CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients

Diabetes

Volumn 60, Issue 11, 2011, Pages 3085-3089

  Hu, Cheng ^a,b,c   Zhang, Rong ^a,b,c   Yu, Weihui ^a,b,c   Wang, Jie ^a,b,c   Wang, Congrong ^a,b,c   Pang, Can ^a,b,c   Ma, Xiaojing ^a,b,c   Bao, Yuqian ^a,b,c   Xiang, Kunsan ^a,b,c   Jia, Weiping ^a,b,c  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai Key Laboratory of Diabetes Mellitus   (China)

^c Shanghai Clinical Center for Diabetes   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CARS GENE; CHINESE; CONTROLLED STUDY; CPVL GENE; DIABETIC RETINOPATHY; FEMALE; FRMD3 GENE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; IRS2 GENE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; AMINO ACYL-TRNA SYNTHETASES; CARBOXYPEPTIDASES; CASE-CONTROL STUDIES; CHINA; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEVERITY OF ILLNESS INDEX; TUMOR SUPPRESSOR PROTEINS;

EID: 80755184658     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0028     Document Type: Article

References (19)

1. Sheetz MJ, King GL. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA 2002;288:2579-2588 (Pubitemid 35386893)
2. Ritz E. Nephropathy in type 2 diabetes. J Intern Med 1999;245:111-126 (Pubitemid 29089108)
3. Thylefors B, Négrel AD, Pararajasegaram R, Dadzie KY. Global data on blindness. Bull World Health Organ 1995;73:115-121
4. Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000;321:405-412 (Pubitemid 30609442)
5. Seaquist ER, Goetz FC, Rich S, Barbosa J. Familial clustering of diabetic kidney disease: evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med 1989;320:1161-1165 (Pubitemid 19124296)
6. Pettitt DJ, Saad MF, Bennett PH, Nelson RG, Knowler WC. Familial predisposition to renal disease in two generations of Pima Indians with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1990;33:438-443 (Pubitemid 20220945)
7. Diabetes Control and Complications Trial Research Group. Clustering of long-term complications in families with diabetes in the diabetes control and complications trial. Diabetes 1997;46:1829-1839
8. Pezzolesi MG, Poznik GD, Mychaleckyj JC, et al. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. Diabetes 2009;58:1403-1410
9. Maeda S, Araki S, Babazono T, et al. Replication study for the association between four loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. Diabetes 2010;59:2075-2079
10. Hu C, Wang C, Zhang R, et al. Association of genetic variants of NOS1AP with type 2 diabetes in a Chinese population. Diabetologia 2010;53:290-298
11. Hu C, Zhang R, Wang C, et al. Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion. PLoS ONE 2010;5:e11761
12. Jia W, Gao X, Pang C, et al. Prevalence and risk factors of albuminuria and chronic kidney disease in Chinese population with type 2 diabetes and impaired glucose regulation: Shanghai Diabetic Complications Study (SHDCS). Nephrol Dial Transplant 2009;24:3724-3731
13. Ma YC, Zuo L, Chen JH, et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 2006;17:2937-2944 (Pubitemid 44484685)
14. Wilkinson CP, Ferris FL 3rd, Klein RE, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 2003;110:1677-1682 (Pubitemid 37025422)
15. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-575 (Pubitemid 47330214)
16. Girach A, Vignati L. Diabetic microvascular complications: can the presence of one predict the development of another? J Diabetes Complications 2006;20:228-237 (Pubitemid 43949349)
17. Bruinsma SP, Baranski TJ. Beta2-chimaerin in cancer signaling: connecting cell adhesion and MAP kinase activation. Cell Cycle 2007;6:2440-2444 (Pubitemid 350058659)
18. Nishiu M, Yanagawa R, Nakatsuka S, et al. Microarray analysis of gene-expression profiles in diffuse large B-cell lymphoma: identification of genes related to disease progression. Jpn J Cancer Res 2002;93:894-901 (Pubitemid 35012251)
19. Mahoney JA, Ntolosi B, DaSilva RP, Gordon S, McKnight AJ. Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages. Genomics 2001;72:243-251 (Pubitemid 32281525)