Conformation-activity relationships of cyclo-constrained μ/δ opioid agonists derived from the N-terminal tetrapeptide segment of dermorphin/deltorphin

Journal of Peptide Science

Volumn 14, Issue 8, 2008, Pages 898-902

  Rodziewicz Motowidło, Sylwia ^a   Czaplewski, Cezary ^a   Łuczak, Sylwia ^a   Ciarkowski, Jerzy ^a  

^a UNIVERSITY OF GDA SK   (Poland)

Author keywords

Conformation; Dermorphin deltorphin; NMR; Opioid cyclopeptides; SAR

Indexed keywords

DELTA OPIATE RECEPTOR; DELTORPHIN; DERMORPHIN; DISULFIDE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; OPIATE AGONIST; PHENYLALANINE; TETRAPEPTIDE; TYROSINE; TYROSYL DEXTRO ARGINYLPHENYLALANYLLYSINAMIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

COMPUTER SIMULATION; CYCLIZATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; OLIGOPEPTIDES; OPIOID PEPTIDES; PROTEIN CONFORMATION; RECEPTORS, OPIOID, DELTA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 50449093624     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.1022     Document Type: Article

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