Neisseria gonorrhoeae NspA induces specific bactericidal and opsonic antibodies in mice

Clinical and Vaccine Immunology

Volumn 18, Issue 11, 2011, Pages 1817-1822

  Li, Guocai ^a   Jiao, Hongmei ^a   Jiang, Guihua ^a   Wang, Jing ^a   Zhu, Litian ^a   Xie, Rushan ^a   Yan, Hua ^a   Chen, Hongju ^a   Ji, Mingchun ^a  

^a YANGZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIUM ANTIBODY; DNA VACCINE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; NEISSERIA GONORRHOEAE SURFACE PROTEIN A; OPSONIN; SECRETORY IMMUNOGLOBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DNA IMMUNIZATION; DRUG DEVELOPMENT; FEMALE; GONORRHEA; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOSTIMULATION; MOUSE; NEISSERIA GONORRHOEAE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; VAGINA DISCHARGE;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL VACCINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; IMMUNIZATION, SECONDARY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INJECTIONS, INTRAMUSCULAR; MICE; MICE, INBRED BALB C; NEISSERIA GONORRHOEAE; OPSONIN PROTEINS; VACCINES, DNA; VAGINA;

EID: 80455179697     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.05245-11     Document Type: Article

References (48)

1. Abdulhaqq, S. A., and D. B. Weiner. 2008. DNA vaccines: developing new strategies to enhance immune responses. Immunol. Res. 42:219-232.
2. Balmelli, C., et al. 1998. Nasal immunization of mice with human papillomavirus type 16 virus-like particles elicits neutralizing antibodies in mucosal secretions. J. Virol. 72:8220-8229. (Pubitemid 28421819)
3. Barh, D., and A. Kumar. 2009. In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae. In Silico Biol. 9:225-231.
4. Beernink, P. T., et al. 2011. A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination. J. Immunol. 186:3606-3614.
5. Blake, M. S., and L. M. Wetzler. 1995. Vaccines for gonorrhea: where are we on the curve? Trends Microbiol. 3:469-474.
6. Cadieux, N., et al. 1999. Bactericidal and cross-protective activities of a monoclonal antibody directed against Neisseria meningitidis NspA outer membrane protein. Infect. Immun. 67:4955-4959. (Pubitemid 29400491)
7. Canessa, C., S. Vierucci, C. Azzari, and A. Vierucci. 2010. The immunity of upper airways. Int. J. Immunopathol. Pharmacol. 23:8-12.
8. Cartwright, C. P., F. Stock, and V. J. Gill. 1994. Improved enrichment broth for cultivation of fastidious organisms. J. Clin. Microbiol. 32:1825-1826. (Pubitemid 24189586)
9. Cole, J. G., and A. E. Jerse. 2009. Functional characterization of antibodies against Neisseria gonorrhoeae opacity protein loops. PLoS One 4:e8108.
10. Furuya, R., and M. Tanaka. 2009. Neisseria gonorrhoeae infections. Nihon Rinsho 67:129-135. [In Japanese.]
11. Gallichan, W. S., et al. 2001. Intranasal immunization with CpG oligodeoxy-nucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract. J. Immunol. 166:3451-3457. (Pubitemid 33117348)
12. Giuntini, S., D. C. Reason, and D. M. Granoff. 2011. Complement-mediated bactericidal activity of anti-factor H binding protein monoclonal antibodies against the meningococcus relies upon blocking factor H binding. Infect. Immun. 79:3751-3759.
13. Gulati, S., J. Ngampasutadol, R. Yamasaki, D. P. McQuillen, and P. A. Rice. 2001. Strategies for mimicking neisserial saccharide epitopes as vaccines. Int. Rev. Immunol. 20:229-250. (Pubitemid 33119078)
14. Halperin, S. A., et al. 2007. Phase 1 first-in-human studies of the reactogenicity and immunogenicity of a recombinant meningococcal NspA vaccine in healthy adults. Vaccine 25:450-457. (Pubitemid 44856095)
15. Heckels, J. E., M. Virji, and C. R. Tinsley. 1990. Vaccination against gonorrhoea: the potential protective effect of immunization with a synthetic peptide containing a conserved epitope of gonococcal outer membrane protein IB. Vaccine 8:225-230. (Pubitemid 20198854)
16. Hedges, S. R., D. A. Sibley, M. S. Mayo, E. R. Hook, and M. W. Russell. 1998. Cytokine and antibody responses in women infected with Neisseria gonorrhoeae: effects of concomitant infections. J. Infect. Dis. 178:742-751. (Pubitemid 28397222)
17. Hou, V. C., G. R. Moe, Z. Raad, T. Wuorimaa, and D. M. Granoff. 2003. Conformational epitopes recognized by protective anti-neisserial surface protein A antibodies. Infect. Immun. 71:6844-6849. (Pubitemid 37475313)
18. Ichinohe, T., et al. 2010. Induction of cross-protective immunity against influenza A virus H5N1 by an intranasal vaccine with extracts of mushroom mycelia. J. Med. Virol. 82:128-137.
19. Ingolotti, M., O. Kawalekar, D. J. Shedlock, K. Muthumani, and D. B. Weiner. 2010. DNA vaccines for targeting bacterial infections. Expert Rev. Vaccines 9:747-763.
20. Ji, M., and H. Chen. 2004. Cloning the NspA gene of Neisseria gonorrhoeae and its expression in eukaryotic cells. Acta Microbiol. Sin. 44:104-106.
21. Johnson, S. C., et al. 1991. Human immunization with Pgh 3-2 gonococcal pilus results in cross-reactive antibody to the cyanogen bromide fragment-2 of pilin. J. Infect. Dis. 163:128-134.
22. Kanazawa, T., et al. 2010. Local gene expression and immune responses of vaginal DNA vaccination using a needle-free injector. Int. J. Pharm. 396:11-16.
23. Klotman, M. E., et al. 2008. Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission. J. Immunol. 180:6176-6185.
24. Kwant, A., and K. L. Rosenthal. 2004. Intravaginal immunization with viral subunit protein plus CpG oligodeoxynucleotides induces protective immunity against HSV-2. Vaccine 22:3098-3104. (Pubitemid 39037213)
25. Lewis, L. A., et al. 2010. The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement. PLoS Pathog. 6:e1001027.
26. Madico, G., et al. 2006. The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance. J. Immunol. 177:501-510. (Pubitemid 43939163)
27. Martin, D., et al. 2000. Candidate Neisseria meningitidis NspA vaccine. J. Biotechnol. 83:27-31.
28. Martin, D., N. Cadieux, J. Hamel, and B. R. Brodeur. 1997. Highly conserved Neisseria meningitidis surface protein confers protection against experimental infection. J. Exp. Med. 185:1173-1183. (Pubitemid 27172898)
29. Matsuka, Y. V., D. A. Dilts, S. Hoiseth, and R. Arumugham. 1998. Characterization of a subunit structure and stability of the recombinant porin from Neisseria gonorrhoeae. J. Protein Chem. 17:719-728. (Pubitemid 28554854)
30. Mestecky, J., and P. N. Fultz. 1999. Mucosal immune system of the human genital tract. J. Infect. Dis. 179(Suppl. 3):S470-S474. (Pubitemid 29198401)
31. Moe, G. R., P. Zuno-Mitchell, S. S. Lee, A. H. Lucas, and D. M. Granoff. 2001. Functional activity of anti-neisserial surface protein A monoclonal antibodies against strains of Neisseria meningitidis serogroup B. Infect. Immun. 69:3762-3771. (Pubitemid 32493295)
32. Moe, G. R., S. Tan, and D. M. Granoff. 1999. Differences in surface expression of NspA among Neisseria meningitidis group B strains. Infect. Immun. 67:5664-5675. (Pubitemid 29508084)
33. Ngampasutadol, J., P. A. Rice, M. T. Walsh, and S. Gulati. 2006. Characterization of a peptide vaccine candidate mimicking an oligosaccharide epitope of Neisseria gonorrhoeae and resultant immune responses and function. Vaccine 24:157-170. (Pubitemid 41753003)
34. Park, H. S., K. P. Francis, J. Yu, and P. P. Cleary. 2003. Membranous cells in nasal-associated lymphoid tissue: a portal of entry for the respiratory mucosal pathogen group A streptococcus. J. Immunol. 171:2532-2537. (Pubitemid 37025563)
35. Pellati, D., et al. 2008. Genital tract infections and infertility. Eur. J. Obstet. Gynecol. Reprod. Biol. 140:3-11.
36. Plante, M., et al. 2000. Intranasal immunization with gonococcal outer membrane preparations reduces the duration of vaginal colonization of mice by Neisseria gonorrhoeae. J. Infect. Dis. 182:848-855.
37. Plante, M., et al. 1999. Antigenic and molecular conservation of the gonococcal NspA protein. Infect. Immun. 67:2855-2861. (Pubitemid 29244700)
38. Price, G. A., M. M. Hobbs, and C. N. Cornelissen. 2004. Immunogenicity of gonococcal transferrin binding proteins during natural infections. Infect. Immun. 72:277-283. (Pubitemid 38018186)
39. Price, G. A., M. W. Russell, and C. N. Cornelissen. 2005. Intranasal administration of recombinant Neisseria gonorrhoeae transferrin binding proteins A and B conjugated to the cholera toxin B subunit induces systemic and vaginal antibodies in mice. Infect. Immun. 73:3945-3953. (Pubitemid 40923133)
40. Sambrook, J., and D. W. Russell. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
41. Takei, M., Y. Yamaguchi, H. Fukuda, M. Yasuda, and T. Deguchi. 2005. Cultivation of Neisseria gonorrhoeae in liquid media and determination of its in vitro susceptibilities to quinolones. J. Clin. Microbiol. 43:4321-4327. (Pubitemid 41298208)
42. Tapsall, J. W. 2009. Neisseria gonorrhoeae and emerging resistance to extended spectrum cephalosporins. Curr. Opin. Infect. Dis. 22:87-91.
43. Thacker, E. L., B. J. Thacker, M. Kuhn, P. A. Hawkins, and W. R. Waters. 2000. Evaluation of local and systemic immune responses induced by intramuscular injection of a Mycoplasma hyopneumoniae bacterin to pigs. Am. J. Vet. Res. 61:1384-1389.
44. Thomas, C. E., et al. 2006. Vaccination of mice with gonococcal TbpB expressed in vivo from Venezuelan equine encephalitis viral replicon particles. Infect. Immun. 74:1612-1620. (Pubitemid 43346794)
45. Wetzler, L. M., M. S. Blake, K. Barry, and E. C. Gotschlich. 1992. Gonococcal porin vaccine evaluation: comparison of Por proteosomes, liposomes, and blebs isolated from rmp deletion mutants. J. Infect. Dis. 166:551-555.
46. World Health Organization. 2001. Global prevalence and incidence of selected curable sexually transmitted infections: overview and estimates. World Health Organization, Geneva, Switzerland. http://www.who.int/hiv/pub/sti/who- hiv-aids-2001.02.pdf.
47. Zhu, W., et al. 2005. Comparison of immune responses to gonococcal PorB delivered as outer membrane vesicles, recombinant protein, or Venezuelan equine encephalitis virus replicon particles. Infect. Immun. 73:7558-7568. (Pubitemid 41587662)
48. Zhu, W., C. E. Thomas, and P. F. Sparling. 2004. DNA immunization of mice with a plasmid encoding Neisseria gonorrhea PorB protein by intramuscular injection and epidermal particle bombardment. Vaccine 22:660-669. (Pubitemid 38114896)