Risk factors for nosocomial primary bloodstream infection in pediatric intensive care unit patients: A 2-year prospective cohort study

Infection Control and Hospital Epidemiology

Volumn 27, Issue 6, 2006, Pages 553-560

  Elward, Alexis M ^a,b   Fraser, Victoria J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST LOUIS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CENTRAL VENOUS CATHETER; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE CONTROL; DISEASE SEVERITY; ERYTHROCYTE; FEMALE; GENETIC DISORDER; GRAM POSITIVE BACTERIUM; HOSPITAL ADMISSION; HOSPITAL INFECTION; HUMAN; INTENSIVE CARE; MALE; MEDICAL CARE; MULTIPLE REGRESSION; PREDICTION; PRESCHOOL CHILD; PROSPECTIVE STUDY; RISK FACTOR; SCHOOL CHILD; VALIDITY;

ADOLESCENT; BACTEREMIA; CATHETERIZATION; CATHETERIZATION, CENTRAL VENOUS; CATHETERIZATION, PERIPHERAL; CHILD; CHILD, PRESCHOOL; CROSS INFECTION; ERYTHROCYTE TRANSFUSION; FEMALE; HOSPITALS, TEACHING; HUMANS; INFANT; INFANT, NEWBORN; INTENSIVE CARE UNITS, PEDIATRIC; MALE; MISSOURI; PROSPECTIVE STUDIES; RISK FACTORS; STAPHYLOCOCCAL INFECTIONS;

EID: 33745767988     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/505096     Document Type: Article

References (36)

1. Milliken J, Tait GA, Ford-Jones EL, et al. Nosocomial infections in a pediatric intensive care unit. Crit Care Med 1988; 16:233-237.
2. Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in the pediatric intensive care units in the United States. National Nosocomial Infections Surveillance System. Pediatrics 1999; 103:e39.
3. Grohskopf LA, Sinkowitz-Cochran RL, Garrett DO, et al. A national point-prevalence survey of pediatric intensive care unit-acquired infections in the United States. J Pediatr 2002; 140:432-438.
4. Yogaraj JS, Elward AM, Fraser VJ. Rate, risk factors and outcomes of nosocomial primary bloodstream infection in pediatric intensive care unit patients. Pediatrics 2002; 110:481-485.
5. Pierce CM, Wade A, Mok Q. Heparin-bonded central venous lines reduce thrombotic and infective complications in critically ill children. Intensive Care Med 2000; 26:967-972.
6. Gray J, Gossain S, Morno K. Three-year survey of bacteremias and fungemia in a pediatric intensive care unit. Pediatr Infect Dis J 2001; 20: 416-421.
7. Stover BH, Shulman ST, Bratcher DF, Brady MT, Levine GL, Jarvis WR. Nosocomial infection rates in US children's hospitals' neonatal and pediatric intensive care units. Am J Infect Control 2001; 29:152-157.
8. Urrea M, Pons M, Serra M, Latorre C, Palomeque A. Prospective incidence study of nosocomial infections in a pediatric intensive care unit. Pediatr Infect Dis J 2003; 22:490-494.
9. The Centers for Disease Control and Prevention. Monitoring hospital-acquired infections to promote patient safety-United States, 1990-1999. MMWR Morb Mortal Wkly Rep 2000; 49:149-153
10. [published correction appears in MMWR Morb Mortal Wkly Rep 2000; 49:189-190].
11. Raymond J, Aujard Y. Nosocomial infections in pediatric patients: a European Multicenter Prospective Study. European Study Group. Infect Control Hosp Epidemiol 2000; 21:260-263.
12. Slonim AD, Kurtines HC, Sprague BM, Singh N. The costs associated with nosocomial bloodstream infections in the pediatric intensive care unit. Pediatr Crit Care Med 2001; 2:170-174.
13. Elward AM, Hollenbeak CS, Warren DK, Fraser VJ. The attributable cost of nosocomial primary bloodstream infection in pediatric intensive care unit patients. Pediatrics 2005; 115:868-872.
14. Dominguez TE, Chalom R, Costarino AT. The impact of adverse patient occurrences on hospital costs in the pediatric intensive care unit. Crit Care Med 2001; 29:169-174.
15. Odetola FO, Moler FW, Dechert RE, VanDerElzen K, Chenoweth C. Nosocomial catheter-related bloodstream infection in a pediatric intensive care unit: risk and rates associated with various intravascular technologies. Pediatr Crit Care Med 2003; 4:432-436.
16. Sing-Naz N, Sprague BM, Patel KM, Pollack M. Risk factors for nosocomial infection in critically ill children: a prospective cohort study. Crit Care Med 1996; 24:875-878.
17. Pollack MM, Patel KM, Ruttimann UE. PRISM III: an updated pediatric risk of mortality score. Crit Care Med 1996; 24:743-752.
18. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definition for nosocomial infections. In: Olmsted RN, ed. Infection Control and Applied Epidemiology: Principle and Practice. St. Louis: Mosby; 1996: A1-A20.
19. Lorente L, Villegas J, Martin M, Jimenez A, Mora M. Catheter-related infection in critically ill patients. Intensive Care Med 2004; 30:1681-1684.
20. Rijnders B, Van Wijngaerden E, Wilmer A, Peetermans W. Use of full sterile barrier precautions during insertion of arterial catheters: a randomized trial. Clin Infect Dis 2003; 36:743-748.
21. Frezza E, Mezghebe H. Indications and complications of arterial catheter use in surgical or medical intensive care units: analysis of 4932 patients. Am Surg 1998; 64:127-131.
22. Furfaro S, Gauthier M, Lacroix J, Nadeau D, Lafleur L, Mathews S. Arterial catheter-related infections in children. Am J Dis Child 1991; 145:1037-1042.
23. Ducharme F, Gauthier M, Lacroix J, Lafleur L. Incidence of infection related to arterial catheterization in children: a prospective study. Crit Care Med 1988; 16:272-276.
24. Niaudet P, Dudley J, Charbit M, Gagnadoux MF, Macleay K, Broyer M. Pretransplant blood transfusions with cyclosporine in pediatric renal transplantation. Pediatr Nephrol 2000; 14:451-456.
25. Opelz G, Sengar DP, Mickey MR, Terasaki PI. Effect of blood transfusions on subsequent kidney transplantations. Transplant Proc 1973; 5:253-259.
26. Van Es AA, Balner H. Effect of pretransplant transfusions on kidney allograft survival. Transplant Proc 1972; 14:608-617.
27. Opelz G, Terasaki PI. Improvement of kidney graft survival with increased numbers of blood transfusions. N Engl J Med 1978; 299:799-803.
28. Opelz G, Varenterghem Y, Kirste G, et al. Prospective evaluation of pretransplant blood transfusions in cadaver kidney recipients. Transplantation 1997; 63:964-967.
29. Park J, Cho K, Johnson J, Perez R. Induction of MIP-1 alpha in Kupffer cell by portal venous transfusion. Transplant Immunology 2004; 13:33-38.
30. Jensen LS, Andersen AJ, Christiansen PM, et al. Postoperative infection and natural killer cell function following blood transfusion inpatients undergoing elective colorectal surgery. Br J Surg 1992; 79:513-516.
31. Mira JP, Cariou A, Grall F, et al. Association of TNF2, a TNF alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study. JAMA 1999; 282:561-568.
32. Arbour NC, Lorenz E, Schutte BC, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000; 25: 187-191.
33. O'Keefe GE, Hybki D, Munford RS. The G to A single nucleotide polymorphism at the -308 position in the tumor necrosis factor alpha promoter increases the risk for severe sepsis after trauma. J Trauma 2002; 52:817-826.
34. Majetschak M, Flobe S, Obertacke U, et al. Relation of TNF gene polymorphism to severe sepsis in trauma patients. Ann Surg 1999; 230:207-214.
35. Gemke RJ, Bonsel GJ, van Vught AJ. Effectiveness and efficiency of a Dutch pediatric intensive care unit: validity and application of the Pediatric Risk of Mortality score. Crit Care Med 1994; 22:1477-1484.
36. van Keulen JG, Gemke RJ, Polderamn KH. Effect of training and strict guidelines on the reliability of risk adjustment systems in paediatric intensive care. Intensive Care Med 2005; 31:1229-1234.