERIVATIVE; 3 (4 PYRIDYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE 3 (4 PYRIDYL) 4 [1 (2 THIENYL)METHYLIDENE]AMINO 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3,6 DI(PYRIDIN 4 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 4 (4 BROMOBENZYLIDENEAMINO) 2 (MORPHOLINOMETHYL) 5 (PYRIDINE 4 YL) 2H 1,2,4 TRIAZOLE 3 (4H) THIONE; 4 (4 CHLOROPHENYLMETHYLIDENE)AMINO 3 (4 PYRIDYL)4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 (4 DIMETHYLAMINO)PHENYLMETHYLIDENE]AMINO 3 (4 PYRIDYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 (4 NITROBENZYLIDENEAMINO) 2 (MORPHOLINOMETHYL) 5 (PYRIDIN 4 YL) 2H 1,2,4 TRIAZOLE 3 (4H) THIONE; 4 (BENZYLIDENAMINO) 2 (MORPHOLINOMETHYL) 5 (PYRIDINE 4 YL) 2H 1,2,4 TRIAZOLE (4H) THIONE; 4 (FURAN 2 YL)METHYLENEAMINO) 2 (MORPHOLINOMETHYL) 5 (PYRIDIN 4 YL) 2H 1,2,4 TRIAZOLE 3 (4H) THIONE; 4 (THIENYL 2 YL)METHYLENEAMINO) 2 (MORPHOLINOMETHYL) 5 (PYRIDIN 4 YL) 2H 1,2,4 TRIAZOLE 3 (4H) THIONE; 4 [(4 CHLOROPHENYL)METHYLIDENE]AMINO 1 (MORPHOLINOMETHYL) 3 (4 PYRIDYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 [1 (2 FURYL)METHYLIDENE]AMINO 3 (4 PYRIDYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 [1 (4 METHOXYPHENYL)METHYLIDENE]AMINO 1 (MORPHOLINOMETHYL) 3 (4 PYRIDYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 [4 BROMOPHENYLMETHYLIDENE]AMINO 3 (4 PYRIDYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 [4 HYDROXYPHENYL)METHYLIDENE]AMINO 1 (MORPHOLINOMETHYL) 3 (4 PYRIDYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 [4 HYDROXYPHENYLMETHYLIDENE]AMINO 3 (4 PYRIDYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 [4 METHOXYPHENYLMETHYLIDENE]AMINO 3 (4 PYRIDYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 [4 NITROPHENYLMETHYLIDENE]AMINO 3 (4 PYRIDYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 [PHENYLMETHYLIDENE]AMINO 3 (4 PYRIDYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 6 (4 CHLOROPHENYL) 3 (PYRIDIN 4 YL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZINE; 6 (4 NITROPHENYL) 3 (PYRIDINE 4 YL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZINE; 6 (PYRIDIN 3 YL) 3 (PYRIDIN 4 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 6 METHYL 3 (PYRIDINE 4YL) [1,2,4]TRIAZOLE[3,4 B][1,3,4]THIADIAZOLE; 6 PHENYL 3 (PYRIDIN 4 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 6 PHENYL 3 (PYRIDINE 4 YL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIZAINE; INDOMETACIN; LIOMETACIN; N,N DIMETHYLAMINO N' [1 (MORPHOLINOMETHYL) 3 (4 PYRIDYL) 5 THIOXO 4,5 DIHYDRO 1H 1,2,4 TRIAZOL 4 YL]IMINOFORMAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANALGESIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; LD 50; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; RAT; ULCEROGENESIS;

ANALGESICS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EDEMA; ESCHERICHIA COLI; HOT TEMPERATURE; LETHAL DOSE 50; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICROBIAL SENSITIVITY TESTS; RATS; STOMACH ULCER; THIADIAZOLES; THIONES; TIME FACTORS; TRIAZOLES;

EID: 80855124930     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0802-z     Document Type: Article

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