Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins

Diabetologia

Volumn 49, Issue 2, 2006, Pages 306-310

  Jamshidi, Y ^a,b   Snieder, H ^c,d   Wang, X ^c   Spector, T D ^d   Carter, N D ^a   O'Dell, S D ^a,b  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Insulin resistance; Insulin sensitivity; Obesity; Weight regulation

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BODY WEIGHT; DIABETIC OBESITY; FEMALE; GENE CLUSTER; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC TRAIT; GENOTYPE; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN SENSITIVITY; LIPID ANALYSIS; LIPID BLOOD LEVEL; MEDICAL ASSESSMENT; MONOZYGOTIC TWINS; MUTATIONAL ANALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; WEIGHT CONTROL;

ADULT; BODY WEIGHT; DATA INTERPRETATION, STATISTICAL; FEMALE; GENE FREQUENCY; GENOTYPE; GREAT BRITAIN; HUMANS; INSULIN; INSULIN RESISTANCE; LINKAGE DISEQUILIBRIUM; LIPIDS; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; REGISTRIES; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 31844441456     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-0093-3     Document Type: Article

References (17)

1. Krebs DL, Hilton DJ (2001) SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19:378-387
2. Munzberg H, Myers MG (2005) Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 8:566-570
3. Pirola L, Johnston AM, Van Obberghen E (2004) Modulation of insulin action. Diabetologia 47:170-184
4. Gylvin T, Nolsoe R, Hansen T et al (2004) Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity. Diabetologia 47:1273-1277
5. Spector TD, MacGregor AJ (2002) The St. Thomas' UK Adult Twin Registry. Twin Res 5:440-443
6. Andrew T, Hart DJ, Snieder H, de Lange M, Spector TD, MacGregor AJ. (2001) Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Res 4:464-477
7. Middelberg RP, Spector TD, Swaminathan R, Snieder H (2002) Genetic and environmental influences on lipids, lipoproteins, and apolipoproteins: effects of menopause. Arterioscler Thromb Vasc Biol 22:1142-1147
8. de Lange M, Snieder H, Ariens RA, Andrew T, Grant PJ, Spector TD (2003) The relation between insulin resistance and hemostasis: pleiotropic genes and common environment. Twin Res 6:152-161
9. Trégouët D-A, Ducimetère P, Tiret, L (1997) Testing association between candidate-gene markers and phenotype in related individuals, by use of estimating equations. Am J Hum Genet 61:189-199
10. Avignon A, Boegner C, Mariano-Goulart D, Colette C, Monnier L (1999) Assessment of insulin sensitivity from plasma insulin and glucose in the fasting or post oral glucose-load state. Int J Obes Relat Metab Disord 23:512-517
11. Hanley AJ, Williams K, Gonzalez C, D'Agostino RB, Jr, Wagenknecht LE, Stern MP, Haffner SM (2003) Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study. Diabetes 52:463-469
12. Zaykin DV, Westfall PH, Young SS, Karnoub MA, Wagner MJ, Ehm MG (2002) Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered 53:79-91
13. Stephens M, Donnelly P (2003) A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73:1162-1169
14. Dong Y, Zhu H, Wang X, Dalageorgou C, Carter N, Spector TD, Snieder H (2004) Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: a study of female dizygotic twins. Pharmacogenetics 14:419-427
15. Christensen K, Vaupel J, Holm NV, Yashin AI (1995) Twin mortality after age six: fetal origin hypothesis versus twin method. BMJ 310:432-436
16. Sham PC, Cherny SS, Purcell S, Hewitt JK (2000) Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. Am J Hum Genet 66:1616-1630
17. Ueki K, Kondo T, Tseng YH, Kahn CR (2004) Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci USA 101:10422-10427