Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China

Acta Pharmacologica Sinica

Volumn 32, Issue 11, 2011, Pages 1381-1386

  Tang, Wei ^a   Zou, Jun Jie ^a   Chen, Xiang Fang ^a   Zheng, Jiao Yang ^b   Zeng, Hua Zong ^a   Liu, Zhi Min ^a   Shi, Yong Quan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b TONGJI UNIVERSITY   (China)

Author keywords

China nationality; obesity; polymorphisms; rs4969168; rs9892622; SOCS3

Indexed keywords

SUPPRESSOR OF CYTOKINE SIGNALING 3;

ADULT; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHINA; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC VARIABILITY; GENOTYPE; HIP; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; SINGLE NUCLEOTIDE POLYMORPHISM; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADULT; AGED; AGED, 80 AND OVER; CHINA; ETHNIC GROUPS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; YOUNG ADULT;

EID: 80755130465     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.84     Document Type: Article

References (14)

1. Marvelle AF, Lange LA, Qin L, Adair LS, Mohlke KL. Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. Diabetes 2008; 57: 1987-91.
2. Mori MA, Araújo RC, Reis FC, Sgai DG, Fonseca RG, Barros CC, et al. Kinin B1 receptor deficiency leads to leptin hypersensitivity and resistance to obesity. Diabetes 2008; 57: 1491-500.
3. Hill JO, Wyatt HR, Reed GW, Peters JC. Obesity and the environment: where do we go from here Science 2003; 299: 853-5.
4. Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, et al. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab 2005; 1: 63-72. (Pubitemid 43960588)
5. Howard JK, Flier JS. Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab 2006; 17: 365-71. (Pubitemid 44596259)
6. Lebrun P, Van Obberghen E. SOCS proteins causing trouble in insulin action. Acta Physiol (Oxf) 2008; 192: 29-36. (Pubitemid 350265362)
7. Münzberg H, Myers MG Jr. Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 2005; 8: 566-70. (Pubitemid 40594195)
8. Talbert ME, Langefeld CD, Ziegler J, Mychaleckyj JC, Haffner SM, Norris JM, et al. Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study. Hum Genet 2009; 125: 153-62.
9. Jamshidi Y, Snieder H, Wang X, Spector TD, Carter ND, O'Dell SD. Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins. Diabetologia 2006; 49: 306-10. (Pubitemid 43185399)
10. Hölter K, Wermter AK, Scherag A, Siegfried W, Goldschmidt H, Hebebrand J, et al. Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents. BMC Med Genet 2007; 8: 21.
11. Fischer-Rosinsky A, Fisher E, Kovacs P, Blüher M, Möhlig M, Pfeiffer AF, et al. Lack of association between the tagging SNP A+930- >G of SOCS3 and type iabetes mellitus: meta-analysis of four independent study populations. PLoS One 2008; 3: e3852.
12. Gylvin T, Nolsøe R, Hansen T, Nielsen EM, Bergholdt R, Karlsen AE, et al. Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type iabetes and insulin sensitivity. Diabetologia 2004; 47: 1273-7. (Pubitemid 39093323)
13. Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 2008; 359: 2558-66.
14. Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ, et al. SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J Biol Chem 2001; 276: 47944-9.