Synthesis, analgesic activity and computational study of new isothiazolopyridines of Mannich base type

Farmaco

Volumn 60, Issue 11-12, 2005, Pages 961-968

  Malinka, W ^a   Swiatek P ^a   Filipek, B ^b   Sapa, J ^b   Jezierska, A ^c   Koll, A ^c  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^c UNIVERSITY OF WROC AW   (Poland)

Author keywords

Analgesic activity; Isothiazolopyridines; Structure toxicity relationships

Indexed keywords

2 [(1,2,3,4 TETRAHYDRO BETA CARBOLIN 2 YL)METHYL] 4,6 DIMETHYL 3 OXO 2,3 DIHYDROISOTHIAZOL[5,4 B]PYRIDINE; 2 [(4 CYANO 4 PHENYLPIPERIDIN 1 YL)METHYL] 4,6 DIMETHYL 3 OXO 2,3 DIHYDROISOTHIAZOL[5,4 B]PYRIDINE; 2 [(4 CYCLOHEXYLPIPERAZIN 1 YL)METHYL] 4,6 DIMETHYL 3 OXO 2,3 DIHYDROISOTHIAZOL[5,4 B]PYRIDINE; 2 [(4 PHENYL 1,2,3,6 TETRAHYDROPYRIDIN 1 YL)METHYL] 4,6 DIMETHYL 3 OXO 2,3 DIHYDROISOTHIAZOL[5,4 B]PYRIDINE; 2 [4 (2 FLUOROPHENYLPIPERAZIN 1 YL)METHYL] 4,6 DIMETHYL 3 OXO 2,3 DIHYDROISOTHIAZOL[5,4 B]PYRIDINE; 2 [4 (5 CHLORO 2 METHYLPHENYL)PIPERAZIN 1 YL)METHYL] 4,6 DIMETHYL 3 OXO 2,3 DIHYDROISOTHIAZOL[5,4 B]PYRIDINE; 2 [[4 (4 BROMOPHENYL) 4 HYDROXYPIPERIDIN 1 YL]METHYL] 4,6 DIMETHYL 3 OXO 2,3 DIHYDROISOTHIAZOL[5,4 B]PYRIDINE; 2 [[4 (4 CHLORO 3 TRIFLUOROMETHYLPHENYL) 4 HYDROXYPIPERIDIN 1 YL]METHYL] 4,6 DIMETHYL 3 OXO 2,3 DIHYDROISOTHIAZOL[5,4 B]PYRIDINE; 2 [[4 (4 CHLOROPHENYL) 4 HYDROXYPIPERIDIN 1 YL]METHYL] 4,6 DIMETHYL 3 OXO 2,3 DIHYDROISOTHIAZOL[5,4 B]PYRIDINE; 2 [[4 (4 FLUOROPHENYL) 1,2,3,6 TETRAHYDROPYRIDIN 1 YL]METHYL] 4,6 DIMETHYL 3 OXO 2,3 DIHYDROISOTHIAZOL[5,4 B]PYRIDINE; 2 [[4 (4 NITROPHENYL)PIPERAZIN 1 YL]METHYL] 4,6 DIMETHYL 3 OXO 2,3 DIHYDROISOTHIAZOL[5,4 B]PYRIDINE; 2 [[N (2 ANILINOETHYL) N METHYLAMINO]METHYL] 4,6 DIMETHYL 3 OXO 2,3 DIHYDROISOTHIAZOL[5,4 B]PYRIDINE; ACETYLSALICYLIC ACID; MANNICH BASE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL PROCEDURES; CHEMICAL STRUCTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DOSE REGIMEN; DRUG POTENCY; DRUG SYNTHESIS; LD 50; MALE; MATHEMATICAL MODEL; MOUSE; NONHUMAN; STATISTICAL SIGNIFICANCE; WRITHING TEST;

ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; BENZOQUINONES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HEAT; LETHAL DOSE 50; MALE; MANNICH BASES; MICE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PAIN THRESHOLD; PIPERAZINES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 27744472897     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2005.08.005     Document Type: Article

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