Simultaneous determination of asperosaponin VI and its active metabolite hederagenin in rat plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 30, 2011, Pages 3407-3414

  Zhu, He ^a   Ding, Li ^a   Shakya, Shailendra ^a   Qi, Xiemin ^a   Hu, Linlin ^a   Yang, Xiaolin ^a   Yang, Zhonglin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Asperosaponin VI; Hederagenin; Ion switching; Liquid chromatography tandem mass spectrometry; Pharmacokinetics

Indexed keywords

ACTIVE METABOLITES; AMMONIUM ACETATE; ASPEROSAPONIN VI; COLLISION ENERGIES; FRAGMENT IONS; GLACIAL ACETIC ACID; GLYCYRRHETIC ACID; GRADIENT ELUTION; HEDERAGENIN; INTERNAL STANDARDS; ION-SWITCHING; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MOBILE PHASE; MOLECULAR IONS; MULTIPLE-REACTION MONITORING MODES; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; PROTONATED MOLECULAR IONS; RAT PLASMA; REVERSED PHASE; SIMULTANEOUS DETERMINATIONS; SODIUM ACETATE; SWITCHING MODES; TANDEM MASS SPECTROMETRY; TARGET COMPOUND; VALIDATED METHODS;

ACETIC ACID; ACETONITRILE; AMMONIUM COMPOUNDS; BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ION SOURCES; IONIZATION; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; METHANOL; ORGANIC SOLVENTS; PHARMACOKINETICS; PLASMAS; RATS; SWITCHING; VOLATILE FATTY ACIDS;

IONS;

ACETIC ACID; ACETONITRILE; AMMONIUM ACETATE; ANALGESIC AGENT; ANION; ASPEROSAPONIN VI; DIAZEPAM; GLYCYRRHETINIC ACID; HEDERAGENIN; METHANOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG SYNTHESIS; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; OLEANOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SAPONINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 80555150575     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.09.014     Document Type: Article

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