Transfusion of leukocyte-depleted red blood cells is not a risk factor for nosocomial infections in critically ill children

Pediatric Critical Care Medicine

Volumn 12, Issue 5, 2011, Pages 519-524

  Van Der Wal, Judith ^a   Van Heerde, Marc ^a   Markhorst, Dick G ^a,b   Kneyber, Martin C J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Critically ill children; Nosocomial infection; Outcome assessment (healthcare); RBC transfusions

Indexed keywords

ANTIBIOTIC AGENT;

ARTICLE; ARTIFICIAL VENTILATION; BLOODSTREAM INFECTION; CENTRAL VENOUS CATHETER; CHILD; COHORT ANALYSIS; CRITICALLY ILL PATIENT; ERYTHROCYTE TRANSFUSION; FEMALE; GENDER; HOSPITAL ADMISSION; HOSPITAL INFECTION; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SCORING SYSTEM; URINARY TRACT INFECTION; VENTILATOR ASSOCIATED PNEUMONIA;

EID: 80455178543     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181fe4282     Document Type: Article

References (43)

1. Armano R, Gauvin F, Ducruet T, et al: Determinants of red blood cell transfusions in a pediatric critical care unit: A prospective, descriptive epidemiological study. Crit Care Med 2005; 33:2637-2644 (Pubitemid 41682119)
2. Nahum E, Ben Ari J, Schonfeld T: Blood transfusion policy among European pediatric intensive care physicians. J Intensive Care Med 2004; 19:38-43 (Pubitemid 44544712)
3. Bateman ST, Lacroix J, Boven K, et al: Anemia, blood loss, and blood transfusions in North American children in the intensive care unit. Am J Respir Crit Care Med 2008; 178:26-33 (Pubitemid 351919190)
4. Kneyber MC, Hersi MI, Twisk JW, et al: Red blood cell transfusion in critically ill children is independently associated with increased mortality. Intensive Care Med 2007; 33: 1414-1422 (Pubitemid 47101723)
5. Markhorst DG, Kneyber MC: Should critically ill patients be routinely transfused to a normal haemoglobin level? Arch Dis Child 2007; 92:1038-1039 (Pubitemid 350043986)
6. Goodman AM, Pollack MM, Patel KM, et al: Pediatric red blood cell transfusions increase resource use. J Pediatr 2003; 142:123-127 (Pubitemid 36232899)
7. Lacroix J, Hebert PC, Hutchison JS, et al: Transfusion strategies for patients in pediatric intensive care units. N Engl J Med 2007; 356:1609-1619 (Pubitemid 46631670)
8. Rouette J, Trottier H, Ducruet T, et al: Red blood cell transfusion threshold in postsurgical pediatric intensive care patients: A randomized clinical trial. Ann Surg 2010; 251: 421-427
9. Willems A, Harrington K, Lacroix J, et al: Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: A subgroup analysis. Crit Care Med 2010; 38: 649-656
10. Gauvin F, Spinella PC, Lacroix J, et al: Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion 2010 Apr 30 [Epub ahead of print]
11. Karam O, Tucci M, Bateman ST, et al: Association between length of storage of red blood cell units and outcome of critically ill children: A prospective observational study. Crit Care 2010; 14:R57
12. Kneyber MC, Gazendam RP, Markhorst DG, et al: Length of storage of red blood cells does not affect outcome in critically ill children. Intensive Care Med 2009; 35:179-180
13. Moore FA, Moore EE, Sauaia A: Blood transfusion. An independent risk factor for postinjury multiple organ failure. Arch Surg 1997; 132:620-624
14. Silliman CC, Moore EE, Johnson JL, et al: Transfusion of the injured patient: Proceed with caution. Shock 2004; 21:291-299
15. Vamvakas EC, Blajchman MA: Deleterious clinical effects of transfusion-associated immunomodulation: Fact or fiction? Blood 2001; 97:1180-1195 (Pubitemid 32183738)
16. Bochicchio GV, Napolitano L, Joshi M, et al: Blood product transfusion and ventilatorassociated pneumonia in trauma patients. Surg Infect (Larchmt) 2008; 9:415-422
17. Elward AM, Fraser VJ: Risk factors for nosocomial primary bloodstream infection in pediatric intensive care unit patients: A 2-year prospective cohort study. Infect Control Hosp Epidemiol 2006; 27:553-560 (Pubitemid 44023389)
18. Shorr AF, Jackson WL, Kelly KM, et al: Transfusion practice and blood stream infections in critically ill patients. Chest 2005; 127:1722-1728 (Pubitemid 46218801)
19. Taylor RW, O'Brien J, Trottier SJ, et al: Red blood cell transfusions and nosocomial infections in critically ill patients. Crit Care Med 2006; 34:2302-2308 (Pubitemid 44260013)
20. Jeschke MG, Chinkes DL, Finnerty CC, et al: Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients. Crit Care Med 2007; 35:579-583 (Pubitemid 46148551)
21. White M, Barron J, Gornbein J, et al: Are red blood cell transfusions associated with nosocomial infections in pediatric intensive care units? Pediatr Crit Care Med 2010; 11: 464-468
22. Marik PE, Corwin HL: Efficacy of red blood cell transfusion in the critically ill: A systematic review of the literature. Crit Care Med 2008; 36:2667-2674
23. Pollack MM, Ruttimann UE, Getson PR: Pediatric Risk of Mortality (PRISM) score. Crit Care Med 1988; 16:1110-1116 (Pubitemid 18267293)
24. Shann F, Pearson G, Slater A, et al: Paediatric Index of Mortality (PIM): A mortality prediction model for children in intensive care. Intensive Care Med 1997; 23:201-207 (Pubitemid 27110398)
25. Miranda DR, de Rijk A, Schaufeli W: Simplified Therapeutic Intervention Scoring System: The TISS-28 items-Results from a multicenter study. Crit Care Med 1996; 24: 64-73
26. Garner JS, Jarvis WR, Emori TG, et al: CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988; 16:128-140
27. Normand SL, Sykora K, Li P, et al: Readers guide to critical appraisal of cohort studies: Analytical strategies to reduce confounding. BMJ 2005; 330:1021-1023 (Pubitemid 40604289)
28. Goncalves de Mello MJ, de Fatima Pessoa Militao de Albuquerque M, Lacerda HR, et al: Risk factors for healthcare-associated infection in a pediatric intensive care unit. Pediatr Crit Care Med 2010; 11:246-252
29. Mireya UA, Marti PO, Xavier KV, et al: Nosocomial infections in paediatric and neonatal intensive care units. J Infect 2007; 54: 212-220
30. de Jonge RC, Polderman KH, Gemke RJ: Central venous catheter use in the pediatric patient: Mechanical and infectious complications. Pediatr Crit Care Med 2005; 6:329-339 (Pubitemid 40724286)
31. Singh-Naz N, Sprague BM, Patel KM, et al: Risk assessment and standardized nosocomial infection rate in critically ill children. Crit Care Med 2000; 28:2069-2075 (Pubitemid 30428776)
32. Singh-Naz N, Sprague BM, Patel KM, et al: Risk factors for nosocomial infection in critically ill children: A prospective cohort study. Crit Care Med 1996; 24:875-878 (Pubitemid 26155734)
33. Gilio AE, Stape A, Pereira CR, et al: Risk factors for nosocomial infections in a critically ill pediatric population: A 25-month prospective cohort study. Infect Control Hosp Epidemiol 2000; 21:340-342
34. Odetola FO, Moler FW, Dechert RE, et al: Nosocomial catheter-related bloodstream infections in a pediatric intensive care unit: Risk and rates associated with various intravascular technologies. Pediatr Crit Care Med 2003; 4:432-436
35. Fayon MJ, Tucci M, Lacroix J, et al: Nosocomial pneumonia and tracheitis in a pediatric intensive care unit: A prospective study. Am J Respir Crit Care Med 1997; 155:162-169 (Pubitemid 27053158)
36. Elward AM, Warren DK, Fraser VJ: Ventilator- associated pneumonia in pediatric intensive care unit patients: Risk factors and outcomes. Pediatrics 2002; 109:758-764 (Pubitemid 34493339)
37. Yogaraj JS, Elward AM, Fraser VJ: Rate, risk factors, and outcomes of nosocomial primary bloodstream infection in pediatric intensive care unit patients. Pediatrics 2002; 110: 481-485 (Pubitemid 34976674)
38. Richards MJ, Edwards JR, Culver DH, et al: Nosocomial infections in medical intensive care units in the United States National Nosocomial Infections Surveillance System. Crit Care Med 1999; 27:887-892 (Pubitemid 29266004)
39. Corwin HL, AuBuchon JP: Is leukoreduction of blood components for everyone? JAMA 2003; 289:1993-1995 (Pubitemid 37430233)
40. Vincent JL, Piagnerelli M: Transfusion in the intensive care unit. Crit Care Med 2006; 34: S96-S101 (Pubitemid 43670473)
41. Hebert PC, Tinmouth A, Corwin HL: Controversies in RBC transfusion in the critically ill. Chest 2007; 131:1583-1590 (Pubitemid 46762372)
42. Concato J, Feinstein AR: Monte Carlo methods in clinical research: Applications in multivariable analysis. J Investig Med 1997; 45: 394-400 (Pubitemid 127454849)
43. Little RJ, Rubin DB: Causal effects in clinical and epidemiological studies via potential outcomes: Concepts and analytical approaches. Annu Rev Public Health 2000; 21: 121-145 (Pubitemid 30480319)