Helicobacter pylori infection and short-term intake of low-dose aspirin have different effects on alpha-1 antitrypsin/alpha-1 peptidase inhibitor (α1-PI) levels in antral mucosa and peripheral blood

Scandinavian Journal of Gastroenterology

Volumn 43, Issue 10, 2008, Pages 1194-1201

  Wex, Thomas ^a   Kuester, Doerthe ^a   Vieth, Michael ^b   Treiber, Gerhard ^c   Krieg, Anja ^a   Roessner, Albert ^a   Malfertheiner, Peter ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b INSTITUTE OF PATHOLOGY   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

a1 PI; Alpha 1 protease inhibitor; H. pylori; Low dose aspirin

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA 1 ANTITRYPSIN;

ADULT; ARTICLE; BLOOD; BLOOD SAMPLING; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DUODENUM MUCOSA; ENZYME LINKED IMMUNOSORBENT ASSAY; ERADICATION THERAPY; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ANTRUM; TREATMENT DURATION; VOLUNTEER;

ADULT; ALPHA 1-ANTITRYPSIN; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTRIC MUCOSA; GENE EXPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; PYLORIC ANTRUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 52149120337     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520802158598     Document Type: Article

References (28)

1. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996;20:1161-81.
2. Matysiak-Budnik T, Laszewicz W, Lamarque D, Chaussade S. Helicobacter pylori and non-malignant diseases. Helicobacter 2006;11 Suppl 1:27-31.
3. Lanas A, Scheiman J. Low-dose aspirin and upper gastrointestinal damage: epidemiology, prevention and treatment. Curr Med Res Opin 2007;23:163-73.
4. Malfertheiner P, Megraud F, O'Morain C, Bazzoli F, El-Omar E, Graham D, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut 2007;56:772-81.
5. Venerito M, Treiber G, Wex T, Kuester D, Roessner A, Di Mario F, et al. Effects of low-dose aspirin on gastric erosions, cyclooxygenase expression and mucosal prostaglandin-E2 do not depend on Helicobacter pylori infection. Aliment Pharmacol Ther 2006;23:1225-33.
6. Wex T, Ye S, Treiber G, Vieth M, Roessner A, Malfertheiner P. Helicobacter pylori infection, but not low-dose aspirin, results in a local reduction of the secretory leukocyte protease inhibitor in gastroduodenal mucosa. Helicobacter 2006;11:31-8.
7. Fitch PM, Roghanian A, Howie SE, Sallenave JM. Human neutrophil elastase inhibitors in innate and adaptive immunity. Biochem Soc Trans 2006;34:279-82.
8. Mulgrew AT, Taggart CC, McElvaney NG. Alpha-1-antitrypsin deficiency: current concepts. Lung 2007;185:191-201.
9. Dobo J, Gettins PG. Alpha1-proteinase inhibitor forms initial non-covalent and final covalent complexes with elastase analogously to other serpin-proteinase pairs, suggesting a common mechanism of inhibition. J Biol Chem 2004;279:9264-9.
10. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002;347:1175-86.
11. Shahid A, Siddiqui AA, Sultana T, Qureshi H, Waqar MA, Zuberi SJ. Determination of alpha-1 antitrypsin genetic deficiency in duodenal ulcer by polymerase chain reaction. J Pak Med Assoc 2002;52:545-58.
12. Elzouki AN, Toth E, Floren CH, Lindgren S, Fork FT, Sjolund K, et al. Alpha1-antitrypsin deficiency may be a risk factor for duodenal ulcer in patients with Helicobacter pylori infection. Scand J Gastroenterol 2000;35:32-5.
13. Allgayer H, Babic R, Grutzner KU, Beyer BC, Tarabichi A, Schildberg FW, et al. Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns. Clin Exp Metastasis 1998;16:62-73.
14. Lee K, Kye M, Jang JS, Lee OJ, Kim T, Lim D. Proteomic analysis revealed a strong association of a high level of alpha1-antitrypsin in gastric juice with gastric cancer. Proteomics 2004;4:3343-52.
15. Hsu PI, Chen CH, Hsieh CS, Chang WC, Lai KH, Lo GH, et al. Alpha1-antitrypsin precursor in gastric juice is a novel biomarker for gastric cancer and ulcer. Clin Cancer Res 2007;13:876-83.
16. Hafeez W, Ciliberto G, Perlmutter DH. Constitutive and modulated expression of the human alpha 1 antitrypsin gene. Different transcriptional initiation sites used in three different cell types. J Clin Invest 1992;89:1214-22.
17. Kalsheker N, Morley S, Morgan K. Gene regulation of the serine proteinase inhibitors alpha1-antitrypsin and alpha1-antichymotrypsin. Biochem Soc Trans 2002;30:93-8.
18. Sallenave JM, Tremblay GM, Gauldie J, Richards CD. Oncostatin M, but not interleukin-6 or leukemia inhibitory factor, stimulates expression of alpha1-proteinase inhibitor in A549 human alveolar epithelial cells. J Interferon Cytokine Res 1997;17:337-46.
19. Faust D, Raschke K, Hormann S, Milovic V, Stein J. Regulation of alpha1-proteinase inhibitor release by proinflammatory cytokines in human intestinal epithelial cells. Clin Exp Immunol 2002;128:279-84.
20. Hatakeyama M, Brzozowski T. Pathogenesis of Helicobacter pylori infection. Helicobacter 2006;11 Suppl 1:14-20.
21. Kandulski A, Wex T, Kuester D, Peitz U, Gebert I, Roessner A, et al. Helicobacter pylori-induced infiltration of regulatory T cells (CD4+, CD25high, FOXP3+) into gastric mucosa is associated with bacterial colonization and expression of the regulatory cytokine TGF-β1. Helicobacter 2008. In press.
22. Dzierzanowska-Fangrat K, Michalkiewicz J, Cielecka-Kuszyk J, Nowak M, Celinska-Cedro D, Rozynek E, et al. Enhanced gastric IL-18 mRNA expression in Helicobacter pylori-infected children is associated with macrophage infiltration, IL-8, and IL-1beta mRNA expression. Eur J Gastroenterol Hepatol 2008;20:314-9.
23. Mulholland G, Ardill JE, Fillmore D, Chittajallu RS, Fullarton GM, McColl KE. Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17. Gut 1993;34:757-61.
24. Tokushima H, Tamura H, Murakawa M, Matsumura O, Itakura Y, Itoyama S, et al. Eradication of Helicobacter pylori restores elevation of serum gastrin concentrations in patients with end-stage renal disease. Intern Med 1998;37:435-9.
25. Sipponen P, Graham DY. Importance of atrophic gastritis in diagnostics and prevention of gastric cancer: application of plasma biomarkers. Scand J Gastroenterol 2007;42:2-10.
26. Wex T, Treiber G, Venerito M, Leodolter A, Peitz U, Kuester D, et al. Helicobacter pylori-induced down-regulation of the secretory leukocyte protease inhibitor (SLPI) in gastric epithelial cell lines and its functional relevance for H. pylori-mediated diseases. Biol Chem 2006;387:893-901.
27. Rudnick DA, Shikapwashya O, Blomenkamp K, Teckman JH. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency. Hepatology 2006;44:976-82.
28. Dallegri F, Ottonello L, Dapino P, Sacchetti C. Effect of nonsteroidal antiinflammatory drugs on the neutrophil-promoted inactivation of alpha-1-proteinase inhibitor. J Rheumatol 1992;19:419-23.