Effects of undenatured whey protein supplementation on CXCL12- and CCL21-mediated B and T cell chemotaxis in diabetic mice

Lipids in Health and Disease

Volumn 10, Issue , 2011, Pages

  Badr, Gamal ^a,b   Mohany, Mohamed ^a   Metwalli, Ali ^c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Assiut University   (Egypt)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

B cells; chemotaxis; diabetes mellitus; F actin polymerization; T cells; whey protein

Indexed keywords

CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; F ACTIN; PROTEIN; ACTIN; CCR7 PROTEIN, MOUSE; CXCL12 PROTEIN, MOUSE; CXCR4 PROTEIN, MOUSE; MILK PROTEIN; SECONDARY LYMPHOID TISSUE CHEMOKINE; STROMAL CELL DERIVED FACTOR 1; WHEY PROTEIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CHEMOTAXIS; CONTROLLED STUDY; DIABETES MELLITUS; DIET SUPPLEMENTATION; FLOW CYTOMETRY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INTAKE; STREPTOZOCIN DIABETES; T LYMPHOCYTE; WHEY; ANIMAL; CAMEL; CELL CULTURE; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION; GENETICS; METABOLISM; PROTEIN MULTIMERIZATION;

MUS;

ACTINS; ANIMALS; B-LYMPHOCYTES; CAMELS; CELLS, CULTURED; CHEMOKINE CCL21; CHEMOKINE CXCL12; CHEMOTAXIS; DIABETES MELLITUS, EXPERIMENTAL; DIETARY SUPPLEMENTS; GENE EXPRESSION; MALE; MICE; MILK PROTEINS; PROTEIN MULTIMERIZATION; RECEPTORS, CCR7; RECEPTORS, CXCR4; T-LYMPHOCYTES;

EID: 80655139141     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-10-203     Document Type: Article

References (32)

1. Animal models of diabetes mellitus: relevance to vascular complications. Thompson CS, Curr Pharm Des 2008 14 309 324 10.2174/138161208783497679 18289058 (Pubitemid 351516856)
2. Infectious emergencies in patients with diabetes mellitus. Smitherman KO, Peacock JE, Med Clin North Am 1995 79 53 77 7808095
3. Numerical defects in CD8+CD28- T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis. Mikulkova Z, Praksova P, Stourac P, Bednarik J, Strajtova L, Pacasova R, Belobradkova J, Dite P, Michalek J, Cell Immunol 2010 262 75 9 10.1016/j.cellimm.2010.02.002 20219185
4. Peripheral insulin insensitivity in the hyperglycemic athymic nude mouse: similarity to noninsulin-dependent diabetes mellitus. Zeidler A, Shargill NS, Chan TM, Proc Soc Exp Biol Med 1991 196 457 460 2008443
5. Lymphocyte activation in type 1 diabetes mellitus: the increased significance of Kv1.3 potassium channels. Toldi G, Vásárhelyi B, Kaposi A, Mészáros G, Pánczél P, Hosszufalusi N, Tulassay T, Treszl A, Immunol Lett 2010 133 35 41 10.1016/j.imlet.2010.06.009 20603149
6. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA, J Immunol 2009 183 4432 9 10.4049/jimmunol.0900576 19748982
7. T-cell function and migration: two sides of the same coin. Von Andrian U, Mackay C, N Engl J Med 2000 343 1020 1034 10.1056/NEJM200010053431407 11018170
8. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. Gunn MD, Kyuwa S, Tam C, Kakiuchi T, Matsuzawa A, Williams LT, Nakano H, J Exp Med 1999 189 451 460 10.1084/jem.189.3.451 9927507 (Pubitemid 29187367)
9. IFN-alpha enhances human B-cell chemotaxis by modulating ligand-induced chemokine receptor signaling and internalization. Badr G, Borhis G, Treton D, Richard Y, Int Immunol 2005 17 459 67 10.1093/intimm/dxh227 15749730 (Pubitemid 40568121)
10. Cellular motility driven by assembly and disassembly of actin filaments. Pollard TD, Borisy GG, Cell 2003 112 453 65 10.1016/S0092-8674(03)00120-X 12600310 (Pubitemid 36263079)
11. Whey proteins influence hepatic glutathione after CCl4 intoxication. Balbis E, Patriarca S, Furfaro A, Millanta S, Sukkar GS, Marinari MU, Pronzato AM, Cottalasso D, Traverso N, Toxico Ind Heal 2009 25 325 328 10.1177/0748233709104870
12. Imunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins. Gauthier SF, Pouliot Y, Saint-Sauveur D, Inter Dairy J 2006 16 1315 1323 10.1016/j.idairyj.2006.06.014 (Pubitemid 44331589)
13. Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients. Micke P, Beeh KM, Schlaak JF, Buhl R, Eur J Clin Invest 2001 31 171 8 10.1046/j.1365-2362.2001.00781.x 11168457 (Pubitemid 32199911)
14. Emerging health properties of whey proteins and their clinical implications. Krissansen GW, J Am Coll Nutr 2007 26 713 23
15. Whey proteins and peptides: beneficial effects on immune health. Beaulieu J, Dupont C, Lemieux P, Therapy 2006 3 1 10 10.2217/14750708.3.1.1
16. A bovine whey protein extract stimulates human neutrophils to generate bioactive IL-1Ra through a NF-kappaB- and MAPK-dependent mechanism. Rusu D, Drouin R, Pouliot Y, Gauthier S, Poubelle PE, J Nutr 2010 140 2 382 91 10.3945/jn.109.109645 20032479
17. GABRIELA study group. The protective effect of farm milk consumption on childhood asthma and atopy: The GABRIELA study. Loss G, Apprich S, Waser M, Kneifel W, Genuneit J, Büchele G, Weber J, Sozanska B, Danielewicz H, Horak E, van Neerven RJ, Heederik D, Lorenzen PC, von Mutius E, Braun-Fahrländer C, J Allergy Clin Immunol 2011 128 766 773 10.1016/j.jaci.2011.07.048 21875744
18. In vitro impact of a whey protein isolate (WPI) and collagen hydrolysates (CHs) on B16F10 melanoma cells proliferation. Castro GA, Maria DA, Bouhallab S, Sgarbieri VC, J Dermatol Sci 2009 56 51 7 10.1016/j.jdermsci.2009.06.016 19695839
19. Protective effect of whey proteins against nonalcoholic fatty liver in rats. Hamad EM, Taha SH, Abou Dawood AG, Sitohy MZ, Abdel-Hamid M, Lipids Health Dis 2011 10 57 10.1186/1476-511X-10-57 21489294
20. Acute effects of whey protein isolate on cardiovascular risk factors in overweight, post-menopausal women. Pal S, Ellis V, Ho S, Atherosclerosis 2010 212 339 44 10.1016/j.atherosclerosis.2010.05.032 20561625
21. Dietary cheese whey protein protects rats against mild dextran sulfate sodium-induced colitis: role of mucin and microbiota. Sprong RC, Schonewille AJ, van der Meer R, J Dairy Sci 2010 93 1364 71 10.3168/jds.2009-2397 20338413
22. Coronins: the return of the crown. Uetrecht AC, Bear JE, Trends Cell Biol 2006 16 421 426 10.1016/j.tcb.2006.06.002 16806932 (Pubitemid 44118779)
23. Increasing neutrophil F-actin corrects CD11b exposure in Type 2 diabetes. Advani A, Marshall SM, Thomas TH, Eur J Clin Invest 2004 34 358 64 10.1111/j.1365-2362.2004.01346.x 15147333 (Pubitemid 38748076)
24. Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Gomez TS, Hamann MJ, McCarney S, Savoy DN, Lubking CM, Heldebrant MP, Labno CM, McKean DJ, McNiven MA, Burkhardt JK, Billadeau DD, Nat Immunol 2005 6 261 270 10.1038/ni1168 15696170 (Pubitemid 41724763)
25. T lymphocytes from malnourished infants are short-lived and dysfunctional cells. Badr G, Sayed D, Alhazza IM, Elsayh KI, Ahmed EA, Alwasel SH, Immunobiology 2011 216 309 15 10.1016/j.imbio.2010.07.007 20822829
26. Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes. Segal MS, Shah R, Afzal A, Perrault CM, Chang K, Schuler A, Beem E, Shaw LC, Li Calzi S, Harrison JK, Tran-Son-Tay R, Grant MB, Diabetes 2006 55 102 9 10.2337/diabetes.55.01.06. db05-0803 16380482 (Pubitemid 43343304)
27. The CXCR4/CXCL12 (SDF-1) signalling pathway protects non-obese diabetic mouse from autoimmune diabetes. Aboumrad E, Madec AM, Thivolet C, Clin Exp Immunol 2007 148 432 9 10.1111/j.1365-2249.2007.03370.x 17374136 (Pubitemid 46701033)
28. Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice. Blades MC, Manzo A, Ingegnoli F, Taylor PR, Panayi GS, Irjala H, Jalkanen S, Haskard DO, Perretti M, Pitzalis C, J Immunol 2002 168 4308 11970972
29. Assessment of lymphocyte proliferation: CFSE kills dividing cells and modulates expression of activation markers. Lastovicka J, Budinsky V, Spisek R, Bartunková J, Cell Immunol 2009 256 79 85 10.1016/j.cellimm.2009.01.007 19233349
30. A bovine whey protein extract can enhance innate immunity by priming normal human blood neutrophils. Rusu D, Drouin R, Pouliot Y, Gauthier S, Poubelle PE, J Nutr 2009 139 386 93 19106313
31. Long-term effects of gestational diabetes on offspring health are more pronounced in skeletal growth than body composition and glucose tolerance. Zhao J, Weiler HA, Br J Nutr 2010 9 1 9
32. Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice. Moratz C, Hayman JR, Gu H, Kehrl JH, Mol Cell Biol 2004 24 5767 75 10.1128/MCB.24.13. 5767-5775.2004 15199133 (Pubitemid 38787962)