Increased hepatic Igf2 gene expression involves C/EBPβ in TCDD-induced teratogenesis in rats

Reproductive Toxicology

Volumn 32, Issue 3, 2011, Pages 313-321

  Wang, Jun ^a   Liu, Xiaoliang ^a   Li, Tingting ^a   Liu, Caixia ^a   Zhao, Yanyan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

CCAAT enhancer binding protein ; Insulin like growth factor 2; TCDD; Teratogenesis

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CCAAT ENHANCER BINDING PROTEIN BETA; SOMATOMEDIN B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; FEMALE; FETUS; FETUS DEATH; FETUS LIVER; FETUS MALFORMATION; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION; INSULIN LIKE GROWTH FACTOR 2 GENE; INTRAUTERINE GROWTH RETARDATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TERATOGENESIS; TRANSACTIVATION; TRANSCRIPTION REGULATION; UPREGULATION; WESTERN BLOTTING;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINE, TUMOR; CLEFT PALATE; CLUBFOOT; FEMALE; FETUS; GENE EXPRESSION; INSULIN-LIKE GROWTH FACTOR II; LIVER; MALE; MATERNAL EXPOSURE; MENINGOMYELOCELE; PREGNANCY; RATS; RATS, WISTAR; TAIL; TERATOGENS; TETRACHLORODIBENZODIOXIN;

RATTUS;

EID: 80755186930     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2011.06.117     Document Type: Article

References (42)

1. Yoshizawa K., Heatherly A., Malarkey D.E., Walker N.J., Nyska A. A critical comparison of murine pathology and epidemiological data of TCDD, PCB126, and PeCDF. Toxicol Pathol 2007, 35:865-879.
2. Cole P., Trichopoulus D., Pastides H., Starr T., Mandel J. Dioxin and cancer: a critical review. Regul Toxicol Pharmacol 2003, 38:378-388.
3. Kakeyama M., Tohyama C. Developmental neurotoxicity of dioxin and its related compounds. Ind Health 2003, 41:215-230.
4. Dragin N., Dalton T.P., Miller M.L., Shertzer H.G., Nebert D.W. For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential. J Biol Chem 2006, 281:18591-18600.
5. Kojima T., Takahashi N. Influence of teratogenic factors on mouse 39 hox gene expression. Biosci Biotechnol Biochem 2009, 73:2416-2421.
6. Reyes H., Reisz-Porszasz S., Hankinson O. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 1992, 256:1193-1195.
7. Franc M.A., Moffat I.D., Boutros P.C., Tuomisto J.T., Tuomisto J., Pohjanvirta R., et al. Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats. Arch Toxicol 2008, 82:809-830.
8. Ovando B.J., Vezina C.M., McGarrigle B.P., Olson J.R. Hepatic gene downregulation following acute and subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 2006, 94:428-438.
9. Goldstone H.M., Stegeman J.J. Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity. Drug Metab Rev 2006, 38:261-289.
10. D'Ercole A.J. Insulin-like growth factors and their receptors in growth. Endocrinol Metab Clin North Am 1996, 25:573-590.
11. Smith F.M., Garfield A.S., Ward A. Regulation of growth and metabolism by imprinted genes. Cytogenet Genome Res 2006, 113:279-291.
12. Weber M., Milligan L., Delalbre A., Antoine E., Brunel C., Cathala G., et al. Extensive tissue-specific variation of allelic methylation in the Igf2 gene during mouse fetal development: relation to expression and imprinting. Mech Dev 2001, 101:133-141.
13. Pedone P.V., Cosma M.P., Ungaro P., Colantuoni V., Bruni C.B., Zarrilli R., et al. Parental imprinting of rat insulin-like growth factor II gene promoters is coordinately regulated. J Biol Chem 1994, 269:23970-23975.
14. Wu Q., Ohsako S., Ishimura R., Suzuki J.S., Tohyama C. Exposure of mouse preimplantation embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2. Biol Reprod 2004, 70:1790-1797.
15. Wang J., Zhao Y.Y., Liu H., Li Y.H., Li G.Y., Sun K.L., et al. The role of insulin-like growth factor-2 gene differentially methylated regions in TCDD-induced malformation. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007, 24:162-166.
16. Li C., Li Y., Li Y., Liu H., Sun Z., Lu J., et al. Glucocorticoid repression of human with-no-lysine (K) kinase-4 gene expression is mediated by the negative response elements in the promoter. Mol Endocrinol 2008, 40:3-12.
17. Li Y., Zhao Y., Li G., Wang J., Li T., Li W., et al. Regulation of neuronal nitric oxide synthase exon 1f gene expression by nuclear factor-kappaB acetylation in human neuroblastoma cells. J Neurochem 2007, 101:1194-1204.
18. Yiangou M., Paraskeva E., Hsieh C.C., Markou E., Victoratos P., Scouras Z., et al. Induction of a subgroup of acute phase protein genes in mouse liver by hyperthermia. Biochim Biophys Acta 1998, 1396:191-206.
19. Giltiay N.V., Karakashian A.A., Alimov A.P., Ligthle S., Nikolova-Karakashian M.N. Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes. J Lipid Res 2005, 46:2497-2505.
20. Kransler K.M., McGarrigle B.P., Olson J.R. Comparative developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the hamster, rat and guinea pig. Toxicology 2007, 229:214-225.
21. Gerber S., Hohlfeld P., Viquerat F., Tolsa J.F., Vial Y. Intrauterine growth restriction and absent or reverse end-diastolic blood flow in umbilical artery (Doppler class II or III): A retrospective study of short- and long-term fetal morbidity and mortality. Eur J Obstet Gynecol Reprod Biol 2006, 126:20-26.
22. Bahtiyar M.O., Copel J.A. Cardiac changes in the intrauterine growth-restricted fetus. Semin Perinatol 2008, 32:190-193.
23. Valsamakis G., Kanaka-Gantenbein C., Malamitsi-Puchner A., Mastorakos G. Causes of intrauterine growth restriction and the postnatal development of the metabolic syndrome. Ann NY Acad Sci 2006, 1092:138-147.
24. Park J.H., Stoffers D.A., Nicholls R.D., Simmons R.A. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. J Clin Invest 2008, 118:2316-2324.
25. Carter A.M., Nygard K., Mazzuca D.M., Han V.K. The expression of insulin-like growth factor and insulin-like growth factor binding protein mRNAs in mouse placenta. Placenta 2006, 27:278-290.
26. Cooper W.N., Luharia A., Evans G.A., Raza H., Haire A.C., Grundy R., et al. Molecular subtypes and phenotypic expression of Beckwith-Wiedemann syndrome. Eur J Hum Genet 2005, 13:1025-1032.
27. Gicquel C., Rossignol S., Cabrol S., Houang M., Steunou V., Barbu V., et al. Epimutation of the telomeric imprinting center region on chromosome 11p15 in Silver-Russell syndrome. Nat Genet 2005, 37:1003-1007.
28. Abu-Amero S.N., Ali Z., Bennett P., Vaughan J.I., Moore G.E. Expression of the insulin-like growth factors and their receptors in term placentas: a comparison between normal and IUGR births. Mol Reprod Dev 1998, 49:229-235.
29. Antonazzo P., Alvino G., Cozzi V., Grati F.R., Tabano S., Sirchia S., et al. Placental IGF2 expression in normal and intrauterine growth restricted (IUGR) pregnancies. Placenta 2008, 29:99-101.
30. McMinn J., Wei M., Schupf N., Cusmai J., Johnson E.B., Smith A.C., et al. Unbalanced placental expression of imprinted genes in human intrauterine growth restriction. Placenta 2006, 27:540-549.
31. Collardeau-Frachon S., Scoazec J.Y. Vascular development and differentiation during human liver organogenesis. Anat Rec (Hoboken) 2008, 291:614-627.
32. Marin J.J., Macias R.I., Briz O., Perez M.J., Blazquez A.G., Arrese M., et al. Molecular bases of the fetal liver-placenta-maternal liver excretory pathway for cholephilic compounds. Liver Int 2008, 28:435-454.
33. Pravtcheva D.D., Wise T.L. Igf2r improves the survival and transmission ratio of Igf2 transgenic mice. Mol Reprod Dev 2008, 75:1678-1687.
34. Lopes S., Lewis A., Hajkova P., Dean W., Oswald J., Forné T., et al. Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions. Hum Mol Genet 2003, 12:295-305.
35. Denison M.S., Fisher J.M., Whitlock J.P. The DNA recognition site for the dioxin-Ah receptor complex: nucleotide sequence and functional analysis. J Biol Chem 1988, 263:17221-17224.
36. Ramji D.P., Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J 2002, 365:561-575.
37. Westmacott A., Burke Z.D., Oliver G., Slack J.M., Tosh D. C/EBPalpha and C/EBPbeta are markers of early liver development. Int J Dev Biol 2006, 50:653-657.
38. Le Bacquer O., Petroulakis E., Paglialunga S., Poulin F., Richard D., Cianflone K., et al. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J Clin Invest 2007, 117:387-396.
39. Schrem H., Klempnauer J., Borlak J. Liver-enriched transcription factors in liver function and development. Part II. the C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation. Pharmacol Rev 2004, 56:291-330.
40. Sylvester S.L., ap Rhys C.M., Luethy-Martindale J.D., Holbrook N.J. Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression. J Biol Chem 1994, 269:20119-20125.
41. Alam T., An M.R., Papaconstantinou J. Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response. J Biol Chem 1992, 267:5021-5024.
42. Vogel C.F., Sciullo E., Park S., Liedtke C., Trautwein C., Matsumura F. Dioxin increases C/EBPbeta transcription by activating cAMP/protein kinase A. J Biol Chem 2004, 279:8886-8894.