Quantification of the fragmentation of rest-activity patterns in elderly individuals using a state transition analysis

Sleep

Volumn 34, Issue 11, 2011, Pages 1569-1581

  Lim, Andrew S P ^a   Yu, Lei ^b   Costa, Madalena D ^c,d   Buchman, Aron S ^b   Bennett, David A ^b   Leurgans, Sue E ^b   Saper, Clifford B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

Actigraphy; Aging; Mathematical modeling; State transition analysis

Indexed keywords

ACTIMETRY; AGE; AGED; AGING; ARTICLE; BODY MASS; COMMUNITY LIVING; COMORBIDITY; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL COMPUTING; MEMORY; POLYSOMNOGRAPHY; PRIORITY JOURNAL; REGRESSION ANALYSIS; REST ACTIVITY PATTERN; SEX; SLEEP WAKING CYCLE; STATE TRANSITION ANALYSIS; STATISTICAL ANALYSIS; TIME;

ACTIGRAPHY; AGE FACTORS; AGED; AGED, 80 AND OVER; ALGORITHMS; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; DATA INTERPRETATION, STATISTICAL; FEMALE; HUMANS; MALE; MIDDLE AGED; SEX FACTORS; SLEEP; WAKEFULNESS;

EID: 80655128150     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.1400     Document Type: Article

References (56)

1. Tartar JL, Ward CP, McKenna JT, et al. Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation. Eur J Neurosci 2006;23:2739-48. (Pubitemid 43801466)
2. Roehrs T, Merlotti L, Petrucelli N, Stepanski E, Roth T. Experimental sleep fragmentation. Sleep 1994;17:438-43. (Pubitemid 24271518)
3. Bonnet MH. The effect of sleep fragmentation on sleep and performance in younger and older subjects. Neurobiol Aging 1989;10:21-5. (Pubitemid 19164496)
4. Martin SE, Engleman HM, Deary IJ, Douglas NJ. The effect of sleep fragmentation on daytime function. Am J Respir Crit Care Med 1996;153:1328-32. (Pubitemid 26112599)
5. Zorick F, Roehrs T, Wittig R, Lamphere J, Sicklesteel J, Roth T. Sleep-wake abnormalities in narcolepsy. Sleep 1986;9:189-93. (Pubitemid 18008494)
6. Roehrs T, Zorick F, Wittig R, Conway W, Roth T. Predictors of objective level of daytime sleepiness in patients with sleep-related breathing disorders. Chest 1989;95:1202-6. (Pubitemid 19160140)
7. Hu K, Van Someren EJ, Shea SA, Scheer FA. Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker. Proc Natl Acad Sci U S A 2009;106:2490-4.
8. Lu J, Greco MA, Shiromani P, Saper CB. Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep. J Neurosci 2000;20:3830-42. (Pubitemid 30266244)
9. Diniz Behn CG, Klerman EB, Mochizuki T, Lin SC, Scammell TE. Abnormal sleep/wake dynamics in orexin knockout mice. Sleep 2010;33:297-306.
10. Bowe TR, Anders TF. The use of the semi-Markov model in the study of the development of sleep-wake states in infants. Psychophysiology 1979;16:41-8. (Pubitemid 9060997)
11. Kemp B, Kamphuisen HA. Simulation of human hypnograms using a Markov chain model. Sleep 1986;9:405-14. (Pubitemid 18026023)
12. Yassouridis A, Steiger A, Klinger A, Fahrmeir L. Modelling and exploring human sleep with event history analysis. J Sleep Res 1999;8:25-36. (Pubitemid 29118873)
13. Karlsson MO, Schoemaker RC, Kemp B, et al. A pharmacodynamic Markov mixed-effects model for the effect of temazepam on sleep. Clin Pharmacol Ther 2000;68:175-88. (Pubitemid 30659173)
14. Lo CC, Chou T, Penzel T, et al. Common scale-invariant patterns of sleep-wake transitions across mammalian species. Proc Natl Acad Sci U S A 2004;101:17545-8. (Pubitemid 39657440)
15. Penzel T, Lo CC, Ivanov P, Kesper K, Becker H, Vogelmeier C. Analysis of sleep fragmentation and sleep structure in patients with sleep apnea and normal volunteers. Conf Proc IEEE Eng Med Biol Soc 2005;3:2591-4. (Pubitemid 46229448)
16. Kishi A, Struzik ZR, Natelson BH, Togo F, Yamamoto Y. Dynamics of sleep stage transitions in healthy humans and patients with chronic fatigue syndrome. Am J Physiol Regul Integr Comp Physiol 2008;294:R1980-7.
17. Chervin RD, Fetterolf JL, Ruzicka DL, Thelen BJ, Burns JW. Sleep stage dynamics differ between children with and without obstructive sleep apnea. Sleep 2009;32:1325-32.
18. Bianchi MT, Cash SS, Mietus J, Peng CK, Thomas R. Obstructive sleep apnea alters sleep stage transition dynamics. PLoS One 2010;5:e11356.
19. Diniz Behn CG, Kopell N, Brown EN, Mochizuki T, Scammell TE. Delayed orexin signaling consolidates wakefulness and sleep: physiology and modeling. J Neurophysiol 2008;99:3090-103.
20. Klerman EB, Davis JB, Duffy JF, Dijk DJ, Kronauer RE. Older people awaken more frequently but fall back asleep at the same rate as younger people. Sleep 2004;27:793-8. (Pubitemid 38823378)
21. Swihart BJ, Caffo B, Bandeen-Roche K, Punjabi NM. Characterizing sleep structure using the hypnogram. J Clin Sleep Med 2008;4:349-55.
22. Norman RG, Scott MA, Ayappa I, Walsleben JA, Rapoport DM. Sleep continuity measured by survival curve analysis. Sleep 2006;29:1625-31. (Pubitemid 44936472)
23. Zung WW, Naylor TH, Gianturco DT, Wilson WP. Computer simulation of sleep EEG patterns with a Markov chain model. Recent Adv Biol Psychiatry 1965;8:335-55.
24. Cole RJ, Kripke DF, Gruen W, Mullaney DJ, Gillin JC. Automatic sleep/wake identification from wrist activity. Sleep 1992;15:461-9.
25. Sokolove PG, Bushell WN. The chi square periodogram: its utility for analysis of circadian rhythms. J Theor Biol 1978;72:131-60. (Pubitemid 8350595)
26. Witting W, Kwa IH, Eikelenboom P, Mirmiran M, Swaab DF. Alterations in the circadian rest-activity rhythm in aging and Alzheimer's disease. Biol Psychiatry 1990;27:563-72. (Pubitemid 20114821)
27. Hu K, Ivanov P, Chen Z, Hilton MF, Stanley HE, Shea SA. Non-random fluctuations and multi-scale dynamics regulation of human activity. Physica A 2004;337:307-18.
28. Boselli M, Parrino L, Smerieri A, Terzano MG. Effect of age on EEG arousals in normal sleep. Sleep 1998;21:351-7. (Pubitemid 128470318)
29. Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 2004;27:1255-73. (Pubitemid 44138893)
30. Redline S, Kirchner HL, Quan SF, Gottlieb DJ, Kapur V, Newman A. The effects of age, sex, ethnicity, and sleep-disordered breathing on sleep architecture. Arch Intern Med 2004;164:406-18. (Pubitemid 38240705)
31. Huang YL, Liu RY, Wang QS, Van Someren EJ, Xu H, Zhou JN. Age-associated difference in circadian sleep-wake and rest-activity rhythms. Physiol Behav 2002;76:597-603. (Pubitemid 34786687)
32. Bennett DA, Schneider JA, Buchman AS, Mendes de Leon C, Bienias JL, Wilson RS. The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort. Neuroepidemiology 2005;25:163-75. (Pubitemid 41540657)
33. Cleveland WS, Devlin SJ. Locally-Weighted Regression: An Approach to Regression Analysis by Local Fitting. Journal of the American Statistical Association 1988;83:596-610.
34. Oosterman JM, van Someren EJ, Vogels RL, Van Harten B, Scherder EJ. Fragmentation of the rest-activity rhythm correlates with age-related cognitive deficits. J Sleep Res 2009;18:129-35.
35. Buchman AS, Wilson RS, Bennett DA. Total daily activity is associated with cognition in older persons. Am J Geriatr Psychiatry 2008;16:697-701.
36. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44. (Pubitemid 14076461)
37. Langston JW, Widner H, Goetz CG, et al. Core assessment program for intracerebral transplantations (CAPIT). Mov Disord 1992;7:2-13.
38. R Development Core Team. R: A language and environment for statistical computing. Vienne, Austria: R Foundation for Statistical Computing, 2008.
39. Yang MC, Hursch CJ. The use of a semi-Markov model for describing sleep patterns. Biometrics 1973;29:667-76.
40. Bernabeu R, Yang T, Xie Y, Mehta B, Ma SY, Longo FM. Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons. Mol Cell Neurosci 2006;31:723-38.
41. Krishnasamy I. Statistical modeling of the sleep hypnogram and an analysis of sufficient statistics for grouped data. New York: New York University, 1994.
42. Saper CB, Fuller PM, Pedersen NP, Lu J, Scammell TE. Sleep state switching. Neuron 2010;68:1023-42.
43. Phillips AJ, Robinson PA, Kedziora DJ, Abeysuriya RG. Mammalian sleep dynamics: how diverse features arise from a common physiological framework. PLoS Comput Biol 2010;6:e1000826.
44. Unruh ML, Redline S, An MW, et al. Subjective and objective sleep quality and aging in the sleep heart health study. J Am Geriatr Soc 2008;56:1218-27.
45. Reyner LA, Horne JA, Reyner A. Gender- and age-related differences in sleep determined by home-recorded sleep logs and actimetry from 400 adults. Sleep 1995;18:127-34.
46. Buysse DJ, Reynolds CF, 3rd, Monk TH, Hoch CC, Yeager AL, Kupfer DJ. Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI). Sleep 1991;14:331-8.
47. Foley DJ, Monjan AA, Brown SL, Simonsick EM, Wallace RB, Blazer DG. Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep 1995;18:425-32.
48. van den Berg JF, Knvistingh Neven A, Tulen JH, et al. Actigraphic sleep duration and fragmentation are related to obesity in the elderly: the Rotterdam Study. Int J Obes (Lond) 2008;32:1083-90. (Pubitemid 351986204)
49. Yoshioka M, Ayabe M, Yahiro T, et al. Long-period accelerometer monitoring shows the role of physical activity in overweight and obesity. Int J Obes (Lond) 2005;29:502-8. (Pubitemid 40592992)
50. Hofman MA, Swaab DF. The sexually dimorphic nucleus of the preoptic area in the human brain: a comparative morphometric study. J Anat 1989;164:55-72. (Pubitemid 19161710)
51. Ohm TG, Busch C, Bohl J. Unbiased estimation of neuronal numbers in the human nucleus coeruleus during aging. Neurobiol Aging 1997;18:393-9. (Pubitemid 27435081)
52. Harper DG, Stopa EG, Kuo-Leblanc V, et al. Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia. Brain 2008;131:1609-17. (Pubitemid 351806453)
53. Gu D, Sautter J, Pipkin R, Zeng Y. Sociodemographic and health correlates of sleep quality and duration among very old Chinese. Sleep 2010;33:601-10.
54. Cirelli C, Bushey D. Sleep and wakefulness in Drosophila melanogaster. Ann N Y Acad Sci 2008;1129:323-9. (Pubitemid 351990287)
55. Raizen DM, Zimmerman JE, Maycock MH, et al. Lethargus is a Caenorhabditis elegans sleep-like state. Nature 2008;451:569-72. (Pubitemid 351186273)
56. Yokogawa T, Marin W, Faraco J, et al. Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol 2007;5:e277.