Mucosal immune system of the human genital tract

Journal of Infectious Diseases

Volumn 179, Issue SUPPL. 3, 1999, Pages

  Mestecky, Jiri ^a   Fultz, Patricia N ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; SECRETORY IMMUNOGLOBULIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIBODY RESPONSE; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; GENITAL SYSTEM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; MUCOSAL IMMUNITY; PLASMA CELL; PRIORITY JOURNAL; SEXUALLY TRANSMITTED DISEASE;

FEMALE; GENITALIA; HIV ANTIBODIES; HIV INFECTIONS; HUMANS; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A, SECRETORY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MALE; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0032896758     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314806     Document Type: Conference Paper

References (58)

1. 1. Alexander NJ, Gabelnick HL, Spieler JM. Heterosexual transmission of AIDS. New York: Wiley-Liss, 1990.
2. 2. Haynes BF, Pantaleo G, Fauci AS. Toward an understanding of the correlates of protective immunity to HIV infection. Science 1996; 271:324-8.
3. 3. Ljunggren HG, Thorpe CJ. Principles of MHC class I-mediated antigen presentation and T cell selection. Histol Histopathol 1996; 11:267-74.
4. 4. Parr MB, Parr EL. Mucosal immunity in the female and male reproductive tracts. In: Ogra PL, Mestecky J, Lamm ME, et al., eds. Handbook of mucosal immunology. San Diego: Academic Press, 1994:677-89.
5. 5. Morrison RP. Immune protection against Chlamydia trachomatis in females. Infect Dis Obstet Gynecol 1996; 4:163-70.
6. 6. Zinkernagel RM, Hengartner H. Antiviral immunity. Immunol Today 1997; 18:258-60.
7. 7. Borrow P, Lewicki H, Wei X, et al. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat Med 1997; 3:205-11.
8. 8. Connick E, Marr DG, Zhang XQ, et al. HIV-specific cellular and humoral immune responses in primary HIV infection. AIDS Res Hum Retroviruses 1996; 12:1129-40.
9. 9. Baum LL, Cassutt KJ, Knigge K, et al. HIV-1 gp120-specific antibody-dependent cell-mediated cytotoxicity correlates with rate of disease progression. J Immunol 1996; 157:2168-73.
10. 10. Lathey JL, Pratt RD, Spector SA. Appearance of autologous neutralizing antibody correlates with reduction in viral load and phenotype switch during primary infection with human immunodeficiency virus type 1. J Infect Dis 1997; 175:231-2.
11. 11. Mazzoli S, Trabattoni D, Lo Caputo S, et al. HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals. Nat Med 1997; 3:1250-7.
12. 12. Alley CD, Mestecky J. The mucosal immune system. In: Bird G, Calvert JE, eds. B lymphocytes in human disease. Oxford, UK: Oxford University Press, 1988:222-54.
13. 13. Mestecky J, Lue C, Russell MW. Selective transport of IgA. Cellular and molecular aspects. Gastroenterol Clin North Am 1991; 20:441-71.
14. 14. Kilian M, Russell MW. Function of mucosal immunoglobulins. In: Ogra PL, Mestecky J, Lamm ME, et al., eds. Handbook of mucosal immunology. San Diego: Academic Press, 1994:127-37.
15. 15. Kutteh WH, Mestecky J. Concept of mucosal immunology. In: Bronson RA, Alexander NJ, Anderson DJ, Branch DW, Kutteh, WH, eds. Reproductive immunology. Cambridge, MA: Blackwell Science, 1996:28-51.
16. 16. Wira CR, Richardson J, Prabhala R. Exocrine regulation of mucosal immunity: effect of sex hormones and cytokines on the afferent and efferent arms of the immune system in the female reproductive tract. In: Ogra PL, Mestecky J, Lamm ME, et al., eds. Handbook of mucosal immunology. San Diego: Academic Press, 1994:705-18.
17. 17. Pudney J, Quayle AJ. Hormonal regulation of mucosal immunity in the male reproductive tract. Mucosal Immunol Update 1995; 3:12-5.
18. 18. Mestecky J, Lue C, Tarkowski A ,et al. Comparative studies of the biological properties of human IgA subclasses. In: Poulik MD, ed. Protides biological fluids. Oxford, UK: Pergamon Press, 1989; 36:173-82.
19. 19. Kutteh WH, Hatch KD, Blackwell RE, Mestecky J. Secretory immune system of the female reproductive tract: I. Immunoglobulin and secretory component-containing cells. Obstet Gynecol 1988; 71:56-60.
20. 20. Kutteh WH, Prince SJ, Hammonds KR, Kutteh CC, Mestecky J. Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation. Clin Exp Immunol 1996; 104:538-42.
21. 21. Crowley-Nowick PA, Bell M, Edwards RP, et al. Normal uterine cervix: characterization of isolated lymphocyte phenotypes and immunoglobulin secretion. Am J Reprod Immunol 1995; 34:241-7.
22. 22. Mestecky J, Edwards RP, Crowley-Nowick PA, Pitts AM, Kutteh WH. Distribution of immunoglobulins in human vaginal mucosa [abstract 25]. Conference on Advances in AIDS Vaccine Development. Eighth Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS, Bethesda, MD, 1996:145.
23. 23. Schultze HE, Heremans JF. The proteins of genital secretions. In: Molecular biology of human proteins. Amsterdam: Elsevier, 1966:848-59.
24. 24. Friberg J. Immunoglobulin concentration in serum and seminal fluid from men with and without sperm-agglutinating antibodies. Am J Obstet Gynecol 1980; 136:671-5.
25. 25. Rumke P. The origin of immunoglobulins in semen. Clin Exp Immunol 1974; 17:287-97.
26. 26. Uehling DT. Secretory IgA in seminal fluid. Fertil Steril 1971; 22:769-73.
27. 27. Kearns DH, O'Reilly RJ, Lee L, Welch BG. Secretory IgA antibodies in the urethral exudate of men with uncomplicated urethritis due to Neisseria gonorrhoeae. J Infect Dis 1973; 127:99-101.
28. 28. Soliman HA, Olesen H. Concentration of the secretory IgA of seminal fluid in normal subjects, in decreased fertility and in aspermia. Clin Chim Acta 1976; 69:543-4.
29. 29. Fowler JE, Mariano M. Immunoglobulin in seminal fluid of fertile, infertile, vasectomy and vasectomy reversal patients. J Urol 1983; 129:869-72.
30. 30. Tauber PF, Zaneveld LJD, Propping D, Schumacher GFB. Components of human split ejaculates. J Reprod Fertil 1975; 43:249-67.
31. 31. Tjokronegoro A, Sirisinha S. Degradation of immunoglobulins by secretions of human reproductive tract. J Reprod Fertil 1974; 38:221-5.
32. 32. Pudney J, Anderson DJ. Immunobiology of the human penile urethra. Am J Pathol 1995; 147:155-65.
33. 33. Brandtzaeg P, Cristiansen E, Muller F, Pruvis K. Humoral immune response patterns of human mucosae, including the reproductive tract. In: Griffin PD, Johnson PM, eds. Local immunity in reproductive tract tissues. Delhi, India: Oxford University Press, 1993:97-130.
34. 34. Anderson DJ, Pudney J. Mucosal immune defense against HIV-1 in the male urogenital tract. Vaccine Res 1992; 1:143-50.
35. 35. Perra MT, Turno F, Sirigu P. Human urethral epithelium: immunohistochemical demonstration of secretory IgA. Arch Androl 1994; 32:227-33.
36. 36. Phillips-Quagliata JM, Lamm ME. Migration of lymphocytes in the mucosal immune system. In: Husband AJ, ed. Migration and homing of lymphoid cells. Boca Raton, FL: CRC Press, 1988:53-75.
37. 37. Scicchitano R, Stanisz A, Ernst PB, Bienenstock J. A common mucosal immune system revisited. In: Husband AJ, ed. Migration and homing of lymphoid cells. Boca Raton, FL: CRC Press, 1988:1-34.
38. 38. McGhee JR, Mestecky J, Elson CO, Kiyono H. Regulation of IgA synthesis and immune response by T cells and interleukins. J Clin Immunol 1989; 9: 175-99.
39. 39. McGhee JR, Mestecky J, Dertzbaugh MT, Eldridge JH, Hirasawa M, Kiyono H. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine 1992; 10:75-88.
40. 40. Brandtzaeg P. Immune functions of human nasal mucosa and tonsils in health. In: Bienenstock J, ed. Immunology of the lung and upper respiratory tract. New York: McGraw-Hill, 1984:28-95.
41. 41. Bergquist C, Johansson EL, Lagergard T, Holmgren J, Rudin A. Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina. Infect Immun 1997; 65:2676-84.
42. 42. Di Tommaso A, Saletti G, Pizza M, et al. Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant. Infect Immun 1996; 64:974-9.
43. 43. Gallichen WS, Rosenthal KL. Specific secretory immune responses in the female genital tract following intranasal immunization with a recombinant adenovirus expressing glycoprotein B of herpes simplex virus. Vaccine 1995; 13:1589-95.
44. 44. Lubeck MD, Natuk RJ, Chengalvala M, et al. Immunogenicity of recombinant adenovirus human immunodeficiency virus vaccines in chimpanzees following intranasal administration. AIDS Res Hum Retroviruses 1994; 10:1443-9.
45. 45. Pal S, Peterson EM, de la Maza LM. Intranasal immunization induces long-term protection in mice against a Chlamydia trachomatis genital challenge. Infect Immun 1996; 64:5341-8.
46. 46. Russell MW, Moldoveanu Z, White PL, Sibert GJ, Mestecky J, Michalek SM. Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunit. Infect Immun 1996; 64:1272-82.
47. 47. Staats HF, Nichols WG, Palker TJ. Systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10 MN(A). J Immunol 1996; 157:462-72.
48. 48. Langman JM, Rowland R. The number and distribution of lymphoid follicles in the human large intestine. J Anat 1986; 149:189-94.
49. 49. O'Leary AD, Sweeney EC. Lympho-glandular complexes of the colon: structure and distribution. Histopathology 1986; 10:267-83.
50. 50. Lehner T. Panagiotidi C, Bergmeier LA, Ping T, Brooks R, Adams SE. A comparison of the immune response following oral, vaginal, or rectal route of immunization with SIV antigens in nonhuman primates. Vaccine Res 1992; 1:319-30.
51. 51. Lehner T, Brookes R, Panagiotidi C, et al. T-and B-cell functions and epitope expression in nonhuman primates immunized with simian immunodeficiency viral antigen by the rectal route. Proc Natl Acad Sci USA 1993; 90:8638-42.
52. 52. Crowley-Nowick PA, Bell MC, Brockwell R, et al. Rectal immunization for induction of specific antibody in the genital tract of women. J Clin Immunol 1997; 17:370-9.
53. 53. Nardelli-Haefliger D, Krahenbuhl JP, Curtiss R III, et al. Oral and rectal immunization of adult female volunteers with a recombinant attenuated Salmonella typhi vaccine strain. Infect Immun 1996; 64:5219-24.
54. 54. Hordnes K, Tynning T, Kvam AI, Jonsson R, Haneberg B. Colonization in the rectum and uterine cervix with group B streptococci may induce specific antibody responses in cervical secretions of pregnant women. Infect Immun 1996; 64:1643-52.
55. 55. Kozlowski PA, Cu-Uvin S, Neutra MR, Flanigan TP. Comparison of the oral, rectal, and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women. Infect Immun 1997; 65: 1387-94.
56. 56. Hopkins S, Krahenbuhl JP, Schodel F, et al. A recombinant Salmonella typhimurium vaccine induces local immunity by four different routes of immunization. Infect Immun 1995; 63:3279-86.
57. 57. Thapar MA, Parr EL, Parr MB. Secretory immune response in mouse vaginal fluid after pelvic, parenteral or vaginal immunization. Immunology 1990; 70:121-5.
58. 58. Marx PA, Compans RW, Gettie A, et al. Protection against vaginal SIV transmission with microencapsulated vaccine. Science 1993; 260:1323-7.