In search of a cytostatic agent derived from the alkaloid lycorine: Synthesis and growth inhibitory properties of lycorine derivatives

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 23, 2011, Pages 7252-7261

  Evdokimov, Nikolai M ^a   Lamoral Theys, Delphine ^b   Mathieu, Véronique ^c   Andolfi, Anna ^d   Frolova, Liliya V ^a   Pelly, Stephen C ^e   Van Otterlo, Willem A L ^e   Magedov, Igor V ^a   Kiss, Robert ^c   Evidente, Antonio ^d   Kornienko, Alexander ^a  

^a NEW MEXICO INSTITUTE OF MINING AND TECHNOLOGY   (United States)

^b Laboratoire de Chimie Analytique   (Belgium)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Alkaloid; Apoptosis resistance; Cancer; Glioblastoma; Lycorine; Melanoma

Indexed keywords

1 HYDROXY 2,3A1,4,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 2 YL BENZOATE; 1 HYDROXY 2,3A1,4,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 2 YL PIVALATE; 1 HYDROXY 4,5,7,12B TETRAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDINE 2(3A1H) ONE; 1,2 DIHYDROXY 3A1,4,5,12B TETRAHYDRO 1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 7(2H) ONE; 1,2,3 TRIHYDROXY 2,3,5,12B TETRAHYDROXY1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 7(3A1H) ONE; 1,2,3,4 TETRAHYDROXY 3,3A,3A1,4,5,12B HEXAHYDRO 1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 7(2H) ONE; 2 (TRIISOPROPYLSILYLOXY) 2,3A1,4,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 1 OL; 2 (TRIISOPROPYLSILYLOXY)2,3A1,4,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 1 YL ACETATE; 2 (TRIISOPROPYLSILYLOXY)2,3A1,4,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 1 YL PALMITATE; 2 HYDROXY 2,3A1,4,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 1 YL ACETATE; 2 HYDROXY 2,3A1,4,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 1 YL BENZOATE; 2 HYDROXY 2,3A1,4,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 1 YL PALMITATE; 2 HYDROXY 2,3A1,4,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 1 YL STEARATE; 2 HYDROXY 4H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 7(5H) ONE; 2,3A,4,5,7,12B HEXAHYDRO 1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDINE 1,2 DIYL DIACETATE; 2,3A1,4,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDINE 1,2 DIYL DIBENZOATE; 3,3A DIHYDROXY 7 OXO 2,3,3A,3A,4,5,7,12B OCTAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDINE 1,2 DIYL DIACETATE; 3A HYDROXY 7 OXO 2,3,3A,3A1,4,5,7,12B OCTAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDINE 1,2,3,TRIYL TRIACETATE; 7 OXO 2,3,3A1,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDINE 1,2,3,TRIYL TRIACETATE; 7 OXO 2,3A1,4,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDINE 1,2 DIYL DIACETATE; 7 OXO 5,7 DIHYDRO 4H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDIN 2 YL ACETATE; 7 THIOXO 2,3,3A,3A1,4,5,7,12B OCTAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDINE 1,2,3,3A TETRAOL; 7 THIOXO 2,3A1,4,5,7,12B HEXAHYDRO1H [1,3]DIOXOLO[4,5 J]PYRROLO[3,2,1 DE]PHENANTHRIDINE 1,2 DIYL DIACETATE; ALKENE; CYTOSTATIC AGENT; HYDROXYL GROUP; LONG CHAIN FATTY ACID; LYCORINE; PACLITAXEL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DERIVATIZATION; DIHYDROXYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; GLIOBLASTOMA; HUMAN; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; MELANOMA; NONHUMAN; SOLID TUMOR; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

AMARYLLIDACEAE ALKALOIDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASMS; PHENANTHRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

AMARYLLIDACEAE;

EID: 80655146928     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.09.051     Document Type: Article

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