A non-motor microtubule binding site is essential for the high processivity and mitotic function of kinesin-8 Kif18A

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Mayr, Monika I ^a   Storch, Marko ^b   Howard, Jonathon ^b   Mayer, Thomas U ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; KINESIN; KINESIN 8; RNA; UNCLASSIFIED DRUG; KIF18A PROTEIN, HUMAN; SMALL INTERFERING RNA;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CENTROMERE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; NUCLEOTIDE SEQUENCE; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA INTERFERENCE; ANIMAL; CELL MOTION; CHROMOSOME POSITIONING; DRUG ANTAGONISM; GENETICS; HELA CELL; IMMUNIZATION; IMMUNOBLOTTING; MALE; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; RABBIT; TESTIS;

VERTEBRATA;

ANIMALS; CELL MOVEMENT; CHROMOSOME POSITIONING; HELA CELLS; HUMANS; IMMUNIZATION; IMMUNOBLOTTING; KINESIN; KINETOCHORES; MALE; MICROTUBULES; MITOSIS; PROTEIN BINDING; RABBITS; RNA, SMALL INTERFERING; TESTIS;

EID: 80755176813     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027471     Document Type: Article

References (28)

1. Scholey JM, Brust-Mascher I, Mogilner A, (2003) Cell division. Nature 422: 746-752.
2. Kline-Smith SL, Walczak CE, (2004) Mitotic spindle assembly and chromosome segregation: refocusing on microtubule dynamics. Molecular Cell 15: 317-327.
3. Yildiz A, Tomishige M, Vale RD, Selvin PR, (2004) Kinesin walks hand-over-hand. Science 303: 676-678.
4. Hirokawa N, Noda Y, (2008) Intracellular transport and kinesin superfamily proteins, KIFs: Structure, function, and dynamics. Physiological Reviews 88: 1089-1118.
5. Miki H, Okada Y, Hirokawa N, (2005) Analysis of the kinesin superfamily: insights into structure and function. Trends Cell Biol 15: 467-476.
6. Walczak CE, (2003) The Kin I kinesins are microtubule end-stimulated ATPases. Molecular Cell 11: 286-288.
7. Mayr MI, Hummer S, Bormann J, Gruner T, Adio S, et al. (2007) The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. Curr Biol 17: 488-498.
8. Stumpff J, von Dassow G, Wagenbach M, Asbury C, Wordeman L, (2008) The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment. Dev Cell 14: 252-262.
9. Savoian MS, Glover DM, (2010) Drosophila Klp67A binds prophase kinetochores to subsequently regulate congression and spindle length. J Cell Sci 123: 767-776.
10. West RR, Malmstrom T, McIntosh JR, (2002) Kinesins klp5(+) and klp6(+) are required for normal chromosome movement in mitosis. J Cell Sci 115: 931-940.
11. Grissom PM, Fiedler T, Grishchuk EL, Nicastro D, West RR, et al. (2009) Kinesin-8 from Fission Yeast: A Heterodimeric, Plus-End-directed Motor that Can Couple Microtubule Depolymerization to Cargo Movement. Molecular Biology of the Cell 20: 963-972.
12. Peters C, Brejc K, Belmont L, Bodey AJ, Lee Y, et al. (2010) Insight into the molecular mechanism of the multitasking kinesin-8 motor. EMBO J.
13. Du Y, English CA, Ohi R, (2010) The kinesin-8 Kif18A dampens microtubule plus-end dynamics. Curr Biol 20: 374-380.
14. Tan EM, Rodnan GP, Garcia I, Moroi Y, Fritzler MJ, et al. (1980) Diversity of antinuclear antibodies in progressive systemic sclerosis. Anti-centromere antibody and its relationship to CREST syndrome. Arthritis Rheum 23: 617-625.
15. Goshima G, Wollman R, Stuurman N, Scholey JM, Vale RD, (2005) Length control of the metaphase spindle. Curr Biol 15: 1979-1988.
16. Jaqaman K, King EM, Amaro AC, Winter JR, Dorn JF, et al. (2010) Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases. J Cell Biol 188: 665-679.
17. Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, et al. (2005) Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell 16: 3187-3199.
18. Varga V, Helenius J, Tanaka K, Hyman AA, Tanaka TU, et al. (2006) Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner. Nat Cell Biol 8: 957-962.
19. Stumpff J, Du Y, English CA, Maliga Z, Wagenbach M, et al. (2011) A Tethering Mechanism Controls the Processivity and Kinetochore-Microtubule Plus-End Enrichment of the Kinesin-8 Kif18A. Mol Cell 43: 764-775.
20. Su X, Qiu W, Gupta ML Jr, Pereira-Leal JB, Reck-Peterson SL, et al. (2011) Mechanisms underlying the dual-mode regulation of microtubule dynamics by kip3/kinesin-8. Mol Cell 43: 751-763.
21. Weaver LN, Ems-McClung SC, Stout JR, Leblanc C, Shaw SL, et al. (2011) Kif18A Uses a Microtubule Binding Site in the Tail for Plus-End Localization and Spindle Length Regulation. Curr Biol 21: 1500-1506.
22. Varga V, Leduc C, Bormuth V, Diez S, Howard J, (2009) Kinesin-8 motors act cooperatively to mediate length-dependent microtubule depolymerization. Cell 138: 1174-1183.
23. Liao H, Li G, Yen TJ, (1994) Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore protein. Science 265: 394-398.
24. Cahu J, Olichon A, Hentrich C, Schek H, Drinjakovic J, et al. (2008) Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindles. PLoS One 3: e3936.
25. Espeut J, Gaussen A, Bieling P, Morin V, Prieto S, et al. (2008) Phosphorylation relieves autoinhibition of the kinetochore motor Cenp-E. Molecular Cell 29: 637-643.
26. Gerlich D, Hirota T, Koch B, Peters JM, Ellenberg J, (2006) Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells. Curr Biol 16: 333-344.
27. Sarli V, Huemmer S, Sunder-Plassmann N, Mayer TU, Giannis A, (2005) Synthesis and biological evaluation of novel EG5 inhibitors. Chembiochem 6: 2005-2013.
28. Hunter AW, Caplow M, Coy DL, Hancock WO, Diez S, et al. (2003) The kinesin-related protein MCAK is a microtubule depolymerase that forms an ATP-hydrolyzing complex at microtubule ends. Molecular Cell 11: 445-457.