Multiple-dose pharmacokinetics and tolerability of gemifloxacin administered orally to healthy volunteers

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 2, 2001, Pages 540-545

  Allen, A ^a   Bygate, E ^a   Vousden, M ^a   Oliver, S ^a   Johnson, M ^a   Ward, C ^a   Cheon, A J ^a   Youn Sung Choo, ^a   Kim, I C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GEMIFLOXACIN;

ADULT; ANTIBACTERIAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CLINICAL CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG POTENCY; DRUG SAFETY; DRUG TOLERABILITY; DRUG URINE LEVEL; ELECTROCARDIOGRAM; HEMATOLOGY; HUMAN; HUMAN EXPERIMENT; KIDNEY CLEARANCE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; SIDE EFFECT; URINARY TRACT INFECTION;

ADULT; ANTI-INFECTIVE AGENTS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOUBLE-BLIND METHOD; FLUOROQUINOLONES; HALF-LIFE; HUMANS; MALE; MASS SPECTROMETRY; NAPHTHYRIDINES;

EID: 0035142088     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.2.540-545.2001     Document Type: Article

References (8)

1. Tolerability of fluoroquinolone antibiotics
2. Antimicrobial activity and spectrum of LB 20304, a novel fluoronaphthyridone
3. International multicenter investigation of LB20304, a new fluoronaphthyridone
4. Anti-streptococcal activity of SB-265805 (LB20304), a novel fluoronaphthyridone, compared with five other compounds, including quality control guidelines
5. In vitro and in vivo evaluations of LB20304, a new fluoronaphthyridone
6. Ciprofloxacin: Review of potential toxicologic effects
7. Norfloxacin disposition after sequentially increasing oral doses
8. Crystalluria and ciprofloxacin, influence of urinary pH and hydration