Antidepressants stimulate hippocampal neurogenesis by inhibiting p21 expression in the subgranular zone of the hipppocampus

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Pechnick, Robert N ^a,b   Zonis, Svetlana ^a   Wawrowsky, Kolja ^a   Cosgayon, Rosemarie ^a   Farrokhi, Catherine ^a   Lacayo, Liliana ^a   Chesnokova, Vera ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 1; DESIPRAMINE; FLUOXETINE; IMIPRAMINE; SHORT HAIRPIN RNA; ANTIDEPRESSANT AGENT; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; SEROTONIN UPTAKE INHIBITOR; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DENTATE GYRUS; DRUG MECHANISM; FORCED SWIMMING TEST; HIPPOCAMPAL NEUROGENESIS; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MACROGLIA; MALE; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN SYNTHESIS REGULATION; SUBGRANULAR ZONE; TISSUE SPECIFICITY; WILD TYPE; ANIMAL; C57BL MOUSE; CYTOLOGY; DEPRESSION; DRUG ANTAGONISM; DRUG EFFECT; ENZYME IMMUNOASSAY; FEMALE; GENETICS; METABOLISM; MOUSE MUTANT; NERVE CELL; PHYSIOLOGY; STEM CELL; SWIMMING; WESTERN BLOTTING;

LENTIVIRUS; MUS;

ANIMALS; ANTIDEPRESSIVE AGENTS; BLOTTING, WESTERN; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DEPRESSION; FEMALE; FLUOXETINE; HIPPOCAMPUS; IMIPRAMINE; IMMUNOENZYME TECHNIQUES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; RNA, SMALL INTERFERING; SEROTONIN UPTAKE INHIBITORS; STEM CELLS; SWIMMING;

EID: 80455149918     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027290     Document Type: Article

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