Serotonin transporter polymorphism in Major Depressive Disorder (MDD), psychiatric disorders, and in MDD in response to stressful life events: Causes and treatment with antidepressant

In Vivo

Volumn 25, Issue 6, 2011, Pages 895-901

  Daniele, Antonella ^a   Divella, Rosa ^a   Paradiso, Angelo ^a   Mattioli, Vittorio ^a   Romito, Francesca ^a   Giotta, Francesco ^a   Casamassima, Porzia ^a   Quaranta, Michele ^a  

^a NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

Author keywords

5 HTT transporter gene; Depression; Polymorphism; Psychiatric disorders; Review; Stressful condition

Indexed keywords

CITALOPRAM; FLUVOXAMINE; PAROXETINE; PINDOLOL; SEROTONIN TRANSPORTER; SERTRALINE;

AGGRESSION; ALLELE; CONTROLLED CLINICAL TRIAL (TOPIC); DISEASE ASSOCIATION; DRUG RESPONSE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; IMPULSIVENESS; LIFE EVENT; MAJOR DEPRESSION; MENTAL DISEASE; PERSONALITY DISORDER; PROMOTER REGION; PSYCHOSIS; REVIEW; STRESS; SUICIDAL BEHAVIOR; SYSTEMATIC REVIEW;

EID: 80755189460     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (51)

1. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD and Petri S: Association of anxiety-related traits with a polymorphism in the serotonion transporter gene regulatory region. Science 274: 1527-1531, 1996. (Pubitemid 26403928)
2. Mann JJ, Huang Y, Underwood MD, Kasasir SA, Oppenheim S, Kelly TM, Dwork AJ and Arango V: A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psych 57: 729-738, 2000. (Pubitemid 30650106)
3. Zemlan FP and Garver DL: Depression and antidepressant therapy: receptor dynamics. Prog Neuropsychopharmacol Biol Psychiatry 14: 503-523, 1990. (Pubitemid 20272344)
4. Cowen PJ: A role for 5-HT in the action of antideopressant drugs. Pharmacol Ther 46: 43-51, 1990.
5. Risch SC and Nemeroff CB: Neurochemical alterations of serotonergic neuronal systems in depression. J Clin Psychiatry 53: 3-7, 1992.
6. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A and Poulton R: Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301: 386-389, 2003. (Pubitemid 36877077)
7. Lotrich FE and Pollock BG: Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatr Genet 14: 121-129, 2004. (Pubitemid 39281818)
8. Kendler KS, Kuhn JW, Vittum J, Presctt CA and Riley B: The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression. Arch Gen Psychiatry 62: 529-535, 2005. (Pubitemid 40628882)
9. Stein MB, Schork NJ and Gelenter J: Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders. Neuropsychopharmacology 33: 312-319, 2008. (Pubitemid 350243362)
10. Kim JM, Stewart R, Kim SJ, Shin IS, Kim YH, and Yoon JS: Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Kore An Elders. Biol Psychiatry 62: 423-428, 2007. (Pubitemid 47284032)
11. Zalsman G, Huang Y, Oquendo MA, Burke AK, Hu X, Brent DA, Ellis SP, Goldmann D and Mann JJ: Association of triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry 163: 1588-1593, 2006. (Pubitemid 44465760)
12. Hoefgen B, Schulze TG, Ohlraun S, von Widdern O, Höfels S, Gross M, Heidmann V, Kovalenko s, Eckermann A, Kölsch H, Mettern M, Zobel A, Becker T, Nöthen MM, Propping P, Heun R, Maier W and Rietschel M: The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder. Biol Psychiatry 57: 247-251, 2005. (Pubitemid 40187368)
13. Massie MJ: Prevalence of depression in patients with cancer. J Natl Cancer Inst Monogr 32: 57-71, 2004.
14. Chochinov H: Depression in cancer patients. Lancet Oncol 2: 499-505, 2001.
15. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A and Poulton R: Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301: 386-389, 2003. (Pubitemid 36877077)
16. Mann JJ: Neurobiology of suicidal behaviour. Nat Rev Neuroscience 4: 819-828, 2003.
17. Dorado P, Peñas-Lledò EM, Gonzales AP, Càceres MC, Cobaleda J and Llerena A: Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR) and the CYP2C9*3 allele. Fund Clin Pharmacol 21: 451-453, 2007. (Pubitemid 47084027)
18. Kendler KS, Kuhn JW, Wittum J, Prescott CA and Riley B: The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episode of major depression. Arch Gen Psychiatry 62: 529-535, 2005. (Pubitemid 40628882)
19. Kiyohara C and Yoshimasu K: Association between major depressive disorder and a functional polymorphism of the 5-hydroxytryptamine (serotonin) transporter gene: a meta-analysis. Psychiatry Genet 20(2): 49-58, 2010.
20. Wurtmann RG: Gene stress and depression. Metabolism Suppl 1: 16-19, 2005.
21. Chorbov VM, Lobos EA and Todorov AA: relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. AM J Med Genet B Neuropsychiatry Genet 144: 830-833, 2007. (Pubitemid 47417217)
22. Schillani G, Martinis E, Capozzo MA, Era D, Cristante T, Mustacchi G, Conte MA, De Vanna M, Grassi L and Giraldi T: Psychological response to cancer: role of 5-HTTLPR genetic polymorphism of serotonin transporter. Anticancer Res 30: 3823-3826, 2010.
23. Grassi L, Rossi E, Cobianchi M, Aguiari L, Capozzo M, Martinis E, Nanni MG, Lelli G, Schillani G, Biancosino B and Giraldi T: depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients. J Affective Disord 124: 346-350, 2010.
24. Garfinkelò BD, Froese A and Hood J: Suicide attemps in children and adolescent. Am J Psychiatry 139: 1257-1261, 1982.
25. Roy A, Rytander G and Sarchiapone M: Genetics of suicide. Family studies and molecular genetics. Ann NY Acad 836: 135-157, 1997. (Pubitemid 28044023)
26. Withaker-Azmitia PM and Peroutka SJ (eds): The Neuropharmacology of Serotonin Vol 600: 1990.
27. Mann JJ, Brent DA and Arago V: The neurobiology and genetics of suicide and attemps suicide: a focus on the serotonergic system. Neuropsychopharmachology 24: 467-477, 2001. (Pubitemid 32244308)
28. Anguelova M, Benkelfat C and Turecki G: A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin trasporter: II. Suicidal behavior. Mol Psychiatry 8: 646-653, 2003. (Pubitemid 36976297)
29. Arango V, Huang Y-Yu, Underwood MD and Mann JJ: Genetics of the serotonergic system in suicidal behaviour. J Psychiatry Res 37: 375-386, 2003. (Pubitemid 36808811)
30. Currier D and Mann JJ: Stress, Genes and the biology of suicidal behaviour. Psychiatry Clin North Am 31(2): 247-269, 2008. (Pubitemid 351551422)
31. Lin PY and Tsai G: Association between serotonin transporter gene promoter polymorphism and suicide: results of meta-analysis. Biol Psychiatry 55: 1023-1030, 2004.
32. Li D and He 1: Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behaviour. Mol Psychiatry 12: 47-54, 2007.
33. Davidson RJ and Putmam KM, Larson CI: Dysfunction in the neural circuitry of emotion regulation- a possible prelude to violence. Science 289: 591-594, 2000. (Pubitemid 30622056)
34. Bah J, Lindström and M, Wesberg L: Serotonin transporter gene polymorphism: effect on serotonin transporter availability in the brain of suicide attempters. Psychiatry Res 162: 221-229, 2008.
35. Neves FS, Silveira G and Romano-Silva MA: Is the 5-HTTLPR polymorphism associated with bipolar disorder or with suicidal behaviour of bipolar disorder patients? Am J Med Genet B Neuropsychiatry Genet 147B: 114-116, 2008.
36. Limosin F, Loze JY and Bonu C: Male-specific association between the 5-HTTLPR S allele and suicide attempts in alcohol-dependent subjects. J Psychiatry Res 39: 179-182, 2005. (Pubitemid 39602642)
37. Helbecque N, Sparks DL and Hunsaker JC 3rd: The serotonin transporter promoter polymorphism and suicide. Neuroscience Lett 400: 13-15, 2006.
38. Lopez de Lara C, Dumais A and Rouleau G: STin2 variant and family history of suicide as significant predictor of suicide completion in major depression. Biol Psichiatry 59: 114-120, 2006. (Pubitemid 43117500)
39. Pungergic G, Videtic A and Pestomik A: Serotonin transporter gene promoter (5-HTTLPR) and intron 2 (VNTR) polymorphisms: a study on Slovenian population of suicide victims. Psychiatry Genet 16: 187-191, 2006. (Pubitemid 44401257)
40. Courtet P, Buresi C and Abbar M: No association between non-violent suicidal behavior and the serotonin transporter promoter polymorphism. Am J Med Genet B Neuropsychiatry Genet 116B: 72-76, 2003. (Pubitemid 37063618)
41. Netto Victoria JM, Correia-Silva JdF, Pimenta FJ, Kalapothakis E and Gomez RS: Serotonin transporter gene polymorphism (5-HTTLPR) in patients with recurrent aphthous stomatitis. J Oral Pathol 34: 494-497, 2005.
42. Fava M: Management of nonresponse and intolerance: switching strategies. J Clin Psychiatry 61(Suppl 2): 10-12, 2000.
43. Heils A, Teufel A, Petri S, Stober G, Riederer P and Bengel D: Allelic variation of human serotonin transporter gene expression. J Neurochem 66: 2621-2624, 1996. (Pubitemid 26159101)
44. Yu YW, Tsai SJ, Chen TJ, Lin CH and Hong CJ: Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders. Molecular Psychiatry 7: 1115-1119, 2002. (Pubitemid 36044271)
45. Zanardi R, Benedetti F and Di Bella D: Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. J Clin Psychopharmacol 20: 105-107, 2000. (Pubitemid 30056365)
46. Smeraldi F, Zanardi R and Benedetti F: Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol Psychiatry 3(6): 508-511, 1998. (Pubitemid 28515526)
47. Luddington NS, Mandadapu A, Husk M and El-Mallakh RS: Clinical implications of genetic variation in the serotonin transporter promoter region: a review. J Clin Psychiatry 11(3): 93-102, 2009.
48. Serretti A, Mandelli L, and Lorenzi C: Serotonin transporter gene influences the time course of improvement of core depressive and somatic anxiety symptoms during treatment with SSRIs for recurrent mood disorders. Psychiatry Res 149: 185-193, 2007. (Pubitemid 46108104)
49. Krah JB, Peters JB and Slager SL: Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample: Biol Psychiatry 61: 734-742, 2007.
50. Hu XZ, Rush AJ and Charney D: Association between a functional serotonin transporter promoter polymorphism and Citalopram treatment in adult outpatients with major depression. Arch Gen Psychiatry 64(7): 783-792, 2007. (Pubitemid 47026374)
51. Glatz K, Mössner R, Heils A and Lesch KP: Glucocorticoid-regulated human serotonin transporter (5-HTT) expression in modulated by the 5-TT gene promoter-linked polymorphic region. J Neurochem 86: 1072-1078, 2003. (Pubitemid 37022183)