Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR

Oncogene

Volumn 30, Issue 44, 2011, Pages 4509-4522

  Rosner, M ^a   Hengstschlager M ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

localization; mTOR; S6K1; TSC2

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN P31; PROTEIN P70; PROTEIN P85; PROTEIN S6; RAPAMYCIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ARTICLE; CELL CYCLE G1 PHASE; CELL FUNCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TSC2 GENE; TUMOR GENE;

CELL LINE; CELL NUCLEUS; CYTOPLASM; FIBROBLASTS; G1 PHASE; GENE EXPRESSION REGULATION; HUMANS; PHOSPHORYLATION; PROTEIN ISOFORMS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SIROLIMUS; TISSUE DISTRIBUTION; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA;

EID: 80455155177     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.165     Document Type: Article

References (31)

1. Cheatham L, Monfar M, Chou MM, Blenis J. (1995). Structural and functional analysis of pp70S6K. Proc Natl Acad Sci USA 92: 11696-11700.
2. Chiang GG, Abraham RT. (2007). Targeting the mTOR signaling network in cancer. Trends Mol Med 13: 433-442. (Pubitemid 47570021)
3. Coffer PJ, Woodgett JR. (1994). Differential subcellular localization of two isoforms of p70 S6 protein kinase. Biochem Biophys Res Com 198: 780-786.
4. Edelmann HML, Kuhne C, Petritsch C, Ballou LM. (1996). Cell cycle regulation of p70 S6 kinase and p42/p44 mitogen-activated protein kinases in swiss mouse 3T3 fibroblasts. J Biol Chem 271: 963-971. (Pubitemid 26034953)
5. Fenton TR, Gout IT. (2011). Functions and regulation of the 70kDa ribosomal S6 kinases. Int J Biochem Cell Biol 43: 47-59.
6. Hengstschlager M, Bettelheim D, Rosner M, Repa C, Deutinger J, Bernaschek G. (2001). Extended prenatal survival of a non-mosaic trisomy 22 with aneuploid cytotrophoblasts. Prenat Diagn 21: 897-899. (Pubitemid 33064092)
7. Holz MK, Ballif BA, Gygi SP, Blenis J. (2005). mTOR and S6K1 mediate assembly of the translation initiation complex through dynamic interchange and ordered phosphorylation events. Cell 123: 569-580. (Pubitemid 41608461)
8. Kanazawa T, Taneike I, Akaishi R, Yoshizawa F, Furuya N, Fujimura S et al. (2004). Amino acids and insulin control autho-phagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes. J Biol Chem 279: 8452-8459. (Pubitemid 38294738)
9. Karni R, Stanchina E, Lowe SW, Sinha R, Mu D, Krainer AR. (2007). The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol 14: 185-193. (Pubitemid 46355578)
10. Kim D, Akcakanat A, Singh G, Sharma C, Meric-Bernstam F. (2009). Regulation and localization of ribosomal protein S6 kinase 1 isoforms. Growth Factors 27: 12-21.
11. Kim JE, Chen J. (2000). Cytoplasmic-nuclear shuttling of FKBP12-rapamycin associated protein is involved in rapamycin-sensitive signaling and translation initiation. Proc Natl Acad Sci USA 97: 14340-14345. (Pubitemid 32016577)
12. Kim S-J, Kahn CR. (1997). Insulin stimulates p70 S6 kinase in the nucleus of cells. Biochem Biophys Res Com 234: 681-685. (Pubitemid 27281179)
13. Knowles MA, Habuchi T, Kennedy W, Cuthbert-Heavens D. (2003). Mutations spectrum of the 9q34 tuberous sclerosis gene TSC1 in translational cell carcinoma of the bladder. Cancer Res 63: 7652-7656. (Pubitemid 37466691)
14. Meyuhas O, Dreazen A. (2010). Ribosomal protein S6 kinase: from TOP mRNAs to cell size. Progr Mol Biol Translat Sci 90: 109-153.
15. Panasyuk G, Nemazanyy I, Zhyvoloup A, Bretner M, Litchfield DW, Filonenko V et al. (2006). Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at Ser17. J Biol Chem 281: 31188-31201. (Pubitemid 46041384)
16. Plas DR, Thomas G. (2009). Tubers and tumors: rapamycin therapy for benign and malignant tumors. Curr Op Cell Biol 21: 230-236.
17. Reinhard C, Fernandez A, Lamb NJC, Thomas G. (1994). Nuclear localization of p85S6K: functional requirement for entry into S phase. EMBO J 13: 1557-1565.
18. Rosner M, Hengstschlager M. (2008). Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1. Hum Mol Genet 17: 2934-2948.
19. Rosner M, Freilinger A, Hanneder M, Fujita N, Lubec G, Tsuruo T et al. (2007). p27Kip1 localization depends on the tumor suppressor protein tuberin. Hum Mol Genet 16: 1541-1556. (Pubitemid 47050668)
20. Rosner M, Fuchs C, Siegel N, Valli A, Hengstschlager M. (2009). Functional interaction of mammalian target of rapamycin complexes in regulating mammalian cell size and cell cycle. Hum Mol Genet 18: 3298-3310.
21. Rosner M, Siegel N, Fuchs C, Slabina N, Dolznig H, Hengstschlager M. (2010). Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem cells. Nat Protoc 5: 1081-1095.
22. Ruvinsky I, Meyuhas O. (2006). Ribosomal protein S6 phosphory-lation: from protein synthesis to cell size. Trends Biochem Sci 31: 342-346.
23. Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Peled L et al. (2008). The Rag GTPases bind raptor and mediate amino acid signalling to mTORC1. Science 320: 1496-1501. (Pubitemid 351929429)
24. Schalm SS, Blenis J. (2002). Identification of a conserved motif required for mTOR signaling. Curr Biol 12: 632-639. (Pubitemid 34315846)
25. Schalm SS, Tee AR, Blenis J. (2005). Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation. J Biol Chem 280: 11101-11106. (Pubitemid 40418414)
26. Sengupta S, Peterson TR, Sabatini DM. (2010). Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 40: 310-322.
27. Shaw RJ. (2008). mTOR signaling: RAG GTPases transmit the amino acid signal. Trends Biochem Sci 33: 565-568.
28. Shin I, Rotty J, Wu FY, Arteaga CL. (2005). Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry. J Biol Chem 280: 6055-6063. (Pubitemid 40280089)
29. Wang X, Proud CG. (2009). Nutrient control of TORC1, a cell-cycle regulator. Trends Cell Biol 19: 260-267.
30. Weng Q-P, Andrabi K, Kozlowski MT, Grove JR, Avruch J. (1995). Multiple independent inputs are required for activation of the p70 S6 kinase. Mol Cell Biol 15: 2333-2340.
31. Yang Q, Guan K-L. (2007). Expanding mTOR signaling. Cell Res 17: 666-681. (Pubitemid 47255937)