Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival

Age

Volumn 33, Issue 4, 2011, Pages 565-578

  Janmaat, Sonja ^a,b,d,e   Akwa, Yvette ^c   Doulazmi, Mohamed ^a,b   Bakouche, Joëlle ^a,b   Gautheron, Vanessa ^a,b   Liere, Philippe ^c   Eychenne, Bernard ^c   Pianos, Antoine ^c   Luiten, Paul ^e   Groothuis, Ton ^e   Baulieu, Etienne Emile ^c   Mariani, Jean ^a,b,f   Sherrard, Rachel M ^a,b   Frédéric, Florence ^a,b  

^a Université Pierre et Marie Curie   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e UNIVERSITY OF GRONINGEN   (Netherlands)

^f HÔPITAL CHARLES FOIX   (France)

Author keywords

Ageing; Cerebellum; Neurosteroids; Purkinje cells; ROR ; Sex steroid hormones

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 5ALPHA PREGNANE 3,20 DIONE; ESTROGEN; GESTAGEN; NEUROSTEROID; PREGNENOLONE; PROGESTERONE; RETINOID RELATED ORPHAN RECEPTOR ALPHA; SEX HORMONE;

AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DEATH; CELL LOSS; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENOTYPE; GONADECTOMY; HETEROZYGOSITY; HORMONE BLOOD LEVEL; LIMIT OF DETECTION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PH; POLYMERASE CHAIN REACTION; PROTEIN FUNCTION; PURKINJE CELL;

AGING; ANIMALS; CASTRATION; CELL COUNT; CELL DEATH; CELL SURVIVAL; CEREBELLUM; ESTRADIOL; FEMALE; GONADAL STEROID HORMONES; HORMONE REPLACEMENT THERAPY; MALE; MICE; MICE, MUTANT STRAINS; MICE, NEUROLOGIC MUTANTS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1; PROGESTERONE; PURKINJE CELLS; TESTOSTERONE;

EID: 80755163539     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-010-9203-3     Document Type: Article

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