-
1
-
-
33750935268
-
New concepts and approaches for drug discovery based on traditional Chinese medicine
-
DOI 10.1016/j.ddtec.2006.09.008, PII S1740674906000564
-
Xu, X. New concepts and approaches for drug discovery based on traditional Chinese medicine. Drug Discovery Today:Technologies, 2006, 3, 247-253. (Pubitemid 44734730)
-
(2006)
Drug Discovery Today: Technologies
, vol.3
, Issue.3
, pp. 247-253
-
-
Xu, X.1
-
2
-
-
70549112019
-
Network systems underlying traditional Chinese medicine syndrome and herb formula
-
Li, S. Network systems underlying traditional Chinese medicine syndrome and herb formula. Current Bioinformatics, 2009, 4, 188-196.
-
(2009)
Current Bioinformatics
, vol.4
, pp. 188-196
-
-
Li, S.1
-
3
-
-
3242794178
-
From magic bullets to designed multiple ligands
-
DOI 10.1016/S1359-6446(04)03163-0, PII S1359644604031630
-
Morphy, R.; Kay, C.Rankovic, Z. From magic bullets to designed multiple ligands. Drug Discov Today, 2004, 9, 641-651. (Pubitemid 38981718)
-
(2004)
Drug Discovery Today
, vol.9
, Issue.15
, pp. 641-651
-
-
Morphy, R.1
Kay, C.2
Rankovic, Z.3
-
4
-
-
43149109308
-
Therapy of chronic myeloid leukemia. Uncommon view of the modern approaches
-
Mayer, J.; Zackova, D.; Klamova, H.Doubek, M. Therapy of chronic myeloid leukemia. Uncommon view of the modern approaches. Cas Lek Cesk, 2008, 147, 206-210.
-
(2008)
Cas Lek Cesk
, vol.147
, pp. 206-210
-
-
Mayer, J.1
Zackova, D.2
Klamova, H.3
Doubek, M.4
-
5
-
-
78650373804
-
Network medicine: A network-based approach to human disease
-
Barabasi, A.L.; Gulbahce, N.Loscalzo, J. Network medicine: a network-based approach to human disease. Nat Rev Genet, 2011, 12, 56-68.
-
(2011)
Nat Rev Genet
, vol.12
, pp. 56-68
-
-
Barabasi, A.L.1
Gulbahce, N.2
Loscalzo, J.3
-
6
-
-
54249155522
-
Network pharmacology: The next paradigm in drug discovery
-
Hopkins, A.L. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol, 2008, 4, 682-690.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
7
-
-
0037079054
-
Computational systems biology
-
DOI 10.1038/nature01254
-
Kitano, H. Computational systems biology. Nature, 2002, 420, 206-210. (Pubitemid 35340131)
-
(2002)
Nature
, vol.420
, Issue.6912
, pp. 206-210
-
-
Kitano, H.1
-
8
-
-
80051595500
-
A Systems Biology Strategy for Predicting Similarities and Differences of Drug Effects: Evidence for Drug- specific Modulation of Inflammation in Atherosclerosis
-
Kleemann, R.; Bureeva, S.; Perlina, A.; Kaput, J.; Verschuren, L.; Wielinga, P.; Hurt-Camejo, E.; Nikolsky, Y.; van Ommen, B.Kooistra, T. A Systems Biology Strategy for Predicting Similarities and Differences of Drug Effects: Evidence for Drug- specific Modulation of Inflammation in Atherosclerosis. BMC systems biology, 2011, 5, 125.
-
(2011)
BMC Systems Biology
, vol.5
, pp. 125
-
-
Kleemann, R.1
Bureeva, S.2
Perlina, A.3
Kaput, J.4
Verschuren, L.5
Wielinga, P.6
Hurt-Camejo, E.7
Nikolsky, Y.8
Van Ommen, B.9
Kooistra, T.10
-
9
-
-
14244255403
-
The "promiscuous drug concept" with applications to Alzheimer's disease
-
DOI 10.1016/j.febslet.2005.01.019
-
Stephenson, V.C.; Heyding, R.A.Weaver, D.F. The "promiscuous drug concept" with applications to Alzheimer's disease. FEBS Lett, 2005, 579, 1338-1342. (Pubitemid 40289177)
-
(2005)
FEBS Letters
, vol.579
, Issue.6
, pp. 1338-1342
-
-
Stephenson, V.C.1
Heyding, R.A.2
Weaver, D.F.3
-
10
-
-
0027121602
-
Multi-component preparations in present-day drug therapy
-
Guzecka-Ruszczynska, E.Czarnecki, A. [Multi-component preparations in present-day drug therapy]. Pol Tyg Lek, 1992, 47, 274-277.
-
(1992)
Pol Tyg Lek
, vol.47
, pp. 274-277
-
-
Guzecka-Ruszczynska, E.1
Czarnecki, A.2
-
11
-
-
0042083702
-
Study on computer simulation for chinese traditional compound medicine
-
Xu, X.J. study on computer simulation for chinese traditional compound medicine. Progress in chemistry 1999 ;11: 202-204.
-
(1999)
Progress in Chemistry
, vol.11
, pp. 202-204
-
-
Xu, X.J.1
-
12
-
-
79959937318
-
New Practice: Study on the Molecular Mechanism of Traditional Chinese Medicine by Computational Pharmacology Methods: Part 1: Pharmacokinetic Modeling and Chemical Space Distribution
-
Wu, D.H.Xu, X.J. A New Practice: Study on the Molecular Mechanism of Traditional Chinese Medicine by Computational Pharmacology Methods: Part 1: Pharmacokinetic Modeling and Chemical Space Distribution. Letters in Drug Design & Discovery, 2011, 8, 652-658.
-
(2011)
Letters in Drug Design & Discovery
, Issue.8
, pp. 652-658
-
-
Wu, D.H.1
Xu, X.J.A.2
-
13
-
-
0029240364
-
Predicting ligand binding to proteins by affinity fingerprinting
-
Kauvar, L.M.; Higgins, D.L.; Villar, H.O.; Sportsman, J.R.; Engqvist-Goldstein, A.; Bukar, R.; Bauer, K.E.; Dilley, H.Rocke, D.M. Predicting ligand binding to proteins by affinity fingerprinting. Chem Biol, 1995, 2, 107-118.
-
(1995)
Chem Biol
, vol.2
, pp. 107-118
-
-
Kauvar, L.M.1
Higgins, D.L.2
Villar, H.O.3
Sportsman, J.R.4
Engqvist-Goldstein, A.5
Bukar, R.6
Bauer, K.E.7
Dilley, H.8
Rocke, D.M.9
-
14
-
-
35148838537
-
Drug-target network
-
DOI 10.1038/nbt1338, PII NBT1338
-
Yildirim, M.A.; Goh, K.I.; Cusick, M.E.; Barabasi, A.L.Vidal, M. Drug-target network Nat Biotechnol, 2007, 25, 1119-1126. (Pubitemid 47538114)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.10
, pp. 1119-1126
-
-
Yildirim, M.A.1
Goh, K.-I.2
Cusick, M.E.3
Barabasi, A.-L.4
Vidal, M.5
-
15
-
-
0034118392
-
Renoprotective benefits of RAS inhibition: From ACEI to angiotensin II antagonists
-
Taal, M.W.Brenner, B.M. Renoprotective benefits of RAS inhibition: from ACEI to angiotensin II antagonists. Kidney Int, 2000, 57, 1803-1819.
-
(2000)
Kidney Int
, vol.57
, pp. 1803-1819
-
-
Taal, M.W.1
Brenner, B.M.2
-
16
-
-
25144517287
-
Effect of PPAR-α and -γ agonist on the expression of visfatin, adiponectin, and TNF-α in visceral fat of OLETF rats
-
DOI 10.1016/j.bbrc.2005.08.203, PII S0006291X05019327
-
Choi, K.C.; Ryu, O.H.; Lee, K.W.; Kim, H.Y.; Seo, J.A.; Kim, S.G.; Kim, N.H.; Choi, D.S.; Baik, S.H.Choi, K.M. Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats. Biochem Biophys Res Commun, 2005, 336, 747-753. (Pubitemid 41338332)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.336
, Issue.3
, pp. 747-753
-
-
Choi, K.C.1
Ryu, O.H.2
Lee, K.W.3
Kim, H.Y.4
Seo, J.A.5
Kim, S.G.6
Kim, N.H.7
Choi, D.S.8
Baik, S.H.9
Choi, K.M.10
-
17
-
-
33846115077
-
Inhibition of TNF-alpha reduces myocardial injury and proinflammatory pathways following ischemia-reperfusion in the dog
-
Gu, Q.; Yang, X.P.; Bonde, P.; Di Paula, A.; Fox-Talbot, K.Becker, L.C. Inhibition of TNF-alpha reduces myocardial injury and proinflammatory pathways following ischemia-reperfusion in the dog. J Cardiovasc Pharmacol, 2006, 48, 320-327.
-
(2006)
J Cardiovasc Pharmacol
, vol.48
, pp. 320-327
-
-
Gu, Q.1
Yang, X.P.2
Bonde, P.3
Di Paula, A.4
Fox-Talbot, K.5
Becker, L.C.6
-
18
-
-
49749146408
-
Effects of HMG-Co A Reductase Inhibition by Simvastatin on Vascular Dysfunction Induced by Lipopolysaccharide in Rats
-
Alvarez S.M.; Vega, S.; Mingorance, C.; Marhuenda, E.Herrera, M.D. Effects of HMG-Co A Reductase Inhibition by Simvastatin on Vascular Dysfunction Induced by Lipopolysaccharide in Rats. Pharmacology, 2008, 82, 89-96.
-
(2008)
Pharmacology
, vol.82
, pp. 89-96
-
-
Alvarez, S.M.1
Vega, S.2
Mingorance, C.3
Marhuenda, E.4
Herrera, M.D.5
-
19
-
-
0036218724
-
Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element
-
DOI 10.1172/JCI200214505
-
Claudel, T.; Sturm, E.; Duez, H.; Torra, I.P.; Sirvent, A.; Kosykh, V.; Fruchart, J.C.; Dallongeville, J.; Hum, D.W.; Kuipers, F.Staels, B. Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element. J Clin Invest, 2002, 109, 961-971. (Pubitemid 34275117)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.7
, pp. 961-971
-
-
Claudel, T.1
Sturm, E.2
Duez, H.3
Torra, I.P.4
Sirvent, A.5
Kosykh, V.6
Fruchart, J.-C.7
Dallongeville, J.8
Hum, D.W.9
Kuipers, F.10
Staels, B.11
-
20
-
-
34547630092
-
Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis
-
DOI 10.1161/ATVBAHA.107.141911, PII 0004360520070800000006
-
Mackman, N.; Tilley, R.E.Key, N.S. Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler Thromb Vasc Biol, 2007, 27, 1687-1693. (Pubitemid 47207163)
-
(2007)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.27
, Issue.8
, pp. 1687-1693
-
-
Mackman, N.1
Tilley, R.E.2
Key, N.S.3
-
21
-
-
34250170510
-
The intrinsic pathway of coagulation: A target for treating thromboembolic disease?
-
DOI 10.1111/j.1538-7836.2007.02446.x
-
Gailani, D.Renne, T. The intrinsic pathway of coagulation: a target for treating thromboembolic disease? J Thromb Haemost, 2007, 5, 1106-1112. (Pubitemid 46902107)
-
(2007)
Journal of Thrombosis and Haemostasis
, vol.5
, Issue.6
, pp. 1106-1112
-
-
Gailani, D.1
Renne, T.2
-
22
-
-
80655144322
-
-
Bioinformatics and drug design group
-
Bioinformatics and drug design group. Therapeutic targets database. http://xin.cz3.nus.edu.sg/group/cjttd/ttd.asp.
-
Therapeutic Targets Database
-
-
-
25
-
-
0038700482
-
Centers of complex networks
-
Wuchty, S.P.F., S. Centers of complex networks. J Theor Biol, 2003, 223, 45-53
-
(2003)
J Theor Biol
, vol.223
, pp. 45-53
-
-
Wuchty, S.P.F.S.1
-
26
-
-
80655144321
-
-
Centralities in Biological Networks
-
Centralities in Biological Networks. http://centibin.ipk- gatersleben.de/.
-
-
-
-
27
-
-
80655144320
-
Tongguan capsule has effect on blood-lipid level and plasma concentration of inflammatory cytokines of the high fat rats
-
Zhao, X.Zhang, M. Tongguan capsule has effect on blood-lipid level and plasma concentration of inflammatory cytokines of the high fat rats. Chinese journal of intergrative medicine on cardio- /cerebro vascular disease, 2007, 5, 951-952.
-
(2007)
Chinese Journal of Intergrative Medicine on Cardio- /Cerebro Vascular Disease
, vol.5
, pp. 951-952
-
-
Zhao, X.1
Zhang, M.2
-
28
-
-
80655144318
-
Tongguang capsule had effected on coagulation-fibrilysis system of unstabe angina pectoris patients
-
Ge, Z.; Zhang, M.; Chen, B.; Wang, D.; Zhou, D.; Bin, D.Li, Y. Tongguang capsule had effected on coagulation-fibrilysis system of unstabe angina pectoris patients. New Medicine, 2010, 41, 794-796.
-
(2010)
New Medicine
, vol.41
, pp. 794-796
-
-
Ge, Z.1
Zhang, M.2
Chen, B.3
Wang, D.4
Zhou, D.5
Bin, D.6
Li, Y.7
-
29
-
-
33144474901
-
What's in the black box?
-
DOI 10.1378/chest.129.1.7
-
Kunz, R. "What's in the black box?". Chest, 2006, 129, 7-10. (Pubitemid 43265236)
-
(2006)
Chest
, vol.129
, Issue.1
, pp. 7-10
-
-
Kunz, R.1
-
30
-
-
0037390017
-
Molecular therapeutics: Is one promiscuous drug against multiple targets better than combinations of molecule-specific drugs?
-
Arteaga, C.L. Molecular therapeutics: is one promiscuous drug against multiple targets better than combinations of molecule- specific drugs? Clin Cancer Res, 2003, 9, 1231-1232. (Pubitemid 36418369)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.4
, pp. 1231-1232
-
-
Arteaga, C.L.1
|