Anti-inflammatory and antiulcerogenic activities of leaf extracts and sesquiterpene from Teucrium ramosissimum (Lamiaceae)

Immunopharmacology and Immunotoxicology

Volumn 33, Issue 4, 2011, Pages 656-662

  Sghaier, Mohamed Ben ^a   Harizi, Hedi ^a   Louhichi, Teheni ^a   Krifa, Mounira ^a   Ghedira, Kamel ^a   Chekir Ghedira, Leila ^a  

^a UNIVERSITY OF MONASTIR   (Tunisia)

Author keywords

Antiulcerogenic activity; Cell proliferation; Immunomodulation; Lysosomal enzyme activity; Nitric oxide; Teucrium ramosissimum

Indexed keywords

ACETIC ACID ETHYL ESTER; BETA EUDESMOL; CHLOROFORM; CIMETIDINE; LECTIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PLANT EXTRACT; SESQUITERPENE; TEUCRIUM RAMOSISSIMUM EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIULCEROGENIC ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PHAGOCYTE; PLANT LEAF; PRIORITY JOURNAL; SOXHLET EXTRACTION; SPLEEN CELL; STOMACH ULCER; TEUCRIUM RAMOSISSIMUM; ULCEROGENESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DISEASE MODELS, ANIMAL; ETHANOL; FEMALE; LYMPHOCYTES; LYSOSOMES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; PLANT EXTRACTS; PLANT LEAVES; RATS; SOLVENTS; STOMACH ULCER; TEUCRIUM; TUNISIA;

LAMIACEAE; RATTUS; TEUCRIUM;

EID: 80755181477     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2011.558903     Document Type: Article

References (53)

1. Bello, R., Barrachina, D., Martinez-Cuesta, M.A., Esplugues, J., Primo Yufera, E. Evaluation of the acute toxicity, analgesic and CNS activities of different species of Teucrium genus. Phytother Res 1995, 9, 277-280.
2. Tutin, T.G., Heywood, V.H., Burges, N.A., Moore, D.M., Valentine, D.H., Webb, D.A. Flora Europaea (Vol. 3). Cambridge: Cambridge University Press, 1976, pp. 129-135.
3. Abdollahi, M., Karimpour, H., Monsef-Esfehani, H.R. Antinociceptive effects of Teucrium polium L. total extract and essential oil in mouse writhing test. Pharmacol Res 2003, 48, 31-35. (Pubitemid 36593357)
4. Barrachina, M.D., Bello, R., Martinez-Cuesta, M.A., Esplugues, J., Primo-Yufera, E. Anti-inflammatory activity and effects on isolated smooth muscle of extracts from different Teucrium species. Phytother Res 1995, 9, 368-371.
5. Tariq, M., Ageel, A.M., al-Yahya, M.A., Mossa, J.S., al-Said, M.S. Anti-inflammatory activity of Teucrium polium. Int J Tissue React 1989, 11, 185-188. (Pubitemid 20123543)
6. Manosroi, A., Saraphanchotiwitthaya, A., Manosroi, J. In vitro immunomodulatory effect of Pouteria cambodiana (Pierre ex Dubard) Baehni extract. J Ethnopharmacol 2005, 101, 90-94. (Pubitemid 41265605)
7. Özkan, G., Kuleas an, H., Çelik, S., Göktürk, R.S., Ünal, O. Screening of Turkish endemic Teucrium montbretii subsp. Pamphylicum extracts for antioxidant and antibacterial activities. Food Control 2007, 18, 509-512. (Pubitemid 44550779)
8. Fernández Puntero, B., Iglesias Peinado, I., Villar del Fresno, A.M. Anti-inflammatory and antiulcer activity of Teucrium buxifolium. J Ethnopharmacol 1997, 55, 93-98. (Pubitemid 27067545)
9. Gross, G.A., Lahloub, M.F., Anklin, C., Shulten, H.R., Sticher, O. Teucroside, a phenylpropanoid glycoside from Teucrium chamaedrys. Phytochemistry 1988, 22, 1459-1463.
10. Kawashty, S.A., Gamal El-Din, E.M., Saleh, N.A.M. The flavonoid chemosystematics of two Teucrium species from Southern Sinai, Egypt. Biochem System Ecol 1999, 27, 657-660. (Pubitemid 29241916)
11. Josep, C., Yudelsy, T. Neo-clerodane diterpenes from Teucrium fruticans. Phytochemistry 2004, 65, 387-392.
12. Menichini, F., Conforti, F., Rigano, D., Formisano, C., Piozzi, F., Senatore, F. Phytochemical composition, anti-inflammatory and antitumour activities of four Teucrium essential oils from Greece. Food Chem 2009, 115, 679-686.
13. Pottier-Alapetite, G. Flore de la Tunisie. Imprimerie officielle de la république. Tunisienne, Tunis, 1976, p. 789.
14. Harizi, H., Juzan, M., Grosset, C., Rashedi, M., Gualde, N. Dendritic cells issued in vitro from bone marrow produce PGE(2) that contributes to the immunomodulation induced by antigenpresenting cells. Cell Immunol 2001, 209, 19-28. (Pubitemid 32568563)
15. Limem, I., Harizi, H., Ghedira, K., Chekir-Ghedira, L. Leaf extracts from Phlomis crinita Cav. subs. mauritanica Munby affect immune ell functions in vitro. Immunopharmacol Immunotoxicol 2010 Doi: 10.3109/08923973.2010.504926.
16. Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S., Tannenbaum, S.R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 1982, 126, 131-138. (Pubitemid 13203451)
17. Manosroi, A., Saraphanchotiwitthaya, A., Manosroi, J. Immunomodulatory activities of Clausena excavata Burm. f. wood extracts. J Ethnopharmacol 2003, 89, 155-160. (Pubitemid 37163815)
18. Mossmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65, 55-63.
19. Robert, A. Cytoprotection by prostaglandins. Gastroenterology 1979, 77, 761-767. (Pubitemid 9257866)
20. Han, S.B., Kim, Y.H., Lee, C.W., Park, S.M., Lee, H.Y., Ahn, K.S., Kim, I.H., Kim, H.M. Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai. Immunopharmacology 1998, 40, 39-48. (Pubitemid 28434952)
21. MacMicking, J., Xie, Q.W., Nathan, C. Nitric oxide and macrophage function. Annu Rev Immunol 1997, 15, 323-350. (Pubitemid 27169284)
22. Ho, S.C., Hwang, L.S., Shen, Y.J., Lin, C.C. Suppressive effect of a proanthocyanidin-rich extract from longan (Dimocarpus longan Lour.) flowers on nitric oxide production in LPS-stimulated macrophage cells. J Agric Food Chem 2007, 55, 10664-10670.
23. Terra, X., Valls, J., Vitrac, X., Mérrillon, J.M., Arola, L., Ardèvol, A., Bladé, C., Fernandez-Larrea, J., Pujadas, G., Salvadó, J., Blay, M. Grape-seed procyanidins act as antiinflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFkB signaling pathway. J Agric Food Chem 2007, 55, 4357-4365. (Pubitemid 46932630)
24. Virgili, F., Kobuchi, H., Packer, L. Procyanidins extracted from Pinus maritima (Pycnogenol): scavengers of free radical species and modulators of nitrogen monoxide metabolism in activated murine RAW 264.7 macrophages. Free Radic Biol Med 1998, 24, 1120-1129. (Pubitemid 28246726)
25. Medeiros, R., Passos, G.F., Vitor, C.E., Koepp, J., Mazzuco, T.L., Pianowski, L.F., Campos, M.M., Calixto, J.B. Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br J Pharmacol 2007, 151, 618-627. (Pubitemid 47016295)
26. Suzuki, I., Tanaka, H., Adachi, Y., Yadomae, T. Rapid measurement of phagocytosis by macrophages. Chem Pharm Bull 1988, 36, 4871-4875. (Pubitemid 19048282)
27. López-Posadas, R., Ballester, I., Abadía-Molina, A.C., Suárez, M.D., Zarzuelo, A., Martínez-Augustin, O., Sánchez de Medina, F. Effect of flavonoids on rat splenocytes, a structure-activity relationship study. Biochem Pharmacol 2008, 76, 495-506.
28. Nakamura, A., Nagai, K., Suzuki, S., Ando, K., Tamura, G. A novel method of screening for immunomodulating substances, establishment of an assay system and its application to culture broths of microorganisms. J Antibiot 1986, 39, 1148-1154. (Pubitemid 16046375)
29. Ammar, R.B., Bouhlel, I., Valenti, K., Sghaier, M.B., Kilani, S., Mariotte, A.M., Dijoux-Franca, M.G., Laporte, F., Ghedira, K., Chekir-Ghedira, L. Transcriptional response of genes involved in cell defense system in human cells stressed by H2O2 and pretreated with (Tunisian) Rhamnus alaternus extracts: combination with polyphenolic compounds and classic in vitro assays. Chem Biol Interact 2007, 168, 171-183. (Pubitemid 46976879)
30. Jiménez-Medina, E., Berruguilla, E., Romero, I., Algarra, I., Collado, A., Garrido, F., Garcia-Lora, A. The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis. BMC Cancer 2008, 8, 78.
31. Benjamini, E., Coico, R., Sunshine, G. Immunology: A Short Course, 4th ed. New York: Wiley, 2000.
32. Middleton, E., Jr, Kandaswami, C., Theoharides, T.C, . The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000, 52, 673-751.
33. Comalada, M., Ballester, I., Bailón, E., Sierra, S., Xaus, J., Gálvez, J., de Medina, F.S., Zarzuelo, A. Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. Biochem Pharmacol 2006, 72, 1010-1021. (Pubitemid 44374465)
34. Dreyling, K.W., Lange, K., Peskar, B.A., Peskar, B.M. Release of leukotrienes by rat and human gastric mucosa and its pharmacological modification. Br J Pharmacol Proc Suppl 1986, 88, 236.
35. Peskar, B.M., Lange, K., Hoppe, U., Peskar, B.A. Ethanol stimulates formation of leukotriene C4 in rat gastric mucosa. Prostaglandins 1986, 31, 283-293. (Pubitemid 16168183)
36. Cho, C.H., Ogle, C.W., Sevilla, E.L. The protective effects of sulphasalazine against ethanol-induced gastric damage in rats. Br J Pharmacol 1987, 92, 31-37. (Pubitemid 17134921)
37. Guth, P.H., Paulsen, G., Nagata, H. Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: effect of prostaglandin cytoprotection. Gastroenterology 1984, 87, 1083-1090. (Pubitemid 14017076)
38. Szabo, S., Trier, J.S., Brown, A., Schnoor, J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 1985, 88, 228-236. (Pubitemid 15224601)
39. Whittle, B.J., Oren-Wolman, N., Guth, P.H. Gastric vasoconstrictor actions of leukotriene C4, PGF2 alpha, and thromboxane mimetic U-46619 on rat submucosal microcirculation in vivo. Am J Physiol 1985, 248, G580-G586. (Pubitemid 15021127)
40. Rujjanawate, C., Kanjanapothi, D., Amornlerdpison, D., Pojanagaroon, S. Anti-gastric ulcer effect of Kaempferia parviflora. J Ethnopharmacol 2005, 102, 120-122. (Pubitemid 41375946)
41. Cho, C.H., Hua, M.F., Chou, C.K., Ho, L.T. Protection of zinc sulphate against necrosis induced by ethanol in rats. Proc Netherland Sci Council Roy Soc 1983, 7, 261-267.
42. Konturek, S.J., Radecki, T., Piastucki, I., Brzozowski, T., Drozdowicz, D. Gastrocytoprotection by colloidal bismuth subcitrate (De-Nol) and sucralfate. Role of endogenous prostaglandins. Gut 1987, 28, 201-205. (Pubitemid 17027392)
43. Ben Sghaier, M., Bhouri, W., Neffati, A., Boubaker, J., Skandrani, I., Bouhlel, I., Kilani, S., Chekir-Ghedira, L., Ghedira, K. Chemical investigation of different crude extracts from Teucrium ramosissimum leaves. Correlation with their antigenotoxic and antioxidant properties. Food Chem Toxicol 2011, 49, 191-201.
44. Ben Sghaier, M., Boubaker, J., Skandrani, I., Bouhlel, I., Limem, I., Ghedira, K., Chekir-Ghedira, L. Antimutagenic, antigenotoxic and antioxidant activities of phenolic-enriched extracts from Teucrium ramosissimum: combination with their phytochemical composition. Environ Toxicol Pharmacol 2011, 31, 220-232.
45. Oliver, B. Medicinal Plants in Nigeria. Ibadan: Nigeria College of Arts and Science and Technology, 1960, p. 358.
46. Aguwa, C.N., Nwako, S.O. Preliminary studies on the root extracts of Nauclea latifolia Smith, for anti-ulcer properties. Nigerian J Pharm Sci 1988, 4, 16-23.
47. John, T.A., Onabanjo, A.O. Gastroprotective effects of an aqueous extract of Entandrophragma utile bark in experimental ethanolinduced peptic ulceration in mice and rats. J Ethnopharmacol 1990, 29, 87-93. (Pubitemid 20115467)
48. Nwafor, P.A., Effraim, K.D., Jacks, T.W. Gastroprotective effects of aqueous extract of Khaya senegalensis bark on indomethacininduced ulceration in rats. West African J Pharmacol Drug Res 1996, 12, 46-50.
49. Aguwa, C.N., Okunji, C.O. Gastrointestinal studies of Pyrenacantha staudtii leaf extracts. J Ethnopharmacol 1986, 15, 45-55. (Pubitemid 16173403)
50. Lewis, D.A., Hanson, P.J. Anti-ulcer drugs of plant origin. Prog Med Chem 1991, 28, 201-231.
51. Hashizume, T., Hirokawa, K., Aibara, S., Ogawa, H., Kasahara, A. Pharmacological and histological studies of gastric mucosal lesion induced by serotonin in rats. Arch Int Pharmacodyn Ther 1978, 236, 96-108. (Pubitemid 9147874)
52. Galati, E.M., Sanogo, R., Tzakou, O., Rossitto, A., Germano, M.P. Antiulcerogenic activity of Teucrium divaricatum helder. ssp. divaricatum. Phytother Res 1997, 11, 572-575. (Pubitemid 28053637)
53. Galati, E.M., Mondello, M.R., D'Aquino, A., Miceli, N., Sanogo, R., Tzakou, O., Monforte, M.T. Effects of Teucrium divaricatum Heldr. ssp. divaricatum decoction on experimental ulcer in rats. J Ethnopharmacol 2000, 72, 337-342.