Reversed phase liquid chromatography method with fluorescence detection of gemifloxacin in rat plasma and its application to the pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 30, 2011, Pages 3639-3644

  Kaiser, Moacir ^a   Grünspan, Lauren D ^b   Costa, Teresa Dalla ^a   Tasso, Leandro ^b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITY OF CAXIAS DO SUL   (Brazil)

Author keywords

Fluorescence detection; Gemifloxacin; LC; Pharmacokinetics; Rat plasma

Indexed keywords

ANALYTES; ATLANTIS; AUTOSAMPLERS; CALIBRATION CURVES; CHROMATOGRAPHIC METHODS; CHROMATOGRAPHIC RESOLUTIONS; CONCENTRATION RANGES; DEPROTEINIZATION; DRUG STABILITY; EMISSION WAVELENGTH; ENDOGENOUS SUBSTANCES; FLUORESCENCE DETECTION; FREEZE-THAW CYCLES; FUROSEMIDES; GEMIFLOXACIN; INJECTION VOLUME; INTERNAL STANDARDS; INTRAVENOUS ADMINISTRATION; LC; LOWER LIMIT OF QUANTITATIONS; MOBILE PHASE; PEAK AREA; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; RAT PLASMA; RELATIVE STANDARD DEVIATION (R.S.D.); RETENTION TIME; REVERSED PHASE LIQUID-CHROMATOGRAPHY; ROOM TEMPERATURE; STANDARD SOLUTIONS; TRIETHYLAMINES; UPPER LIMITS;

ACETONITRILE; BODY FLUIDS; CALIBRATION; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; METHANOL; PHARMACOKINETICS; PLASMAS; RATS;

PLASMA STABILITY;

FUROSEMIDE; GEMIFLOXACIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; DRUG STRUCTURE; FLOW RATE; FLUORESCENCE ANALYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; ROOM TEMPERATURE;

ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, REVERSE-PHASE; DRUG STABILITY; FLUOROQUINOLONES; LINEAR MODELS; MALE; NAPHTHYRIDINES; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE;

RATTUS;

EID: 80555149388     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.09.011     Document Type: Article

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