Apoptosis-inducing effect of Akebia saponin D from the roots of Dipsacus asper Wall in U937 cells

Archives of Pharmacal Research

Volumn 31, Issue 11, 2008, Pages 1399-1404

  Jeong, Seung Il ^a,b   Zhou, Beng ^a   Bae, Jin Beom ^a   Kim, Nam Seok ^a   Kim, Sun Geun ^a   Kwon, Jin ^c   Kim, Dae Keun ^a   Shin, Tae Yong ^a   Jeon, Hoon ^a   Lim, Jong Phil ^a   Kim, Hongjun ^a   Kim, Ho Kyoung ^d   Oh, Chan Ho ^a  

^a Woosuk University   (South Korea)

^b Jeonju Bio Materials Institute   (South Korea)

^c Korea National College of Rehabilitation and Welfare   (South Korea)

^d Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

Akebia saponin D; Apoptosis; Bax gene; Dipsacus asper; P53; U937 cells

Indexed keywords

AKEBIA SAPONIN D; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; DOXORUBICIN; NITRIC OXIDE; PROTEIN BAX; SAPONIN;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL STRAIN U937; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DIPSACACEAE; DNA FRAGMENTATION; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; PHYSIOLOGY; PLANT ROOT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL SURVIVAL; DIPSACACEAE; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION; GENES, P53; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITRIC OXIDE; PLANT ROOTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SAPONINS; U937 CELLS;

EID: 56749132289     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-001-2123-0     Document Type: Article

References (27)

1. J. M. Adams S. Corry 1998 The Bcl-2 protein family: Arbiters of cell survival Science 28 1322 1326
2. E. Bedir H. Kirmizipekmez O. Sticher I. Calis 2000 Triterpene saponins from the fruits of Hedera helix Phytochemistry 53 905 909
3. A. H. Ding C. F. Nathan D. J. Steuhr 1988 Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages J. Immunol. 141 2407 2412
4. Dowdy, S. and Wearden, S., Statistics for research. Wiley, New York, p. 262 (1983).
5. X. Z. Feng M. Dong Z. J. Gao S. X. Xu 2003 Three new triterpenoid saponins from Ixeris sonchifolia and their cytotoxic activity Planta Med. 69 1036 1040
6. D. Fukumura S. Kashiwagi R. K. Jain 2006 The role of nitric oxide in tumor progression Nat. Rev. Cancer 6 521 534
7. T. M. Hung W. Jin P. T. Thuong K. S. Song Y. H. Seong K. Bae 2005 Cytotoxic saponins from the root of Dipsacus asper Wall Arch. Pharm. Res. 28 1053 1056
8. Jung, K. Y., Studies on the terpenoid constituents from the roots of Dipsacus asper Wall. Ph.D. Thesis, Yeungam University (1995).
9. K. Y. Jung J. C. Do K. H. Son 1993 Triterpene glycosides from the roots of Dipsacus asper J. Nat. Prod. 56 1912 1916
10. I. Kouno A. Tsuboi M. Nanri M. Kawano 1990 Acylated triterpene glycoside from roots of Dipsacus asper Phytochemistry 29 338 339
11. D. J. McConkey G. Greene C. A. Pettaway 1996 Apoptosis resistance increases with metastatic potential in cells of the human LNCaP prostate carcinoma line Cancer Res. 56 5594 5599
12. T. Miyashita S. Krajewski M. Krajewska H. G. Wang H. K. Lin D. A. Liebermann B. Hoffmann J. C. Reed 1994 Tumor suppressor p53 is a regulator of Bcl-2 and bax gene expression in vitro and in vivo Oncogene 9 1799 1805
13. T. Mosmann 1983 Rapid colorimetric assay for cellular growth and survival application to proliferation and cytotoxic assays J. Immunol. Methods 65 55 63
14. A. Nakadai Q. Li T. Kawada 2006 Chlorpyrifos induces apoptosis in human monocyte cell line U937 Toxicology 224 202 209
15. Namba, T., The encyclopedia of waken-yaku (traditional sino-japan medicines) with color pictures, vol. 1. Hoikusha Publishing, Osaka, pp. 185-186 (1993).
16. K. Ohkusu K. Isobe H. Hidaka I. Nakashima 1995 Elucidation of the protein kinase C-dependent apoptosis pathway in distinct subsets of T lymphocytes in MRL-lpr/lpr mice Eur. J. Immunol. 31 3180 3186
17. S. R. Oh K. Y. Jung K. H. Son S. H. Park I. S. Lee K. S. Ahn H. K. Lee 1999 In vitro anticomplementary activity of hederagenin saponins isolated from roots of Dipsacus asper Arch. Pharm. Res. 22 317 319
18. C. Shijun S. R. Jonathan B. M. Romeo J. A. Jroge 1994 Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or independent mechanisms Cancer Res. 54 2462 2467
19. H. W. Suh D. K. Song S. O. Huh K. H. Son Y. H. Kim 2000 Antinociceptive mechanisms of Dipsacus saponin C administered intrathecally in mice J. Ethnopharmacol. 71 211 218
20. L. L. Thomsen D. W. Miles 1998 Role of nitric oxide in tumour progression: lessons from human tumours Cancer Metastasis Rev 17 107 118
21. 2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells Anticancer Res. 26 1965 1971
22. H. Uramoto K. Sugio T. Oyama S. Nakata K. Ono T. Nozoe K. Yasumoto 2006 Expression of the p53 family in lung cancer Anticancer Res. 26 1785 1790
23. H. B. Wang R. Mayer G. Rcker 1993 Triterpenoid glycosides from Stauntonia hexaphylla Phytochemistry 33 1469 1473
24. J. L. Williams N. Nath J. Chen T. R. Hundley J. Gao L. Kopelovich K. Kashfi B. Rigas 2003 Growth inhibition of human colon cancer cells by nitric oxide (NO) Anticancer Res. 63 7613 7618
25. G. Y. Yang J. Liao K. H. Kim E. J. Yurkow C. S. Yang 1998 Inhibition of growth and induction of apoptosis in human cancer lines by tea polyphenols Carcinogenesis 19 611 616
26. C. Y. Yin C. M. Knudson S. J. Korsmeyer T. VanDyke 1997 Bax suppresses tumorigenesis and stimulates apoptosis in vivo Nature 385 637 640
27. Q. Zhan S. Fan I. Bae C. Guillouf D. A. Liebermann P. M. O'Connor 1994 Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis Oncogene 9 3743 3751