(2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: An aldose reductase inhibitor and antioxidant of zwitterionic nature

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 23, 2011, Pages 7181-7185

  Stefek, Milan ^a   Tsantili Kakoulidou, Anna ^b   Milackova, Ivana ^a   Juskova, Maria ^a   Snirc, Vladimir ^a   Triantos, Nikos ^b  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Aldose reductase inhibition; Antioxidant; Diabetic complications; Zwitterions

Indexed keywords

(2 BENZYL 2,3,4,5 TETRAHYDRO 1H PYRIDO[4,3 B]INDOL 8 YL)ACETIC ACID; ALDOSE REDUCTASE INHIBITOR; AMPHOLYTE; ANTIOXIDANT; PEROXY RADICAL; SORBITOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ERYTHROCYTE; HEMOLYSIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOELECTRIC POINT; LIPOPHILICITY; MALE; MORNING DOSAGE; NONHUMAN; PH; PHARMACOPHORE; PHYSICAL CHEMISTRY; RAT; STREPTOZOCIN DIABETES;

ACETIC ACIDS; ALDEHYDE REDUCTASE; ANIMALS; ANTIOXIDANTS; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; ERYTHROCYTES; MALE; RATS; RATS, WISTAR; SORBITOL;

RATTUS;

EID: 80655132873     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.09.053     Document Type: Article

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